Below, please find links to all of the clinical trials involving internal medicine. The studies include a multitude of information, including (but not limited to) the study’s purpose, benefits for participating, and financial incentive information. If you have any questions, please contact the individual outlined at the end of each trial summary.
Please visit the Internal Medicine service webpage at the Veterinary Medical Teaching Hospital (VMTH) if you would like to learn more about the amazing things that our veterinarians can do for you and your animal.
Title: Evaluation of Post-operative Outcome in Cats Undergoing Ureteral Stent Placement to Relieve Ureteral Obstruction
Purpose of Study: The purpose of this project is to record the intra-operative and postoperative complications associated with the procedure and determine the outcome of the procedure based on objective measures.
Participation Requirements: Cats with benign ureteral obstruction
Initial Evaluation for Participation: Contact Dr. Culp for details at email@example.com or (530) 752-1393
Procedures: Cats with a diagnosis of benign ureteral obstruction will be enrolled in the study. Bloodwork values that can be utilized to determine the function of the kidney (should improve with the passage of urine) as well as variables such as the size of the kidney collecting system and ureter (should decrease with passage of urine) in cats both pre- and postoperatively will be evaluated. Lastly, the change in the urine output of cats with ureteral stents will be assessed to determine if the stents improve output.
Benefits: The benefits of enrolling a patient in this study are financial. Some of the pre- and post-stent placement bloodwork and pre- and post-stent placement ultrasound evaluations will be paid for by the study.
If this therapy proves to be beneficial, it will have important clinical applications for other cats with the same condition.
Owner Responsibilities: The owner is responsible for returning with their cat 2 weeks and 3 months after stent placement.
Contact: Contact Dr. Culp for details at firstname.lastname@example.org or (530) 752-1393.
Title: Evaluation of the Use of Cystoscopic-Guided Laser Ablation in the Treatment of Canine Ureteral Ectopia
Purpose of Study: To evaluate urethral pressure profiles (UPPs) in patients undergoing laser ablation of their ectopic ureters. The goal is to determine if pre-treatment UPP values can help to predict continence rates after laser ablation.
Participation Requirements: Any dog with ectopic ureters that will be undergoing laser ablation may be included in the study. Owners must give approval for pre-treatment UPP measurements to be performed.
Initial Evaluation for Participation: Patients must undergo evaluation and diagnostic workup for ectopic ureters and there must be a high clinical suspicion that the patient has an ectopic ureter.
Procedures: The procedures that will be performed as part of this study are currently utilized in the diagnostic workup and treatment of ureteral ectopia, and include:
- Urethral pressure profilometry (UPP) - Performed in a manner similar to what has been described previously and involves the placement of a urinary catheter into the urethra via a transvulvar approach (non-invasive).
- Cystoscopic-guided laser ablation procedure - Performed via a transvulvar approach and involves the use of a laser to ablate the intramural portion of ectopic ureteral tissue.
Benefits: The benefits of enrolling in this study include financial support for pre-procedure diagnostics as well as support towards the performance of the cystoscopic-guided laser ablation procedure. Additionally, funding from this grant will be applied towards the anesthetic event.
Owner Responsibilities: Owners will need to give their approval for urethral pressure profilometry evaluation.
Contact: Dr. Carrie Palm (email@example.com)
Title: Assessment of Outcome in Dogs Undergoing Percutaneous Transvenous Coil Embolization to Treat Intrahepatic Portosystemic Shunts
Purpose of Study: The purposes of this project are to:
- Evaluate serum bile acid concentrations and hepatic biochemical functional parameters (BUN, albumin, cholesterol, glucose, and bilirubin) in dogs with intrahepatic portosystemic shunts both pre- and post-treatment to objectively evaluate each patient for improvement in hepatic function.
- Assess the improvement in the clinical signs of dogs with IHPSS after the performance of PTCE.
- To perform imaging studies pre- and post-PTCE that provide objective assessment of outcome associated with the PTCE procedure.
Participation Requirements: Dogs with intrahepatic portosystemic shunts
Initial Evaluation for Participation: Contact Dr. Culp for details at firstname.lastname@example.org or (530) 752-1393.
Procedures: Dogs with a diagnosis of intrahepatic portosystemic shunts (IHPSS) will be enrolled in the study. The dog will undergo percutanous transvenous coil embolization (PTCE) to treat his/her IHPSS. Prior to and after this procedure, diagnostics including bloodwork, nuclear scintigraphy, abdominal ultrasound and computed tomography (CT) scan will be performed and compared.
Benefits: Enrolling a dog in this study results in a significant financial incentive towards diagnostics that would be recommended for the dog whether or not he/she is enrolled in the study. This benefit includes payment of the preoperative CT scan and the postoperative bloodwork (1 chemistry panel at 3 months postoperative), ultrasound (1 at 3 months postoperative), nuclear scintigraphy scan (1 at 3 months postoperative) and CT scan (1 at 3 months postoperative).
Owner Responsibilities: Return the patient 3 months after treatment for further assessment.
Contact: Contact Dr. Culp for details at email@example.com or (530) 752-1393.
Title: Evaluation of CT pneumocolonography as a diagnostic tool in veterinary patients
Purpose of Study: The purpose of this study is to evaluate the impact of imaging findings on surgical decision-making in dogs with colonic and rectal disease of any kind (cancer or non-cancer). This part of the body can be a very difficult region examine with current imaging methods, which also do not provide optimal spatial information important if a surgical procedure is needed. In early studies, we have demonstrated the safety and efficacy of the CT pneumocolonography procedure in normal dogs, but it is important that we learn to accurately interpret the imaging findings for a wide variety of disease processes in clinical patients so that our CT diagnoses are accurate. Our goal is to compare the imaging findings obtained with CT pneumocolonography with the current standard of care of colonoscopy and colonoscopic biopsies.
Participation Requirements: In order to participate in this study, a colonoscopic exam must have been recommended for workup of your dog’s problem, and your dog must be scheduled to receive a colonoscopic exam under general anesthesia at UC Davis.
Initial Evaluation for Participation: None.
Procedures: If you agree to participate, your dog will receive a CT scan (with and without intravenous contrast material) in conjunction with carbon dioxide gas insufflated into the rectal lumen. Following CT pneumocolonography, your dog will receive the scheduled colonoscopy, which is the current standard of care for assessment of these masses, and if clinically indicated for the care of your dog, biopsies will be obtained.
Benefits: In return for participation in this study, your dog will receive a free CT scan (an approximately $800 value to you), which may directly benefit your dog, as it can provide important information for treatment recommendations that other types of imaging cannot. CT evaluation of local lymph nodes is an additional benefit as CT has been demonstrated to be helpful in the evaluation of regional lymph nodes for metastatic disease in other types of cancer in other locations.
Owner Responsibilities: There is no additional cost to you for your dog’s participation in the study. You are financially responsible for hospital costs associated with the standard care of your dog, including abdominal ultrasound, general anesthesia, colonoscopy, hospitalization, biopsies, and any other diagnostic tests recommended for evaluation of your dog’s disease by your attending clinician.
Contact: Drs. Michele Steffey and Stanley Marks (530-752-1393)