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Cecilia Giulivi- MS, PhD
Professor and Researcher
Molecular Biosciences


cgiulivi@ucdavis.edu

   

Research Focus

- Oxygen and nitrogen free radical biochemistry and chemistry in in vitro and in vivo model systems. Mechanistic aspects of oxygen and nitrogen free radical damage.

- Role of mitochondria in fragile-X, tremor, ataxia syndrome, autism, and Huntington's disease.


Specialty Focus

Mechanisms of mitochondrial dysfunction in autism, fragile X tremor and ataxia syndrome, Hungton's disease, diabetes and nutrional imbalances as well as in malaria hosts.

Education

1989 PhD Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
1985 MS Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina

Honors and Awards

2011 National Institute for Enviornmental Health and Safety (NIEHS) as the author of one of the top 10 scientific papers of 2011. http://www.niehs.nih.gov/news/newsletter/2012/1/papers/index.htm
2010 Autism Science Top 10 Achievement for 2010
2007-2009 None.
1990 Award from Sociedad Argentina de Gerontologia y Geriatria to the research project Free radicals as a cause for ageing and atherosclerosis. Co-authors: Dr. A Boveris, Mosso, Vaccarezza
1989 Fellowship from Fundación Antorchas, Buenos Aires
1988 Award Sandoz to the project Human ageing. Sandoz Laboratories, Switzerland
1986 ICRO-IUB Fellowship, University Autónoma of Mexico, Mexico DF, Mexico
1986 Young Investigator Award, School of Pharmacy and Biochemistry, University of Buenos Aires
1985-1987 Fellowship from National Research Council (CONICET) Buenos Aires, Argentina

Active Research Grants

Co-Investigator, Autism risk, prenatal environmental exposures, and pathophysiologic markers, Hertz-Picciotto (Contact), Pessah, Ozenoff (MPI) (Principal Investigator), NIH

Co-Investigator, Genotype-phenotype relationships in fragile X families, Hagerman (Principal Investigator), NIH

Co-Investigator, Harnessing midgut mitochondrial dynamics to enhance anopheline mosquito fitness, Brown M, Luckhart S and Riehle A - MPI (Principal Investigator), NIH

Co-Investigator, Evaluating Urinary Porphyrins as a Biomarker for a Subset of ASD, MPI Heyer/Hertz-Picciotto (PI of UCD subcontract) (Principal Investigator), NIH

