Publications from Clinical Trials

General Translational Medicine
  • Kol, A., Arzi, B., Athanasiou, K.A., Farmer, D.L., Nolta, J.A., Rebhun, R.B., Chen, X., Griffiths, L.G., Verstraete, F.J.M., Murphy, C.J., & Borjesson, D.L. (2015).  Companion animals: Translational scientist's new best friends. Science Translational Medicine,  7(308), 1-8 (DOI: 10.1126/scitranslmed.aaa9116)
  • Lairmore, M.D., & Khanna, C. (2014). "Naturally Occurring Diseases in Animals: Contributions to Translational Medicine". Institute of Laboratory Animal Research, 55(1): 1-3. (DOI:10.1093/ilar/ilu022)
Anesthesia & Pain Management
  • Guedes, A.G.P., Morisseau, C., Sole, A., Soares, J.H.N., Ulu, A., Dong, H., & Hammock, B.D. (2013). "Use of a soluable epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis". Veterinary Anaesthesia and Analgesia, ePub, 7 Mar 2013. (DOI:10.1111/vaa.12030)
  • Woodhouse, K.J., Brosnan, R.J., Nguyen, K.Q., Moniz, G.W., & Galuppo, L.D. (2013). Effects of postanesthetic sedation with romifidine or xylazine on quality of recovery from isoflurane anesthesia in horses. Journal of the American Veterinary Medical Association, 242(4), 533-539. (DOI: 10.2460/javma.242.4.533)
  • Bain, M.J., Hart, B.L., Cliff, K.D. & Ruehl, W.W. (2001). Prevalence of behavioral changes associated with age-related cognitive impairment in dogs. Journal of the American Veterinary Medical Association, 218(11), 1792-5. (DOI:10.2460/javma.2001.218.1792)
  • Bergman, L., Hart, B.L., Bain, M.J., & Cliff, K. (2002). Evaluation of urine marking by cats as a model for understanding veterinary diagnostic and treatment approaches and client attitudes. Journal of the American Veterinary Medical Association, 221(9), 1282-86. (DOI:10.2460/javma.2002.221.1282)
  • Gaskins, L.A., & Bergman, L. (2011). Surveys of Avian Practitioners and Pet Owners Regarding Common Behavior Problems in Psittacine Birds. Journal of Avian Medicine and Surgery, 25(2), 111-8. (DOI:
  • Hart, B.L. (2001). Effect of gonadectomy on subsequent development of age-related cognitive impairment in dogs. Journal of the American Veterinary Medical Association, 219(1), 51-56. (DOI:10.2460/javma.2001.219.51)
  • Hart, B.L., Cliff, K.D., Tynes, V.V. & Bergman, L. (2005). Control of urine marking by use of long-term treatment with fluoxetine or clomipramine in cats. Journal of the American Veterinary Medical Association, 226(3), 378-82. (DOI:10.2460/javma.2005.226.378)
  • Helms, T.D. & Bain, M.J. (2009). Evaluation of owner attachment to dogs on the basis of whether owners are legally considered guardians of their pets. Journal of the American Veterinary Medical Association, 234(7), 896-900. (DOI:10.2460/javma.234.7.896)
  • Kwan, J.Y., & Bain, M.J. (2013). Owner Attachment and Problem Behaviors Related to Relinquishment and Training Techniques of Dogs. Journal of Applied Animal Welfare Science, 16(2), 168-83. (DOI:10.1080/10888705.2013.768923)
  • Malamed, R., Berger, J., Bain, M.J., Kass, P., & Spier, S.J. (2011). Retrospective evaluation of crib-biting and windsucking behaviours and owner-perceived behavioural traits as risk factors for colic in horses. Equine Veterinary Journal, 42(8), 686-92. (DOI:10.1111/j.2042-3306.2010.00096.x)
  • Neilson, J.C., Hart, B.L., Cliff, K.D., & Ruehl, W.W. (2001). Prevalence of behavioral changes associated with age-related cognitive impairment in dogs. Journal of the American Veterinary Medical Association, 218(11), 1787-91. (DOI:10.2460/javma.2001.218.1787)
  • Pryor, P.A., Hart, B.L., Cliff, K. & Bain, M.J. (2001). Effects of a selective serotonin reuptake inhibitor on urine spraying behavior in cats. Journal of the American Veterinary Medical Association, 221(11), 1557-61. (DOI:10.2460/javma.2001.219.1557)
  • Pryor, P.A., Hart, B.L., Bain, M.J. & Cliff, K. (2001). Causes of urine marking in cats and effects of environmental management on frequency of marking. Journal of the American Veterinary Medical Association, 219(12), 1709-13. (DOI:10.2460/javma.2001.219.1709)
