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Equine Viral Disease Laboratory
UC Davis School of Veterinary Medicine
 
ceh photo
 
 

Researchers in the Equine Viral Disease Laboratory publish the results of their studies in a number of major scientific journals. Some publications are listed below.

 
Development and characterization of an infectious cDNA clone of the virulent Bucyrus strain of equine arteritis virus. U. B. Balasuriya, E. J. Snijder, H. W. Heidner, J. Zhang, J. C. Zevenhoven-Dobbe, J. D. Boone, W. H. McCollum, P. J. Timoney, and N. J. MacLachlan, J. Gen. Virol., 88: 918-924, 2007.
 
Recombinant canarypox virus vaccine co-expressing genes encloding the VP2 and VP5 outer capside proteins of bluetongue virus induces high level protection in sheep. J. D. Boone, U. B. Balasuriya, K. Karaca, J-C. Audonnet, J. Yao, L. He, R. Nordgren, F. Monaco, G. Savini, I. A. Gardner, and N. J. MacLachlan, Vaccine, 25:672-678, 2007.
 
Experiences with new generation vaccines against equine viral arteritis, West Nile disease and African horse sickness. N. J. MacLachlan, U. B. Balasuriya, N. L. Davis, M. Collier, R. E. Johnson, and A. D. Guthrie, Vaccine, in press.
 
Incidence and effects of West Nile virus infection in vaccinated and unvaccinated horses. I. A. Gardner, S. J. Wong, G. L. Ferraro, U. B. Balasuriya, P. J. Hullinger, W. D. Wilson, P. Y. Shi, and N. J. MacLachlan, Vet. Res., 38:109-116, 2007.
 
Detection of antibodies to West Nile virus in eqine sera using microsphere immunoassay. U. B. Balasuriya, P. Y. Shi, S. J. Wong, V. L. Demarest, I. A. Gardner, P. J. Hullinger, G. L. Ferraro, J. D. boone, C. L. DeCino, A. L. Glaser, R. W. Renshaw, M. Ledizet, R. A. Koski, and N. J. MacLachlan, J. Vet. Diagn. Invest., 18:392-395, 2006.
 

Isolation of equine herpesvirus-5 from blood mononuclear cells of a California gelding. S. A. Bell, U. B. Balasuriya, R. W. Nordhausen, and N. J. MacLachlan, J. Vet. Diagn. Invest., 18:472-475, 2006.

 
Temporal detection of equine herpesvirus infections of a cohort of mares and their foals. S. A. Bell, U. B. Balasuriya, I. A. Gardner, P. A. Barry, W. D. Wilson, G. L. Ferraro, and N. J. MacLachlan, Vet. Microbiol., 116:249-257, 2006.
 

Adenovirus infection of hospitalized and healthy foals and horses. S. A. Bell, M. Leclere, I. A. Gardner, and N. J. MacLachlan, Eq. Vet. J., 38:379-381, 2006.

 
Acute encephalitis, polyarthritis and myocarditis associated with West Nile virus infection in a dog. A. B. Cannon, J. Luff, A. C. Brault, N. J. MacLachlan, J. B. Case, E. N. Green, and J. E. Sykes, J. Vet. Int. Med., 20:1219-1223, 2006.
 
Prevalence of antibodies against Saint Louis encephalitis and Jamestown Canyon viruses in California horses. D. M. Nelson, I. A. Gardner, R. F. Chiles, U. B. Balasuriya, B. F. Eldridge, T. W. Scott, W. K. Reisen, and N. J. MacLachlan, Comp. Immunol. Microbiol. Infect. Dis., 27: 209-215, 2004.
 
Genetic characterization of equine arteritis virus during persistent infection of stallions. U.B.R. Balasuriya, J. F. Hedges, V. L. Smalley, A. Navarette, W. H. McCollum, P. J. Timoney, and N. J. MacLachlan, J. Gen. Virol., 85: 379-390, 2004.
 
Characterization of the neutralization determinants of equine arteritis virus using recombinant
chimeric viruses and site-directed mutagenesis of an infectious cDNA clone.
U.B.R. Balasuriya, J. C. Dobbe, H. W. Heidner, V. L. Smalley, A. Navarrette, E. J. Snijder, and N. J. MacLachlan, Virology, 321: 235-246, 2004.
 

The immune response to equine arteritis virus: Potential lessons for other arteriviruses. U.B.R. Balasuriya and N. J. MacLachlan, Vet. Immunol. Immunopathol., 102: 107-129, 2004.

 
Progressive swelling, hyperkeratosis and fibrosis of distal limbs in Clydesdale, Shires and Belgian draft horses suggestive of primary lymphedema. H. E. DeCock, V. K. Affolter, E. R. Wisner, G. L. Ferraro, N. J. and MacLachlan, Lymphatic Res. Biol., 1: 191-199, 2003.
 

Lateral transmission of equine arteritis virus amongst Lipizzaner stallions in South Africa. A. J. Guthrie, P. G. Howell, J. F. Hedges, A. M. Bosman, U.B.R. Balasuriya, W. H. McCollum, P. J. Timoney, and N. J. MacLachlan, Eq. Vet. J., 35:596-600, 2003.

 
West Nile virus infection of Thoroughbred horses in South Africa, 2000-2001. A. J. Guthrie,
P. G. Howell, I. A. Gardner, R. E. Swanepoel, J. P. Nurton, C. K. Harper, A. Pardini, D. Groenewald, C. W. Visage, J. F. Hedges, U. B. Balasuriya, A. J. Cornel, and N. J. MacLachlan, Eq. Vet. J., 35:601-605, 2003.
 
Virulent and avirulent strains of equine arteritis virus induce different amounts of TNF-α and other proinflammatory cytokines in alveolar and blood-derived equine macrophages. B. D. Moore, U.B.R. Balasuriya, J. L. Watson, C. M. Bosio, R. J. MacKay, and N. J. MacLachlan, Virology, 314: 662-670, 2003.
 
The serologic response of horses to equine arteritis virus as determined by competitive enzyme-linked immuosorbent assays to structural and non-structural viral proteins. H. Wagner, U.B.R. Balasuriya, and N. J. MacLachlan, Comp. Immunol. Microbiol. Infect. Dis., 26: 251-260, 2003.
 

Detection of equine arteritis virus by real-time TaqMan reverse transcription-PCR assay. U.B.R. Balasuriya, C. M. Leutenegger, J. B. Topol, W. H. McCollum, P. J. Timoney, and N. J. MacLachlan, J. Virol. Methods, 101: 21-28, 2002.

 
Alphavirus replicon particles expressing the two major envelope proteins of equine arteritis
virus induce high level protection against challenge with virulent virus in vaccinated horses.
U.B.R. Balasuriya, H. W. Heidner, N. L. Davis, R. E. Johnston, H. M. Wagner, P. J. Hullinger, J. F. Hedges, W. D. Wilson, I. K. Liu, M. Scott, and N. J. MacLachlan, Vaccine, 20: 1609-1617, 2002.
 
Growth kinetics of an avirulent, a moderately virulent and a highly virulent strain of equine arteritis virus in primary equine endothelial cells are predictive of their virulence to horses. B. D. Moore, J. F. Hedges, U.B.R. Balasuriya, C. D. DeMaula, and N. J. MacLachlan, Virology, 298: 39-44, 2002.