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Photo: Kevork Hagopian

Kevork Hagopian- Baccalaureate, BSc, PhD
Project Scientist
Molecular Biosciences

2163 Haring Hall
Davis, CA 95616

+1 530 752 3758


Research Focus

Influence of aging, caloric restriction, nutritional and genetic manipulations on metabolic pathways. The role mitochondria play in the aging process and the effects of the above mentioned interventions on various mitochondrial functions. Oxidative stress and free radical generation during the aging process and under various dietary manipulation and the role mitochondria play in the process.

Specialty Focus



1970 Baccalaureate , Armenian Private School, Basra, Iraq
1974 BSc Biology, University of Basra, Iraq
1985 PhD Biochemistry, University College Dublin, Ireland

Honors and Awards

1979 Gulbenkian Foundation (Portugal) Scholarship for postgraduate studies in Dublin, Ireland
1983 & 1984 Boghos Nubar Pacha Foundation (Belgium) Scholarship for postgraduate studies in Dublin Ireland
2007-Present None.

Active Research Grants

Co-Investigator, A mitochondrial longevity pathway: p66Shc mechanisms, Jon Ramsey is Co PI, Gino Cortopassi is PI (Principal Investigator), NIH PO1

Co-Investigator, Alterations in membrane composition and function with calorie restriction, Jon Ramsey (Principal Investigator), NIH RO1

Most Recent 10 Publications

  • Link Icon 2011 Hagopian K, Chen Y, Simmons Domer, K, Soo Hoo R, Bentley T, McDonald RB, Ramsey JJ Caloric restriction influences hydrogen peroxide generation in mitochondrial sub-populations from mouse liver J Bioenerg Biomembr,
  • Link Icon 2011 Tomilov AA, Ramsey JJ, Hagopian K, Giorgio M, Kim KM, Lam A, Migliaccio E, Lloyd KC, Berniakovich I, Prolla TA, Pelicci P, Cortopassi GA The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell,
  • Link Icon 2010 Hagopian, K, Weber, KL, Hwee, DT, Van Eenennaam, AL, López-Lluch, G, Villalba, JM, Burón, I, Navas, P, German, JB, Watkins, SM, Chen, Y, Wei, A, McDonald, RB, Ramsey, JJ Complex I-associated hydrogen peroxide production is decreased and electron transport chain enzyme activities are altered in n-3 enriched fat-1 mice. PloS One,
  • Link Icon 2010 Tomilov AA, Bicocca V, Schoenfeld RA, Giorgio M, Migliaccio E, Ramsey JJ, Hagopian K, Pelicci PG, Cortopassi GA Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice J Biol Chem,
  • Link Icon 2009 Hagopian K, Ramsey JJ, Weindruch R Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver Biogerontology,
  • Link Icon 2008 Asami DK, McDonald RB, Hagopian K, Horwitz BA, Warman D, Hsiao A, Warden C, Ramsey JJ Effect of aging, caloric restriction, and uncoupling protein 3 (UCP3) on mitochondrial proton leak in mice Exp Gerontol,
  • Link Icon 2008 Hagopian K, Ramsey JJ, Weindruch R Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities Biosci Rep,
  • Link Icon 2007 Hagopian K Rat liver xanthine oxidoreductase: effect of adenine on the oxidase and dehydrogenase activities Ital J Biochem,
  • Link Icon 2006 Ramsey JJ, Hagopian K Energy expenditure and restriction of energy intake: could energy restriction alter energy expenditure in companion animals? J Nutr,
  • Link Icon 2005 Bevilacqua L, Ramsey JJ, Hagopian K, Weindruch R, Harper ME Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria Am J Physiol Endocrinol Metab,

Most Recent 5 Book Chapters

2007 Ramsey JJ, Hagopian K: Bioenergenetics, , Encyclopedia of Gerontology: Age, Aging and the Aged. Second Edition, Oxford, UK. 170-177.