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Photo: Dori L Borjesson

Dori L Borjesson- BA, DVM, MPVM, PhD
Pathology, Microbiology & Immunology

4325 Vet Med 3A
Davis, CA 95616

+1 530 754 5202


Research Focus

I have been actively engaged in research on adult-derived mesenchymal stem cells (MSC). We have developed canine, feline and equine models to assess MSC safety and efficacy. My current research expertise is in MSC biology and immunomodulation. We have begun to define the mechanisms by which MSC alter the immune response and interact with cells of the immune system. Our most significant contribution is in the use of naturally occurring large animal models of disease to study cell therapy for inflammatory diseases. Specifically we are focused on naturally occurring inflammatory bowel disease in dogs, chronic gingivostomatitis in cats and spinal cord injury in dogs. With our canine work, we have focused on how MSCs interact with microbes important to GI health.

Specialty Focus

Clinical Pathology


1988 BA Biology, The Colorado College, Colorado Springs, CO
1995 MPVM Epidemiology/Wildlife Health, University of California, Davis, CA
1995 DVM Pathology, University of California, Davis, CA
2002 PhD Comparative Pathology, University of California, Davis, CA

Honors and Awards

2001 CL Davis Student Scholarship Award
1997 ASVCP Excellence in Scientific Presentation Award
1995 Phi Zeta Veterinary Honor Society
1994 Hanson-Welles Memorial Scholarship
1991 Best research/presentation award for undergraduate thesis research
1988 Graduation with Distinction, The Colorado College


Diplomate American College of Veterinary Pathology (Clinical Pathology)

Active Research Grants

Trainer, Dynamics of neutrophil trafficking in Granulocytic Anaplasmosis, Jennifer Johns (Principal Investigator), NIH, NCRR

Principal Investigator, Development of the Feline Chronic Gingivostomatitis Model for Stem Cell-Based Regenerative Medicine, (Principal Investigator), NIH (NIDCR) R21

Co-Principal Investigator, Allogeneic Adipose-Derived Mesenchymal Stem Cell Therapy for Syncytial Foamy Virus-positive Cats with Chronic, Non-Responsive Gingivostomatitis, (Principal Investigator), Winn Feline Foundation

Principal Investigator, Immunomodulation by MSCs in canine inflammatory bowel disease, (Principal Investigator), Center for Companion Animal Health

Principal Investigator, Stem Cells Therapy to Facilitate Wound Healing in Horses, (Principal Investigator), Center for Equine Health

Principal Investigator, Exploring the niche - a proposed role for hematopoietic niche dysregulation in the pathogenesis of pancytopenia in dogs with chronic Ehrlichia canis infection, (Principal Investigator), Center for Companion Animal Health

Co-Principal Investigator, Tracking mesenchymal stem cells to target the liver, Spriet (Principal Investigator), Center for Companion Animal Health

Co-Investigator, Autologous Adipose-Derived Mesenchymal Stem-Cell Therapy for Cats with Chronic, Non-responsive Gingivostomatitis, Arzi (Principal Investigator), Winn Feline Foundation

Principal Investigator, Equine mesenchymal stem cells for cutaneous wound repair, (Principal Investigator), Center for Equine Health

Co-Investigator, Xenogeneic Scaffolds for Heart Valve Tissue Engineering, Griffiths (Principal Investigator), NIH (NHBLI), RO1

Principal Investigator, Using Stem Cell Therapy to Treat Canine Inflammatory Bowel Disease, (Principal Investigator), CEH, Randall Grant

