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Photo: Gregory Lanzaro

Gregory Lanzaro- BS, MS, PhD
Professor and Researcher
Pathology, Microbiology & Immunology

2086 Haring Hall
Davis, CA 95616

+1 530 752 5652
gclanzaro@ucdavis.edu

   

Research Focus

Vector biology, population genetics. My overall research interest is in the population genetics of insect vectors of human and animal diseases. I have developed a program that pursues knowledge that may be applied to the control of vectorborne diseases but at the same time addresses critical issues in basic evolutionary genetics. My work has transitioned from classical population genetics to a more contemporary population genomics approach. Whereas the earlier work was based on analyses using genic markers, such as microsatellite DNA and single nucleotide polymorphisms, our current work applies next generation sequencing to study individual insect genomes, allowing us to explore problems with far greater depth and to address questions that were intractable just a few years ago. In parallel with our increasing use of genomics I have established a program in bioinformatics which is essential for both the management and analysis of the large body of data we are generating using next generation sequencing. I am pursuing this interest within the context of four major avenues of research: 1) Population genetics of the human malaria vector, Anopheles gambiae in west and central Africa: This work deals with describing the genetic structure of populations, understanding the forces responsible for this structure and how patterns of gene flow influence the distribution of traits critical to understanding and managing malaria transmission. I have been working at field sites in Africa since 1991 and my current program has been supported continuously since 1996 with support in the form of a series of R01 grants from NIH on which I serve as P.I. 2) Genome-wide association mapping (GWAS) in the mosquito Anopheles arabiensis, the most important malaria vector in east Africa: Our focus is to understand the genetic basis of two critically import behavioral phenotypes in this mosquito: host preference (animal vs human blood feeding) and adult resting behavior (indoor vs outdoor). This project is funded by NIH with me as the PI and in collaboration with the Ifakara Health Institute in Tanzania. 3) Interactions between the South American vector, Anopheles darlingi and the human malaria parasite Plasmodium vivax. We are using a genomics approach to identify innate immune pathway related genes that are associated with the mosquito's ability kill the malaria parasite in the mosquito before it becomes infective to man. This project is being funded by the Brazilian government through a program called Brazil Science without Borders and conducted in collaboration with the Oswaldo Cruz Institute in Belo Horizonte, Brazil and the National Institute of Amazon Research, Manaus, Brazil

Specialty Focus

Entomology, population genetics, genomics

Education

1972 BS Secondary Education, Kansas State University, Manhattan, Kansas
1978 MS Entomology, University of Arizona, Tucson, Arizona
1986 PhD Entomology, University of Florida, Gainesville, Florida
1988 Post-doctoral , Mississippi State University, Starkville, MS
1991 Post-doctoral , University of California, Davis,
1995 MacArthur Fellow , National Institutes of Health,

Honors and Awards

2014 Award of Honour/Plenary Speaker, presented by Association of Entomologists, Department of Zoology and Environmental Sciences, Punjabi University
2013 Delegate, Albert Schweitzer Centennial, Libreville, Gabon, Central Africa
2013 Distinguished Service Award, Society for Vector Ecology
2011 President, Society for Vector Ecology
2010 President Elect
2010 Plenary Speaker, Keystone Symposia on Molecular and Cell Biology
2010 Keynote Speaker, 10th Annual Symposium, Center for Host-Parasite Interactions, McGill University
2010 Keynote Speaker, 14th Annual Arthromint Meeting, Oswaldo Cruz Institute, Ilha Grande, Brazil
2010 Invited Speaker, Biology of Mosquito Vectors Symposium, Johns Hopkins University
2010 2010 Editor's Choice Award by the Entomological Society of America
2009 Elected Vice-President/President Elect, Society for Vector Ecology
2009 Plenary Speaker, 34th Annual Meeting, Human Biology Association
2009 2009 Student Selected Speaker, Department of Entomology, University of Arkansas
2007 Excellence in Research Award, Academic Federation, UC Davis
2007 Plenary Speaker, Annual Meeting, Society of Vector Ecology
2006 Service Award, Entomological Society of America
2005 Rogoff Lectureship, Department of Entomology, Cornell University
2002-2010 Member, External Advisory Panel, Johns Hopkins University Malaria Institute
2000-2006 Faculty, International Biology of Disease Vectors Course
1991-1995 MacArthur Foundation Fellowship, Molecular Biology of Disease Vectors

Active Research Grants

Co-Principal Investigator, An. gambiae immune signaling gene SNPs and natural P. falciparum infection, Luckhart S (Principal Investigator), NIAID/NIH