  • Segurson, S.A., Serpell, J.A., & Hart, B.L. (2005). Evaluation of a behavioral assessment questionnaire for use in the characterization of behavioral problems of dogs relinquished to animal shelters. Journal of the American Veterinary Medical Association, 227(11), 1755-61. (DOI:10.2460/javma.2005.227.1755)
  • Stepita, M.E., Bain, M.J., & Kass, P.H. (2013). Frequency of CPV Infection in Vaccinated Puppies that Attended Puppy Socialization Classes. Journal of the American Animal Hospital Association, 49(2), 95-100. (DOI:1053526/JAAHA-MS-5825)
  • Sueda, K.L.C., Hart, B.L., & Cliff, K.D. (2008).  Characterisation of plant eating in dogs.  Applied Animal Behaviour Science, 111(1-2), 120-132.  (DOI:10.1016/j.applanim.2007.05.018)
  • Takeuchi, Y., Kaneko, F., Hasizume, C., Masuda, K., Ogata, N., Maki, T., Inoue-Muramyama, M., Hart, B.L., & Mori, Y. (2009).  Association analysis between canine behavioural traits and genetic polymorphisms in the Shiba Inu breed.  Animal Genetics, 40(5), 616-622.  (DOI:10.1111/j.1365-2052.2009.01888.x)
  • Torres de la Riva, G., Hart, B.L., Farver, T.B., Oberbauer, A.M., Messam, L.L.M., Willits, N., & Hart, L.A. (2013). Neutering Dogs: Effects on Joint Disorders and Cancers in Golden Retrievers. Public Library of Science One, 8(2), e55937. (DOI:10.1371/journal.pone.0055937)
  • Tynes, V.V., Hart, B.L. & Bain, M.J. (2007). Human-directed aggression in miniature pet pigs. Journal of the American Animal Hospital Association, 230(3), 385-89. (DOI:10.2460/javma.230.3.385)
  • Tynes, V.V., Hart, B.L., Pryor, P.A., Bain, M.J., & Messam, L.L.M. (2003). Evaluation of the role of lower urinary tract disease in cats with urine-marking behavior. Journal of the American Veterinary Medical Association, 223(4), 457-61. (DOI:10.2460/javma.2003.223.457)
Cardiology (Heart)
  • Stern, J.A., White, S.N., Lehmkuhi, L.B., Reina-Doreste, Y., Ferguson, J.L., Nascone-Yodeer, N.M., & Meurs, K.M. (2014). A single codon insertion in PICALM is associated with development of familial subvalvular aortic stenosis in Newfoundland dogs. Human Genetics, 133(9), 1139-48. (DOI: 10.007/s00439-014-1454-0)
Dentistry and Oral Surgery (Mouth and Face)
  • Arzi, B., Mills-Ko, E., Verstraete, F.J.M., Kol, Amir, Walker, N.J., Badgley, M.R., Fazel, N., Murphy, W.J., Vapniarsky, N., & Borjesson, D.L. (2016).  Therapeutic Efficacy of Fresh, Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats.  Stem Cells Translational Medicine, 5:1-12.  (DOI: 10.5966/sctm.2015-0127)
  • Arzi, B., Kol, A., Murphy, B., Walker, N.J., Wood, J.A., Clark, K., Verstraete, F.J.M., & Borjesson, D.L. (2015)  Feline Foamy Virus Adversely Affects Feline Mesenchymal Stem Cell Culture and Expansion: Implications for Animal Model Development.  Stem Cells and Development, 24(7): 814-23. (DOI: 10.1089/scd.2014.0317)
  • Arzi, B. & Verstraete, F.J.M. (2014). Internal Fixation of Severe Maxillofacial Fractures in Dogs. Veterinary Surgery, ePub, 11 Feb 2014 (DOI: 10.1111/j.1532-950X.2014.12161.x)
  • Arzi, B. & Verstraete, F.J.M. (2014). Regenerating Mandibular Bone Using rhBMP-2: Part 1 - Immediate Reconstruction of Segmental Mandibulectomies. Veterinary Surgery, ePub, 10 Jan 2014 (DOI: 10.1111/j.1532-950X.2014.12123.x)
  • Farcas, N., Lommer, M.J., Kass, P.H., & Verstraete, F.J.M. (2014). Dental radiographic findings in cats with chronic gingivostomatitis (2002-2012). Journal of the American Veterinary Medical Association, 244, 339-45. (DOI: 10.2460/javma.244.3.339)
  • Henry, T., Pusterla, N., Guedes, A.G., & Verstraete, F.J.M. (2014). Evaluation and clinical use of an intraoral inferior alveolar nerve block int he horse. Equine Veterinary Journal, ePub, 22 Nov 2013. (DOI: 10.1111/evj.12219)
  • Loutonen, N., Kuntsi-Vaattovaara, H., Sarkiala-Kessel, E., Junnila, J.J.T., Laitinen-Vapaavuori, O., & Verstraete, F.J.M. (2014). Vital pulp therapy in dogs: 190 cases (2001-2011). Journal of the American Veterinary Medical Association, 244 (4); 449-59. (DOI: 10.2460/javma.244.4.449)
  • Nemec, A., Daniaux, L., Johnson, E., Peralta, S., & Verstraete, F.J.M. (2014). Craniomaxillofacial Abnormalities in Dogs with Congenital Palatal Defects: Computed Tomographic Findings.  Veterinary Surgery, ePub 16 Jan 2014 (DOI: doi: 10.1111/j.1532-950X.2014.12129.x.)
