Nutrition

Flyer for Healthy Dog Clinical Trial for Assessing Amino Acid Concentrations in Urine

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Below, please find links to all of the clinical trials involving nutrition. The studies include a multitude of information, including (but not limited to) the study’s purpose, benefits for participating, and financial incentive information. If you have any questions, please contact the individual outlined at the end of each trial summary.

Please visit the Nutrition service webpage at the Veterinary Medical Teaching Hospital (VMTH) if you would like to learn more about the amazing things that our nutritionists can do for you and your animal.

Dogs

NEW! Healthy Dogs: Assessing Amino Acid Concentrations in Urine

Title: Amino Acid Concentrations in the Urine of Healthy Dogs

Purpose:  Amino acids are the building blocks of protein. We are trying to establish normal reference ranges for urinary amino acids in healthy dogs consuming dry, canned or commercial raw diets or home-prepared diets.

Contact:

Participation Requirements:

  • Healthy dogs consuming dry, canned or commercial raw diets or home-prepared diets
  • Ineligible:
    • Beagles and Greyhounds
    • Dogs consuming foreign or domestic jerky treats in the past 12 months

Initial Evaluation for Participation: Before your pet begins the study, you will need to complete the Feeding History Form asking about your pet and what they currently eat at home to find out if he/she qualifies to be in the study.

Procedures: You will need to complete a questionnaire about your dog and what your dog is currently eating at home, collect a small amount of urine (a minimal amount of 15 ml or 1 TB) in a clean cup we provide, and submit 2-3 photographs of the label of the diet you are currently feeding your dog.

Benefits: 

  • There is no cost to you to participate in this trial.
  • Results from this study may contribute to the development of a reference range for urinary amino acids in canine urine that will be used as part of a larger study to understand the severity and duration of urinary amino acid loss in dogs that develop acquired Fanconi syndrome.

Owner Responsibilities: If you wish to have your pet participate in this study, you will be responsible for completing the questionnaire to the best of your ability, collecting a small urine sample, taking 2-3 photographs of the label of your pet’s food and submitting those to the study investigators.

Printable Flyer (PDF)

Cystine Bladder Stones: Investigating an Oral Nutraceutical Treatment

Title: The effects of an oral nutraceutical on the solubility of cystine in canine urine

Purpose: 

  • Cystine bladder stones are common in both dogs and humans. This disease occurs due to a genetic predisposition, which occurs in many breeds of dogs. Therapeutic preventive strategies are limited.
  • Clinical signs can be mild or result in urethral obstruction in male dogs.
  • In a collaborative effort between the University of California San Francisco and The Buck Institute, the aim of this study is to evaluate the effects of an oral nutraceutical on cystine solubility in the urine.

Contact: Jodi L. Westropp DVM PhD DACVIM at stonelab@ucdavis.edu, Sean Hulsebosch DVM DACVIM at shulsebosch@ucdavis.edu, or make an appointment by calling (530) 752 – 1393.

Participation Requirements:

  • Dogs with a history of cystine stones
  • Healthy dogs with no history of cystine stones of similar breeds

Initial Evaluation for Participation: Known documented history of cystine stones

Procedures: 

  • A physical exam, abdominal ultrasound, blood and urine testing will be performed.
  • No follow-up visits will be required; however, urine samples will need to be collected at home after receiving the oral nutraceutical for one week.

Benefits: 

  • Free screening and diagnostic testing for your pet, including abdominal ultrasound, bloodwork and urinalyses
  • We hope that the data acquired in this study will allow us to advance the prevention of cystine bladder stones in both pets and people.

Owner Responsibilities:

  • Keeping the scheduled appointment
  • Administering the oral nutraceutical for 7 days
  • Three, at-home, urine collections while administering the medication to your dog

Printable Flyer (PDF)

Bladder Stones (Struvite): Dissolution via Diet

Title: Use of Canine Struvite Dissolution Diet in the Management of Infection Induced Struvite Stones in Dogs

Purpose: We hope to provide another option to struvite stone dissolution in dogs. The purpose of this trial is to evaluate the efficacy of a therapeutic diet for struvite dissolution in dogs.

Contact: Dr. Jodi Westropp at stonelab@ucdavis.edu or make an appointment by calling (530) 752-1393

Participation Requirements:

  • Dogs with radiodense bladder stone(s) and concurrent UTI with a urease-producing bacteria, such as Staphylococcus spp., Klebsiella spp. or Proteus spp.
  • Exclusion Criteria:
    • Dogs with concurrent disorders (e.g., diabetes mellitus)
    • Dogs consuming urinary prevention/dissolution diets
    • Dogs receiving antibiotics for more than 5 days (NOTE: Contact us when you are aware of these cases and we can usually see them within 24 hours)

Initial Evaluation for Participation: None.

Procedures: 

  • Blood and urine collection
  • Abdominal x-rays and ultrasound to document the size of the bladder stones (sedation and/or a cleansing enema may also be required)
  • Completion of a short daily questionnaire regarding your pet’s clinical signs during the study duration
  • Recheck evaluations will be scheduled at 2, and 4 weeks, and then monthly until stone dissolution or study failure.
  • If your dog’s stones do not dissolve in the time period stated, they will be removed via the most appropriate method (e.g., laser lithotripsy, surgery, or voiding urohydropropulsion) following a discussion with you.

Benefits: The study will cover all costs associated with participation and provide food free of charge for the duration of the study.

Results from this trial may help determine another dietary method for non-invasive struvite dissolution in dogs.

Owner Responsibilities: We expect that participation in this clinical trial will last approximately 4-28 weeks unless otherwise discussed. If you allow your dog to participate in this study, you will be responsible for coming to all scheduled appointments, feeding the test diet exclusively, and completing the questionnaire as described previously.

Owner - Printable Flyer (PDF
Referring Veterinarian - Printable Flyer (PDF)

If you cannot find what you are looking for, please email us or call (530) 752-5366.