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Photo: Dori L Borjesson

Dori L Borjesson- BA, DVM, MPVM, PhD
Professor
Pathology, Microbiology & Immunology

4325 Vet Med 3A
Davis, CA 95616

+1 530 754 5202
dlborjesson@ucdavis.edu

   

Research Focus

I have two major research areas in my lab. The first is regenerative medicine with an emphasis on equine mesenchymal stem cells (MSCs) for use in orthopedic injury (bone and tendon damage). Current emphases include the immunomodulatory effects of equine MSCs and mechanisms of MSC homing to sites of injury.

The second area of focus is on tick-borne infectious disease, specifically, Anaplasma phagocytophilum infection, and its affects on hematopoiesis, bone marrow function and progenitor cell proliferation, differentiation and mobilization.

Specialty Focus

Clinical Pathology

Education

1988 BA Biology, The Colorado College, Colorado Springs, CO
1995 MPVM Epidemiology/Wildlife Health, University of California, Davis, CA
1995 DVM Pathology, University of California, Davis, CA
2002 PhD Comparative Pathology, University of California, Davis, CA

Honors and Awards

2001 CL Davis Student Scholarship Award
1997 ASVCP Excellence in Scientific Presentation Award
1995 Phi Zeta Veterinary Honor Society
1994 Hanson-Welles Memorial Scholarship
1991 Best research/presentation award for undergraduate thesis research
1988 Graduation with Distinction, The Colorado College

Licenses

Diplomate American College of Veterinary Pathology (Clinical Pathology)

Active Research Grants

Principal Investigator, The effects of mixing pharmaceutical products with equine stem cells prior to treatment of orthopedic injuries., (Principal Investigator), Center for Equine Health, UC Davis

Principal Investigator, Mesenchymal stem cell activation and immunomodulation, (Principal Investigator), Center for Equine Health, The Randall Grant

Principal Investigator, The affect of mesenchymal stem cells derived from fat, bone marrow and umbilical cord tissue on lymphocyte proliferation and phenotype in vivo and in vitro, (Principal Investigator), Center for Equine Health, The Randall Grant

Principal Investigator, Investigation into adverse reactions associated with mesenchymal stem cell injection: incident rate, risk factors and test development, (Principal Investigator), Center for Equine Health, The Randall Grant

Trainer, Dynamics of neutrophil trafficking in Granulocytic Anaplasmosis, Jennifer Johns (Principal Investigator), NIH, NCRR

Co-Investigator, Molecular profile fo equine hematopoietic stem/progenitor cells from peripheral blood, bone marrow and umbilical cord blood, Johanna Watson (Principal Investigator), Center for Equine Health

Most Recent 10 Publications

  • Link Icon 2011 Davies RS, Madigan JE, Hodzic E, Borjesson DL, Dumler JS Dexamethasone-induced cytokine changes associated with diminished disease severity in horses infected with Anaplasma phagocytophilum Clinical and Vaccine Immunology,
  • Link Icon 2011 Troese MJ, Kahlon A, Ragland SA, Ottens AK, Ojogun N, Nelson KT, Walker NJ, Borjesson DL, Carlyon JA Proteomic analysis of Anaplasma phagocytophilum during infection of human myeloid cells identifies a protein that is pronouncedly upregulated on the infectious dense-cored form Infection Immunity,
  • Link Icon 2011 Mylonakis ME, Borjesson DL, Leontides L, Siarkou VI, Theodorou K, Koutinas AF Cytologic patterns of lymphadenopathy in canine monocytic ehrlichiosis Vet Clin Pathol,
  • Link Icon 2011 Vidal MA, Walker NJ, Napoli E, Borjesson DL Evaluation of senescence in mesenchymal stem cells isolated from equine bone marrow, adipose tissue and umbilical cord tissue Stem Cells Dev,
  • Link Icon 2011 Kim MH, Granick JL, Kwok C, Walker NJ, Borjesson DL, Curry FR, Miller LS, Simon SI Neutrophil survival and c-kit+-progenitor proliferation in Staphylococcus aureus-infected skin wounds promote resolution Blood,
  • Link Icon 2010 Huang B, Troese MJ, Ye S, Sims JT, Galloway NL, Borjesson DL, Carlyon JA Anaplasma phagocytophilum APH_1387 is expressed throughout bacterial intracellular development and localizes to the pathogen-occupied vacuolar membrane Infect Immun,
  • Link Icon 2010 Schaff UY, Trott KA, Chase S, Tam K, Johns JL, Carlyon JA, Genetos DC, Walker NJ, Simon SI, Borjesson DL Neutrophils exposed to A. phagocytophilum under shear stress fail to fully activate, polarize, and transmigrate across inflamed endothelium Am J Physiol Cell Physiol,
  • Link Icon 2010 Owens SD, Johns JL, Walker NJ, Librach FA, Carrade DD, Tablin F, Borjesson DL Use of an in vitro biotinylation technique for determination of posttransfusion survival of fresh and stored autologous red blood cells in Thoroughbreds Am J Vet Res,
  • Link Icon 2010 Toupadakis CA, Wong A, Genetos DC, Cheung WK, Borjesson DL, Ferraro GL, Galuppo LD, Leach JK, Owens SD, Yellowley CE Comparison of the osteogenic potential of equine mesenchymal stem cells from bone marrow, adipose tissue, umbilical cord blood, and umbilical cord tissue Am J Vet Res,
  • Link Icon 2010 Huang B, Troese MJ, Howe D, Ye S, Sims JT, Heinzen RA, Borjesson DL, Carlyon JA Anaplasma phagocytophilum APH_0032 is expressed late during infection and localizes to the pathogen-occupied vacuolar membrane Microb Pathog,

Most Recent 5 Book Chapters

2011 Peroni J, and Borjesson DL: Anti-Inflammatory and Immuno-Modulatory Activities of Stem Cells, Stewart A, and Stewart M, (ed), Veterinary Clinics of North America: Equine Practice (Regenerative Medicine), Philadelphia. .

2011 Borjesson DL, Peroni JF: The regenerative medicine laboratory: facilitating stem cell therapy for equine disease, , Clin Lab Med. 109-23.

2009 Borjesson DL, DeJong KD: Cytologic examination of the urinary tract, Raskin RE and Meyer DJ, (ed), Atlas of Canine and Feline Cytology, Philadelphia PA. .

2008 Borjesson DL: Culture, isolation, and labeling of Anaplasma phagocytophilum for subsequent infection of human neutrophils, , Methods Mol Biol, Totowa, NJ. 159-71.

2008 Borjesson DL: Pancreas Cytology, Cowell RL, Tyler RD, Meinkoth JH, De Nicola, (ed), Diagnostic Cytology and Hematology of the Dog and Cat, St Louis. .