Dentistry and Oral Surgery

Photo: Flyer for Chronic Gingivostomatitis Trial in Cats

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Below, please find links to all of the clinical trials involving dentistry and/or oral surgery. The studies include a multitude of information, including (but not limited to) the study’s purpose, benefits for participating, and financial incentive information. If you have any questions, please contact the individual outlined at the end of each trial summary.

Please visit the Dentistry and Oral Surgery service webpage at the Veterinary Medical Teaching Hospital (VMTH) if you would like to learn more about the amazing things that our veterinarians can do for you and your animal.

Cats

NEW! Chronic Gingivostomatitis: Assessing Stem Cell Therapy in Cats that Have Not Had A Full Mouth Dental Extraction

Title: Fat-derived stem cells for treatment of feline gingivostomatitis

Purpose of Study: Feline chronic gingivostomatitis (FCGS) is a poorly defined disease characterized by inflammatory lesion, mostly ulcerative or proliferative in nature, affecting the gums and the back of the mouth. None of the treatments that are currently available are ideal, predictable and without possible complications. In our previous studies in over 20 cats, systemic (intravenous) administration autologous feline stem cells were shown to not only be safe, but, in most cases (about 70%), substantially improved or completely resolved the stomatitis. Therefore, the purpose of this study is use stem cells to treat cats diagnosed with chronic gingivostomatitis that have not had a full mouth extraction.

Contact: Dr. Boaz Arzi, DVM, DAVDC via phone (530-752-2470), fax (530-752-9620), or email (dosclinicaltrials@ucdavis.edu

Participation Requirements: Cats diagnosed with gingivostomatitis that have not had full mouth dental extractions

Initial Evaluation for Participation: The cats will be evaluated by the Dentistry and Oral Surgery Service to assess eligibility to be enrolled in the study.

Procedures and Owner Responsibilities: 

  • Full mouth radiographs, periodontal treatment and extraction of periodontally affected teeth at owner’s expense
  • Blood collection for analysis before the treatment and at the recheck appointments
  • Oral biopsy under general anesthesia performed at the first and last appointment (at 6 months)
  • Surgical collection of fat from the area under the belly for the production of stem cells
  • Administration of the stem cells (or placebo) to your cat systemically two times in 4 weeks interval (each treatment may be under sedation)
  • Hospitalization for 1-3 days after every stem cells administration
  • A small biopsy sample from the healed oral mucosa with your permission at the end of the study

Owner Responsibilities:

  • Bringing your cat to all scheduled appointments
  • Covering costs of full mouth dental radiographs, periodontal treatment, extraction of periodontally affected teeth, general anesthesia, take-home pain medication and any adverse events

Benefits: There is no cost to participate in this trial. If successful, your cat may not need additional treatment. This study may lead to the resolution of clinical signs that can change the quality of life of your cat. If this study will prove to be beneficial, it will have important clinical applications for other cats with the same condition and possibly even human medicine for similar indications.

Printable Flyers (PDF)

Chronic Gingivostomatitis: Assessing Stem Cell Therapy in Cats that Have Had a Full Mouth Dental Extraction

Title: Fat-derived stem cells for treatment of feline gingivostomatitis

Purpose of Study: Feline chronic gingivostomatitis (FCGS) is a poorly defined disease characterized by inflammatory lesion, mostly ulcerative or proliferative in nature, affecting the gums and the back of the mouth. None of the treatments that are currently available are ideal, predictable and without possible complications. In our previous studies in over 20 cats, systemic (intravenous) administration autologous feline stem cells were shown to not only be safe, but, in most cases (about 70%), substantially improved or completely resolved the stomatitis. Therefore, the purpose of this study is to treat cats for which all current treatment modalities have failed and have a poor quality of life.

Contact: Dr. Boaz Arzi, DVM, DAVDC via phone (530-752-2470), fax (530-752-9620), or email (dosclinicaltrials@ucdavis.edu

Participation Requirements: Cats diagnosed with gingivostomatitis that have failed to improve with all current treatments and have had full mouth dental extractions

Initial Evaluation for Participation: The cats will be evaluated by the Dentistry and Oral Surgery Service to assess eligibility to be enrolled in the study.

