Gregory Lanzaro- BS, MS, PhD
2086 Haring Hall
+1 530 752 5652
Vector biology, population genetics. My overall research interest is in the population genetics of insect vectors of human and animal disease. I have developed a program that pursues knowledge that may be applied to the control of vectorborne diseases but at the same time addresses critical issues in basic evolutionary genetics. An additional goal is the application of cutting edge molecular biological methods to problems at the level of populations. I am pursuing this interest within the context of four major avenues of research: 1) Population genetics of the human malaria vector, Anopheles gambiae in west and central Africa: This work deals with describing the genetic structure of populations, understanding the forces responsible for this structure and how patterns of gene flow influence the distribution of traits critical to understanding and managing malaria transmission. I have been working at field sites in Africa since 1991 and my current program has been supported continuously since 1996 with support in the form of a series of R01 grants from NIH on which I serve as P.I. 2) The biology of pharmacologically active salivary substances in blood-feeding insects: The interaction among vector insects, pathogens and mammalian hosts converge at the site in the host skin at which the insect feeds. We therefore reasoned that if one were interested in exploring the evolution of the relationships among these organisms that vector salivary proteins and the genes that encode them would be a good place to look. Our research model is visceral leishmaniasis in the New World. This is a serious zoonotic disease identified by WHO and the NIH as one of the most important neglected diseases of the developing world. This research has been supported since 1995 by a series of R01 grants from NIH for which I serve as P.I. 3) The population genetics of Lutzomyia longipalpis, the vector of visceral leishmaniasis in Latin America: This work is closely related to our research on salivary proteins. This species is the system we are using for the salivary protein research and much of our work on understanding the biology of salivary proteins is at the population level. This research is supported by NIH grants as described above. 4) Genetics of population of the West Nile virus (WNV) vector, Culex pipiens in California. C. pipiens is the major urban vector of WNV in California. This mosquito exists in the state as a group of closely related species that can not be distinguished based on morphology and are poorly known. We have been working on the development of single nucleotide polymorphisms that can be used to define populations and as an aid to improve our understanding of the population biology of this group. This work was supported from 2003 through 2008 by a U01 grant from NIH for which I served as P.I. and is currently being supported on an NIH T32 grant, on which I also serve as PI.
1972 BS Secondary Education, Kansas State University, Manhattan, Kansas
Honors and Awards
1991-1995 MacArthur Foundation Fellowship, Molecular Biology of Disease Vectors
Active Research Grants
Principal Investigator, An. gambiae immune signaling gene SNPs and natural P. falciparum infection, (Principal Investigator), NIAID/NIH
Principal Investigator, The role of sand fly saliva in visceralization of Leishmania parasites, (Principal Investigator), NIAID/NIH
Principal Investigator, Ecology and genetics of An. gambiae on islands, (Principal Investigator), NIAID/NIH
Principal Investigator, Training Program in the Biology of Disease Vectors, (Principal Investigator), NIAID/NIH
Most Recent 10 Publications
Most Recent 5 Book Chapters
2005 Lanzaro GC, Nuzhdin S, Tripet F: Tools for monitoring the genetic structure and stability of mosquito populations, , In: Proceedings: Working Group on Strategic Plan to Bridge Laboratory and Field Research In Disease Vector Control 14-16 July 2004, ICIPE, Nairobi, Kenya, The Netherlands. .
2003 Lanzaro, GC, Tripet, F: Gene flow among populations of Anopheles gambiae: A critical review, Takken, W, Scott, TW, (ed), Ecological Aspects for the Application of Genetically Modified Mosquitoes, Wageningen, The Netherlands. 109-132.