Retinal epithelial dystrophy (central progressive retinal degeneration)

Source dog
Fixative Zenker's
Stain hematoxylin & eosin
Notes retinal epithelial cells are enlarged due to accumulation of lipofuscin which is fluorescent
See also another H&E section
another H&E section
another H&E section
fluorescence microscopy section
Legend onl - outer nuclear layer (photoreceptor cell bodies); r - retinal epithelium: most of cytoplasm of these enlarged cells filled with light brown pigment which is lipofuscin; arrows - mercurial precipitates often seen as an artifact of Zenker's fixation
Illustration click on image to see larger picture