Procedures and Owner Responsibilities: Please contact Boaz Arzi, DVM, DAVDC via phone (530-752-2470), fax (530-752-9620), or email (dosclinicaltrials@ucdavis.edu) for details

Benefits: This study may lead to the resolution of clinical signs that can change the quality of life of your cat. If this study will prove to be beneficial, it will have important clinical applications for other cats with the same condition and possibly even human medicine for similar indications.

Printable Flyers (PDF) - #1#2

Dental Disease: Assessing Better Diagnostics

Title: The diagnostic yield of dental radiographs and cone-beam computed tomography in cats with dental disorders

Purpose of Study: Because of the highly detailed images, cone-beam computed tomography (CBCT) scans are commonly used as diagnostic tools in human medicine with great success; however, these scans are only now being introduced to the veterinary field. Therefore, the purpose of this study is to establish CBCT scans as the ideal imaging modality for mesaticephalic and brachycephalic cats with dental disorders.

Contact: Dr. Colleen Geisbush in the Dentistry and Oral Surgery Service via phone (530-752-2470) or email (cmgeisbush@ucdavis.edu)

Participation Requirements: Cats diagnosed with dentoalveolar disease that are referred to or are currently being treated by the Dentistry and Oral Surgery service (DOSS) at the UCD Veterinary Medical Teaching Hospital (VMTH).

Initial Evaluation for Participation: Examination by DOSS

Procedures: As part of the diagnostic work-up, we will image your cat via CBCT scan under general anesthesia. The CBCT scan will be done during your scheduled appointment with DOSS.

Benefits: You will not be charged for the CBCT scan; however, you will be charged for the general anesthesia and dental treatment.

We cannot promise any benefits to your cat from your taking part in this clinical trial; however, we hope that this study will lead to better diagnostics techniques. This study may also benefit other species with the same condition in the future.

Owner Responsibilities: Participation in this study does not require any additional visits beyond your scheduled appointment with DOSS.

With the exception the CBCT scan, you will be responsible for bringing your cat to DOSS and paying for all other fees associated with your cat’s visit and treatment.

Root Canal Treatment: Evaluating the Outcome

Title: Outcome of orthograde root canal treatment in cats

Purpose of Study: Long-term evaluation of root canal treatments by evaluating the dental x-rays is essential to assess the appropriateness of this treatment modality in cats. In receiving care of a specialized nature such as root canal treatment, patients need and deserve treatment that meets the standard of care and this study will shine a light on the efficacy of such treatment if rendered. Although root canal treatment is commonly performed in dogs and humans with a high success rate, the purpose of this study to evaluate the success rate of root canal treatment in cats, as we believe this treatment is just as appropriate for cats and with a similar high success rate.

ContactDentistry and Oral Surgery Service at (530) 752-2470

Participation Requirements: Cats that have had a root canal treatment performed.

Initial Evaluation for Participation: None.

Procedures: Your cat will receive routine periodontal treatment under general anesthesia as part of the standard of care. While under anesthesia dental radiographs of the teeth of interest will be obtained.

Benefits: The study will cover the dental radiographs pertaining to the teeth of interest and the anesthesia to obtain those radiographs (induction plus the first 15 minutes). However, you will need to pay for any other charges estimated by the DOSS beyond that mentioned above.

We cannot promise any benefits to your cat or other animals from your taking part in this clinical trial; however, possible benefits include appropriate evaluation and treatment of the root canal procedure, along with diagnosis of other current dental or periodontal diseases.

Owner Responsibilities: You will be responsible for bringing your cat to the Dentistry and Oral Surgery Service (DOSS) and cover the costs of anesthesia for procedures related to the routine periodontal treatment (cleaning, extraction etc.), possible medications if needed, housing and recovery fee while at the hospital. You will not pay for dental radiographs necessary to evaluate the teeth of interest to the study, the initial induction fee for anesthesia and the time spend, obtained the dental radiographs, which is no more than 15 min.

