Dentistry and Oral Surgery

Below, please find links to all of the clinical trials involving dentistry and/or oral surgery. The studies include a multitude of information, including (but not limited to) the study’s purpose, benefits for participating, and financial incentive information. If you have any questions, please contact the individual outlined at the end of each trial summary.

Please visit the Dentistry and Oral Surgery service webpage at the Veterinary Medical Teaching Hospital (VMTH) if you would like to learn more about the amazing things that our veterinarians can do for you and your animal.

Cats

Chronic Gingivostomatitis: Assessing the Immune Profile

Title: The immune profile of cats with Chronic Gingivostomatitis before and after full-mouth tooth extraction

Purpose of Study: Feline chronic gingivostomatitis (FCGS) is a poorly defined, debilitating disease characterized by inflammatory lesion, mostly ulcerative or proliferative in nature, that affect the gums and the back of the mouth, and necessitates medical or surgical treatments, which include full-mouth extractions, antibiotic treatment, and corticosteroids. In-depth immune changes that occur in the body before and after extraction therapy are currently unknown. The purpose of this trial is therefore to understand the immune system of cats undergoing tooth extraction therapy, which will hopefully help us design new, less invasive treatment modalities.

Contact: Boaz Arzi, DVM, DAVDC via phone (530-752-2470), fax (530-752-9620), or email (dosclinicaltrials@ucdavis.edu)

Participation Requirements: Cats diagnosed with chronic gingivostomatitis that must undergo extractions therapy at the UC Davis Dentistry and Oral Surgery Service (DOSS).

Initial Evaluation for Participation: The cats will be evaluated by the Dentistry and Oral Surgery Service to assess eligibility to be enrolled in the study.

Procedures: The following procedures will be performed:

  • Collection of blood sample before treatment and then at 3 and 6 months after tooth extraction treatment. This sample will not be obtained if clinically contraindicated such as in patients with moderate or severe anemia (low numbers of red blood cells) or in patients that are dehydrated or have an impaired ability to clot their blood (coagulation or bleeding problems).
  • If your cat does not respond to the extractions therapy, opioid pain medication can and will be administered for the period of the study. Antibiotic therapy if needed can be administered; however, steroid or other immunosuppressive therapy will not be permitted. If you wish to give your cat any immunosuppressive therapy, we would need to exit your cat from the study.

Benefits: The study will cover all charges associated with participation, including the charges for blood work and recheck visits. The study will not cover the charges for the extractions, hospitalization and medication.

We cannot promise any benefits to your cat or other animals from your taking part in this clinical trial; however, possible benefits include better understanding of feline chronic gingivostomatitis that can hopefully lead to new designs for less invasive, more effective therapies.

Owner Responsibilities: Participation in this clinical trial will involve 3 visits over the course of 6 months, so you will be responsible for bringing your cat in for all study-related appointments.

Chronic Gingivostomatitis: Finding a Treatment with Stem Cells

Title: Fat-derived Mesenchymal Stem-Cell Therapy for Cats with Chronic Gingivostomatitis

Purpose of Study: Feline chronic gingivostomatitis (FCGS) is a poorly defined disease characterized by inflammatory lesion, mostly ulcerative or proliferative in nature, affecting the gums and the back of the mouth. Moreover, FCGS is a painful and debilitating disease in cats that necessitates medical or surgical treatments. These include full-mouth extractions, antibiotic treatment, and corticosteroids. Recently, feline interferon treatment (currently unavailable in the USA) has been proposed for non-responsive stomatitis. However, none of these treatments are ideal, predictable and without possible complications. The quality of life to both pet and owner is significantly affected.

A form of stem cell therapy where stem cells are extracted from fat tissue has come to the forefront in recent years as a potential therapeutic option for chronic inflammatory diseases. This cell therapy may help to correct abnormalities of the immune system that may be involved with stomatitis in cats. Moreover, stem cells are shown to help in regenerating damaged tissues. Feline stem cells has shown to be easily generated in large quantities from a small amount of fat collected via minor surgical procedure but safely of systemic administration in cats was not reported previously.

In this study, our aim is to treat cats in which all current treatment modalities have failed and that have a poor quality of life. If the proposed stem cell treatment will prove to be beneficial, it may revolutionize the treatment options for cats with FCGS.

Contact: Boaz Arzi, DVM, DAVDC via phone (530-752-2470), fax (530-752-9620), or email (dosclinicaltrials@ucdavis.edu)

Participation Requirements:

  • Cats that had full-mouth extractions performed that have not resulted in a cure from the disease
  • Ineligible: Cats that did not have full-mouth extractions performed or have other concurrent systemic diseases

Initial Evaluation for Participation: Evaluation for eligibility by Dr. Boaz Arzi

Procedures: The following procedures will be performed:

  1. Collection of blood and urine for analysis before the treatment and at 4-6 recheck appointments
  2. Collection of fat tissue from under the skin via a small incision. The fat will then be processed and stem cells extracted.
  3. Two-weeks following collection of the fat tissue, we will administer the stem cells to the affected cats via intravenous administration. The treatment will need to be repeated one and two months after the first administration of stem-cells (2-3 treatments).
  4. Recheck appointment is required initially at 1 month intervals and later at 3 month. Blood sample will be collected and will not exceed 5 milliliters (1 teaspoon).

