Dentistry and Oral Surgery

Below, please find links to all of the clinical trials involving dentistry and/or oral surgery. The studies include a multitude of information, including (but not limited to) the study’s purpose, benefits for participating, and financial incentive information. If you have any questions, please contact the individual outlined at the end of each trial summary.

Please visit the Dentistry and Oral Surgery service webpage at the Veterinary Medical Teaching Hospital (VMTH) if you would like to learn more about the amazing things that our veterinarians can do for you and your animal.

Cats

Chronic Gingivostomatitis: Finding a Treatment with Stem Cells

Title: Fat-derived Mesenchymal Stem-Cell Therapy for Cats with Chronic Gingivostomatitis

Purpose of Study: Feline chronic gingivostomatitis (FCGS) is a poorly defined disease characterized by inflammatory lesion, mostly ulcerative or proliferative in nature, affecting the gums and the back of the mouth. Moreover, FCGS is a painful and debilitating disease in cats that necessitates medical or surgical treatments. These include full-mouth extractions, antibiotic treatment, and corticosteroids. Recently, feline interferon treatment (currently unavailable in the USA) has been proposed for non-responsive stomatitis. However, none of these treatments are ideal, predictable and without possible complications. The quality of life to both pet and owner is significantly affected.

A form of stem cell therapy where stem cells are extracted from fat tissue has come to the forefront in recent years as a potential therapeutic option for chronic inflammatory diseases. This cell therapy may help to correct abnormalities of the immune system that may be involved with stomatitis in cats. Moreover, stem cells are shown to help in regenerating damaged tissues. Feline stem cells has shown to be easily generated in large quantities from a small amount of fat collected via minor surgical procedure but safely of systemic administration in cats was not reported previously.

In this study, our aim is to treat cats in which all current treatment modalities have failed and that have a poor quality of life. If the proposed stem cell treatment will prove to be beneficial, it may revolutionize the treatment options for cats with FCGS.

Participation Requirements:

  • Cats that had full-mouth extractions performed that have not resulted in a cure from the disease
  • Ineligible: Cats that did not have full-mouth extractions performed or have other concurrent systemic diseases

Initial Evaluation for Participation: Evaluation for eligibility by Dr. Boaz Arzi

Procedures: The following procedures will be performed:

  1. Collection of blood and urine for analysis before the treatment and at 4-6 recheck appointments
  2. Collection of fat tissue from under the skin via a small incision. The fat will then be processed and stem cells extracted.
  3. Two-weeks following collection of the fat tissue, we will administer the stem cells to the affected cats via intravenous administration. The treatment may need to be repeated one month after the first administration of stem-cells.
  4. Recheck appointment is required initially at 2 weeks interval and later at 1 month. Blood sample will be collected and will not exceed 5 milliliters (1 teaspoon).

Benefits: The proposed treatment strategy could have beneficial effects that may change the quality of life of your cat. We will also perform blood and urine test at no costs to you at each visit during the study. You will not be charged for the biopsy of fat tissue, the rechecks or the administration of the stem cells. You will only have to pay for take home medication, such as pain medication, as needed.

If this study will prove to be beneficial, it will have important clinical applications for other cats with the same condition.

Owner Responsibilities: The owner only needs to bring the cats to the VMTH for fat collection and for the scheduled recheck appointments.

Contact: Contact Dr. Boaz Arzi for details

Boaz Arzi, DVM, DAVDC
Tel: (530) 752-2470
Fax: (530) 752-9620
dosclinicaltrials@ucdavis.edu

Printable Flyer (PDF)

Dental Disease: Assessing Better Diagnostics

Title: The diagnostic yield of dental radiographs and cone-beam computed tomography in cats with dental disorders

Purpose of Study: Because of the highly detailed images, cone-beam computed tomography (CBCT) scans are commonly used as diagnostic tools in human medicine with great success; however, these scans are only now being introduced to the veterinary field. Therefore, the purpose of this study is to establish CBCT scans as the ideal imaging modality for mesaticephalic and brachycephalic cats with dental disorders.

Participation Requirements: Cats diagnosed with dentoalveolar disease that are referred to or are currently being treated by the Dentistry and Oral Surgery service (DOSS) at the UCD Veterinary Medical Teaching Hospital (VMTH).

Initial Evaluation for Participation: Examination by DOSS

Procedures: As part of the diagnostic work-up, we will image your cat via CBCT scan under general anesthesia. The CBCT scan will be done during your scheduled appointment with DOSS.

Benefits: You will not be charged for the CBCT scan; however, you will be charged for the general anesthesia and dental treatment.

We cannot promise any benefits to your cat from your taking part in this clinical trial; however, we hope that this study will lead to better diagnostics techniques. This study may also benefit other species with the same condition in the future.

Owner Responsibilities: Participation in this study does not require any additional visits beyond your scheduled appointment with DOSS.

With the exception the CBCT scan, you will be responsible for bringing your cat to DOSS and paying for all other fees associated with your cat’s visit and treatment.

