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Chris Miller- BS, DVM, PhD
Professor in Residence
Pathology, Microbiology & Immunology

+1 530 752 8584
cjmiller@ucdavis.edu

   

Research Focus

Dr. Miller's research is focused on primate models of human viral diseases, and the immunopathology and pathogenesis of diseases caused by lentiviruses in particular. He has a focused emphasis on the rhesus macaque model of human acquired immunodeficiency syndrom (AIDS) and on mucosal immunity in the genital tract.

Specialty Focus

Dr. Miller's research is focused on primate models of human viral diseases, and the immunopathology and pathogenesis of diseases caused by lentiviruses in particular. He has a focused emphasis on the rhesus macaque model of human acquired immunodeficiency syndrom (AIDS) and on mucosal immunity in the genital tract.

Education

1982 BS , University of California, Davis,
1987 DVM , University of California, Davis,
1991 PhD , University of California, Davis,

Honors and Awards

2007 Rising Star in Microbiology, achieved the highest percent increase in total citations in microbiology from October to December 2006 according to Essential Sciene Indicators

Active Research Grants

Collaborator, California National Primate Research Center, Lewin (Principal Investigator), NIH/NCRR

Principal Investigator, Biology of SIV in Male NHP, (Principal Investigator), NIH/NIAID

Co-Principal Investigator, The Impact of Antibody and pH on Female-to-Male SIV Infection, Donald Forthal (Principal Investigator), NIH/NIAID

Principal Investigator, Modeling Inflammation in HIV Transmission, (Principal Investigator), NIH/NIAID

Most Recent 10 Publications

  • Link Icon 2013 Fieni F, Stone M, Ma Z-M, Dutra J, Fritts L, Miller CJ Viral RNA levels and env variants in semen and tissues of mature male Rhesus macaques infected with SIV by penile inoculation PLoS One,
  • Link Icon 2013 Cammock CE, Halnon NJ, Skoczylas J, Blanchard J, Bohm R, Miller CJ, Lai C, Krogstad, PA Myocarditis, disseminated infection, and early viral persistence following experimental Coxsackievirus B infection of Cynomolgus monkeys PLoS ONE,
  • Link Icon 2013 Asmuth DM, Ma ZM, Albanese A, Sandler NG, Devaraj S, Knight TH, Flynn NM, Yotter T, Tsuchida E, Wu TT, Douek DC, Miller CJ Oral serum-derived bovine immunoglobulin improves duodenal immune reconstitution and absorption function in patients with HIV enteropathy AIDS,
  • Link Icon 2013 Del Prete GQ, Scarlotta M, Newman L, Reid C, Parodi LM, Roser JD, Oswald K, Marx PA, Miller CJ, Desrosiers RC, Barouch DH, Pal R, Piatak M Jr, Chertova E, Giavedoni LD, O'Connor DH, Lifson JD, Keele BF Comparative characterization of transfection- and infection-derived simian immunodeficiency virus challenge stocks for in vivo nonhuman primate studies J Virol,
  • Link Icon 2013 Vaccari M, Keele BF, Bosinger SE, doster MN, Ma ZM, Pollara J, Hryniewicz A, Ferrari G, Guan Y, Forthal DN, Venzon D, Fenizia C, Morgan T, Montefiori D, Lifson JD, Miller CJ, Silvestri G, Rosati M, Felber BK, Pavlakis GN, Tartglia J, Franchini G Protection afforded by an HIV vaccine candidate in macaques depends on the dose of SIVmac251 at challenge exposure J Virol,
  • Link Icon 2013 Matzinger SR, Carroll TD, Dutra JC, Ma ZM, Miller CJ Myxovirus resistance gene A (MxA) expression suppresses Influenza A virus replication in alpha interferon-treated primate cells J Virol,
  • Link Icon 2012 Spear G, Rothaeulser K, Fritts L, Gillevet PM, Miller CJ. In captive rhesus macaques, cervicovaginal inflammation is common but not associated with the stable polymicrobial microbiome PLoS One,
  • Link Icon 2012 Schmitz J, Ma ZM, Hagan E, Furr K, Wilks A, Linde C, Zahn R, Brenchley J, Miller C, Permar S Memory CD4+ T lymphocytes in the gastrointestinal tract are a major source of cell-associated simian immunodeficiency virus in chronic nonpathogenic infection of African green monkeys J Virol,
  • Link Icon 2012 Asmuth DM, Ma ZM, Mann S, Knight TH, Yotter T, Albanese A, Melcher GP, Troia-Cancio P, Hayes T, Miller CJ, Pollard RB Gastrointestinal-associated lymphoid tissue immune reconstitution in a randomized clinical trial of raltegravir versus non-nucleoside reverse transcriptase inhibitor-based regimens AIDS,
  • Link Icon 2012 GenescĂ  M, Ma ZM, Wang Y, Assaf B, Qureshi H, Fritts L, Huang Y, McChesney MB, Miller CJ Live-attenuated lentivirus immunization modulates innate immunity and inflammation while protecting rhesus macaques from vaginal simian immunodeficiency virus challenge J Virol,

Most Recent 5 Book Chapters

2008 Marthas ML, Miller CJ: Simian Immunodeficiency Virus: Animal Models of Disease, Mahy B, van Regenmortel M, (ed), The Encyclopedia of Virology 3rd edition, Oxford, UK. 594-603.

2005 Barry PA, Marthas ML, Lerche NW, McChesney MB, Miller CJ: Handbook of Experimental Animals, Wolfe-Coote S, (ed), Current Uses in Biomedical Research: Virology, in the Laboratory Primate, San Diego. 561-74.

2005 McElrath JM, Miller CJ: Mucosal immunity and vaccines to SIV and HIV, Mestecky J, Bienenstock J, Lamm ME, Mayer L, McGhee JR, Strober W, (ed), Mucosal Limmunology. 937-957.

1999 McChesney MB, Sawai E, Miller CJ: Simian Immunodeficiency Virus, Ahmed R, Chen IY, (ed), Persistent Viral Infections. 321-45.

1996 Miller CJ: Mucosal immune responses to SIV infection, Ahmed R, (ed), Seminars in Virology: Immunity to Viruses, San Diego, CA. 139-49.