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Photo: Helen Raybould

Helen Raybould- BS, PhD
Professor and Researcher
Anatomy, Physiology & Cell Biology

2021 Vet Med 3B
Davis, CA 95616

+1 530 754 6555


Research Focus

I am an intergrative physiologist with training in neurophysiology and gastrointestinal physiology. My research focuses on understanding the mechanisms by which gut luminal contents are sensed by chemosensing cells in the epithelium and activation of the vagal afferent (gut-brain) pathway. The research focuses on how both nutrients and bacterially-derived factors activate gut endocrine cells and how this information is transmitted to the brain to alter GI function and food intake. We study how these pathways are altered in metabolic disease, including obesity and type 2 diabetes. The research focuses on alterations in the gut microbiota and intestinal permeability in obesity, and how these factors may drive changes in the gut-brain pathway. We also work on the beneficial effects of prebiotic milk oligosaccharides and prebiotic bacteria in metabolic disease.


1977 BS Biological Sciences, University of Birmingham, UK,
1986 PhD Gastrointestinal Physiology, University of Liverpool, UK,

Honors and Awards

2008 Outstanding Women in Gastroenterology, American Gastroenterology Association Institute

Active Research Grants

Principal Investigator, Cholecystokinin: role in postprandial gastric motility, (Principal Investigator), NIH RO1

Co-Investigator, Protecting the fragile intestine: integrating microbiota and mucosal health, Satya Dandekar (Principal Investigator), UC RISE

Co-Principal Investigator, Activation of probiotic bacteria by milk glycans, (Principal Investigator), NIH

Most Recent 10 Publications

  • Link Icon 2014 de Lartigue, G, Ronveaux, CC, Raybould, HE Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity. Molecular metabolism,
  • Link Icon 2014 Vegezzi, G, Anselmi, L, Huynh, J, Barocelli, E, Rozengurt, E, Raybould, H, Sternini, C Diet-induced regulation of bitter taste receptor subtypes in the mouse gastrointestinal tract. PloS one,
  • Link Icon 2014 Ronveaux CC, de Lartigue G, Raybould HE Ability of GLP-1 to decrease food intake is dependent on nutritional status Physiology & Behavior,
  • Link Icon 2014 Kilpatrick LA, Coveleskie K, Connolly L, Labus JS, Ebrat B, Stains J, Jiang Z, Suyenobu BY, Raybould HE, Tillisch K, Mayer EA Influence of sucrose ingestion on brainstem and hypothalamic intrinsic oscillations in lean and obese women Gastroenterology,
  • Link Icon 2013 Raybould HE The heat is on: does direct application of capsaicin to autonomic nerves produce a specific deafferentation? J Physiol,
  • Link Icon 2013 Connolly L, Coveleskie K, Kilpatrick LA, Labus JS, Ebrat B, Stains J, Jiang Z, Tillisch K, Raybould HE, Mayer EA Differences in brain responses between lean and obese women to a sweetened drink Neurogastroenterol Motil,
  • Link Icon 2013 Eisner F, Martin EM, K├╝per MA, Raybould HE, Glatzle J CCK1-Receptor Stimulation Protects Against Gut Mediator-Induced Lung Damage During Endotoxemia Cell Physiol Biochem,
  • Link Icon 2012 de Lartigue G, Barbier de la Serre C, Esper, E, Lee, J, Raybould HE Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats PLoS One,
  • Link Icon 2012 Lee J, Cummings BP, Martin E, Sharp JW, Graham JL, Stanhope KL, Havel PJ, Raybould HE Glucose sensing by gut endocrine cells and activation of the vagal afferent pathway is impaired in a rodent model of type 2 diabetes mellitus. Am J Physiol Regul Integr Comp Physiol,
  • Link Icon 2012 Chichlowski M, De Lartigue G, German JB, Raybould HE, Mills DA Bifidobacteria isolated from infants and cultured on human milk oligosaccharides affect intestinal epithelial function. J Pediatr Gastroenterol Nutr,

Most Recent 5 Book Chapters

2012 De Lartigue G, Raybould HE: The Gastrointestinal Tract and Control of Food Intake, Johnson, (ed), Physiology of The Gastrointestinal Tract. 1963-1078.

2009 Pandol SJ, Raybould HE, Yee HF: Integrative responses of the gastrointestinal tract and liver to a meal, Yamada T, (ed), Textbook of Gastroenterology, Oxford, UK. .

2008 Barrett K, Raybould HE: Section VI: Gastrointestinal physiology, Koeppen BM, Stanton BA, (ed), Berne and Levy Physiology. .

2003 Raybould HE, Pandol SJ, Yee H: The integrative responses of the gastrointestinal tract and liver to a meal, Yamada T, Alpers DH, Kaplowitz N, Laine L, Owyang C, Powell DW, (ed), Textbook of Gastroenterology, Philadelphia, PA. 1-12.

1999 Raybould HE: CCK: hormonal and neurocrine regulator of postprandial gastrointestinal function, Greeley, G., (ed), Gastrointestinal Endocrinology, New Jersey. 161-181.