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Cecilia Giulivi- MS, PhD
Professor and Researcher
Molecular Biosciences


cgiulivi@ucdavis.edu

   

Research Focus

- Biosynthesis and metabolism of nitric oxide in mammalian cells.

- Role of nitric oxide and oxygen free radicals on mitochondria and celll functions.

- Mitochondrial nitrated proteins: role of nitration, metabolism of nitrated proteins, implications for pathophysiology.

- Oxygen and nitrogen free radical biochemistry and chemistry in in vitro and in vivo model systems. Mechanistic aspects of oxygen and nitrogen free radical damage.

- Proteomics of aging and oxidative damage of mitochondria.

- Role of mitochondria in fragile-X, tremor, ataxia syndrome, autism, and Huntington's disease.


Specialty Focus

Mechanisms of mitochondrial dysfunction in autism, fragile X tremor and ataxia syndrome, Hungton's disease, diabetes and nutrional imbalances as well as in malaria hosts.

Education

1989 PhD Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
1985 MS Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina

Honors and Awards

2011 National Institute for Enviornmental Health and Safety (NIEHS) as the author of one of the top 10 scientific papers of 2011. http://www.niehs.nih.gov/news/newsletter/2012/1/papers/index.htm
2010 Autism Science Top 10 Achievement for 2010
2007-2009 None.
1990 Award from Sociedad Argentina de Gerontologia y Geriatria to the research project Free radicals as a cause for ageing and atherosclerosis. Co-authors: Dr. A Boveris, Mosso, Vaccarezza
1989 Fellowship from Fundación Antorchas, Buenos Aires
1988 Award Sandoz to the project Human ageing. Sandoz Laboratories, Switzerland
1986 ICRO-IUB Fellowship, University Autónoma of Mexico, Mexico DF, Mexico
1986 Young Investigator Award, School of Pharmacy and Biochemistry, University of Buenos Aires
1985-1987 Fellowship from National Research Council (CONICET) Buenos Aires, Argentina

Active Research Grants

Principal Investigator, Surgical amelioration of type 2 diabetes: hormones, microbiota and mitochondria, Peter Havel(Contact)/Cecilia Giulivi (MPI) (Principal Investigator), NIH

Co-Investigator, Autism risk, prenatal environmental exposures, and pathophysiologic markers, Hertz-Picciotto (Contact), Pessah, Ozenoff (MPI) (Principal Investigator), NIH

Principal Investigator, Mitochondrial dysfunction in HD-Affected Human Fibroblasts, (Principal Investigator), CHDI Foundation, Inc.

Co-Principal Investigator, Uncovering the molecular basis of malignant hyperthermia, Paul Allen / Issach Pessah PI on project 2 (Principal Investigator), NIH / Brigham and Womens Hospital

Co-Investigator, Genotype-phenotype relationships in fragile X families, Hagerman (Principal Investigator), NIH

Most Recent 10 Publications

  • Link Icon 2013 Napoli, E., Wong, S., Hung, C., Ross-Inta, C., Bomdica, P., Giulivi, C. Defective mitochondrial disulfide relay system, altered mitochondrial morphology and function in Huntington's disease Hum Mol Genet,
  • Link Icon 2013 Napoli, E., Wong, S., Giulivi, C. Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism Mol Autism,
  • Link Icon 2013 Grodzki, A. C., Giulivi, C., Lein, P. J. Oxygen tension modulates differentiation and primary macrophage functions in the human monocytic THP-1 cell line PLoS One,
  • Link Icon 2013 Vernau, K. M., Runstadler, J. A., Brown, E. A., Cameron, J. M., Huson, H. J., Higgins, R. J., Ackerley, C., Sturges, B. K., Dickinson, P. J., Puschner, B., Giulivi, C., Shelton, G. D., Robinson, B. H., Dimauro, S., Bollen, A. W., Bannasch, D. L. Genome-Wide Association Analysis Identifies a Mutation in the Thiamine Transporter 2 (SLC19A3) Gene Associated with Alaskan Husky Encephalopathy PLoS One,
  • Link Icon 2013 Luckhart, S., Giulivi, C., Drexler, A. L., Antonova-Koch, Y., Sakaguchi, D., Napoli, E., Wong, S., Price, M. S., Eigenheer, R., Phinney, B. S., Pakpour, N., Pietri, J. E., Cheung, K., Georgis, M., Riehle, M. Sustained Activation of Akt Elicits Mitochondrial Dysfunction to Block Plasmodium falciparum Infection in the Mosquito Host PLoS Pathog,
  • Link Icon 2013 Napoli, E., Hung, C., Wong, S., Giulivi, C. Toxicity of the Flame-Retardant BDE-49 on Brain Mitochondria and Neuronal Progenitor Striatal Cells Enhanced by a PTEN-Deficient Background Toxicol Sci,
  • Link Icon 2013 Cummings, B. P., Bettaieb, A., Graham, J. L., Kim, J., Ma, F., Shibata, N., Stanhope, K. L., Giulivi, C., Hansen, F., Jelsing, J., Vrang, N., Kowala, M., Chouinard, M. L., Haj, F. G., Havel, P. J. Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats Dis Model Mech,
  • Link Icon 2012 Li, Y., Lein, P. J., Liu, C., Bruun, D. A., Giulivi, C., Ford, G. D., Tewolde, T., Ross-Inta, C., Ford, B. D. Neuregulin-1 is neuroprotective in a rat model of organophosphate-induced delayed neuronal injury Toxicol Appl Pharmacol,
  • Link Icon 2012 Napoli, E., Ross-Inta, C., Wong, S., Hung, C., Fujisawa, Y., Sakaguchi, D., Angelastro, J., Omanska-Klusek, A., Schoenfeld, R., Giulivi, C. Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53 PLoS One,
  • Link Icon 2011 Giulivi C, Ross-Inta C, Omanska-Klusek A, Napoli E, Sakaguchi D, Barrientos G, Allen PD, Pessah IN Basal bioenergetic abnormalities in skeletal muscle from ryanodine receptor malignant hyperthermia-susceptible R163C knock-in mice J Biol Chem,

Most Recent 5 Book Chapters

2003 Giulivi C, Oursler MJ: Role of mitochondrial oxygen and nitrogen reactive species in signaling. Chapter 17, M. Torres, J. Fukuto, and H. J. Forman, (ed), Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles, New York. 311-332.

1999 Giulivi C, Boveris A, Cadenas E: The steady-state concentrations of oxygen radicals in mitochondria, Daniel L. Gilbert and Carol A. Colton, (ed), Reactive Oxygen Species in Biological Systems: Selected Topics, New York, NY. 77-102.

1994 Romero FJ, Ordoñez I, Giulivi C, Cadenas E: The interaction of sulfur compounds with ferrylmyoglobin, L. Packer and E. Cadenas, (ed), Biological Oxidants and Antioxidants. 49-56.

1994 Cadenas E, Giulivi C, Ursini F, Boveris A: Electronically-excited state formation. Chapter 32, C. A. Tyson & J. M. Frazier, (ed), Methods of Toxicology, Vol. I, Part B: In Vitro Toxicity Indicators. 384-399.

1993 Giulivi C, Cadenas E: Interaction of ferrylmyoglobin with trolox, vitamin E, and unsaturated fatty acids, F. Ursini and E. Cadenas, (ed), Dietary Lipids, Antioxidants, and the Prevention of Atherosclerosis. 169-178.