Benefits: The proposed treatment strategy could have beneficial effects that may change the quality of life of your cat. We will also perform blood and urine test at no costs to you at each visit during the study. You will not be charged for the biopsy of fat tissue, stem cell treatments, or rechecks or the administration of the stem cells. You will only have to pay for take home medication, such as pain medication, as needed.

If this study will prove to be beneficial, it will have important clinical applications for other cats with the same condition.

Owner Responsibilities: The owner only needs to bring the cats to the VMTH for fat collection and for the scheduled recheck appointments.

Printable Flyer (PDF)

Dental Disease: Assessing Better Diagnostics

Title: The diagnostic yield of dental radiographs and cone-beam computed tomography in cats with dental disorders

Purpose of Study: Because of the highly detailed images, cone-beam computed tomography (CBCT) scans are commonly used as diagnostic tools in human medicine with great success; however, these scans are only now being introduced to the veterinary field. Therefore, the purpose of this study is to establish CBCT scans as the ideal imaging modality for mesaticephalic and brachycephalic cats with dental disorders.

Contact: Dr. Peter Strøm in the Dentistry and Oral Surgery Service via phone (530-752-2470) or email (pcstroem@ucdavis.edu)

Participation Requirements: Cats diagnosed with dentoalveolar disease that are referred to or are currently being treated by the Dentistry and Oral Surgery service (DOSS) at the UCD Veterinary Medical Teaching Hospital (VMTH).

Initial Evaluation for Participation: Examination by DOSS

Procedures: As part of the diagnostic work-up, we will image your cat via CBCT scan under general anesthesia. The CBCT scan will be done during your scheduled appointment with DOSS.

Benefits: You will not be charged for the CBCT scan; however, you will be charged for the general anesthesia and dental treatment.

We cannot promise any benefits to your cat from your taking part in this clinical trial; however, we hope that this study will lead to better diagnostics techniques. This study may also benefit other species with the same condition in the future.

Owner Responsibilities: Participation in this study does not require any additional visits beyond your scheduled appointment with DOSS.

With the exception the CBCT scan, you will be responsible for bringing your cat to DOSS and paying for all other fees associated with your cat’s visit and treatment.

Root Canal Treatment: Evaluating the Outcome

Title: Outcome of orthograde root canal treatment in cats

Purpose of Study: Long-term evaluation of root canal treatments by evaluating the dental x-rays is essential to assess the appropriateness of this treatment modality in cats. In receiving care of a specialized nature such as root canal treatment, patients need and deserve treatment that meets the standard of care and this study will shine a light on the efficacy of such treatment if rendered. Although root canal treatment is commonly performed in dogs and humans with a high success rate, the purpose of this study to evaluate the success rate of root canal treatment in cats, as we believe this treatment is just as appropriate for cats and with a similar high success rate.

Contact: Erica or Megan in the Dentistry and Oral Surgery Service via phone (530-752-2470)

Participation Requirements: Cats that have had a root canal treatment performed.

Initial Evaluation for Participation: None.

Procedures: Your cat will receive routine periodontal treatment under general anesthesia as part of the standard of care. While under anesthesia dental radiographs of the teeth of interest will be obtained.

Benefits: The study will cover the dental radiographs pertaining to the teeth of interest and the anesthesia to obtain those radiographs (induction plus the first 15 minutes). However, you will need to pay for any other charges estimated by the DOSS beyond that mentioned above.

We cannot promise any benefits to your cat or other animals from your taking part in this clinical trial; however, possible benefits include appropriate evaluation and treatment of the root canal procedure, along with diagnosis of other current dental or periodontal diseases.

Owner Responsibilities: You will be responsible for bringing your cat to the Dentistry and Oral Surgery Service (DOSS) and cover the costs of anesthesia for procedures related to the routine periodontal treatment (cleaning, extraction etc.), possible medications if needed, housing and recovery fee while at the hospital. You will not pay for dental radiographs necessary to evaluate the teeth of interest to the study, the initial induction fee for anesthesia and the time spend, obtained the dental radiographs, which is no more than 15 min.

Dogs

Dental Disease: Assessing Better Diagnostics in Brachycephalic Dogs

Title: The diagnostic yield of dental radiographs and cone-beam computed tomography in brachycephalic dogs with dental disorders

Purpose of Study: Because of the highly detailed images, cone-beam computed tomography (CBCT) scans are commonly used as diagnostic tools in human medicine with great success; however, these scans are only now being introduced to the veterinary field. Therefore, the purpose of this study is to establish CBCT scans as the ideal imaging modality for brachycephalic dogs with dental disorders.

