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Cecilia Giulivi- MS, PhD
Professor
Molecular Biosciences


cgiulivi@ucdavis.edu

   

Research Focus

- Oxygen and nitrogen free radical biochemistry and chemistry in in vitro and in vivo model systems. Mechanistic aspects of oxygen and nitrogen free radical damage.

- Role of mitochondria in fragile-X, tremor, ataxia syndrome, autism, and Huntington's disease.


Specialty Focus

Mechanisms of mitochondrial dysfunction in autism, fragile X tremor and ataxia syndrome, Hungton's disease, diabetes and nutrional imbalances as well as in malaria hosts.

Education

1989 PhD Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
1985 MS Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina

Honors and Awards

2011 National Institute for Enviornmental Health and Safety (NIEHS) as the author of one of the top 10 scientific papers of 2011. http://www.niehs.nih.gov/news/newsletter/2012/1/papers/index.htm
2010 Autism Science Top 10 Achievement for 2010
2007-2009 None.
1990 Award from Sociedad Argentina de Gerontologia y Geriatria to the research project Free radicals as a cause for ageing and atherosclerosis. Co-authors: Dr. A Boveris, Mosso, Vaccarezza
1989 Fellowship from Fundación Antorchas, Buenos Aires
1988 Award Sandoz to the project Human ageing. Sandoz Laboratories, Switzerland
1986 ICRO-IUB Fellowship, University Autónoma of Mexico, Mexico DF, Mexico
1986 Young Investigator Award, School of Pharmacy and Biochemistry, University of Buenos Aires
1985-1987 Fellowship from National Research Council (CONICET) Buenos Aires, Argentina

Active Research Grants

Co-Investigator, Autism risk, prenatal environmental exposures, and pathophysiologic markers, Hertz-Picciotto (Contact), Pessah, Ozenoff (MPI) (Principal Investigator), NIH

Co-Principal Investigator, Uncovering the molecular basis of malignant hyperthermia, Paul Allen / Issach Pessah PI on project 2 (Principal Investigator), NIH / Brigham and Womens Hospital

Co-Investigator, Genotype-phenotype relationships in fragile X families, Hagerman (Principal Investigator), NIH

Principal Investigator, Environmental exposure unveils mitochondrial dysfunction in autism, (Principal Investigator), Simons Foundation

Principal Investigator, Agilent Microarray Grant Program, (Principal Investigator), Agilent Technologies

Most Recent 10 Publications

  • Link Icon 2013 Giulivi C, Napoli E, Schwartzer J, Careaga M, Ashwood P Gestational exposure to a viral mimetic poly (I:C) results in long-lasting changes in mitochondrial function by leucocytes in the adult offspring Mediators of Inflammation, vol. 2013, Article ID 609602, 8 pages, 2013. doi:10.1155/2013/609602,
  • Link Icon 2013 Napoli E, Wong S, Giulivi C Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism Mol Autism,
  • Link Icon 2013 Vernau KM, Runstadler JA, Brown EA, Cameron JM, Huson HJ, Higgins RJ, Ackerley C, Sturges BK, Dickinson PJ, Puschner B, Giulivi C, Shelton GD, Robinson BH, DiMauro S, Bollen AW, Bannasch DL Genome-wide association analysis identifies a mutation in the thiamine transporter 2 (SLC19A3) gene associated with Alaskan Husky encephalopathy. PloS One,
  • Link Icon 2013 Grodzki AC, Giulivi C, Lein PJ Oxygen tension modulates differentiation and primary macrophage functions in the human monocytic THP-1 cell line PLoS One,
  • Link Icon 2013 Croft L, Napoli E, Hung CK, St. Leger J, Gearhart S, Heym K, Wong S, Sakaguchi D, Lin A, Puschner B, Giulivi C Clinical evaluation and biochemical analyses of thiamine deficiency in Pacific harbor seals (Phoca vitulina) maintained at a zoological facility Journal of the American Veterinary Medicine Association,
  • Link Icon 2013 Napoli E, Hung C, Wong S, Giulivi C Toxicity of the flame-retardant BDE-49 on brain mitochondria and neuronal progenitor striatal cells enhanced by a PTEN-deficient background Toxicol Sci,
  • Link Icon 2013 Cummings BP, Bettaieb A, Graham JL, Kim J, Ma F, Shibata N, Stanhope KL, Giulivi C, Hansen F, Jelsing J, Vrang N, Kowala M, Chouinard ML, Haj FG, Havel PJ Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats Dis Model Mech,
  • Link Icon 2013 Luckhart S, Giulivi C, Drexler AL, Antonova-Koch Y, Sakaguchi D, Napoli E, Wong S, Price MS, Eigenheer R, Phinney BS, Pakpour N, Pietri JE, Cheung K, Georgis M, Riehle M Sustained activation of Akt elicits mitochondrial dysfunction to block Plasmodium falciparum infection in the mosquito host PLoS Pathog,
  • Link Icon 2013 Napoli E, Wong S, Hung C, Ross-Inta C, Bomdica P, Giulivi C Defective mitochondrial disulfide relay system, altered mitochondrial morphology and function in Huntington's disease Human Molecular Genetics,
  • Link Icon 2012 Napoli E, Ross-Inta C, Wong S, Hung C, Fujisawa Y, Sakaguchi D, Angelastro J, Omanska-Klusek A, Schoenfeld R, Giulivi C Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53 PLoS One,

Most Recent 5 Book Chapters

2003 Giulivi C, Oursler MJ: Role of mitochondrial oxygen and nitrogen reactive species in signaling. Chapter 17, Torres M, Fukuto J, Forman HJ, (ed), Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles, New York. 311-332.

1999 Giulivi C, Boveris A, Cadenas E: The steady-state concentrations of oxygen radicals in mitochondria, Daniel L. Gilbert and Carol A. Colton, (ed), Reactive Oxygen Species in Biological Systems: Selected Topics, New York, NY. 77-102.

1994 Romero FJ, Ordoñez I, Giulivi C, Cadenas E: The interaction of sulfur compounds with ferrylmyoglobin, L. Packer and E. Cadenas, (ed), Biological Oxidants and Antioxidants. 49-56.

1994 Cadenas E, Giulivi C, Ursini F, Boveris A: Electronically-excited state formation. Chapter 32, C. A. Tyson & J. M. Frazier, (ed), Methods of Toxicology, Vol. I, Part B: In Vitro Toxicity Indicators. 384-399.

1993 Giulivi C, Cadenas E: Interaction of ferrylmyoglobin with trolox, vitamin E, and unsaturated fatty acids, F. Ursini and E. Cadenas, (ed), Dietary Lipids, Antioxidants, and the Prevention of Atherosclerosis. 169-178.