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Photo: N. James MacLachlan

N. James MacLachlan- BVSc, MS, PhD
Professor
Pathology, Microbiology & Immunology

5325 Vet Med 3A
Davis, CA 95616

+1 530 754 8125
njmaclachlan@ucdavis.edu

   

Research Focus

I study viral diseases of livestock that impact international commerce, notably emerging diseases such as bluetongue and African horse sickness that are transmitted by Culicoides biting midges. These diseases and their vectors are poorly characterized and are of increasing global concern, thus I serve regularly as an expert advisor to numerous organizations including the World Organization for Animal Health (O.I.E), the United States Departments of Agriculture and Homeland Security, and the European Union. My research laboratory is productively engaged in studying these diseases both locally and internationally and, in the process, training research scientists (including veterinarians) for careers in academia, industry and government.

Specialty Focus

Anatomic Pathology

Education

1975 BVSc Veterinary Medicine, Massey University, New Zealand
1979 MS Virology, University of Missouri, Columbia
1982 PhD Comparative Pathology, University of California, Davis,

Honors and Awards

2012 Sir Arnold Theiler Memorial Lecture, University of Pretoria, South Africa
2008, 2010 Keynote speaker, Senior Banquet, Veterinary School Classes of 2008 and 2010
2008 Recombinant vaccine against bluetongue virus, Patent WO/2008/030282; granted March 13, 2008: N James MacLachlan one of four listed inventors. http://www.wipo.int/pctdb/en/wo/jsp?wo=2008030282
2008 Recombinant African horse sickness vaccine, US Provisional application number 61/108,075 filed October 24, 2008. N. J. MacLachlan one of five listed investors. http://www.faqs.org/patents/app/20100119546
2007-2015 Appointed Extraordinary Professor, Department of Tropical Veterinary Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa
2007 Alumni Achievement Award, School of Veterinary Medicine, University of California, Davis
2007 Invited Visiting Scientist, Institute of Virology and Immunoprophylaxis, Mittlehausern, Switzerland
2003 Pfizer Animal Health Award for Research Excellence, School of Veterinary Medicine, University of California
1998 President, American College of Veterinary Pathologists
1994 Commencement speaker, School of Veterinary Medicine, University of California
1993-2010 Outstanding/Favorite Teacher Award, Sophomore year 1993, 2003, 2006, 2008; UC Davis Veterinary Classes of 1995, 2005, 2008 and 2010
1993 Norden Distinguished Teaching Award, School of Veterinary Medicine, University of California

Licenses

Diplomate American College of Veterinary Pathologists

Active Research Grants

Principal Investigator, Bernard and Gloria Salick Equine Viral Disease Laboratory, (Principal Investigator), Salick Foundation

Principal Investigator, Characterization of the ecological drivers of bluetongue virus (BTV) infection of livestock for the predictive modeling of an emerging, economically important arboviral disease, (Principal Investigator), National Institute of Food and Agriculture

Principal Investigator, Bluetongue virus infection of ruminants in California: Pathogenesis and epizootiology, (Principal Investigator), Center for Food Animal Health

Principal Investigator, Research: $15,556, Principal Investigator, Host-virus interactions in bluetongue virus-infected ruminants, (Principal Investigator), USDA Formula Funds

Principal Investigator, Epizootic Hemorragic Disease (EHD): Epidemiology and Development of Vacine for White-tailed deer (Odocoileus Virginianus), (Principal Investigator), Kansas State University

Most Recent 10 Publications

  • Link Icon 2014 Mayo CE, Mullens B, Reisen W, Gibbs EP, Gardner IA, MacLachlan NJ. Seasonal and interseasonal dynamics of bluetongue virus infection of dairy cattle and Culicoides sonorensis midges in Northern California - implications for virus overwintering in temperate zones PLoS One,
  • Link Icon 2014 Gaudreault NN, Mayo C, Jasperson DC, Crossley BM, Breitmeyer RE, Johnson DJ, Ostlund EN, MacLachlan NJ, Wilson WC Whole genome sequencing and phylogenetic analysis of bluetongue serotype 2 viruses isolated in the Americas including one novel to the western United States. Journal of Veterinary Diagnostic Investigation,
  • Link Icon 2014 Balasuriya UB, Zhang J, Go YY, Maclachlan NJ. Experiences with infectious cDNA clones of equine arteritis virus: lessons learned and insights gained. Virology,
  • Link Icon 2014 Osborne CJ, Mayo CE, Mullens BA, Maclachlan NJ Estimating Culicoides sonorensis biting midge abundance using digital image analysis. Medical and Veterinary Entomology, doi: 10.1111/mve.12060,
  • Link Icon 2014 Mayo CE, Osborne CJ, Mullens BA, Gerry AC, Barker CM, Gardner IA, Reisen WK, Maclachlan NJ Seasonal variation and impact of waste-water lagoons as larval habitat on the population dynamics of Culicoides sonorensis midges at two dairy farms in Northern California PLoS ONE,
  • Link Icon 2014 Maclachlan NJ, Henderson C, Schwartz-Cornil I, Zientara S The immune response of ruminant livestock to bluetongue virus infection: From type I interferon to antibodies Virus Research,
  • Link Icon 2014 Crafford JE, Lourens CW, Smit TK, Gardner IA, Maclachlan NJ, Guthrie AJ Serological response of foals to polyvalent and monovalent live-attenuated African horse sickness virus vaccines. Vaccine,
  • Link Icon 2013 Maclachlan NJ, Wilson WC, Crossley BM, Mayo CE, Jasperson DC, Breitmeyer RE, Whiteford AM Novel serotype of bluetongue virus, western North America. Emerging Infectious Diseases,
  • Link Icon 2013 Maclachlan NJ, Mayo CE Potential strategies for control of bluetongue, a globally emerging, Culicoides-transmitted arboviral disease of ruminant livestock and wildlife Antiviral Research,
  • Link Icon 2013 Balasuriya UB, Go YY, Maclachlan NJ Equine arteritis virus Veterinary Microbiology,

Most Recent 5 Book Chapters

2014 Maclachlan NJ, Mayo CE: Bluetongue, Smith BP, (ed), Large Animal Internal Medicine, 5th edition. 745-747.

2013 Balasuriya UBR, MacLachlan NJ: Equine viral arteritis, Sellon DC, Long MT, (ed), Equine Infectious Diseases. .

2010 MacLachlan NJ, Dubovi EJ: BOOK: Fenner's Veterinary Virology, Fourth Edition, MacLachlan & Dubovi, (ed), . .

2008 MacLachlan NJ: Bluetongue, Brown CC, Torres A, (ed), Foreign Animal Diseases "The Gray Book.". 159-165.

2008 MacLachlan NJ, Gard GP: Clinical signs and pathology, in Pastoret, Mertens PP, Baylis M, Mellor P, (ed), Bluetongue. 285-293.