Center for Companion Animal Health
CCAH Supported Research Accomplishments

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up Anesthesia

Dexmedetomidine for balanced anesthesia in cats
Principle Investigators: Bruno Pypendop, Jan Ilkiw, Kristine Siao (2008-2009)

Evaluation of xenon for anesthesia in cats
Principle Investigators: Bruno Pypendop, Jan Ilkiw (2007-2008)

Pharmacokinetics and Anesthetic Effects of Fentanyl in Red-Tailed Hawks
Principle Investigators: Michelle Hawkins, Peter Pascoe, Theresa Baumgartner (2007-2008)

Comparison of the effect of isoflurane and propofol on urodynamics in cats
Principle Investigators: Jodi Westropp, Bruno Pypendop, Todd Cohen (2006-2007)

up Behavior

Support for the Companion Animal Behavior Program
Principle Investigator: Ben Hart (Multiyear)

Effects of catnip and feline facial pheromone on behavioral health of cats
Principle Investigators: Leslie Lyons, Eranda Rajapaksha (2007-2008)

Exploration of the use of antioxidants and mitochondrial cofactors to improve behavioral abnormalities of aging dog. (Matching Funds - AVMF Grant #CON-04-01).
Principle Investigators: Ben Hart, Laurie Bergman (2006-2007)

Effect of anti-anxiety medicines on urine spraying
Principle Investigator: Ben Hart (2001-2002)

up Cancer

Immunohistochemical profiling of feline oral squamous cell carcinoma and correlation with clinical data
Principle Investigators: Katherine Skorupski, Ellen Sparger (2007-2008)

The canine Immunoglobulin Kappa locus: A target for clonality assessment in B cell lymphoma
Principle Investigator: Peter F. Moore (2007-2008)

Deciphering the inheritance pattern and genetics of feline lymphosarcoma
Principle Investigator: Leslie A. Lyons (2006-2007)

Chromosome aberrations and Bcl-2 / P-glycoprotein expression in feline intestinal lymphoma
Principle Investigators: William Vernau, Peter Moore, Leslie Lyons, Lutz Froenicke (2006-2007)

Targeted imaging of canine lymphoma
Principle Investigator: Allison Zwingenberger, Michael S.Kent, Erik Wisner, Kit Lam (2006-2007)

Lymphoma - retro study of the results of chemotherapy
Principle Investigator: B.R. Madewell (1999)

Laser therapy (Photo dynamic Therapy) for cancer
Principle Investigators: B.R. Madewell, R. Higgins (1993-1998)

up Genetics

Mapping a canine dwarfism locus
Principle Investigator: Danika L. Bannasch (2007-2008)

Linkage disequilibrium mapping in feline progressive retinal atrophy
Principle Investigator: Leslie A. Lyons (2007-2008)

Genetic mapping of the feline craniofacial defect
Principle Investigator: Leslie A. Lyons (2007-2008)

DNA markers for genetic analysis of ferrets with cancer
Principle Investigators: Holly B. Ernest, Michelle Hawkins (2007-2008)

Correcting metabolic errors in the cat with adult stem cells
Principle Investigators: Phillip R. Vulliet, Quinton R. Rogers, Leslie A. Lyons (2006-2007)

Refinement of the candidate gene list for hyperuricosuria in the Dalmatian
Principle Investigator: Danika L. Bannasch (2005-2006)

1st Residency in Veterinary Genetics (worldwide)
Principle Investigators: N.C. Pedersen, D. Bannasch-Metallinos (1998)

International Feline Genetics Conference 2000
Principle Investigator: Leslie A. Lyons

up Infectious Disease

Oral shedding of Bartonella in cats: Correlation with bacteremia
Principle investigators: Bruno Chomel, Kate Hurley (2007-2008)

Campylobacter virulence genes: Detection and role in disease
Principle Investigator: Barbara A. Byrne, Stanley Marks, Nadira Chouicha (2007-2008)

Phase III Studies on the heritability of resistance/susceptibility to feline enteric coronavirus infection in randomly-bred, colony reared, domestic cats
Principle Investigators: Niels C. Pedersen, Leslie A. Lyons (2006-2007)

Pathogenicity of 'Candidatus Mycoplasma haemominutum' in cats
Principle Investigator: Jane Sykes (2006-2007)

Could Cat Scratch Disease pose a dangerous risk to cat owners who are immune-compromised (such as AIDs patients)?
Principle Investigator: Bruno Chomel

1st Shelter Medicine Program (worldwide).

