About Us

Mission Statement

Provide expertise in pharmacokinetic/pharmacodynamic (PK/PD) study design technically advanced instrumentation for detection and quantitation of drug and metabolite concentrations, and pharmacokinetic analyses. The Core specializes in PK/PD studies at preclinical and clinical stages of drug development specifically targeting oncologic drugs.

The School of Veterinary Medicine and the University of California, Davis (SVM) provides an exceptionally rich environment for multidisciplinary investigations. The SVM is the largest veterinary school in the nation, conducting an integrated, statewide mission of teaching, research, and service benefiting animal, human, and environmental health. A strong multidisciplinary research infrastructure ensures that the sciences will continue to expand in the years ahead. The Bioanalytical Research Core (BARC) is a unique interdisciplinary analytical core that provides method development and validation for therapeutics and toxicants according to the Food and Drug Administration’s (FDA) Compliance Guidelines for Analytical Method Validation. Core Co-Directors and staff have advanced training and experience both in the pharmaceutical industry (preclinical drug development) and academia as well as extensive experience with pharmacokinetic modeling of drug and metabolite concentration data in a variety of biological matrices (blood, urine, milk, synovial fluid, tissue).

Our Expertise:

BARC is led by Co-Directors Puschner and Knych who have advanced training and experience in veterinary pharmacology and toxicology. Expertise is also provided through full-time Staff Research Associates and post-doctoral fellows. The laboratory team is competent in sample extraction, GC-MS/MS, LC-MS/MS analysis and method development. Collectively, the staff, post-docs and faculty member have over 30 years of experience developing and validating analytical methods for measurement of drug and toxicant concentrations. Both Co-Directors have a demonstrated publication record in the field of pharmacokinetic/pharmacodynamics relationships and toxicological investigations.  Faculty members have additional expertise in the field of drug metabolism in numerous veterinary species, specifically with respect to the development and use of in vitro models.