Pain Management

Below, please find links to all of the clinical trials investigating pain management. The studies are organized by species and include a multitude of information, including (but not limited to) the study’s purpose, benefits for participating, and financial incentive information. If you have any questions, please contact the individual outlined at the end of each trial summary.

Please visit the Anesthesiology service webpage at the Veterinary Medical Teaching Hospital (VMTH) if you would like to learn more about the amazing things that our anesthesiologists do for you and your animal.


Osteoarthritis: Examining a New Pain Relief Medication

Title: Analgesic evaluation of gabapentin in osteoarthritic geriatric cats

Purpose of Study: The objective of this study is to increase the available options for pain relief in cats with osteoarthritis, which should directly impact their health and well-being.

Contact: Dr. Alonso Guedes (; please add "cat pain study" in the subject line)

Participation Requirements:

  • Cats must be indoor-only, with owner-identified mobility impairment
  • Cats whose owners have noticed altered activity, with radiographic evidence of osteoarthritis and decreased muscle mass (for non-axial joints), with no detectable systemic disease and no clinically significant abnormalities on blood work
  • Ineligible:
    • Female cats cannot not be pregnant
    • Cats cannot be receiving any anti-inflammatory or other analgesic medications. Administration of glucosamine-chondroitin sulphate or similar medication (e.g., chondroprotectants) is acceptable as long as they have been administered for at least 10 weeks and the administration does not change during the study period.

Initial Evaluation for Participation:

  • Cats will be evaluated via general physical, orthopedic and neurological examinations, complete blood cell count and serum biochemical analyzes.
  • Orthogonal radiographs will be taken of joints suspected to have osteoarthritis based on history and physical examination.


  • Gabapentin at a dose of 10 mg/kg or placebo will be given orally twice per day for two weeks to senior cats (10 years old or older). Each cat will be treated with gabapentin or placebo in random order.
  • Owners will evaluate the pain relief on a weekly basis through a questionnaire tailored specifically for their cat.
  • Cats will wear an activity monitor device (e.g., a type of “pedometer”) on their neck to measure their activity level at home.

Benefits: This is a fully funded study, so the owner will not pay for any procedures required for the animal to participate in the study.

Owner Responsibilities: Owner must have a stable routine of daily living that is unlikely to change during the proposed study period (e.g., no impending changes such as moving to a new location, vacations, introduction of new pets or people into the household).  In addition, cats will be excluded if they miss more than one gabapentin dose per week.

Printable Flyer (PDF)