Search for Faculty

Photo: Isaac Pessah

Isaac Pessah- BS, MS, PhD
Professor and Researcher
Molecular Biosciences

2203 VM3B
Davis, CA 95616

+1 530 752 6696
inpessah@ucdavis.edu

   

Research Focus

Molecular and Cellular Signaling

 

Molecular and cellular mechanisms regulating cellular Ca2+ signaling. The structure, function, and pharmacology of ryanodine-sensitive calcium channels of sarcoplasmic and endoplasmic reticulum in striated muscle and mammalian brain. Role of immunophilins in Ca2+-dependent and independent signaling cascades. Genetic and xenobiotic factors influencing malignant hyperthermia susceptibility Mechanisms responsible for the developmental neurotoxicity of halogenated aromatics Genetic and environmental factors influencing neurodevelopment

Specialty Focus

Toxicology

 

Education

1977 BS , Cornell University, Ithaca, New York,
1981 MS , University of Maryland, Baltimore,
1983 PhD Toxicology, University of Maryland, College Park

Honors and Awards

2012 NIH Honor Isaac Pessah has accepted the invitation of the NIH Center for Scientific Review to serve in the Neurotoxicology and Alcohol Study Section from July 2012 through June 2016. Members are selected for the quality of their research accomplishments, publications in scientific journals, and other significant scientific activities, achievements and honors. Pessah’s participation is important in assuring the quality of the NIH peer review process. Membership in this group is both an honor and a major commitment of professional time and energy resulting in a unique opportunity to contribute to the national biomedical research effort.
2011 Neurobehavioral Toxicology Society's Elsevier Distinguished Lectureship presented at their June 2011 meeting in San Diego, CA
2006-2008 Cure Autism Now, Environmental Innovator Award (Inaugural)
2002 Larry L. Hillblom Endowed Chair in Developmental Disorders in Children (nominated)
1997 Pfizer Award for Research Excellence
1988-1993 NIH First Award
1982-1983 Recipient of USDA, Predoctoral Fellowship
1980-1981 Sea Grant Predoctoral Research Grant, University of Maryland, College park, MD

Active Research Grants

Co-Principal Investigator, Center for Children's Environmental Health and Disease Prevention Research, (Principal Investigator), PHS/NIEHS

Co-Principal Investigator, Subaward of Autism Risk, Prenatal Environmental Exposures and Pathophysiologic Markers, Hertz-Picciotto (Principal Investigator), NIH

Principal Investigator, Project 2: Uncovering Basis of Malignant Hyperthermia, (Principal Investigator), Brigham & Women's Hospital

Co-Investigator, CounterACT Project 3 - NIH Grant Number 5 U54 NS079202 , Pamela Lein (Principal Investigator), NIH

Co-Investigator, Targeted upregulation of FMRP Expression, Paul Hagerman (Principal Investigator), DOD

Co-Investigator, CCEH Project 4 (EPA), Judith Van de Water (Principal Investigator), EPA

Principal Investigator, MIND Institute RESEARCH SUPPORT, (Principal Investigator), UCD MIND

Co-Principal Investigator, Molecular and Cellular Basis of PCB Developmental Neurotoxicity, (Principal Investigator), NIH

Most Recent 10 Publications

  • Isaac Pessah: Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures 2015 Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures Neuropharmacology,
  • Isaac Pessah: Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture. 2015 Cao Z, Zou X, Cui Y, Hulsizer S, Lein PJ, Wulff H, Pessah IN Rapid throughput analysis demonstrates that chemicals with distinct seizurogenic mechanisms differentially alter Ca2+ dynamics in networks formed by hippocampal neurons in culture. Molecular pharmacology,
  • Isaac Pessah: The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant. 2015 Coleman N, Nguyen HM, Cao Z, Brown BM, Jenkins DP, Zolkowska D, Chen YJ, Tanaka BS, Goldin AL, Rogawski MA, Pessah IN, Wulff H The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics,
  • Isaac Pessah: Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. 2015 Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. Neuropharmacology,
  • Isaac Pessah: Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA 2015 Fritsch EB, Stegeman JJ, Goldstone JV, Nacci DE, Champlin D, Jayaraman S, Connon RE, Pessah IN Expression and function of ryanodine receptor related pathways in PCB tolerant Atlantic killifish (Fundulus heteroclitus) from New Bedford Harbor, MA, USA Aquatic toxicology (Amsterdam, Netherlands),
  • Isaac Pessah: Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity. 2014 Cao Z, Cui Y, Nguyen HM, Jenkins DP, Wulff H, Pessah IN Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity. Molecular pharmacology,
  • Isaac Pessah: Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle. 2014 Altamirano F, Eltit JM, Robin G, Linares N, Ding X, Pessah IN, Allen PD, López JR Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle. The Journal of biological chemistry,
  • Isaac Pessah: Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome 2014 Berman RF, Buijsen RA, Usdin K, Pintado E, Kooy F, Pretto D, Pessah IN, Nelson DL, Zalewski Z, Charlet-Bergeurand N, Willemsen R, Hukema RK Mouse models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome Journal of neurodevelopmental disorders,
  • Isaac Pessah: Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor/ataxia syndrome 2014 Pretto DI, Kumar M, Cao Z, Cunningham CL, Durbin-Johnson B, Qi L, Berman R, Noctor SC, Hagerman RJ, Pessah IN, Tassone F Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expression in the cerebellum of fragile X mental retardation gene 1 premutation carriers with fragile X-associated tremor/ataxia syndrome Neurobiology of aging,
  • Isaac Pessah: PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms 2014 Yang D, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler HJ, Lein PJ PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms Toxicological sciences: An official journal of the Society of Toxicology,

Most Recent 5 Book Chapters

2014 Zhou J, Allen PD, Pessah IN: Malignant Hyperthermia and Other Related Disorders, , Miller RD, Eriksson LI, Fleisher L, Wiener-Kronish JP, Cohen NH, (ed), Elsevier Health Sciences, NY, NY. 1033-1052.

2011 Bose DD, Pessah IN: Ryanodine receptor type 1, , Nature Signaling Gateway: Molecule Page. .

2011 Lein PJ, Barnhart CD, Pessah IN: Acute Hippocampal Slice Preparation and Hippocampal Slice Cultures, Chapter 8, L Costa, (ed), In vitro Toxicology, Methods in molecular biology, Clifton, NJ. 115-134.

2011 Stafstrom CE, Hagerman PJ, Pessah IN: Pathophysiology of epilepsy in autism spectrum disorders, Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, (ed), Jasper's Basic Mechanisms of the Epilepsies, Fourth Edition. .

2010 Lein PJ, Kim KH, Berman RF, Pessah IN: Exposure of the Developing Brain to Polychlorinated Biphenyls Influences the Susceptibility of the Adult Brain to Stress, Wang C, Slikker W, (ed), Developmental Neurotoxicity Research: Principles, Models, Techniques, Strategies and Mechanisms, Somerset, NJ. .