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Chris Miller- BS, DVM, PhD
Professor in Residence
Center for Comparative Medicine
Pathology, Microbiology & Immunology

+1 530 752 8584
cjmiller@ucdavis.edu

   

Research Focus

Dr. Miller's research is focused on primate models of human viral diseases, and the immunopathology and pathogenesis of diseases caused by lentiviruses in particular. He has a focused emphasis on the rhesus macaque model of human acquired immunodeficiency syndrom (AIDS) and on mucosal immunity in the genital tract.

Specialty Focus

Dr. Miller's research is focused on primate models of human viral diseases, and the immunopathology and pathogenesis of diseases caused by lentiviruses in particular. He has a focused emphasis on the rhesus macaque model of human acquired immunodeficiency syndrom (AIDS) and on mucosal immunity in the genital tract.

Education

1982 BS , University of California, Davis,
1987 DVM , University of California, Davis,
1991 PhD , University of California, Davis,

Honors and Awards

2007 Rising Star in Microbiology, achieved the highest percent increase in total citations in microbiology from October to December 2006 according to Essential Sciene Indicators

Active Research Grants

Principal Investigator, Biology of SIV in Male NHP, (Principal Investigator), NIH/NIAID

Principal Investigator, Modeling Inflammation in HIV Transmission, (Principal Investigator), NIH/NIAID

Principal Investigator, How Did a Vaccine Enhance HIV Acquisition, (Principal Investigator), NIH/NIAID

Principal Investigator, NHP model of Vaginal Zika Virus Transmission, (Principal Investigator), NIH/OD

Other, Optimizing AAV-1 vectors for gene expression in rhesus macaques , Mark Kay, (Stanford) PI of Project (Principal Investigator), Gates Foundation Award

Most Recent 10 Publications

  • Chris Miller: Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition 2016 Vaccari M, Gordon SN, Fourati S, Schifanella L, Liyanage NP, Cameron M, Keele BF, Shen X, Tomaras GD, Billings E, Rao M, Chung AW, Dowell KG, Bailey-Kellogg C, Brown EP, Ackerman ME, Vargas-Inchaustegui DA, Whitney S, Doster MN, Binello N, Pegu P, Montefiori DC, Foulds K, Quinn DS, Donaldson M, Liang F, Loré K, Roederer M, Koup RA, McDermott A, Ma ZM, Miller CJ, Phan TB, Forthal DN, Blackburn M, Caccuri F, Bissa M, Ferrari G, Kalyanaraman V, Ferrari MG, Thompson D, Robert-Guroff M, Ratto-Kim S, Kim JH, Michael NL, Phogat S, Barnett SW, Tartaglia J, Venzon D, Stablein DM, Alter G, Sekaly RP, Franchini G Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition Nat Med,
  • Chris Miller: Lymphatic dissemination of Simian Immunodeficiency Virus after penile inoculation 2016 Ma ZM, Dutra J, Fritts L, Miller CJ Lymphatic dissemination of Simian Immunodeficiency Virus after penile inoculation J Virol,
  • Chris Miller: Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial 2016 Serrano-Villar S, Sainz T, Ma ZM, Utay NS, Chun TW, Mann S, Kashuba AD, Siewe B, Albanese A, Troia-Cancio P, Sinclair E, Somasunderam A, Yotter T, Deeks SG, Landay A, Pollard RB, Miller CJ, Moreno S, Asmuth DM Effects of Combined CCR5/Integrase Inhibitors-Based Regimen on Mucosal Immunity in HIV-Infected Patients Naïve to Antiretroviral Therapy: A Pilot Randomized Trial PLoS Pathog,
  • Chris Miller: Regulatory and Helper Follicular T Cells and Antibody Avidity to Simian Immunodeficiency Virus Glycoprotein 120 2015 Blackburn MJ, Zhong-Min M, Caccuri F, McKinnon K, Schifanella L, Guan Y, Gorini G, Venzon D, Fenizia C, Binello N, Gordon SN, Miller CJ, Franchini G, Vaccari M Regulatory and Helper Follicular T Cells and Antibody Avidity to Simian Immunodeficiency Virus Glycoprotein 120 J Immunol,
  • Chris Miller: Immunophenotype of simian immunodeficiency virus-infected cells in the spleen of a rhesus monkey 2015 Ma ZM, Miller CJ Immunophenotype of simian immunodeficiency virus-infected cells in the spleen of a rhesus monkey AIDS Res Hum Retroviruses,
  • Chris Miller: A discrete-time survival model with random effects for designing and analyzing repeated low-dose challenge experiments 2015 Kang C, Huang Y, Miller CJ A discrete-time survival model with random effects for designing and analyzing repeated low-dose challenge experiments Biostatistics,
  • Chris Miller: Enhanced in vitro transcytosis of simian immunodeficiency virus mediated by vaccine-induced antibody predicts transmitted/founder strain number after rectal challenge 2015 Gupta S, Pegu P, Venzon DJ, Gach JS, Ma ZM, Landucci G, Miller CJ, Franchini G, Forthal DN Enhanced in vitro transcytosis of simian immunodeficiency virus mediated by vaccine-induced antibody predicts transmitted/founder strain number after rectal challenge J Infect Dis,
  • Chris Miller: Infection with host-range mutant adenovirus 5 suppresses innate immunity and induces systemic CD4+ T cell activation in rhesus macaques 2014 Qureshi H, Genescà M, Fritts L, McChesney MB, Robert-Guroff M, Miller CJ Infection with host-range mutant adenovirus 5 suppresses innate immunity and induces systemic CD4+ T cell activation in rhesus macaques PLoS One,
  • Chris Miller: Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques 2014 Vaccari M, Fenizia C, Ma ZM, Hryniewicz A, Boasso A, Doster MN, Miller CJ, Lindegardh N, Tarning J, Landay AL, Shearer GM, Franchini G Transient increase of interferon-stimulated genes and no clinical benefit by chloroquine treatment during acute simian immunodeficiency virus infection of macaques AIDS Res Hum Retroviruses,
  • Chris Miller: Efficacy of influenza vaccination of elderly Rhesus macaques is dramatically improved by addition of a cationic lipid/DNA adjuvant 2014 Carroll TD, Matzinger SR, Barry PA, McChesney MB, Fairman J, Miller CJ Efficacy of influenza vaccination of elderly Rhesus macaques is dramatically improved by addition of a cationic lipid/DNA adjuvant J Infect Dis,

Most Recent 5 Book Chapters

2014 Genescà M, Miller CJ: HIV-1 prevention using Live-attenuated vaccines, Richman D, Stevenson M, Hope T, (ed), Encyclopedia of AIDS. 1-8.

2008 Marthas ML, Miller CJ: Simian Immunodeficiency Virus: Animal Models of Disease, Mahy B, van Regenmortel M, (ed), The Encyclopedia of Virology 3rd edition, Oxford, UK. 594-603.

2005 Barry PA, Marthas ML, Lerche NW, McChesney MB, Miller CJ: Handbook of Experimental Animals, Wolfe-Coote S, (ed), Current Uses in Biomedical Research: Virology, in the Laboratory Primate, San Diego. 561-74.

2005 McElrath JM, Miller CJ: Mucosal immunity and vaccines to SIV and HIV, Mestecky J, Bienenstock J, Lamm ME, Mayer L, McGhee JR, Strober W, (ed), Mucosal Limmunology. 937-957.

1999 McChesney MB, Sawai E, Miller CJ: Simian Immunodeficiency Virus, Ahmed R, Chen IY, (ed), Persistent Viral Infections. 321-45.