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Laura Van Winkle- BS, PhD
Researcher and Adjunct Professor
Anatomy, Physiology & Cell Biology

508 CHE
Davis, CA 95616

+1 530 754 7547
lsvanwinkle@ucdavis.edu

   

Research Focus

The role of sex-differences and xenobiotic metabolism in lung pathology and toxicology. Air pollution including tobacco smoke, particulates and ozone. Growth factors and cell-cell interactions in lung wound healing, in lung disease (lung cancer and asthma) and during lung development. Cell proliferation and progenitor cells. Microscopes and imaging methods.

Specialty Focus

Toxicology of the lung. Diplomate American Board of Toxicology (DABT)

Education

1987 BS Pharmacology, University of California, Santa Barbara
1995 PhD Pharmacology and Toxicology, University of California, Davis

Honors and Awards

1997-1999 American Lung Association Research Fellow
1995-1997 NHLBI Pulmonary Postdoctoral Training Fellowship
1994 Robert Emrie Smith Memorial Research Fellowship in Physiology
1993-1995 NIEHS Training Fellowship in Environmental Toxicology
1992-1993 Graduate Fellowship in Environmental Health Sciences

Licenses

Diplomate American Board of Toxicology (General Toxicology)

Active Research Grants

Principal Investigator, Engineered Nanomaterials: Linking Physical and Chemical Properties to Biology, (Principal Investigator), NIH/NIEHS

Co-Investigator, Health Effects of Central Valley Particulate Matter, Wexler (Principal Investigator), California Air Resources Board

Co-Investigator, Superfund Basic Research Program - Biomarkers to Hazardous Chemicals: Project 4: Urinary Protein Biomarkers for assessing the potential for toxicity, Hammock PI of P42/Buckpitt PI of Project 4 (Principal Investigator), NIH/NIEHS

Principal Investigator, Monkey Nasal explant responses to naphthalene, (Principal Investigator), American Petroleum Institute

Principal Investigator, Metabolic mechanisms of naphthalene toxicity in lung, (Principal Investigator), NIH/NIEHS/NHLBI

Principal Investigator, Prenatal Bisphenol A and Lung Maturation, (Principal Investigator), NIEHS/NHLBI/NICCHD

Most Recent 10 Publications

  • Link Icon 2013 Chan JK, Vogel CF, Baek J, Kodani SD, Uppal,RS, Bein KJ, Anderson DS, Van Winkle LS Combustion derived ultrafine particles induce cytochrome P-450 expression in specific lung compartments in the developing neonatal and adult rat Am J Physiol Lung Cell Mol Physiol,
  • Link Icon 2013 Chan JK, Kodani SD, Charrier JG, Morin D, Edwards PC, Anderson DS, Anastasio C, Van Winkle LS Age-specific effects on rat lung glutathione and antioxidant enzymes after inhaling ultrafine soot American journal of respiratory cell and molecular biology,
  • Link Icon 2013 Murphy SR, Schelegle ES, Miller LA, Hyde DM, Van Winkle LS Ozone exposure alters serotonin and serotonin receptor expression in the developing lung Toxicological sciences : an official journal of the Society of Toxicology,
  • Link Icon 2013 Buckpitt A, Morin D, Murphy S, Edwards P, Van Winkle L Kinetics of naphthalene metabolism in target and non-target tissues of rodents and in nasal and airway microsomes from the Rhesus monkey Toxicol Appl Pharmacol,
  • Link Icon 2013 Abid AD, Anderson DS, Das GK, Van Winkle LS, Kennedy IM Novel lanthanide-labeled metal oxide nanoparticles improve the measurement of in vivo clearance and translocation Particle and fibre toxicology,
  • Link Icon 2013 Van Winkle LS, Murphy SR, Boetticher MV, Vandevoort CA Fetal exposure of rhesus macaques to bisphenol a alters cellular development of the conducting airway by changing epithelial secretory product expression Environmental health perspectives,
  • Link Icon 2013 Chan JK, Charrier JG, Kodani SD, Vogel CF, Kado SY, Anderson DS, Anastasio C, Van Winkle LS Combustion-derived flame generated ultrafine soot generates reactive oxygen species and activates Nrf2 antioxidants differently in neonatal and adult rat lungs Particle and fibre toxicology,
  • Link Icon 2013 Gharib SA, Altemeier WA, Van Winkle LS, Plopper CG, Schlesinger SY, Buell CA, Brauer R, Lee V, Parks WC, Chen P Matrix metalloproteinase-7 coordinates airway epithelial injury response and differentiation of ciliated cells American journal of respiratory cell and molecular biology,
  • Link Icon 2012 Murphy SR, Schelegle ES, Edwards PC, Miller LA, Hyde DM, Van Winkle LS Postnatal exposure history and airways: oxidant stress responses in airway explants American journal of respiratory cell and molecular biology,
  • Link Icon 2012 Plopper CG, Joad JP, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdalovic MV, Evans MJ, Lasley WL, Buckpitt AR, Pinkerton KE, Tarkington BK, Davis S, Nishio SJ, Gershwin LJ, Wu R, Hyde DM Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,

Most Recent 5 Book Chapters

2010 Pinkerton KE, Smiley-Jewell S, Van Winkle LS: Tracheobronchial airways, Yost et al, (ed), Toxicology of the Respiratory System, Comprehensive Toxicology, 2nd Edition. .

2010 Van Winkle LS: Cell damage and cell renewal in the lung, Yost et al, (ed), Toxicology of the Respiratory System, Comprehensive Toxicology, 2nd Edition. .

2008 Plopper CG, Smiley-Jewell SM, Miller LA, Fanucchi MV, Evans MJ, Buckpitt AR, Avdalovic M, Gershwin LJ, Joad JP, Kajekar R, Larson S, Pinkerton KE, Van Winkle LS, Schelegle ES, Pieczarka EM, Wu R, Hyde DM: Primate Models of Allergic Asthma, Kay AB et al, (ed), Allergy and Allergic Diseases, London. Chapter 54.

2008 Hyde DM, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdolovic MV, Evans MJ, Kajekar R, Buckpitt AR, Pinkerton KE, Joad JP, Gershwin LJ, Wu R, Plopper CG: Chronic airway disease in nonhuman primates, Voelkel & MacVee, (ed), Chronic Obstructive Lung Disease. Chapter 17.

2006 Witschi HR, Pinkerton KE, Van Winkle LS, Last JA: Chapter 15: Toxic Responses of the Respiratory System, Klaassen, (ed), Casarett and Doull's Toxicology: the basic science of poisons. .