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Edward Schelegle- BS, MS, PhD
Anatomy, Physiology & Cell Biology

1270B Haring Hall
Davis, CA 95616

+1 530 752 1177


Research Focus

My area of interest is pulmonary physiology with a focus on the role that lung vagal afferents and efferents play in lung function, control of breathing pattern, epithelial injury, inflammation and repair in models of acute and chronic lung injury and/or disease.

Specialty Focus



1976 BS Animal Physiology, University of California, Davis, CA
1981 MS Exercise Physiology, University of California, Davis, CA
1988 PhD Cardiorespiratory Physiology & Environmental Toxicology, University of California, Davis, CA

Honors and Awards

1990-1992 Tobacco Related Disease Research Program Postdoctoral Fellowship, Department of Human Physiology, UC Davis
1988-1990 National Institute Health Postdoctoral Traineeship, Department of Internal Medicine, UC Davis
1979 Graduate Research Award, Department of Physical Education, UC Davis

Active Research Grants

Co-Investigator, California Regional Primate Research Center base grant, Barry Klein (Principal Investigator), NIH

Co-Investigator, Biomarkers of pulmonary arterial hypertension, Roblee Allen (Principal Investigator), Gilead, Inc

Principal Investigator, Persistent Immune Effects of Wildfire PM Exposure During Childhood Development, Lisa Miller (Principal Investigator), California Air Resources Board

Most Recent 10 Publications

  • Link Icon 2012 Plopper CG, Joad JP, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdalovic MV, Evans MJ, Lasley WL, Buckpitt AR, Pinkerton KE, Tarkington BK, Davis S, Nishio SJ, Gershwin LJ, Wu R, Hyde DM Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma Clin Exp Allergy,
  • Link Icon 2012 McDonnell WF, Stewart PW, Smith MV, Kim CS, Schelegle ES Prediction of lung function response for populations exposed to a wide range of ozone conditions Inhal Toxicol,
  • Link Icon 2012 Schelegle ES, Adams WC, Walby WF, Marion MS Modelling of individual subject ozone exposure response kinetics Inhal Toxicol,
  • Link Icon 2012 Schelegle ES, Walby WF Vagal afferents contribute to exacerbated airway responses following ozone and allergen challenge Respir Physiol Neurobiol,
  • Link Icon 2012 Moore BD, Hyde D, Miller L, Wong E, Frelinger J, Schelegle ES Allergen and Ozone Exacerbate Serotonin-Induced Increases in Airway Smooth Muscle Contraction in a Model of Childhood Asthma Respiration,
  • Link Icon 2011 Chou DL, Gerriets JE, Schelegle ES, Hyde DM, Miller LA IncreasedCCL24/eotaxin-2 with postnatal ozone exposure in allergen-sensitized infant monkeys is not associated with recruitment of eosinophils to airway mucosa. Toxicology and applied pharmacology,
  • Link Icon 2011 Abbas AR, Jackman JK, Bullens SL, Davis SM, Choy DF, Fedorowicz G, Tan M, Truong BT, Gloria Meng Y, Diehl L, Miller LA, Schelegle ES, Hyde DM, Clark HF, Modrusan Z, Arron JR, Wu LC Lung gene expression in a rhesus allergic asthma model correlates with physiologic parameters of disease and exhibits common and distinct pathways with human asthma and a mouse asthma model Am J Pathol,
  • Link Icon 2011 Capitanio JP, Miller LA, Schelegle ES, Mendoza SP, Mason WA, Hyde DM Behavioral Inhibition Is Associated With Airway Hyperresponsiveness but not Atopy in a Monkey Model of Asthma Psychosom Med,
  • Link Icon 2010 Van Winkle LS, Baker GL, Chan JK, Schelegle ES, Plopper CG Airway mast cells in a rhesus model of childhood allergic airways disease Toxicol Sci,
  • Link Icon 2010 Lee D, Wallis C, Wexler AS, Schelegle ES, Van Winkle LS, Plopper CG, Fanucchi MV, Kumfer B, Kennedy IM, Chan JK Small particles disrupt postnatal airway development J Appl Physiol,

Most Recent 5 Book Chapters

2009 Plopper CG, Smiley-Jewell SM, Miller LA, Fanucchi MV, Evans MJ, Buckpitt AR, Avdalovic MV, Gershwin LJ, Joad JP, Kajekar R, Larson SD, Pinkerton KE, Van Winkle LS, Schelegle ES, Pieczarka EM, Wu R, Hyde DM: Primate Models of Allergic Asthma, Kay AB, Kaplan AP, Bousquet J, Holt PG, (ed), Allergy and Allergic Diseases, Oxford, UK. Chapter 54.

2008 Hyde DM, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdalovic MV, Evans MJ, Kajekar R, Buckpitt AR, Pinkerton KKE, Joaj JP, Gershwin LJ, Wu R, Plopper CG: Chronic Airway Disease in Nonhuman Primates, NF Voelkel, W MacNee, (ed), Chronic Obstructive Lung Diseases, Hamilton. 235-268.

2001 Plopper CG, Paige R, Schelegle ES, Buckpitt A, Wong V, Tarkington B, Putney L, Hyde DM: Time-response profiles: Implications for injury, repair, and adaptation to ozone, Relationships Between Acute and Chronic Effects of Air Pollution, (ed), U. Heinrich and U. Mohr, Washington, DC. 23-37.

2000 Folinsbee LJ, Schelegle ES: Air pollutants and endurance performance, RJ Shephard and PO Astrand, (ed), Encyclopaedia of Sports Medicine, Endurance in Sports, 2nd Edition, Oxford, UK. 628-38.

1999 Costa DL Schelegle ES: Irritant air pollutants, DL Swift and WM Foster, (ed), Air Pollutants and the Respiratory Tract, New York. 119-45.