Search for Faculty

 

Laura Van Winkle- BS, PhD
Adjunct Professor
Anatomy, Physiology & Cell Biology

508 CHE
Davis, CA 95616

+1 530 754 7547
lsvanwinkle@ucdavis.edu

   

Research Focus

The role of sex-differences and xenobiotic metabolism in lung pathology and toxicology. Air pollution including tobacco smoke, particulates and ozone. Growth factors and cell-cell interactions in lung wound healing, in lung disease (lung cancer and asthma) and during lung development. Cell proliferation and progenitor cells. Microscopes and imaging methods.

Specialty Focus

Toxicology of the lung. Diplomate American Board of Toxicology (DABT)

Education

1987 BS Pharmacology, University of California, Santa Barbara
1995 PhD Pharmacology and Toxicology, University of California, Davis

Honors and Awards

1992-1993 Graduate Fellowship in Environmental Health Sciences
1993-1995 NIEHS Training Fellowship in Environmental Toxicology
1994 Robert Emrie Smith Memorial Research Fellowship in Physiology
1995-1997 NHLBI Pulmonary Postdoctoral Training Fellowship
1997-1999 American Lung Association Research Fellow

Licenses

Diplomate American Board of Toxicology (General Toxicology)

Active Research Grants

Principal Investigator, San Joaquin Health Effects Research Center Project 1: Pulmonary metabolic response, Dr. Wexler is the PI on the entire $8 million Project. Dr. Van Winkle's Project #1 is funded in the amount of $1,285,200 (Principal Investigator), US EPA

Principal Investigator, Engineered Nanomaterials: Linking Physical and Chemical Properties to Biology, Pinkerton/Van Winkle (Principal Investigator), NIH/NIEHS

Co-Investigator, Novel approaches to evaluate carbon nanotube health impacts, Pinkerton (Principal Investigator), NIH/NIEHS

Principal Investigator, Comparative kinetics of metabolism of naphthalene in nasal epithelial microsomes from the mouse and monkey, Buckpitt/Van Winkle (Principal Investigator), American Petroleum Institute (API)

Co-Investigator, Health Effects of Central Valley Particulate Matter, Wexler (Principal Investigator), California Air Resources Board

Co-Investigator, Superfund Basic Research Program - Biomarkers to Hazardous Chemicals: Project 4: Urinary Protein Biomarkers for assessing the potential for toxicity, Hammock PI of P42/Buckpitt PI of Project 4 (Principal Investigator), NIH/NIEHS

Co-Investigator, Pulmonary Effects of Environmental Oxidant Pollutants - Project 3: Innervation & Neural Control, Hyde PI of P01/Schelegle PI of Project 3 (Principal Investigator), NIH/NIEHS

Most Recent 10 Publications

  • Link Icon 2011 Mitchell VL, Van Winkle LS, Gershwin LJ Environmental tobacco smoke and progesterone alter lung inflammation and mucous metaplasia in mouse model of allergic airway disease Cinic Rev Allerg Immunol,
  • Link Icon 2011 Wu D, Nishimura N, Kuo V, Fiehn O, Shahbaz S, Van Winkle L, Matsumura F, and Vogel C Activation of aryl hydrocarbon receptor induces vascular inflammation and promotes atherslerosis in ApoE-/- mice Arteriosclerosis, Thrombosis and Vascular Biology,
  • Link Icon 2011 Lee DY, Wallis C, Van Winkle LS, Wexler AS Disruption of tracheobronchial airway growth following postnatal exposure to ozone and ultrafine particles Inhalation Toxicology,
  • Link Icon 2010 Van Winkle LS, Baker GL, Chan JK, Schelegle ES, Plopper CG Airway mast cells in a rhesus model of childhood allergic airways disease Toxicol Sci,
  • Link Icon 2010 Lee D, Wallis C, Wexler AS, Schelegle ES, Van Winkle LS, Plopper CG, Fanucchi MV, Kumfer B, Kennedy IM, Chan JK Small particles disrupt postnatal airway development J Appl Physiol,
  • Link Icon 2010 Sutherland KM, Combs TJ, Edwards PC, Van Winkle LS Site-specific differences in gene expression of secreted proteins in the mouse lung: comparison of methods to show differences by location J Histochem Cytochem,
  • Link Icon 2010 Van Winkle LS, Chan JK, Anderson DS, Kumfer BM, Kennedy IM, Wexler AS, Wallis C, Abid AD, Sutherland KM, Fanucchi MV Age specific responses to acute inhalation of diffusion flame soot particles: cellular injury and the airway antioxidant response Inhal Toxicol,
  • Link Icon 2009 Coppens JT, Plopper CG, Murphy SR, Van Winkle LS Postnatal lung development of rhesus monkey airways: cellular expression of Clara cell secretory protein Dev Dyn,
  • Link Icon 2009 Greeley MA, Van Winkle LS, Edwards PC, Plopper CG Airway trefoil factor expression during naphthalene injury and repair Toxicol Sci,
  • Link Icon 2008 Yildirim AO, Veith M, Rausch T, Müller BKilb P, Van Winkle LS, Fehrenbach H Keratinocyte growth factor protects against Clara cell injury induced by naphthalene Eur Respir J,

Most Recent 5 Book Chapters

2010 Pinkerton KE, Smiley-Jewell S, Van Winkle LS: Tracheobronchial airways, Yost et al, (ed), Toxicology of the Respiratory System, Comprehensive Toxicology, 2nd Edition. .

2010 Van Winkle LS: Cell damage and cell renewal in the lung, Yost et al, (ed), Toxicology of the Respiratory System, Comprehensive Toxicology, 2nd Edition. .

2008 Plopper CG, Smiley-Jewell SM, Miller LA, Fanucchi MV, Evans MJ, Buckpitt AR, Avdalovic M, Gershwin LJ, Joad JP, Kajekar R, Larson S, Pinkerton KE, Van Winkle LS, Schelegle ES, Pieczarka EM, Wu R, Hyde DM: Primate Models of Allergic Asthma, Kay AB et al, (ed), Allergy and Allergic Diseases, London. Chapter 54.

2008 Hyde DM, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdolovic MV, Evans MJ, Kajekar R, Buckpitt AR, Pinkerton KE, Joad JP, Gershwin LJ, Wu R, Plopper CG: Chronic airway disease in nonhuman primates, Voelkel & MacVee, (ed), Chronic Obstructive Lung Disease. Chapter 17.

2006 Witschi HR, Pinkerton KE, Van Winkle LS, Last JA: Chapter 15: Toxic Responses of the Respiratory System, Klaassen, (ed), Casarett and Doull's Toxicology: the basic science of poisons. .