Helen Raybould- BS, PhD
Anatomy, Physiology & Cell Biology
1329 Haring Hall
Davis, CA 95616
+1 530 752 1174
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The research focus is to understand the cellular mechanisms and neural pathways by which macronutrients are detected in the intestine, and to determine the way in which these processed are altered in pathology and disease, such as long term changes in the macronutrient content of the diet, obesity, inflammatory bowel disease.
1977 BS Biological Sciences, University of Birmingham, UK,
1986 PhD Gastrointestinal Physiology, University of Liverpool, UK,
Honors and Awards
2008 Outstanding Women in Gastroenterology, American Gastroenterology Association Institute
Active Research Grants
Principal Investigator, Cholecystokinin: role in postprandial gastric motility, (Principle Investigator), NIH RO1
Co-Investigator, T32 Year-long exposure to advance research program for veterinary students, Dr. K. Lloyd (Principle Investigator), NIH NCRR
Principal Investigator, Activation of Host-Probiotic Communication by Prebiotic Milk Oligosaccharides, (Principle Investigator), NIH
Most Recent 10 Publications
- 2012 de Lartigue G, Barbier de la Serre C, Esper, E, Lee, J, Raybould HE Leptin resistance in vagal afferent neurons inhibits cholecystokinin signaling and satiation in diet induced obese rats PLoS One,
- 2012 Lee J, Cummings BP, Martin E, Sharp JW, Graham JL, Stanhope KL, Havel PJ, Raybould HE Glucose sensing by gut endocrine cells and activation of the vagal afferent pathway is impaired in a rodent model of type 2 diabetes mellitus. Am J Physiol Regul Integr Comp Physiol,
- 2012 Chichlowski M, De Lartigue G, German JB, Raybould HE, Mills DA Bifidobacteria isolated from infants and cultured on human milk oligosaccharides affect intestinal epithelial function. J Pediatr Gastroenterol Nutr,
- 2011 Tam CS, Berthoud HR, Bueter M, Chakravarthy MV, Geliebter A, Hajnal A, Holst J, Kaplan L, Pories W, Raybould H, Seeley R, Strader A, Ravussin E Could the mechanisms of bariatric surgery hold the key for novel therapies? Report from a Pennington Scientific Symposium Obes Rev,
- 2011 Wexler EM, Rosen E, Lu D, Osborn GE, Martin E, Raybould H, Geschwind DH Genome-Wide Analysis of a Wnt1-Regulated Transcriptional Network Implicates Neurodegenerative Pathways Sci Signal,
- 2011 Vincent KM, Sharp JW, Raybould HE Intestinal glucose-induced calcium-calmodulin kinase signaling in the gut-brain axis in awake rats Neurogastroenterol Motil,
- 2011 Liou AP, Lu X, Sei Y, Zhao X, Pechhold S, Carrero RJ, Raybould HE, Wank S The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin Gastroenterology,
- 2011 de Lartigue G, de La Serre CB, Raybould HE Vagal afferent neurons in high fat diet-induced obesity; intestinal microflora, gut inflammation and cholecystokinin Physiol Behav,
- 2011 Garrido D, Kim JH, German JB, Raybould HE, Mills DA Oligosaccharide binding proteins from Bifidobacterium longum subsp. infantis reveal a preference for host glycans PLoS One,
- 2011 Liou AP, Sei Y, Zhao X, Feng J, Lu X, Thomas C, Pechhold S, Raybould HE, Wank SA The extracellular calcium-sensing receptor is required for cholecystokinin secretion in response to L-phenylalanine in acutely isolated intestinal I cells Am J Physiol Gastrointest Liver Physiol,
Most Recent 5 Book Chapters
2012 De Lartigue G, Raybould HE: The Gastrointestinal Tract and Control of Food Intake, Johnson, (ed),
Physiology of The Gastrointestinal Tract. 1963-1078.
2009 Pandol SJ, Raybould HE, Yee HF: Integrative responses of the gastrointestinal tract and liver to a meal, Yamada T, (ed),
Textbook of Gastroenterology, Oxford, UK. .
2008 Barrett K, Raybould HE: Section VI: Gastrointestinal physiology, Koeppen BM, Stanton BA, (ed),
Berne and Levy Physiology. .
2003 Raybould HE, Pandol SJ, Yee H: The integrative responses of the gastrointestinal tract and liver to a meal, Yamada T, Alpers DH, Kaplowitz N, Laine L, Owyang C, Powell DW, (ed),
Textbook of Gastroenterology, Philadelphia, PA. 1-12.
1999 Raybould HE: CCK: hormonal and neurocrine regulator of postprandial gastrointestinal function, Greeley, G., (ed),
Gastrointestinal Endocrinology, New Jersey. 161-181.