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Photo: Wensheng Yan

Wensheng Yan- MD, MS, PhD
Project Scientist
Surgical & Radiological Sciences

2119 Tupper Hall
Davis, CA 95616

+1 530 754 0641


Research Focus

p53 Tumor Suppressor; The p53 family; Gene Regulation; Carcinogenesis in Human and Companion Animals

Specialty Focus



2000 PhD Pathology and Pathophysiology, The First Military Medical University, Guangzhou, China
1994 MS Environmental Medicine, Tongji Medical University, Wuhan, China
1991 MD Preventive Medicine, Henan Medical University, Zhengzhou, Chian

Honors and Awards

2005-2006 UAB Career Enhancement Award

Active Research Grants

Assistant Researcher, Mechanism of p73-dependent tumor suppression, Dr. Xinbin Chen (Principal Investigator), NIH/NCI

Assistant Researcher, Molecular ongocenic properties of mutant P53, Dr. Xinbin Chen (Principal Investigator), NIH/NCI

Assistant Researcher, Mechanism of p63-dependent tumor suppression, Dr. Xinbin Chen (Principal Investigator), NIH/NCI

Most Recent 10 Publications

  • Link Icon 2013 Yan W, Liu S, Xu E, Zhang J, Zhang Y, Chen X, Chen, X Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8. Oncogene,
  • Link Icon 2012 Yan W, Zhang Y, Zhang J, Cho SJ, Chen X. HuR Is Necessary for Mammary Epithelial Cell Proliferation and Polarity at Least in Part via ?Np63 PLoS One,
  • Link Icon 2012 Chen X, Zhang J, Zhang M, Liu S, Yan W, Jung J, Chen X Serine 123 Phosphorylation Modulates p21 Protein Stability and Activity by Suppressing Ubiquitin-Independent Proteasomal Degradation J Biol Chem,
  • Link Icon 2012 Yan W, Zhang J, Zhang Y, Jung YS, Chen X p73 Expression Is Regulated by RNPC1, a Target of the p53 Family, via mRNA Stability Mol Cell Biol,
  • Link Icon 2012 Zhang Y, Yan W, Jung YS, Chen X Mammary epithelial cell polarity is regulated differentially by p73 isoforms via epithelial-to-mesenchymal transition J Biol Chem,
  • Link Icon 2012 Zwingenberger AL, Vernau W, Shi C, Yan W, Chen X, Gordon IK, Kent MS Development and characterization of 5 canine B-cell lymphoma cell lines Leuk Res,
  • Link Icon 2011 Zhang J, Cho SJ, Shu L, Yan W, Guerrero T, Kent M, Skorupski K, Chen H, Chen X Translational repression of p53 by RNPC1, a p53 target overexpressed in lymphomas Genes Dev,
  • Link Icon 2011 Zhang Y, Yan W, Chen X Mutant p53 disrupts MCF-10A cell polarity in three-dimensional culture via epithelial-to-mesenchymal transitions J Biol Chem,
  • Link Icon 2011 Yan W, Zhang Y, Zhang J, Liu S, Cho SJ, Chen X Mutant p53 protein is targeted by arsenic for degradation and plays a role in arsenic-mediated growth suppression J Biol Chem,
  • Link Icon 2010 Xu Y, Yan W, Chen X SNF5, a core component of the SWI/SNF complex, is necessary for p53 expression and cell survival, in part through eIF4E Oncogene,