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Photo: Wensheng Yan

Wensheng Yan- MD, MS, PhD
Project Scientist
Surgical & Radiological Sciences

2119 Tupper Hall
Davis, CA 95616

+1 530 754 0641
wyan@ucdavis.edu

   

Research Focus

p53 Tumor Suppressor; The p53 family; Gene Regulation; Carcinogenesis in Human and Companion Animals

Specialty Focus

Oncology

Education

2000 PhD Pathology and Pathophysiology, The First Military Medical University, Guangzhou, China
1994 MS Environmental Medicine, Tongji Medical University, Wuhan, China
1991 MD Preventive Medicine, Henan Medical University, Zhengzhou, Chian

Honors and Awards

2005-2006 UAB Career Enhancement Award

Active Research Grants

Assistant Researcher, Mechanism of p73-dependent tumor suppression, Dr. Xinbin Chen (Principal Investigator), NIH/NCI

Assistant Researcher, Molecular ongocenic properties of mutant P53, Dr. Xinbin Chen (Principal Investigator), NIH/NCI

Assistant Researcher, Mechanism of p63-dependent tumor suppression, Dr. Xinbin Chen (Principal Investigator), NIH/NCI

Most Recent 10 Publications

  • Wensheng Yan:  Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors. 2014 Zhang J, Xu E, Ren C, Yan W, Zhang M, Chen M, Cardiff RD, Imai DM, Wisner E, Chen X Mice deficient in Rbm38, a target of the p53 family, are susceptible to accelerated aging and spontaneous tumors. Proc Natl Acad Sci U S A,
  • Wensheng Yan:  Arsenic trioxide reactivates proteasome-dependent degradation of mutant p53 protein in cancer cells in part via enhanced expression of Pirh2 E3 ligase 2014 Yan W, Jung YS, Zhang Y, Chen X. Arsenic trioxide reactivates proteasome-dependent degradation of mutant p53 protein in cancer cells in part via enhanced expression of Pirh2 E3 ligase PLoS One,
  • Wensheng Yan: P63 regulates tubular formation via epithelial?-to-mesenc?hymal transition 2014 Zhang Y, Yan W, Chen X P63 regulates tubular formation via epithelial?-to-mesenc?hymal transition Oncogene,
  • Wensheng Yan: Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63 2013 Jung YS, Qian Y, Yan W, Chen X Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63 J Invest Dermatol,
  • Wensheng Yan:  Mutant p53 cooperates with knockdown of endogenous wild-type p53 to disrupt tubulogenesis in Madin-Darby canine kidney cells 2013 Zhang Y, Yan W, Chen X. Mutant p53 cooperates with knockdown of endogenous wild-type p53 to disrupt tubulogenesis in Madin-Darby canine kidney cells PLoS One,
  • Wensheng Yan:  Arsenic suppresses cell survival via Pirh2-mediated proteasomal degradation of ?Np63 2013 Yan W, Chen X, Zhang Y, Zhang J, Jung YS, Chen X Arsenic suppresses cell survival via Pirh2-mediated proteasomal degradation of ?Np63 J Biol Chem.,
  • Wensheng Yan: PUMA cooperates with p21 to regulate mammary epithelial morphogenesis and epithelial-to-mesenchymal transition 2013 Zhang Y, Yan W, Jung YS, Chen X. PUMA cooperates with p21 to regulate mammary epithelial morphogenesis and epithelial-to-mesenchymal transition PLoS One,
  • Wensheng Yan:  Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality 2013 Cho SJ, Rossi A, Jung YS, Yan W, Liu G, Zhang J, Zhang M, Chen X. Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality Proc Natl Acad Sci U S A,
  • Wensheng Yan: Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8. 2013 Yan W, Liu S, Xu E, Zhang J, Zhang Y, Chen X, Chen, X Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8. Oncogene,
  • Wensheng Yan: Serine 123 Phosphorylation Modulates p21 Protein Stability and Activity by Suppressing Ubiquitin-Independent Proteasomal Degradation 2012 Chen X, Zhang J, Zhang M, Liu S, Yan W, Jung J, Chen X Serine 123 Phosphorylation Modulates p21 Protein Stability and Activity by Suppressing Ubiquitin-Independent Proteasomal Degradation J Biol Chem,