Dogs

NEW! Oral Tumors: Optimizing the Identification of Tumor Spread To Lymph Nodes

Title: Preoperative sentinel lymph node mapping in dogs

Purpose of Study: Successful treatment of many cancers depends on the extent of disease present at the time of diagnosis, and on accurate detection of that disease. Some oral cancers commonly spread from the mouth to nearby lymph nodes. Lymph node metastasis, if present, can influence the prognosis and treatment recommendations made for a patient. Currently, however, our standard veterinary staging protocol (aspiration cytology of the geographically nearest lymph node) misses a diagnosis of lymph node metastasis in a concerning number of patients. Because lymphatic pathways and lymph nodes of the head are very complicated and the closest lymph node is not necessarily the most likely to show disease, it is possible to miss disease because we do not know which is the best lymph node to evaluate. Lymph node mapping, a technique to visualize the lymphatic drainage of tumors, is increasingly used to improve cancer staging and treatment protocols in the treatment of cancer in people. Mapping allows identification of the “sentinel lymph node,” or lymph node that is most likely to demonstrate evidence of metastatic disease. This lymph node can then be aspirated or surgically removed with the primary tumor to be evaluated microscopically for spread of cancer. This trial is being performed to optimize a method of sentinel lymph node mapping that can be accessible to a greater number of veterinary practitioners in an effort to improve the accuracy of cancer diagnoses and treatment recommendations we make for our veterinary patients, improving their quality of life and length of time with us following diagnosis with this cancer.

Contact: If you are interested in determining whether your dog is eligible for the trial, please schedule an appointment for evaluation with one of the participating clinical services by calling the Small Animal Clinic at (530) 752-1393 and following the prompts for either Soft Tissue Surgery, Dentistry and Oral Surgery or Oncology. For general questions not related to your own dog’s eligibility, please contact Dr. Steffey (530-752-3799, masteffey@ucdavis.edu).

Participation Requirements:

  • Dogs diagnosed with an oral tumor with owners that have elected to surgically remove the tumor.
  • Ineligible: Dogs with pre-existing, palpably very large lymph nodes

Initial Evaluation for Participation: If you choose to enroll your dog, your dog will receive two CT scans on separate days: the first done for standard diagnostic/surgical planning, and the second done immediately prior to surgery. Both CT scans will be performed with contrast while under general anesthesia.

Benefits: All costs associated with this study, including the second CT scan and the 1 hour of extra anesthesia time associated with each CT scans will be paid by the sponsor. Additionally, a financial benefit of $500 will be credited to your VMTH account after your dog completes the second CT scan on the day of his/her surgery.

Owner Responsibilities: If you allow your dog to participate in this study, you will be responsible for bringing your dog to the UC Davis VMTH for his/her scheduled appointments, covering costs associated with the standard diagnostic workup of your dog’s tumor, the first (diagnostic/surgical planning) CT scan, and standard costs associated with surgical removal of the oral tumor, and allowing him/her to be hospitalized for the required length of time pre- and postoperatively.

Printable Flyer (PDF)

Discolored Teeth: Evaluating Tooth Vitality

Title: Thermal assessment of pulp vitality of discolored canine teeth in dogs

Purpose of Study: To date, we relied on clinical assessment and dental radiographs of discolored teeth to decide whether or not those teeth require treatment. Both modalities have limitations. With the use of a newly developed diagnostic tool called the TOTEM device, we will hopefully be able to assess tooth vitality much more accurately via tooth temperature. Therefore, the purpose of this study is to evaluate the clinical application of the TOTEM device to assess tooth vitality.

Contact: Dentistry and Oral Surgery Service at (530) 752-2470

Participation Requirements: Dogs with discolored canine teeth.

Procedures: If you agree to let your dog participate in this study, the following will happen:

  • General anesthesia, clinical assessment and intraoral radiographs
  • Thermal assessment of the pulp vitality of the discolored canine tooth, which will take approximately 10 minutes
  • Appropriate, standard treatment (e.g., monitoring, extraction or root canal treatment)

Benefits: There is no charge for you to allow your dog to participate in this clinical trial as you will not be charged for the thermal measurement. However, you will need to pay the invoice that will be issued to you by the Dentistry and Oral Surgery Service for the regular diagnostics and the treatment of your dog.

At this point in the clinical trial we cannot promise any benefits to your dog or other animals. However, we are confident that this diagnostic tool will help to increase the accuracy of future treatment planning in regards to discolored teeth, no matter the species. Ultimately, our aim is to establish a new tool for diagnosis and treatment planning in regards to discolored teeth in dogs, but also in other animals.

Owner Responsibilities: Although the study will cover the costs for the thermal assessment of the discolored tooth, you will be responsible for bringing your dog to the Dentistry and Oral Surgery Service and paying for all costs associated with standard dental care.