Deslorelin for reproductive regulation in birds

Birds in captive environments are not exposed to the same natural cues for reproduction as wild birds. In addition, bonding and socializing with owners may promote excessive reproductive activity. These factors contribute to common and potentially life-threatening problems such as egg binding, egg yolk coelomitis, and cloacal prolapse. These problems may improve with adjustments in the bird’s physical and social environment, but often do not completely resolve. Deslorelin is a contraceptive hormone used in many species, formulated as a long-term sustained release implant, which suppresses the animal’s own reproductive activity. However, the strength and duration of effect vary widely between species, so CZAR researchers are conducting studies to determine the appropriate dose and duration for use of deslorelin implants in birds.

Grants:

  • 2011 CCAH Resident Grant: Effects of deslorelin on egg production and sex hormones in Japanese quail (Coturnix coturnix japonica)
  • 2012 CCAH Resident Grant: Effects of 9.4 mg deslorelin acetate implants in quail as a model for parrots

Publications:

Petritz OA, Sanchez-Migallon Guzman D, Paul-Murphy J, Fecteau K, Mete A, Kass PH, Hawkins MG. Evaluation of the efficacy and safety of single administration of 4.7-mg deslorelin acetate implants on egg production and plasma sex hormones in Japanese quail (Coturnix coturnix japonica). Am J Vet Res. 2013; 74(2):316-323.