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Photo: Dori L Borjesson

Dori L Borjesson- BA, DVM, MPVM, PhD
Professor
Pathology, Microbiology & Immunology

4325 Vet Med 3A
Davis, CA 95616

+1 530 754 5202
dlborjesson@ucdavis.edu

   

Research Focus

I have been actively engaged in research on adult-derived mesenchymal stem cells (MSC). We have developed canine, feline and equine models to assess MSC safety and efficacy. My current research expertise is in MSC biology and immunomodulation. We have begun to define the mechanisms by which MSC alter the immune response and interact with cells of the immune system. Our most significant contribution is in the use of naturally occurring large animal models of disease to study cell therapy for inflammatory diseases. Specifically we are focused on naturally occurring inflammatory bowel disease in dogs, chronic gingivostomatitis in cats and spinal cord injury in dogs. With our canine work, we have focused on how MSCs interact with microbes important to GI health.

Specialty Focus

Clinical Pathology

Education

1988 BA Biology, The Colorado College, Colorado Springs, CO
1995 MPVM Epidemiology/Wildlife Health, University of California, Davis, CA
1995 DVM Pathology, University of California, Davis, CA
2002 PhD Comparative Pathology, University of California, Davis, CA

Honors and Awards

2001 CL Davis Student Scholarship Award
1997 ASVCP Excellence in Scientific Presentation Award
1995 Phi Zeta Veterinary Honor Society
1994 Hanson-Welles Memorial Scholarship
1991 Best research/presentation award for undergraduate thesis research
1988 Graduation with Distinction, The Colorado College

Licenses

Diplomate American College of Veterinary Pathology (Clinical Pathology)

Active Research Grants

Co-Investigator, Xenogeneic Scaffolds for Heart Valve Tissue Engineering, Griffiths (Principal Investigator), NIH (NHBLI), RO1

Most Recent 10 Publications

  • Dori L Borjesson: Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome. 2017 Clark, KC, Fierro, FA, Ko, EM, Walker, NJ, Arzi, B, Tepper, CG, Dahlenburg, H, Cicchetto, A, Kol, A, Marsh, L, Murphy, WJ, Fazel, N, Borjesson, DL Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome. Stem cell research & therapy,
  • Dori L Borjesson: Anaplasma phagocytophilum APH0032 Is exposed on the cytosolic face of the pathogen-occupied vacuole and co-opts host cell SUMOylation 2016 Oki AT, Huang B, Beyer AR, May LJ, Truchan HK, Walker NJ, Galloway NL, Borjesson DL, Carlyon JA Anaplasma phagocytophilum APH0032 Is exposed on the cytosolic face of the pathogen-occupied vacuole and co-opts host cell SUMOylation Front Cell Infect Microbiol,
  • Dori L Borjesson: Allogeneic esenchymal stem cell treatment induces specific alloantibodies in horses 2016 Owens SD, Kol A, Walker NJ, Borjesson DL Allogeneic esenchymal stem cell treatment induces specific alloantibodies in horses Stem Cells Int,
  • Dori L Borjesson: Canine and equine mesenchymal stem cells grown in serum free media have altered immunophenotype 2016 Clark KC, Kol A, Shahbenderian S, Granick JL, Walker NJ, Borjesson DL Canine and equine mesenchymal stem cells grown in serum free media have altered immunophenotype Stem Cell Rev,
  • Dori L Borjesson: Th17 pathway as a target for multipotent stromal cell therapy in dogs: Implications for translational research 2016 Kol A, Walker NJ, Nordstrom M, Borjesson DL Th17 pathway as a target for multipotent stromal cell therapy in dogs: Implications for translational research PLoS One,
  • Dori L Borjesson: Therapeutic efficacy of fresh, autologous mesenchymal stem cells for severe refractory gingivostomatitis in cats 2016 Arzi B, Mills-Ko E, Verstraete FJ, Kol A, Walker NJ, Badgley MR, Fazel N, Murphy WJ, Vapniarsky N, Borjesson DL Therapeutic efficacy of fresh, autologous mesenchymal stem cells for severe refractory gingivostomatitis in cats Stem Cells Transl Med,
  • Dori L Borjesson: Companion animals: Translational scientist's new best friends 2015 Kol A, Arzi B, Athanasiou KA, Farmer DL, Nolta JA, Rebhun RB, Chen X, Griffiths LG, Verstraete FJ, Murphy CJ, Borjesson DL Companion animals: Translational scientist's new best friends Sci Transl Med,
  • Dori L Borjesson: Feasibility study of canine epidermal neural crest stem cell transplantation in the spinal cords of dogs 2015 McMahill BG, Spriet M, Sisó S, Manzer MD, Mitchell G, McGee J, Garcia TC, Borjesson DL, Sieber-Blum M, Nolta JA, Sturges BK Feasibility study of canine epidermal neural crest stem cell transplantation in the spinal cords of dogs Stem Cells Transl Med,
  • Dori L Borjesson: Cartilage immunoprivilege depends on donor source and lesion location 2015 Arzi B, DuRaine GD, Lee CA, Huey DJ, Borjesson DL, Murphy BG, Hu JC, Baumgarth N, Athanasiou KA Cartilage immunoprivilege depends on donor source and lesion location Acta Biomater,
  • Dori L Borjesson: Serial hemostatic monitoring of dogs with multicentric lymphoma 2015 Kol A, Marks SL, Skorupski KA, Kass PH, Guerrero T, Gosselin RC, Borjesson DL Serial hemostatic monitoring of dogs with multicentric lymphoma Vet Comp Oncol,

Most Recent 5 Book Chapters

2011 Peroni J, and Borjesson DL: Anti-Inflammatory and Immuno-Modulatory Activities of Stem Cells, Stewart A, and Stewart M, (ed), Veterinary Clinics of North America: Equine Practice (Regenerative Medicine), Philadelphia. .

2011 Borjesson DL, Peroni JF: The regenerative medicine laboratory: facilitating stem cell therapy for equine disease, , Clin Lab Med. 109-23.

2009 Borjesson DL, DeJong KD: Cytologic examination of the urinary tract, Raskin RE and Meyer DJ, (ed), Atlas of Canine and Feline Cytology, Philadelphia PA. .

2008 Borjesson DL: Culture, isolation, and labeling of Anaplasma phagocytophilum for subsequent infection of human neutrophils, , Methods Mol Biol, Totowa, NJ. 159-71.

2008 Borjesson DL: Pancreas Cytology, Cowell RL, Tyler RD, Meinkoth JH, De Nicola, (ed), In: Diagnostic Cytology and Hematology of the Dog and Cat, St Louis. .