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Photo: Leigh G Griffiths

Leigh G Griffiths- PhD, VMB
Associate Professor and Associate Researcher
Medicine & Epidemiology

228 Vet Med 2 Building
Davis, CA 95616

+1 530 754 0334


Research Focus

I run the UC Davis Cardiovascular surgery program, including the development and maintenance of the programs website. I also run the Cardiovascular Research Laboratory in the veterinary school, which undertakes cardiovascular tissue engineering and transplant rejection research projects. I also perform clinical cardiology research, mentoring cardiology residents on a daily basis and supervising clinical cardiology cases in the VMTH.

Specialty Focus

Medical cardiology, cardiac surgery, echocardiography, interventional cardiology, cardiovascular tissue engineering and xenogeneic transplant immunology


1995 VetMB, MRCVS , Emmanuel College Cambridge, Cambridge University, Cambridge, UK
2007 PhD Cardiology, Colorado State University, Fort Collins, CO


Diplomate Royal College of Veterinary Surgeons (Soft Tissue Surgery)
Diplomate American College of Veterinary Internal Medicine (Cardiology)

Active Research Grants

Principal Investigator, Generation and recellularization of an inert, mechanically sound xenegeneic scaffold for heart valve tissue engineering, (Principal Investigator), American Heart Association

Principal Investigator, Generation of immunologically acceptable xenogeneic scaffolds for tissue engineering applications, (Principal Investigator), Center for Equine Health

Principal Investigator, Effect of pimobendan on the incidence of arrhythmias, (Principal Investigator), Center for Companion Animal Health

Principal Investigator, Coumadin versus Clopidogrel in canine aortic thrombus, (Principal Investigator), Center for Companion Animal Health

Principal Investigator, Xenogeneic scaffolds for myocardial patch tissue engineering: Antigen removal and mesenchymal stem cell immunomodulation, (Principal Investigator), UC Davis, Howard Hughes Medical Institute Translational Research Training Program

Principal Investigator, Xenogeneic Scaffolds for Heart Valve Tissue Engineering, (Principal Investigator), NIH R01

Principal Investigator, The effect of IV infusion of doxorubicin on the incidence of cardiac arrhythmias and cardiac troponin I levels in dogs, (Principal Investigator), AKC canine health foundation

Collaborator, Extracellular Matrix Bioscaffold Augmented with Human Stem Cells for Cardiovascular Repair, Douglas Boyd (Principal Investigator), California Institute for Regenerative Medicine, Early Translational Research Awards

Most Recent 10 Publications

  • Link Icon 2013 Wong ML, Wong JL, Athanasiou KA, Griffiths LG Stepwise solubilization-based antigen removal for xenogeneic scaffold generation in tissue engineering. Acta Biomater,
  • Link Icon 2012 Jung SW, Orvalho J, Griffiths LG Aortopulmonary window characterized with two- and three-dimensional echocardiogram in a dog J Vet Cardiol,
  • Link Icon 2012 Lake-Bakaar GA, Johnson EG, Griffiths LG Aortic Thrombus in Dogs: 31 cases (2000-2010) JAVMA,
  • Link Icon 2012 Singh MK, Kittleson MD, Kass PH, Griffiths LG Occlusion devices and approaches in canine patent ductus arteriosus: comparison of outcomes J Vet Intern Med,
  • Link Icon 2011 Wong ML, Leach JK, Athanasiou KA, Griffiths LG The role of protein solubilization in antigen removal from xenogeneic tissue for┬áheart valve tissue engineering Biomaterials,
  • Link Icon 2011 Griffiths LG, Fransioli JR, Chigerwe M Echocardiographic Assessment of Interventricular and Intraventricular Mechanical Synchrony in Normal Dogs J Vet Cardiol,
  • Link Icon 2011 Arai S, Griffiths LG, Mama K, Hackett T, Campbell V, Hellyer P, Monnet E, Boon J, Carter L, Orton EC Bioprosthesis valve replacement in dogs with congenital tricuspid valve dysplasia: technique and outcome J Vet Cardiol,
  • Link Icon 2011 Jung SW, Griffiths LG ECG of the Month JAVMA,
  • Link Icon 2010 Blossom JE, Bright JM, Griffiths LG Transvenous occlusion of patent ductus arteriosus in 56 consecutive dogs J Vet Cardiol,
  • Link Icon 2008 Griffiths LG, Choe L, Lee KH, Reardon KF, Orton EC Protein extraction and 2-DE of water- and lipid-soluble proteins from bovine pericardium, a low-cellularity tissue Electrophoresis,

Most Recent 5 Book Chapters

2010 Griffiths LG: General Anesthesia for the Cardiac Patient, Ettinger SJ, Feldman EC, (ed), 7th Edition of Ettinger: Textbook of Veterinary Internal Medicine. 1238-1243.