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Photo: Reen Wu

Reen Wu
Anatomy, Physiology & Cell Biology



1965 B.S. Agricultural Chemistry, National Taiwan University, Taipei, Taiwan
l968 M.S. Biochemistry, National Taiwan University, School of Medicine, Taipei, Taiwan
l972 Ph.D. Biochemistry, University of Arkansas, School of Medicine, Little Rock, Arkansas
1976 Postdoc Training Molecular and Cell Biology, University of California, San Diego, La Jolla, San Diego

Honors and Awards

l974-l976 NIH, National Research Service Award
l972- l973 NIH National Research Service Award, Postdoctoral Fellowship
l966-l968 Chinese National Science Council, Scholarship
2007 Dean's Excellence in Mentoring Award, School of Medicine, UC Davis
2006 Pfizer Award for Reserach Excellence, VM School, UC Davis
1996 Faculty Research Award, School of Medicine, UC Davis
1995 NIH Merit Award, R37 HL35635
1993 Joan Oettinger Memorial Award, School of Medicine, UC Davis
1981 Quality Increase Award, National Institute of Environmental Health Sciences
1972-1974 American Cancer Society, Postdoctoral Fellowship

Active Research Grants

Co-Investigator, Pulmonary Effects of Environmental Oxidant Pollutants, Dallas M. Hyde (Principal Investigator), NIH

Principal Investigator, Role of Epithelium in Airway Immunity, (Principal Investigator), NIH/NHLBI

Principal Investigator, Roles of IL-17-induced Gene Expression in Airway Epithelial Host Defense, (Principal Investigator), NIH/NHLBI

Principal Investigator, Training in Comparative Lung Biology and Medicine, (Principal Investigator), NIH/NHLBI

Principal Investigator, Regulation of Airway Mucin Gene Expression by Epigenetic Mechanism, (Principal Investigator), NIH/NHLBI

Most Recent 10 Publications

  • Link Icon 2010 Oslund KL, Adamson G, Wu R Evaluation of MUC5AC Epression and Upregulation in Airway Epithelial Cells of Horses American Journal of Veterinary Research,
  • Link Icon 2009 Fujisawa T, Velichko S, Thai P, Hung LY, Huang F, Wu R Regulation of airway MUC5AC expression by IL-1beta and IL-17A; the NF-kappaB paradigm Journal of Immunology,
  • Link Icon 2008 Lee YC, Chuang CY, Lee PK, Lee JS, Harper RW, Buckpitt AB, Wu R, Oslund K TRX-ASK1-JNK signaling regulation of cell density-dependent cytotoxicity in cigarette smoke-exposed human bronchial epithelial cells The American Journal of Physiology-Lung Cellular and Molecular Physiology,
  • Link Icon 2008 Kao CY, Kim C, Huang F, Wu R Requirements for two proximal NF-kappa B binding sites and Ikappa B-zeta in IL-17A-induced human beta-defensin 2 expression by conducting airway epithelium Journal of Bological Chemistry,
  • Link Icon 2008 Zhu L, Pi J, Wachi S, Andersen ME, Wu R, Chen Y Identification of Nrf2-dependent airway epithelial adaptive response to proinflammatory oxidant-hypochlorous acid challenge by transcription profiling American Journal of Phsyiology-Lung Cellular and Molecular Physiology,
  • Link Icon 2008 Hung LY, Velichko S, Huang F, Thai P, Wu R Regulation of airway innate and adaptive immune responses: the IL-17 paradigm Critical Reviews in Immunology,
  • Link Icon 2008 Huang F, Wachi S, Thai P, Loukoianov A, Tan KH, Forteza RM, Wu R Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: important implications in asthma Journal of Allergy and Clinical Immunology,
  • Link Icon 2008 Thai P, Loukoianov A, Wachi S, and Wu R Regulation of airway mucin gene expression Annual Reviews of Physiology,
  • Link Icon 2007 Huang F, Kao CY, Wachi S, Thai P, Ryu J, Wu R Requirement for both JAK-mediated PI3K signaling and ACT1/TRAF6/TAK1-dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells Journal of Immunology,
  • Link Icon 2007 Wu DY, Wu R, Chen Y, Tarasova N, Chang MM PMA stimulates MUC5B gene expression through an Sp1-based mechanism in airway epithelial cells American Journal of Respiratory Cell and Molecular Biology,

Most Recent 5 Book Chapters

2008 Hyde DM, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdalovic MV, Evans MJ, Kajekar R, Buckpitt AR, Pinkerton KE, Joad JP, Gershwin LJ, Wu R, and Plopper CG: Chronic Airway Disease in Nonhuman Primates., In N.F. Voelkel and W. MacNee, Chronic Obstructive Lung Diseases, Second Ed., (ed), , Hamilton, Chapter 17. 235-268.

2007 Chang, M.M., L. Shih and R. Wu: Pulmonary epithelium: Cell types and functions, David Proud, (ed), The Pulmonary Epithelium in Health and Disease. .

2001 Chang, M.M.J., Chen, Y., Zhao, Y.H., Peck, K., Li, C., and Wu, R.: Application of high density DNA microarray membrane to study gene expression patterns associated with human airway epithelial cell differentiation in culture, Cilia, Mucus, and Mucociliary Interactions; eds. By Salathe, M., Boucher, R.C., and Adler, K.B., (ed), , New York. Chapter 21, 225-237.

1998 Wu, R.: Culture of normal human airway epithelial cells and measurement of mucin synthesis and secretion, K.F. Chung and I. Adcock, (ed), Methods in Molecular Medicine: Asthma, Totowa, New Jersey. Chapter 26.

1997 Wu, R: Growth and differentiation of tracheobronchial epithelium, Chapter 8, J.A. McDonald, (ed), Lung Growth and Development, New York. 211-241.