Alan Buckpitt- BS, MS, PhD
220 Everson Hall
+1 530 752 7674
My laboratory has focused on low molecular weight aromatic hydrocarbons that produce lung injury. These chemicals undergo metabolic activation to generate reactive metabolites which become bound covalently to proteins. Work in the lab is attempting to understand what proteins are critical to the cytotoxicity that ensues from exposure to these reactive metabolites, which amino acid residues are adducted and how these alter the structure/function of the adducted proteins. These data will be used to develop biomarkers of adducted urinary peptides that are tightly tied to the mechanisms of toxicity and that could be applied to exposed human populations.
1970 BS , College of William & Mary, Willamsburg,
Honors and Awards
2000 Pfizer Award for Research Excellence
Active Research Grants
Principal Investigator, Biomarkers of exposure to cytotoxic agents SUPERFUND, Hammock (Principal Investigator), NIH NIEHS PHS
Co-Investigator, Pulmonary effects of oxidant pollutants, Hyde (Principal Investigator), NIH NIEHS
Co-Investigator, Metabolic study of ozone and nitronaphthalene toxicity, Hammock (Principal Investigator), NIH NIEHS
Principal Investigator, Kinetics of naphthalene metabolism in target and non target tissues of rodents and non human primates, (Principal Investigator), American Petroleum Institute
Principal Investigator, Measurement of soluble thiols in respiratory and olfactory nasal epithelium-dose response study, (Principal Investigator), American Petroleum Institute
Most Recent 10 Publications
Most Recent 5 Book Chapters
2010 Buckpitt AR, Lin C Yu, Spiess P: Biochemical Function of the Respiratory Tract: Metabolism of Xenobiotics, Charlene A McQueen, (ed), Comprehensive Toxicology. 171-9.
2002 Shultz M, Morin D, Chan K, Buckpitt A: Measurement of glutathione adducts, Donald Reed and Lucio Costa, (ed), Current Protocols in Toxicology, New York. .
1997 Plopper CG, Cheek JM, Wu R, Reddy S, Zhao Y, Duan X, Buckpitt A: In vitro assessment of ozone induced injury to alveolar and tracheobronchial epithelium, D. Dungworth, K. Adler, C. Harris and C. Plopper, (ed), Correlations between in vitro and in vivo investigations in inhalation toxicology, Washington, DC. 252-70.
1997 Buckpitt A, Cruikshank M: Biochemical functions of the respiratory tract: Metabolism of xenobiotics, G Sipes, CA McQuen and AJ Gandolfi, (ed), Comprehensive Toxicology, Volume 8, Toxicology of the Respiratory System, Ed. 1. 159-86.
1996 Plopper C, Hyde D, Buckpitt A: Clara cells, R. Crystal, and J. West, (ed), The Lung: Scientific Foundations, Philadelphia, PA. 215-28.