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Photo: Gregory Lanzaro

Gregory Lanzaro- BS, MS, PhD
Professor
Pathology, Microbiology & Immunology

2086 Haring Hall
Davis, CA 95616

+1 530 752 5652
gclanzaro@ucdavis.edu

  

Research Focus

Vector biology, population genetics. My overall research interest is in the population genetics of insect vectors of human and animal disease. I have developed a program that pursues knowledge that may be applied to the control of vectorborne diseases but at the same time addresses critical issues in basic evolutionary genetics. An additional goal is the application of cutting edge molecular biological methods to problems at the level of populations. I am pursuing this interest within the context of four major avenues of research: 1) Population genetics of the human malaria vector, Anopheles gambiae in west and central Africa: This work deals with describing the genetic structure of populations, understanding the forces responsible for this structure and how patterns of gene flow influence the distribution of traits critical to understanding and managing malaria transmission. I have been working at field sites in Africa since 1991 and my current program has been supported continuously since 1996 with support in the form of a series of R01 grants from NIH on which I serve as P.I. 2) The biology of pharmacologically active salivary substances in blood-feeding insects: The interaction among vector insects, pathogens and mammalian hosts converge at the site in the host skin at which the insect feeds. We therefore reasoned that if one were interested in exploring the evolution of the relationships among these organisms that vector salivary proteins and the genes that encode them would be a good place to look. Our research model is visceral leishmaniasis in the New World. This is a serious zoonotic disease identified by WHO and the NIH as one of the most important neglected diseases of the developing world. This research has been supported since 1995 by a series of R01 grants from NIH for which I serve as P.I. 3) The population genetics of Lutzomyia longipalpis, the vector of visceral leishmaniasis in Latin America: This work is closely related to our research on salivary proteins. This species is the system we are using for the salivary protein research and much of our work on understanding the biology of salivary proteins is at the population level. This research is supported by NIH grants as described above. 4) Genetics of population of the West Nile virus (WNV) vector, Culex pipiens in California. C. pipiens is the major urban vector of WNV in California. This mosquito exists in the state as a group of closely related species that can not be distinguished based on morphology and are poorly known. We have been working on the development of single nucleotide polymorphisms that can be used to define populations and as an aid to improve our understanding of the population biology of this group. This work was supported from 2003 through 2008 by a U01 grant from NIH for which I served as P.I. and is currently being supported on an NIH T32 grant, on which I also serve as PI.

Specialty Focus

Entomology

Education

1972 BS Secondary Education, Kansas State University, Manhattan, Kansas
1978 MS Entomology, University of Arizona, Tucson, Arizona
1986 PhD Entomology, University of Florida, Gainesville, Florida

Honors and Awards

1991-1995 MacArthur Foundation Fellowship, Molecular Biology of Disease Vectors
2000-2006 Faculty, International Biology of Disease Vectors Course
2002-2010 Member, External Advisory Panel, Johns Hopkins University Malaria Institute
2005 Rogoff Lectureship, Department of Entomology, Cornell University
2006 Service Award, Entomological Society of America
2007 Excellence in Research Award, Academic Federation, UC Davis
2007 Plenary Speaker, Annual Meeting, Society of Vector Ecology
2009 Elected Vice-President/President Elect, Society for Vector Ecology
2009 Plenary Speaker, 34th Annual Meeting, Human Biology Association
2009 2009 Student Selected Speaker, Department of Entomology, University of Arkansas
2010 President Elect
2010 Plenary Speaker, Keystone Symposium on Molecular and Cell Biology
2010 Keynote Speaker, 10th Annual Symposium of the Center for Host-Parasite Interactions, McGill University
2010 Keynote Speaker, 14th Annual Arthromint Meeting, Oswaldo Cruz Institute, Ilha Grande, Brazil

Active Research Grants

Principal Investigator, An. gambiae immune signaling gene SNPs and natural P. falciparum infection, (Principal Investigator), NIAID/NIH

Principal Investigator, The role of sand fly saliva in visceralization of Leishmania parasites, (Principal Investigator), NIAID/NIH

Principal Investigator, Ecology and genetics of An. gambiae on islands, (Principal Investigator), NIAID/NIH

Principal Investigator, Training Program in the Biology of Disease Vectors, (Principal Investigator), NIAID/NIH

