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Photo: Wayne Wei Feng

Wayne Wei Feng- BA, MS, PhD
Project Scientist
Molecular Biosciences

2213 VM3B
Davis, CA 95616

+1 530 752 2174
wfeng@ucdavis.edu

   

Research Focus

Molecular and bipphysical aspects reveling structure and function of ion channels, especially ryanodine receptors with associated proteins in mammalian skeletal, cardiac muscles and brain; Molecular mechamisms of genetic and environmental influences on cellular Ca2+ signaling.

Specialty Focus

Ion channels, Biochemistry and Biophysics.

Education

1984 BA , ,
1987 MS , ,
1997 PhD , ,

Honors and Awards

1996 Award of Zlowtovtsky Neuroscience Foundation, Israel.
1991 Third Award, Achievements in Sciences and Technology, The Ministry of Agriculture of P.R. China No. 911885
1990 Second Award, Academy Award, The Chinese Academy of Fishery Sciences No 90-ykc-2-06-13

Active Research Grants

Collaborator, Uncovering the molecular basis of malignant hyperthermia, Project 2, Isaac N. Pessah (Principal Investigator), Brigham & Women's Hospital/NIH

Collaborator, Molecular and cellular basis of PCB developmental neurotoxicity, Pamela Lein (Principal Investigator), NIH

Collaborator, CounterACT - Project 3, Pamela Lein, Isaac Pessah (Principal Investigator), NIH

Most Recent 10 Publications

  • Wayne Wei Feng: Triclosan impairs swimming behavior and alters expression of Excitation Contraction coupling
proteins in fathead minnow (Pimephales promelas) 2013 Fritsch EB, Connon RE, Werner I, Davies R, Beggel S, Feng W, Pessah IN Triclosan impairs swimming behavior and alters expression of Excitation Contraction coupling proteins in fathead minnow (Pimephales promelas) Environmental Science & Technology,
  • Wayne Wei Feng: Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage 2012 Yuen B, Boncompagni S, Feng W, Yang T, Lopez JR, Matthaei KI, Goth SR, Protasi F, Franzini-Armstrong C, Allen PD, Pessah IN Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage The FASEB Journal,
  • Wayne Wei Feng: Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle 2012 Barrientos GC, Feng W, Truong K, Matthaei KI, Yang T, Allen PD, Lopez JR, Pessah IN Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle J Biol Chem,
  • Wayne Wei Feng: Triclosan impairs excitation–contraction coupling
and Ca2+ dynamics in striated muscle 2012 Cherednychenko G, Zhang R, Bannister RA, Timofeyev V, Li N, Fritsch EB, Feng W, Barrientos GC, Schebb NH, Hammock BD, Beam KG, Chiamvimonvat N, Pessah IN Triclosan impairs excitation–contraction coupling and Ca2+ dynamics in striated muscle PNAS,
  • Wayne Wei Feng: Coordinated regulation of murine cardiomyocyte contractility by nanomolar (-)-epigallocatechin-3-gallate, the major green tea catechin 2012 Feng W, Hwang HS, Kryshtal DO, Yang T, Padilla IT, Tiwary AK, Puschner B, Pessah IN, Knollmann BC Coordinated regulation of murine cardiomyocyte contractility by nanomolar (-)-epigallocatechin-3-gallate, the major green tea catechin Mol Pharmacol,
  • Wayne Wei Feng: Functional and Biochemical Properties of Ryanodine Receptor
Type 1 Channels from Heterozygous R163C Malignant
Hyperthermia-Susceptible Mice 2011 Feng W, Barrientos GC, Cherednichenko G, Yang T, Padilla IT, Truong K, Allen PD, Lopez JR, Pessah IN Functional and Biochemical Properties of Ryanodine Receptor Type 1 Channels from Heterozygous R163C Malignant Hyperthermia-Susceptible Mice Mol Pharmacol,
  • Wayne Wei Feng: Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca<sup>2+</sup> 2010 Eltit JM, Feng W, Lopez JR, Padilla IT, Pessah IN, Molinski TF, Fruen BR, Allen PD, Perez CF Ablation of skeletal muscle triadin impairs FKBP12/RyR1 channel interactions essential for maintaining resting cytoplasmic Ca2+ Journal of Biological Chemistry,
  • Wayne Wei Feng: Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors 2010 Morisseau C, Merzlikin O, Lin A, He G, Feng W, Padilla I, Denison MS, Pessah IN, Hammock BD Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors Environ Health Perspect,
  • Wayne Wei Feng: Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1) 2010 Feng W, Cherednichenko G, Ward CW, Padilla IT, Cabrales E, Lopez JR, Eltit JM, Allen PD, Pessah IN Green tea catechins are potent sensitizers of ryanodine receptor type 1 (RyR1) Biochem Pharmacol,
  • Wayne Wei Feng: Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating 2009 Samsó M, Feng W, Pessah IN, Allen PD Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating PLoS Biol,

Most Recent 5 Book Chapters

2002 Feng W and Pessah IN: Detection of redox sensor of ryanodine receptor complexes, C.K. Son and L. Packer, (ed), Methods in Enzymology. 240-253.

1998 Shoshan-Barmatz V and Feng W: Chemical modification of ryanodine receptor/Ca2+ release channel activity, R. Sitsapesan and A. J. Williams, (ed), The Structure and Function of Ryanodine Receptors, Landes BioScience, Austin, Texas. 203-226.

1994 Wang WJ, Feng W, Li LX, Yu Y, Liu JX, Yao WJ, Xiao CX, Wang GT and Feng S: Parasitic infection state of fishes and its impact on the fishery in Wuling Mountain (In Chinese, translation not available), , Resources and Evaluation of Animal Species in Wuling Mountain Area of Southwest China, China. 98-114.

1993 Feng W and Wang WJ: Parasitic cestodes in freshwater fishes from Wuling mountain area In Chinese, translation not available), , Invertebrates in Wuling Mountain Area, China. 235-239.

1993 Feng W and Wang WJ: New digenetic trematodes of fishes in Wuling Mountain area (In Chinese, translation not available), , Invertebrates in Wuling Mountain Area, China. 223-234.