Most Recent 10 Publications

  • Link Icon 2014 Seidman D, Ojogun N, Walker NJ, Mastronunzio J, Kahlon A, Hebert KS, Karandashova S, Miller DP, Tegels BK, Marconi RT, Fikrig E, Borjesson DL, Carlyon JA Anaplasma phagocytophilum surface protein AipA mediates invasion of mammalian host cells. Cellular Microbiology,
  • Link Icon 2014 Morgan JT, Wood JA, Walker NJ, Raghunathan VK, Borjesson DL, Murphy CJ, Russell P Human trabecular meshwork cells exhibit several characteristics of, but are distinct from, adipose-derived mesenchymal stem cells. Journal of Ocular Pharmacology and Therapeutics,
  • Link Icon 2014 Kol A, Foutouhi S, Walker NJ, Kong NT, Weimer BC, Borjesson DL Gastrointestinal microbes interact with canine adipose-derived mesenchymal stem cells in vitro and enhance immunomodulatory functions. Stem Cells and Development,
  • Link Icon 2014 McMahill BG, Borjesson DL, Sieber-Blum M, Nolta JA, Sturges BK Stem Cells in Canine Spinal Cord Injury - Promise for Regenerative Therapy in a Large Animal Model of Human Disease. Stem Cell Reviews,
  • Link Icon 2014 Carrade Holt DD, Wood JA, Granick JL, Walker NJ, Clark KC, Borjesson DL Equine mesenchymal stem cells inhibit T cell proliferation through different mechanisms depending on tissue source. Stem Cells and Development,
  • Link Icon 2014 Screven R, Kenyon E, Myers MJ, Yancy HF, Skasko M, Boxer L, Bigley EC, Borjesson DL, Zhu M Immunophenotype and gene expression profile of mesenchymal stem cells derived from canine adipose tissue and bone marrow. Veterinary Immunology and Immunopathology,
  • Link Icon 2014 Gericota B, Anderson JS, Mitchell G, Borjesson DL, Sturges BK, Nolta JA, Sieber-Blum M Canine Epidermal Neural Crest Stem Cells (cEPI-NCSC) - Characterization and Potential as a Therapy Candidate for a Large Animal Model of Spinal Cord Injury Stem Cells Transl Med,
  • Link Icon 2013 Toupadakis CA, Granick JL, Sagy M, Wong A, Ghassemi E, Chung DJ, Borjesson DL, Yellowley CE Mobilization of endogenous stem cell populations enhances fracture healing in a murine femoral fracture model. Cytotherapy,
  • Link Icon 2013 Park SA, Reilly CM, Wood JA, Chung DJ, Carrade DD, Deremer SL, Seraphin RL, Clark KC, Zwingenberger AL, Borjesson DL, Hayashi K, Russell P, Murphy CJ Safety and immunomodulatory effects of allogeneic canine adipose-derived mesenchymal stromal cells transplanted into the region of the lacrimal gland, the gland of the third eyelid and the knee joint. Cytotherapy,
  • Link Icon 2013 Kol A, Nelson RW, Gosselin RC, Borjesson DL Characterization of thrombelastography over time in dogs with hyperadrenocorticism. Vet J,

Most Recent 5 Book Chapters

2011 Peroni J, and Borjesson DL: Anti-Inflammatory and Immuno-Modulatory Activities of Stem Cells, Stewart A, and Stewart M, (ed), Veterinary Clinics of North America: Equine Practice (Regenerative Medicine), Philadelphia. .

2011 Borjesson DL, Peroni JF: The regenerative medicine laboratory: facilitating stem cell therapy for equine disease, , Clin Lab Med. 109-23.

2009 Borjesson DL, DeJong KD: Cytologic examination of the urinary tract, Raskin RE and Meyer DJ, (ed), Atlas of Canine and Feline Cytology, Philadelphia PA. .

2008 Borjesson DL: Culture, isolation, and labeling of Anaplasma phagocytophilum for subsequent infection of human neutrophils, , Methods Mol Biol, Totowa, NJ. 159-71.

2008 Borjesson DL: Pancreas Cytology, Cowell RL, Tyler RD, Meinkoth JH, De Nicola, (ed), In: Diagnostic Cytology and Hematology of the Dog and Cat, St Louis. .