Most Recent 10 Publications

  • Link Icon 2010 Arensburger P, Megy K, Waterhouse RM, Abrudan J, Amedeo P, Antelo B, Batholomay L, Bidwell S, Caler E, Camara F, Campbell CL, Campbell KS, Casola C, Castro MT, Chandramouliswaran I, Chapman SB, Christley S, Costas J, Eisenstadt E, Feschotte C, Fraser-Liggett CF, Guigo R, Haas B, Hammond M, Hansson BS, Hemingway J, Hill SR, Howarth C, Ignell R, Kennedy RC, Kodira CD, Lobo NF, Mao C, Mayhew G, Michel K, Mori A, Liu N, Naveira H, Nene V, Nguyen N, Pearson MD, Pritham EJ, Puiu D, Qui Y, Ranson H, Ribeiro JMC, Robertston HM, Severson DW, Shumway M, Stanke M, Strausberg RL, Sun C, Suton G, Tu Z, Tubio JMC, Unger MF, Vanlandingham DL, Vilella AJ, White O, White JR, Wondji CS, Wortman J, Zdobnov EM, Birren B, Christensen BM, Collins FH, Cornel A, Dimopoulos G, Hannick LI, Higgs S, Lanzaro GC, Lawson D, Lee NH, Muskavitch MAT, Raikhel AS, Atkinson PW Sequencing of Culex quinquefasciatus establishes a platform for mosquito comparative genomics Science,
  • Link Icon 2010 Horton AA, Lee Y, Coulibaly CA, Rashbrook VK, Cornel AJ, Lanzaro GC, Luckhart S Identification of three single nucleotide polymorphisms in Anopheles gambiae immune signaling genes that are associated with natural Plasmodium falciparum infection Malar J,
  • Link Icon 2009 Ndjemaï HN, Patchoké S, Atangana J, Etang J, Simard F, Bilong CF, Reimer L, Cornel A, Lanzaro GC, Fondjo E The distribution of insecticide resistance in Anopheles gambiae s.l. populations from Cameroon: an update Trans R Soc Trop Med Hyg,
  • Link Icon 2009 Lee Y, Meneses CR, Fofana A, Lanzaro GC Desiccation resistance among subpopulations of Anopheles gambiae s.s. from Selinkenyi, Mali J Med Entomol,
  • Link Icon 2009 Lee Y, Cornel AJ, Meneses CR, Fofana A, Andrianarivo AG, McAbee RD, Fondjo E, Traoré SF, Lanzaro GC Ecological and genetic relationships of the Forest-M form among chromosomal and molecular forms of the malaria vector Anopheles gambiae sensu stricto Malar J,
  • Link Icon 2009 Goltsev Y, Rezende GL, Vranizan K, Lanzaro G, Valle D, Levine M Developmental and evolutionary basis for drought tolerance of the Anopheles gambiae embryo Dev Biol,
  • Link Icon 2008 Milleron RS, Meneses CR, Elnaiem DA, Lanzaro GC Effects of varying moisture on egg production and longevity of Lutzomyia longipalpis (Diptera: Psychodidae) J Med Entomol,
  • Link Icon 2008 Reimer L, Fondjo E, Patchoké S, Diallo B, Lee Y, Ng A, Ndjemai HM, Atangana J, Traore SF, Lanzaro G, Cornel AJ Relationship between kdr mutation and resistance to pyrethroid and DDT insecticides in natural populations of Anopheles gambiae J Med Entomol,
  • Link Icon 2008 Moncayo AC, Lanzaro G, Kang W, Orozco A, Ulloa A, Arredondo-Jiménez J, Weaver SC Vector competence of eastern and western forms of Psorophora columbiae (Diptera: Culicidae) mosquitoes for enzootic and epizootic Venezuelan equine encephalitis virus Am J Trop Med Hyg,
  • Link Icon 2008 Wong J, Tripet F, Rasgon JL, Lanzaro GC, Scott TW SSCP analysis of scnDNA for genetic profiling of Aedes aegypti Am J Trop Med Hyg,

Most Recent 5 Book Chapters

2005 Lanzaro GC, Nuzhdin S, Tripet F: Tools for monitoring the genetic structure and stability of mosquito populations, , In: Proceedings: Working Group on Strategic Plan to Bridge Laboratory and Field Research In Disease Vector Control 14-16 July 2004, ICIPE, Nairobi, Kenya, The Netherlands. .

2003 Lanzaro, GC, Tripet, F: Gene flow among populations of Anopheles gambiae: A critical review, Takken, W, Scott, TW, (ed), Ecological Aspects for the Application of Genetically Modified Mosquitoes, Wageningen, The Netherlands. 109-132.