Contact: Dr. Sophie Döring (Resident) in the Dentistry and Oral Surgery Service via phone (530-752-2470) or email (doering@ucdavis.edu)

Participation Requirements: Brachycephalic dogs diagnosed with dental disease that are referred to or are currently being treated by the Dentistry and Oral Surgery service (DOSS) at the UCD Veterinary Medical Teaching Hospital (VMTH).

Initial Evaluation for Participation: Examination by DOSS

Procedures: As part of the diagnostic work-up, we will image your dog via CBCT scan under general anesthesia. The CBCT scan will be done during your scheduled appointment with DOSS.

Benefits: You will not be charged for the CBCT scan; however, you will be charged for the general anesthesia and dental treatment.

We cannot promise any benefits to your dog from your taking part in this clinical trial; however, we hope that this study will lead to better diagnostics techniques. This study may also benefit other species with the same condition in the future.

Owner Responsibilities: Participation in this study does not require any additional visits beyond your scheduled appointment with DOSS.

With the exception of the CBCT scan, you will be responsible for bringing your dog to DOSS and paying for all other fees associated with your dog’s visit and treatment.

Discolored Teeth: Evaluating Tooth Vitality

Title: Thermal assessment of pulp vitality of discolored canine teeth in dogs

Purpose of Study: To date, we relied on clinical assessment and dental radiographs of discolored teeth to decide whether or not those teeth require treatment. Both modalities have limitations. With the use of a newly developed diagnostic tool called the TOTEM device, we will hopefully be able to assess tooth vitality much more accurately via tooth temperature. Therefore, the purpose of this study is to evaluate the clinical application of the TOTEM device to assess tooth vitality.

Contact: Dentistry and Oral Surgery Service (530) 752-2470

Participation Requirements: Dogs with discolored canine teeth.

Procedures: If you agree to let your dog participate in this study, the following will happen:

  • General anesthesia, clinical assessment and intraoral radiographs
  • Thermal assessment of the pulp vitality of the discolored canine tooth, which will take approximately 10 minutes
  • Appropriate, standard treatment (e.g., monitoring, extraction or root canal treatment)

Benefits: There is no charge for you to allow your dog to participate in this clinical trial as you will not be charged for the thermal measurement. However, you will need to pay the invoice that will be issued to you by the Dentistry and Oral Surgery Service for the regular diagnostics and the treatment of your dog.

At this point in the clinical trial we cannot promise any benefits to your dog or other animals. However, we are confident that this diagnostic tool will help to increase the accuracy of future treatment planning in regards to discolored teeth, no matter the species. Ultimately, our aim is to establish a new tool for diagnosis and treatment planning in regards to discolored teeth in dogs, but also in other animals.

Owner Responsibilities: Although the study will cover the costs for the thermal assessment of the discolored tooth, you will be responsible for bringing your dog to the Dentistry and Oral Surgery Service and paying for all costs associated with standard dental care.

Exotic Animals

Dental Disease: Assessing Better Diagnostics in Rabbits

Title: Cone-beam computed tomography anatomy of the rabbit dentition in health and disease

Purpose of Study: Because of the highly detailed images, cone-beam computed tomography (CBCT) scans are commonly used as diagnostic tools in human medicine with great success; however, these scans are only now being introduced to the veterinary field. Therefore, the purpose of this study is to establish CBCT scans as the ideal imaging modality for rabbits with dental disorders.

Contact: Dr. G.G. Comet Riggs (Resident) in the Dentistry and Oral Surgery Service via phone (530-752-2470) or email (griggs@ucdavis.edu)

Participation Requirements: Rabbits diagnosed with dental disease, including (but not limited to) periapical lesions, malocclusion, root elongation, lingual and buccal sharp points, that are referred to or are currently being treated by the Companion Exotic Animal Medicine and Surgery Service (CAPE) and Dentistry and Oral Surgery Service (DOSS) at the UCD Veterinary Medical Teaching Hospital (VMTH).

Exclusion criteria: Rabbits with any other concurrent diseases

Initial Evaluation for Participation: Examination by CAPE and DOSS

Procedures: As part of the diagnostic work-up, we will image your rabbit via CBCT scan under general anesthesia. The CBCT scan will be done during your scheduled appointment with our CAPE Service.

Benefits: You will not be charged for the CBCT scan. However, you will be charged for the general anesthesia and dental treatment.

We cannot promise any benefits to your rabbit from your taking part in this clinical trial; however, we hope that this study will lead to better diagnostics, and in turn, a reduction in the time that rabbits spend under anesthesia. This study may also benefit other species with the same condition in the future.

Owner Responsibilities: Participation in this study does not require any additional visits beyond your scheduled appointment with CAPE.

With the exception the CBCT scan, you will be responsible for bringing your rabbit to the CAPE service and paying for all other fees associated with your rabbit’s visit and treatment.