Most Recent 10 Publications

  • Cecilia Giulivi: Granulosa cell and oocyte mitochondrial abnormalities in a mouse model of fragile X primary ovarian insufficiency. 2016 Conca Dioguardi, C, Uslu, B, Haynes, M, Kurus, M, Gul, M, Miao, DQ, De Santis, L, Ferrari, M, Bellone, S, Santin, A, Giulivi, C, Hoffman, G, Usdin, K, Johnson, J Granulosa cell and oocyte mitochondrial abnormalities in a mouse model of fragile X primary ovarian insufficiency. Molecular human reproduction,
  • Cecilia Giulivi: Plasma Biomarkers for Monitoring Brain Pathophysiology in FMR1 Premutation Carriers. 2016 Giulivi, C, Napoli, E, Tassone, F, Halmai, J, Hagerman, R Plasma Biomarkers for Monitoring Brain Pathophysiology in FMR1 Premutation Carriers. Frontiers in molecular neuroscience,
  • Cecilia Giulivi: Plasma metabolic profile delineates roles for neurodegeneration, pro-inflammatory damage and mitochondrial dysfunction in the FMR1 premutation. 2016 Giulivi, C, Napoli, E, Tassone, F, Halmai, J, Hagerman, R Plasma metabolic profile delineates roles for neurodegeneration, pro-inflammatory damage and mitochondrial dysfunction in the FMR1 premutation. The Biochemical journal,
  • Cecilia Giulivi: Premutation in the Fragile X Mental Retardation 1 (FMR1) Gene Affects Maternal Zn-milk and Perinatal Brain Bioenergetics and Scaffolding. 2016 Napoli, E, Ross-Inta, C, Song, G, Wong, S, Hagerman, R, Gane, LW, Smilowitz, JT, Tassone, F, Giulivi, C Premutation in the Fragile X Mental Retardation 1 (FMR1) Gene Affects Maternal Zn-milk and Perinatal Brain Bioenergetics and Scaffolding. Frontiers in neuroscience,
  • Cecilia Giulivi: Warburg effect linked to cognitive-executive deficits in FMR1 premutation. 2016 Napoli, E, Song, G, Schneider, A, Hagerman, R, Eldeeb, MA, Azarang, A, Tassone, F, Giulivi, C Warburg effect linked to cognitive-executive deficits in FMR1 premutation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
  • Cecilia Giulivi: Altered Bioenergetics in Primary Dermal Fibroblasts from Adult Carriers of the FMR1 Premutation Before the Onset of the Neurodegenerative Disease Fragile X-Associated Tremor/Ataxia Syndrome. 2016 Napoli, E, Song, G, Wong, S, Hagerman, R, Giulivi, C Altered Bioenergetics in Primary Dermal Fibroblasts from Adult Carriers of the FMR1 Premutation Before the Onset of the Neurodegenerative Disease Fragile X-Associated Tremor/Ataxia Syndrome. Cerebellum (London, England),
  • Cecilia Giulivi: Two insulin-like peptides differentially regulate malaria parasite infection in the mosquito through effects on intermediary metabolism. 2016 Pietri, JE, Pakpour, N, Napoli, E, Song, G, Pietri, E, Potts, R, Cheung, KW, Walker, G, Riehle, MA, Starcevich, H, Giulivi, C, Lewis, EE, Luckhart, S Two insulin-like peptides differentially regulate malaria parasite infection in the mosquito through effects on intermediary metabolism. The Biochemical journal,
  • Cecilia Giulivi: Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine. 2016 Song, G, Napoli, E, Wong, S, Hagerman, R, Liu, S, Tassone, F, Giulivi, C Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine. Molecular medicine (Cambridge, Mass.),
  • Cecilia Giulivi: Autism, Mitochondria and Polybrominated Diphenyl Ether Exposure. 2016 Wong, S, Giulivi, C Autism, Mitochondria and Polybrominated Diphenyl Ether Exposure. CNS & neurological disorders drug targets,
  • Cecilia Giulivi: Role of p53, Mitochondrial DNA Deletions, and Paternal Age in Autism: A Case-Control Study. 2016 Wong, S, Napoli, E, Krakowiak, P, Tassone, F, Hertz-Picciotto, I, Giulivi, C Role of p53, Mitochondrial DNA Deletions, and Paternal Age in Autism: A Case-Control Study. Pediatrics,

Most Recent 5 Book Chapters

2003 Giulivi C, Oursler MJ: Role of mitochondrial oxygen and nitrogen reactive species in signaling. Chapter 17, Torres M, Fukuto J, Forman HJ, (ed), Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles, New York. 311-332.

1999 Giulivi C, Boveris A, Cadenas E: The steady-state concentrations of oxygen radicals in mitochondria, Daniel L. Gilbert and Carol A. Colton, (ed), Reactive Oxygen Species in Biological Systems: Selected Topics, New York, NY. 77-102.

1994 Romero FJ, Ordoñez I, Giulivi C, Cadenas E: The interaction of sulfur compounds with ferrylmyoglobin, L. Packer and E. Cadenas, (ed), Biological Oxidants and Antioxidants. 49-56.

1994 Cadenas E, Giulivi C, Ursini F, Boveris A: Electronically-excited state formation. Chapter 32, C. A. Tyson & J. M. Frazier, (ed), Methods of Toxicology, Vol. I, Part B: In Vitro Toxicity Indicators. 384-399.

1993 Giulivi C, Cadenas E: Interaction of ferrylmyoglobin with trolox, vitamin E, and unsaturated fatty acids, F. Ursini and E. Cadenas, (ed), Dietary Lipids, Antioxidants, and the Prevention of Atherosclerosis. 169-178.