Residency and training program; managing health, with a goal to increase adaptability and decrease euthanasia
Principle Investigator: J.E. Foley (2001)

Determining causes/risk factors for and the management of cats living in multi-cat facilities (esp. life threatening diseases such as FIP, FeCV)
Principle Investigators: NC Pedersen, J.E. Foley

2001 Gastrointestinal: helicobacter - association with G.I. disorders
Principle Investigator: S.L. Marks (1997)

Molecular cloning of Feline Immunodeficiency Virus (Feline AIDS). Principle Investigator: E.E. Sparger

up Medicine and Epidemiology

Cardiology: Analysis of platelet function in feline hypertrophic cardiomyopathy Principle Investigators: Karl Jandrey, Fern Tablin, Mark Kittleson (2007-2008)

Epidemiology: Discovered vaccination could cause a type of cancer (fibrosarcomas) in cats Principle Investigator: P. Kass

Study on Relinquishment - why do owners give up their pets or animals to shelters? Principle Investigator: P. Kass (1996)

Endocrinology: Effectiveness of diagnostics: CT, MRI in cats with insulin resistant and non insulin resistant diabetes mellitus
Principle Investigator: E. Feldman (1999)

Determining proper concentrations of drugs for treatment of diabetes mellitus
Principle Investigator: R.W. Nelson (2000)

Use of high fiber diet for treatment of diabetes
Principle Investigator: R.W. Nelson

1st hemodialysis for cats in kidney failure (worldwide)
Principle Investigator: L.D. Cowgill (1994)

up Nutrition

Plasma amino acid concentrations in cats consuming commercial diets
Principle Investigators: Andrea Fascetti, Phil Kass, Jennifer Larsen; and Resident Cailin Heinze (2007-2008)

Can the water content in canned foods promote weight loss in obese cats?
Principle Investigators: Jon Ramsey, Andrea Fascetti, Alfreda Wei (2007-2008)

Do domestic cats (Felis Catus) adapt protein oxidation rates to dietary protein intake?
Principle Investigators: Andrea Fascetti, Jon Ramsey, Alice Green (graduate student) (2005-2006)

Determining optimum levels in commercial diets: Taurine (Note – This team discovered that the absence/low levels of Taurine in commercial cat food caused a devastating but common heart disease in cats; once added, virtually eliminated the disease) Principle Investigators: Morris, Q.R. Rogers, SL Marks, R. Backus (1992-1999)

Identifying optimal requirements, metabolism and toxicity levels: Vitamins A, B, K, Choline and chloride for cats Principle Investigators: Morris, Q.R. Rogers, SL Marks, R. Backus (1992-1999)

Copper influences reproductive efficiency in queens
Principle Investigators: Morris, Q.R. Rogers, SL Marks, R. Backus (1999)

Nutritional requirements of growing kittens: Folate
Principle Investigators: Morris, Q.R. Rogers, SL Marks, R. Backus (1999)

Vitamin D & kidney effects
Principle Investigators: Morris, Q.R. Rogers, SL Marks, R. Backus (1999)

Obesity and rapid weight loss
Principle Investigators: Morris, Q.R. Rogers, SL Marks, R. Backus (1994)

Requirements of vitamin D & kidney effects
Principle Investigators: Morris, Q.R. Rogers, SL Marks, R. Backus (1995)

Discovered decreased zinc in pregnant queens results in cleft palate of the kittens Principle Investigators: Morris, Q.R. Rogers, SL Marks, R. Backus (2000)

up Reproduction

The role of ovarian hormones in endometrial hyperplasia in queens
Principle Investigators: Linda Munson, Anneke Moresco (2006-2007)

Linking pregnancy failure in cats with low taurine levels
Principle Investigator: B.L. Lasley (2000)

Origin of ovarian interstitial tissue and incidence of endometrial hyperplasia in domestic and feral cats Principle Investigator: B.L. Lasley (2000)

up Urology

Urodynamic evaluation of cats with feline idiopathic cystitis
Principle Investigators: Jodi Westropp, Christine Wu (2007-2008)

Investigation of the role of Oxalobacter formigenes in canine hyperoxaluria and calcium oxalate urolithiasis
Principle Investogators: Stanley Marks, Gerald Ling (2002-2003)

Described the ultra structure of urinary calculi in cats
Principle Investigator: G.V. Ling (1996)

UC Davis Center for Companion Animal Health, School of Veterinary Medicine, UC Davis, Tel 530.752.7295