Contact:

Dentistry and Oral Surgery Service
Tel: (530) 752-2470
Dr. Peter Strøm (pcstroem@ucdavis.edu)

Dogs

Dental Disease: Assessing Better Diagnostics in Brachycephalic Dogs

Title: The diagnostic yield of dental radiographs and cone-beam computed tomography in brachycephalic dogs with dental disorders

Purpose of Study: Because of the highly detailed images, cone-beam computed tomography (CBCT) scans are commonly used as diagnostic tools in human medicine with great success; however, these scans are only now being introduced to the veterinary field. Therefore, the purpose of this study is to establish CBCT scans as the ideal imaging modality for brachycephalic dogs with dental disorders.

Participation Requirements: Brachycephalic dogs diagnosed with dental disease that are referred to or are currently being treated by the Dentistry and Oral Surgery service (DOSS) at the UCD Veterinary Medical Teaching Hospital (VMTH).

Initial Evaluation for Participation: Examination by DOSS

Procedures: As part of the diagnostic work-up, we will image your dog via CBCT scan under general anesthesia. The CBCT scan will be done during your scheduled appointment with DOSS.

Benefits: You will not be charged for the CBCT scan; however, you will be charged for the general anesthesia and dental treatment.

We cannot promise any benefits to your dog from your taking part in this clinical trial; however, we hope that this study will lead to better diagnostics techniques. This study may also benefit other species with the same condition in the future.

Owner Responsibilities: Participation in this study does not require any additional visits beyond your scheduled appointment with DOSS.

With the exception of the CBCT scan, you will be responsible for bringing your dog to DOSS and paying for all other fees associated with your dog’s visit and treatment.

Contact:

Dentistry and Oral Surgery Service
Tel: (530) 752-2470
Dr. Sophie Döring (Resident) (doering@ucdavis.edu)

Discolored Teeth: Evaluating Tooth Vitality

Title: Thermal assessment of pulp vitality of discolored canine teeth in dogs

Purpose of Study: To date, we relied on clinical assessment and dental radiographs of discolored teeth to decide whether or not those teeth require treatment. Both modalities have limitations. With the use of a newly developed diagnostic tool called the TOTEM device, we will hopefully be able to assess tooth vitality much more accurately via tooth temperature. Therefore, the purpose of this study is to evaluate the clinical application of the TOTEM device to assess tooth vitality.

Participation Requirements: Dogs with discolored canine teeth.

Procedures: If you agree to let your dog participate in this study, the following will happen:

  • General anesthesia, clinical assessment and intraoral radiographs
  • Thermal assessment of the pulp vitality of the discolored canine tooth, which will take approximately 10 minutes
  • Appropriate, standard treatment (e.g., monitoring, extraction or root canal treatment)

Benefits: There is no charge for you to allow your dog to participate in this clinical trial as you will not be charged for the thermal measurement. However, you will need to pay the invoice that will be issued to you by the Dentistry and Oral Surgery Service for the regular diagnostics and the treatment of your dog.

At this point in the clinical trial we cannot promise any benefits to your dog or other animals. However, we are confident that this diagnostic tool will help to increase the accuracy of future treatment planning in regards to discolored teeth, no matter the species. Ultimately, our aim is to establish a new tool for diagnosis and treatment planning in regards to discolored teeth in dogs, but also in other animals.

Owner Responsibilities: Although the study will cover the costs for the thermal assessment of the discolored tooth, you will be responsible for bringing your dog to the Dentistry and Oral Surgery Service and paying for all costs associated with standard dental care.

Contact: Dentistry and Oral Surgery Service (530) 752-2470

Exotic Animals

Dental Disease: Assessing Better Diagnostics in Rabbits

Title: Cone-beam computed tomography anatomy of the rabbit dentition in health and disease

Purpose of Study: Because of the highly detailed images, cone-beam computed tomography (CBCT) scans are commonly used as diagnostic tools in human medicine with great success; however, these scans are only now being introduced to the veterinary field. Therefore, the purpose of this study is to establish CBCT scans as the ideal imaging modality for rabbits with dental disorders.

Participation Requirements: Rabbits diagnosed with dental disease, including (but not limited to) periapical lesions, malocclusion, root elongation, lingual and buccal sharp points, that are referred to or are currently being treated by the Companion Exotic Animal Medicine and Surgery Service (CAPE) and Dentistry and Oral Surgery Service (DOSS) at the UCD Veterinary Medical Teaching Hospital (VMTH).

Exclusion criteria: Rabbits with any other concurrent diseases

Initial Evaluation for Participation: Examination by CAPE and DOSS

Procedures: As part of the diagnostic work-up, we will image your rabbit via CBCT scan under general anesthesia. The CBCT scan will be done during your scheduled appointment with our CAPE Service.

Benefits: You will not be charged for the CBCT scan. However, you will be charged for the general anesthesia and dental treatment.

We cannot promise any benefits to your rabbit from your taking part in this clinical trial; however, we hope that this study will lead to better diagnostics, and in turn, a reduction in the time that rabbits spend under anesthesia. This study may also benefit other species with the same condition in the future.

Owner Responsibilities: Participation in this study does not require any additional visits beyond your scheduled appointment with CAPE.

With the exception the CBCT scan, you will be responsible for bringing your rabbit to the CAPE service and paying for all other fees associated with your rabbit’s visit and treatment.

Contact:

Dentistry and Oral Surgery Service
Tel: (530) 752-2470
Dr. G.G. Comet Riggs (Resident) (griggs@ucdavis.edu)