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Photo: Alan Buckpitt

Alan Buckpitt- BS, MS, PhD
Professor Emeritus
Molecular Biosciences

220 Everson Hall
Davis, CA 95616

+1 530 752 7674


Research Focus

My laboratory has focused on low molecular weight aromatic hydrocarbons that produce lung injury. These chemicals undergo metabolic activation to generate reactive metabolites which become bound covalently to proteins. Work in the lab is attempting to understand what proteins are critical to the cytotoxicity that ensues from exposure to these reactive metabolites, which amino acid residues are adducted and how these alter the structure/function of the adducted proteins. These data will be used to develop biomarkers of adducted urinary peptides that are tightly tied to the mechanisms of toxicity and that could be applied to exposed human populations.

Specialty Focus



1970 BS , College of William & Mary, Willamsburg,
1973 MS , Indiana University, Bloomington,
1975 PhD , Indiana University, Bloomington,

Honors and Awards

2010 Norden Distinguished Teaching Award, nominated
2000 Pfizer Award for Research Excellence

Most Recent 10 Publications

  • Link Icon 2015 Ayala DC, Morin D, Buckpitt AR Simultaneous quantification of multiple urinary naphthalene metabolites by liquid chromatography tandem mass spectrometry. PloS one,
  • Link Icon 2015 K├╝ltz D, Li J, Sacchi R, Morin D, Buckpitt A, Van Winkle L Alterations in the proteome of the respiratory tract in response to single and multiple exposures to naphthalene. Proteomics,
  • Link Icon 2014 Cichocki JA, Smith GJ, Mendoza R, Buckpitt AR, Van Winkle LS, Morris JB Sex differences in the acute nasal antioxidant/antielectrophilic response of the rat to inhaled naphthalene Toxicol Sci,
  • Link Icon 2014 Schebb NH, Muvvala JB, Morin D, Buckpitt AR, Hammock BD, Rice RH Metabolic Activation of the Antibacterial Agent Triclocarban by Cytochrome P450 1A1 Yielding Glutathione Adducts Drug Metab Dispos,
  • Link Icon 2013 Buckpitt A, Morin D, Murphy S, Edwards P, Van Winkle L Kinetics of naphthalene metabolism in target and non-target tissues of rodents and in nasal and airway microsomes from the Rhesus monkey Toxicol Appl Pharmacol,
  • Link Icon 2012 Plopper CG, Joad JP, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdalovic MV, Evans MJ, Lasley WL, Buckpitt AR, Pinkerton KE, Tarkington BK, Davis S, Nishio SJ, Gershwin LJ, Wu R, Hyde DM Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma Clin Exp Allergy,
  • Link Icon 2012 Pham NT, Jewell WT, Morin D, Jones AD, Buckpitt AR Characterization of model peptide adducts with reactive metabolites of naphthalene by mass spectrometry PloS one,
  • Link Icon 2012 Pham NT, Jewell WT, Morin D, Buckpitt AR Analysis of naphthalene adduct binding sites in model proteins by tandem mass spectrometry Chem Biol Interact,
  • Link Icon 2010 Buchholz BA, Haack KW, Sporty JL, Buckpitt AR, Morin D Free flow electrophoresis separation and AMS quantitation of C-naphthalene-protein adducts Nucl Instrum Methods Phys Res B,
  • Link Icon 2010 DeStefano-Shields C, Morin D, Buckpitt A Formation of covalently bound protein adducts from the cytotoxicant naphthalene in nasal epithelium: species comparisons Environ Health Perspect,

Most Recent 5 Book Chapters

2010 Buckpitt AR, Lin C Yu, Spiess P: Biochemical Function of the Respiratory Tract: Metabolism of Xenobiotics, Charlene A McQueen, (ed), Comprehensive Toxicology. 171-9.

2002 Shultz M, Morin D, Chan K, Buckpitt A: Measurement of glutathione adducts, Donald Reed and Lucio Costa, (ed), Current Protocols in Toxicology, New York. .

1997 Plopper CG, Cheek JM, Wu R, Reddy S, Zhao Y, Duan X, Buckpitt A: In vitro assessment of ozone induced injury to alveolar and tracheobronchial epithelium, D. Dungworth, K. Adler, C. Harris and C. Plopper, (ed), Correlations between in vitro and in vivo investigations in inhalation toxicology, Washington, DC. 252-70.

1997 Buckpitt A, Cruikshank M: Biochemical functions of the respiratory tract: Metabolism of xenobiotics, G Sipes, CA McQuen and AJ Gandolfi, (ed), Comprehensive Toxicology, Volume 8, Toxicology of the Respiratory System, Ed. 1. 159-86.

1996 Plopper C, Hyde D, Buckpitt A: Clara cells, R. Crystal, and J. West, (ed), The Lung: Scientific Foundations, Philadelphia, PA. 215-28.