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Photo: Francisco A. Uzal

Francisco A. Uzal- DVM, MS, PhD
Professor of Clinical
California Animal Health and Food Safety Lab

San Bernardino Lab
San Bernardino, CA 92408

+1 909 383 4287
fuzal@cahfs.ucdavis.edu

   

Research Focus

Clostridial diseases of animals; pathogenesis and diagnosis

Specialty Focus

Pathology of diseases of food animals, with special emphasis in infectious diseases

Education

1982 DVM Veterinary Medicine, Faculty of Veterinary Sciences, Buenos Aires University, Buenos Aires, Argentina
1989 MS Veterinary Pathology, Swedish University of Agricultural Sciences, Uppsala, Sweden
1998 PhD Veterinary Pathology, University of Queensland, Brisbane, Australia
2010 Forensic pathology, CLDavis foundation,

Honors and Awards

1997 Award: Best scientific presentation. Polymerase chain reaction detection of different Clostridium perfringens types in faeces of goats. rnational Meeting on the Molecular Biology and Pathogen
1995-1997 Overseas Postgraduate Research Scholarship. Australian Government. Brisbane, Australia
1995-1997 Scholarship of teh National Council of Technical and Scientific Research (Argentina). Brisbane, Australia
1988-1989 Scholarship of the National Institute of Agricultural Technology (INTA) and The Interamerican Development Bank (BID). Uppsala, Sweden
1983-1987 Scholarship of the National Institute of Agricultural Technology (INTA). Bariloche, Argentina
1982-1983 Scholarship of the Council of Deans of National Universities (CRUN). La Plata, Argentina
1981-1982 Scholarship of the National Institute of Agricultural Technology (INTA). Castelar, Argentina

Licenses

Diplomate American College of Veterinary Pathologists

Active Research Grants

Co-Principal Investigator, The mechanism of action of C. perfringens enterotoxin, Bruce McClane (Principal Investigator), NIAID thru University of Pittsburgh subaward

Co-Principal Investigator, Clostridium perfringens type B-D virulence plasmids, Bruce McClane (Principal Investigator), NIAID thru University of Pittsburgh subaward

Co-Principal Investigator, Monoclonal immunoprotectants for select agent toxins, Larry Zetlin (Principal Investigator), NIAID thru MAPP Biopharmaceutical, Inc. subaward

Co-Principal Investigator, Early interactions between Clostridium perfringens epsilon toxin and host cells, Myron Levine (Principal Investigator), NIAID thru University of Maryland subaward

Co-Principal Investigator, An Antibody Immunoprotectant for Category B Toxins, Larry Zeitlin (Principal Investigator), NIAID thru MAPP Biopharmaceutical, Inc. subaward

Most Recent 10 Publications

  • Link Icon 2014 Ma M, Gurjar A, Theoret JR, Garcia JP, Beingesser J, Freedman JC, Fisher DJ, McClane BA, Uzal FA Synergistic Effects of Clostridium perfringens Enterotoxin and Beta Toxin in Rabbit Small Intestinal Loops Infect Immun,
  • Link Icon 2014 Garcia JP, Li J, Shrestha A, Freedman JC, Beingesser J, McClane BA, Uzal FA Clostridium perfringens type A enterotoxin damages the rabbit colon Infect Immun,
  • Link Icon 2014 Wiedner E, Holland J, Trupkiewicz J, Uzal F Severe laminitis in multiple zoo species Vet Q,
  • Link Icon 2014 Uzal FA, Freedman JC, Shrestha A, Theoret JR, Garcia J, Awad MM, Adams V, Moore RJ, Rood JI, McClane BA Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease Future Microbiol,
  • Link Icon 2014 Garcia JP, Giannitti F, Finnie JW, Manavis J, Beingesser J, Adams V, Rood JI, Uzal FA Comparative Neuropathology of Ovine Enterotoxemia Produced by Clostridium perfringens Type D Wild-Type Strain CN1020 and Its Genetically Modified Derivatives Vet Pathol,
  • Link Icon 2014 Garcia JP, Beingesser J, Bohorov O, Bohorova N, Goodman C, Kim D, Pauly M, Velasco J, Whaley K, Zeitlin L, Roy CJ, Uzal FA Prevention and treatment of Clostridium perfringens epsilon toxin intoxication in mice with a neutralizing monoclonal antibody (c4D7) produced in Nicotiana benthamiana Toxicon,
  • Link Icon 2014 Adaska JM, Aly SS, Moeller RB, Blanchard PC, Anderson M, Kinde H, Uzal F Jejunal hematoma in cattle: a retrospective case analysis J Vet Diagn Invest,
  • Link Icon 2014 Mukai M, Woods LW, Stump S, Ebel JG, Levitt AS, Frey MW, Smith J, Uzal FA, Poppenga RH, Puschner B Detection of diisocyanates in nesting material associated with mortality in pigeon chicks J Vet Diagn Invest,
  • Link Icon 2014 Giannitti F, Barr BC, Brito BP, Uzal FA, Villanueva M, Anderson M Yersinia pseudotuberculosis infections in goats and other animals diagnosed at the California Animal Health and Food Safety Laboratory System: 1990-2012. J Vet Diagn Invest,
  • Link Icon 2013 Diab SS, Songer G, Uzal FA Clostridium difficile infection in horses: a review Vet Microbiol,

Most Recent 5 Book Chapters

2006 McClane BA, Uzal FA, Fernandez-Miyakawa ME, Lyerly DM, Wilkins T: The enterotoxigenic clostridia, Dworkin and Falkow, (ed), The Procaryotes, New York. 698-752.

2002 Uzal FA: Enfermedades clostridiales en ovinos (Clostridial diseases of sheep), Tadich N, (ed), Salud y producción ovina (Sheep Health and Production), Valdivia, Chile. 35-50.

2002 Uzal FA: Enfermedades infectocontagiosas de la reproducción (Infecto-contagious diseases of reproduction), Aisen EG, (ed), Reproducción ovina y caprina. 153-68.

2000 Uzal FA: Salud animal en engorde a corral (Animal health in feed lots), Mueller JP, Taddeo HR, Uzal FA, (ed), Actualización en producción ovina. 165-8.

2000 Uzal FA: Enfermedades clostridiales (Clostridial diseases), Mueller JP, Taddeo HR, Uzal FA, (ed), Actualización en producción ovina (Update on sheep production). 101-12.