  • Peralta, S., Nemec, A., Fiani, N., & Verstraete, F.J.M. (2014). Staged Double-Layer Closure of Palatal Defects in 6 Dogs. Veterinary Surgery, ePub, 29 Jan 2014. (DOI:10.1111/j.1532-950X.2014.12131.x.)
  • Verstraete, F.J.M., Arzi, B., Huey, D.J., Cissell, D.D., & Kyriacos, A. (2014). Regenerating Mandibular Bone Using rhBMP-2: Part 2 - Treatment of Chronic, Defect Non-Union Fractures. Veterinary Surgery, ePub, 10 Jan 2014. (DOI: 10.1111/j.1532-950X.2014.12122.x)
  • Pedersen, N.C., Brucker, L., Green Tessier, N., Liu, H., Penedo, M.C.T., Hughes, S., Oberbauer, A., & Sacks,B. (2015).  The Effect of Genetic Bottlenecks and Inbreeding on the Incidence of Two Major Autoimmune Diseases in Standard Poodles, Sebaceous Adenitis and Addison's Disease.  Canine Genetics and Epidemiology, 2:14. (DOI:10.1186/s40575-015-0026-5)
  • Truve, K., Dickinson, P., Xiong, A., York, D., Jayashankar, K., Pielberg, G., et al. (2016). Utilizing the Dog Genome in the Search for Novel Candidate Genes Involved in Glioma Development - Genome Wide Association Mapping followed by Targeted Massive Parallel Sequencing Identifies a Strongly Associated Locus. Public LIbrary of Science Genetics, e1006000. (DOI: 10.1371/journal.pgen.1006000)
  • Safra, N., Bassuk, A.G., Ferguson, P.J., Aguilar, M., Coulson, R.L., Thomas, N., Hitchens, P.L., Dickinson, P.J., Vernau, K.M., Wolf, Z.T., Bannasch, D.L. (2013). Genome-Wide Association Mapping in Dogs Enables Identification of the Homeobox Gene, NKX2-8, as a Genetic Component of Neural Tube Defects in Humans. Public Library of Science One Genetics, 9(7): e1003646. (DOI:10.1371/journal.pgen.1003646)
  • Vernau, K., Runstadler, J.A., Brown, E.A., Cameron, J.M., Juson, H.J., Higgins, R.J., Ackerley, C., Sturges, B.K., Dickinson, P.J., Purschner, B., Giulivi, C., Shelton, D., Robinson, B.H., DiMauro, S., Bollen, A.W., & Bannasch, D. (2013). Genome-Wide Association Analysis Identifies a Mutation in the Thiamine Transporter 2 (SLC19A3) Gene Associated with Alaskan Husky Encephalopathy. Public Library of Science One, 8(3): e57195. (DOI:10.1371/journal.pone.0057195)
Oncology (Cancer)
  • Burton, J., & Khanna, C. (2014). The Role of Clinical Trials in Veterinary Oncology. Veterinary Clinics of North America: Small Animal Practice, 44(5): 977-87.  (DOI:
  • Frazier, S.A., McKemie, D.S., Guerrero, T.A., Lachapelle, H., Skorupski, K.A., Kass, P.H., & Rodriguez, Jr., C.O. (2012). Phase I clinical trial of oral rosiglitazone in combination with intraveous carboplatin in cancer-bearing dogs.  Veterinary and Comparative Oncology, ePub 24 Feb 2012.  (DOI: 10.1111/j.1476-5829.2012.00322.x)
Ophthalmology (Eyes)
  • Labelle, A.L., Hamor, R.E., Townsend, W.M., Mitchelle, M.A., Zarfoss, M.K., Breaux, C.B., Thomasy, S.M., & Hall, T. (2011). Ophthalmic lesions in neonatal foals evaluated for nonophthalmic disease at referral hospitals. Journal of the American Veterinary Medical Association, 239 (4), 486-92. (DOI:10.2460/javma.239.4.486)
  • Thomasy, S.M., Covert, J.C., Stanley, S.D., & Maggs, D.J. (2012). Pharmacokinetics of famciclovir and penciclovir in tears following oral administration of famciclovir to cats: a pilot study. Veterinary Ophthalmology, 1-8. (DOI:10.1111/j.1463-5224.2011.00984.x)