Principal Investigator, Ecological and genetic determinants of malaria-transmitting behaviors in the African mosquito An. arabiensis, (Principal Investigator), NIH

Principal Investigator, The influence of A. gambiae molecular form genome introgression on immunity to P. falciparum infection, (Principal Investigator), NIH Diversity Supplement Grant

Most Recent 10 Publications

  • Link Icon 2014 Sanford MR, Cornel AJ, Nieman CC, Dinis J, Marsden CD, Weakley AM, Han S, Rodrigues A, Lanzaro GC, Lee Y. Plasmodium falciparum infection rates for some Anopheles spp. from Guinea-Bissau, West Africa. F1000 Research,
  • Link Icon 2014 Marsden CD, Lee Y, Kreppel K, Weakley A, Cornel A, Ferguson HM, Eskin E, Lanzaro GC. Diversity, differentiation and linkage disequilibrium: prospects for association mapping in the malaria vector, Anopheles arabiensis. G3,
  • Link Icon 2013 Lee Y, Marsden CD, Norris, LC, Collier TC, Main Bradley, Fofana A, Cornel AJ, Lanzaro GC. Spatiotemporal dynamics of gene flow and hybrid fitness between the M and S forms of the malaria mosquito, Anopheles gambiae. Proc Nat Acad Sci,
  • Link Icon 2013 Marsden CD, Cornel A, Lee Y, Sanford MR, Norris LC, Goodell PB, Nieman CC, Han S, Rodrigues A, Denis J, Ouledi A, Lanzaro GC An analysis of two island groups as potential sites for trials of transgenic mosquitoes for malaria control. Evol Appl,
  • Link Icon 2013 Lee Y, Collier TC, Sanford MR, Marsden CD, Fofana A, Cornel AJ, Lanzaro GC Chromosome inversions, genomic differentiation and speciation in the African malaria mosquito Anopheles gambiae. PLoS One,
  • Link Icon 2013 Lee Y, Marsden CD, Nieman C, Lanzaro GC. A new multiplex SNP genotyping assay for detecting hybridization and introgression between the M and S molecular forms of Anopheles gambiae. Mol Ecol Resourc,
  • Link Icon 2013 Sanford MR, Ramsay S, Cornel AJ, Marsden CD, Norris LC, Patchoke S, Fondjo E, Lanzaro GC, Lee Y A preliminary investigation of the relationship between water quality and Anopheles gambiae larval habitats in Western Cameroon. Malar J,
  • Link Icon 2012 Trout-Fryxell RT, Neiman CC, Fofana A, Lee Y, Traore SF, Cornel AJ, Luckhart S, Lanzaro GC Differential Plasmodium falciparum infection of Anopheles gambiae s.s. molecular and chromosomal forms in Mali Malar J,
  • Link Icon 2012 Lee Y, Seifert SN, Fornadel CM, Norris DE, Lanzaro GC Single-nucleotide polymorphisms for high-throughput genotyping of Anopheles arabiensis in East and southern Africa. J Med Entomol,
  • Link Icon 2012 Lee Y, Seifert SN, Nieman CC, McAbee RD, Goodell P, Fryxell RT, Lanzaro GC, Cornel AJ High degree of single nucleotide polymorphisms in California Culex pipiens (Diptera: Culicidae) sensu lato. J Med Entomol,

Most Recent 5 Book Chapters

2013 Lanzaro GC, Lee Y: Chapter 6. Speciation in Anopheles gambiae - The distribution of genetic polymorphism and patterns of reproductive isolation among natural populations., Manguin S, (ed), Anopheles mosquitoes - New insights into malaria vectors. 173-96.

2011 Dorn P, Noireau F, Krafsur ES, Lanzaro GC, Cornel AJ: Chapter 18: Genetics of major insect vectors, Tibayrenc M, (ed), Genetics and Evolution of Infectious Disease, London / Burlington, MA. .

2005 Lanzaro GC, Nuzhdin S, Tripet F: Tools for monitoring the genetic structure and stability of mosquito populations, , In: Proceedings: Working Group on Strategic Plan to Bridge Laboratory and Field Research In Disease Vector Control 14-16 July 2004, ICIPE, Nairobi, Kenya, The Netherlands. .

2003 Lanzaro, GC, Tripet, F: Gene flow among populations of Anopheles gambiae: A critical review, Takken, W, Scott, TW, (ed), Ecological Aspects for the Application of Genetically Modified Mosquitoes, Wageningen, The Netherlands. 109-132.