Dentistry & Oral Surgery

Below, please find links to all of the clinical trials involving dentistry and/or oral surgery. The studies include a multitude of information, including (but not limited to) the study’s purpose, benefits for participating, and financial incentive information. If you have any questions, please contact the individual outlined at the end of each trial summary.

Please visit the Dentistry and Oral Surgery service webpage at the Veterinary Medical Teaching Hospital (VMTH) if you would like to learn more about the amazing things that our veterinarians can do for you and your animal.


Chronic Gingivostomatitis: Finding a Treatment with Stem Cells

Title: Fat-derived Mesenchymal Stem-Cell Therapy for Cats with Chronic Gingivostomatitis

Purpose of Study: Feline chronic gingivostomatitis (FCGS) is a poorly defined disease characterized by inflammatory lesion, mostly ulcerative or proliferative in nature, affecting the gums and the back of the mouth. Moreover, FCGS is a painful and debilitating disease in cats that necessitates medical or surgical treatments. These include full-mouth extractions, antibiotic treatment, and corticosteroids. Recently, feline interferon treatment (currently unavailable in the USA) has been proposed for non-responsive stomatitis. However, none of these treatments are ideal, predictable and without possible complications. The quality of life to both pet and owner is significantly affected.

A form of stem cell therapy where stem cells are extracted from fat tissue has come to the forefront in recent years as a potential therapeutic option for chronic inflammatory diseases. This cell therapy may help to correct abnormalities of the immune system that may be involved with stomatitis in cats. Moreover, stem cells are shown to help in regenerating damaged tissues. Feline stem cells has shown to be easily generated in large quantities from a small amount of fat collected via minor surgical procedure but safely of systemic administration in cats was not reported previously.

In this study, our aim is to treat cats in which all current treatment modalities have failed and that have a poor quality of life. If the proposed stem cell treatment will prove to be beneficial, it may revolutionize the treatment options for cats with FCGS.

Participation Requirements:

  • Cats that had full-mouth extractions performed that have not resulted in a cure from the disease
  • Ineligible: Cats that did not have full-mouth extractions performed or have other concurrent systemic diseases

Initial Evaluation for Participation: Evaluation for eligibility by Dr. Boaz Arzi

Procedures: The following procedures will be performed:

  1. Collection of blood and urine for analysis before the treatment and at 4-6 recheck appointments
  2. Collection of fat tissue from under the skin via a small incision. The fat will then be processed and stem cells extracted.
  3. Two-weeks following collection of the fat tissue, we will administer the stem cells to the affected cats via intravenous administration. The treatment may need to be repeated one month after the first administration of stem-cells.
  4. Recheck appointment is required initially at 2 weeks interval and later at 1 month. Blood sample will be collected and will not exceed 5 milliliters (1 teaspoon).

Benefits: The proposed treatment strategy could have beneficial effects that may change the quality of life of your cat. We will also perform blood and urine test at no costs to you at each visit during the study. You will not be charged for the biopsy of fat tissue, the rechecks or the administration of the stem cells. You will only have to pay for take home medication, such as pain medication, as needed.

If this study will prove to be beneficial, it will have important clinical applications for other cats with the same condition.

Owner Responsibilities: The owner only needs to bring the cats to the VMTH for fat collection and for the scheduled recheck appointments.

Contact: Contact Dr. Boaz Arzi for details

Boaz Arzi, DVM, DAVDC
Tel: (530) 752-2470
Fax: (530) 752-9620

Printable Flyer (PDF)