M3 Mouse Barrier Facility Description
The M3 barrier offers the best protection CLAS can provide for maintaining breeding colonies of transgenic and knockout mice. The M3 building provides space for a mouse production facility and the Murine Targeted Genomics Laboratory behind a restricted access barrier. Added security is provided through a code entry system. The M3 building has a back up generator providing redundant power capability to supply the HVAC system. The building is monitored 24 hours a day through a silent night system. Each animal room is individually alarmed using the appropriate temperature parameters. Each piece of equipment integral to the operation of the building has an alarm point as well. CLAS maintains records regarding building function, sanitation, and animal health ensuring barrier standards are maintained.
CLAS provides a full-spectrum of animal care (including animal husbandry and veterinary care) services for animal acquisition and disposition, consulting services, veterinary diagnostic services, and mouse colony management. All mice within the barrier are covered in the Rodent Health Surveillance Program. The AAALAC-accredited facilities and animal programs are managed to provide quality humane animal care in compliance with federal, state, and university laws, regulations and policies. CLAS provides these services on a recharge basis.
The Murine Targeted Genomics Laboratory (MTGL) is a full service, teaching and research laboratory dedicated to microinjection and embryo manipulation and cryopreservation procedures. Investigators wanting specific pathogen-free mice can have the MTGL rederive their mice by embryo transfer into dedicated barrier housing space. The MTGL performs these and associated procedures on a recharge basis and by research collaborations.
All mice to be housed in the M3 barrier must go through the rederivation process. At this time the only exception is mice that come directly from The Jackson Laboratory foundation rooms which go through a quarantine process.
CLAS and MTGL work closely together to provide specific pathogen free barrier housing for the Mutant Mouse Regional Resource Center's (MMRRC) and UC Davis Research Investigator's transgenic and knockout mouse colonies.
Colony management staf will meet with interested investigators to discuss the research for the strain, develop a breeding plan based on those research needs, monitor the breeding program, and modify the plan under the direction of the investigator as the needs for the strain change. Mice used in studies will be removed from the barrier and placed in other suitable housing or delivered to the investigator's lab for investigator use by way of placing a work order in the CLAS Headquarters office (752-1390)
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