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Edward Schelegle- BS, MS, PhD
Professor in Residence
Anatomy, Physiology & Cell Biology

2023 VM3B
Davis, CA 95616

+1 530 752 1177


Research Focus

My area of interest is pulmonary physiology with a focus on the role that lung vagal afferents and efferents play in lung function, control of breathing pattern, epithelial injury, inflammation and repair in models of acute and chronic lung injury and/or disease.

Specialty Focus



1976 BS Animal Physiology, University of California, Davis, CA
1981 MS Exercise Physiology, University of California, Davis, CA
1988 PhD Cardiorespiratory Physiology & Environmental Toxicology, University of California, Davis, CA

Honors and Awards

1990-1992 Tobacco Related Disease Research Program Postdoctoral Fellowship, Department of Human Physiology, UC Davis
1988-1990 National Institute Health Postdoctoral Traineeship, Department of Internal Medicine, UC Davis
1979 Graduate Research Award, Department of Physical Education, UC Davis

Active Research Grants

Co-Investigator, California Regional Primate Research Center base grant, Barry Klein (Principal Investigator), NIH

Co-Investigator, Biomarkers of pulmonary arterial hypertension, Roblee Allen (Principal Investigator), Gilead, Inc

Principal Investigator, Persistent Immune Effects of Wildfire PM Exposure During Childhood Development, Lisa Miller (Principal Investigator), California Air Resources Board

Most Recent 10 Publications

  • Link Icon 2013 Davis BB, Zeki AA, Bratt JM, Wang L, Filosto S, Walby WF, Kenyon NJ, Goldkorn T, Schelegle ES, Pinkerton KE Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy. Eur Respir J,
  • Link Icon 2013 Chun K, Miller LA, Schelegle ES, Hyde DM, Capitanio JP Behavioral inhibition in rhesus monkeys (Macaca mulatta) is related to the airways response, but not immune measures, commonly associated with asthma PloS one,
  • Link Icon 2013 Murphy SR, Schelegle ES, Miller LA, Hyde DM, Van Winkle LS Ozone exposure alters serotonin and serotonin receptor expression in the developing lung. Toxicol Sci,
  • Link Icon 2012 Murphy SR, Schelegle ES, Edwards PC, Hyde DM, Van Winkle LS Postnatal Exposure History and Airways: Oxidant Stress Responses in Airway Explants Am J Respir Cell Mol Biol,
  • Link Icon 2012 Plopper CG, Joad JP, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdalovic MV, Evans MJ, Lasley WL, Buckpitt AR, Pinkerton KE, Tarkington BK, Davis S, Nishio SJ, Gershwin LJ, Wu R, Hyde DM Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma Clin Exp Allergy,
  • Link Icon 2012 Avdalovic MV, Tyler NK, Putney L, Nishio SJ, Quesenberry S, Singh PJ, Miller LA, Schelegle ES, Plopper CG, Vu T, Hyde DM Ozone Exposure During the Early Postnatal Period Alters the Timing and Pattern of Alveolar Growth and Development in Nonhuman Primates Anat Rec (Hoboken),
  • Link Icon 2012 McDonnell WF, Stewart PW, Smith MV, Kim CS, Schelegle ES Prediction of lung function response for populations exposed to a wide range of ozone conditions Inhal Toxicol,
  • Link Icon 2012 Schelegle ES, Adams WC, Walby WF, Marion MS Modelling of individual subject ozone exposure response kinetics Inhal Toxicol,
  • Link Icon 2012 Schelegle ES, Walby WF Vagal afferents contribute to exacerbated airway responses following ozone and allergen challenge Respir Physiol Neurobiol,
  • Link Icon 2012 Moore BD, Hyde D, Miller L, Wong E, Frelinger J, Schelegle ES Allergen and Ozone Exacerbate Serotonin-Induced Increases in Airway Smooth Muscle Contraction in a Model of Childhood Asthma Respiration,

Most Recent 5 Book Chapters

2009 Plopper CG, Smiley-Jewell SM, Miller LA, Fanucchi MV, Evans MJ, Buckpitt AR, Avdalovic MV, Gershwin LJ, Joad JP, Kajekar R, Larson SD, Pinkerton KE, Van Winkle LS, Schelegle ES, Pieczarka EM, Wu R, Hyde DM: Primate Models of Allergic Asthma, Kay AB, Kaplan AP, Bousquet J, Holt PG, (ed), Allergy and Allergic Diseases, Oxford, UK. Chapter 54.

2008 Hyde DM, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdalovic MV, Evans MJ, Kajekar R, Buckpitt AR, Pinkerton KKE, Joaj JP, Gershwin LJ, Wu R, Plopper CG: Chronic Airway Disease in Nonhuman Primates, NF Voelkel, W MacNee, (ed), Chronic Obstructive Lung Diseases, Hamilton. 235-268.

2001 Plopper CG, Paige R, Schelegle ES, Buckpitt A, Wong V, Tarkington B, Putney L, Hyde DM: Time-response profiles: Implications for injury, repair, and adaptation to ozone, Relationships Between Acute and Chronic Effects of Air Pollution, (ed), U. Heinrich and U. Mohr, Washington, DC. 23-37.

2000 Folinsbee LJ, Schelegle ES: Air pollutants and endurance performance, RJ Shephard and PO Astrand, (ed), Encyclopaedia of Sports Medicine, Endurance in Sports, 2nd Edition, Oxford, UK. 628-38.

1999 Costa DL Schelegle ES: Irritant air pollutants, DL Swift and WM Foster, (ed), Air Pollutants and the Respiratory Tract, New York. 119-45.