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Photo: Pamela J Lein

Pamela J Lein- BS, MS, PhD
Professor and Researcher
Molecular Biosciences

2009 Vet Med 3B
Davis, CA 95616

+1 530 752 1970
pjlein@ucdavis.edu

   

Research Focus

Cellular and molecular mechanisms of neurotoxicology; nerve-immune interactions in the developing nervous system and in asthma; medical countermeasures for acute intoxication with seizurogenic compounds

Specialty Focus

Neurotoxicology and neuropharmacology

Education

1992 Postdoctroal training Molecular Immunology, Roswell Park Cancer Institute, Buffalo, NY
1990 PhD Pharmacology and Toxicology, State University of New York at Buffalo, Buffalo, NY
1983 MS Enviornmental Health, East Tennessee Stat University, Johnson City, TN
1981 BS Biology , Cornell University, Ithaca, NY

Honors and Awards

1996-1999 Howard Hughes Medical Institute Program for Undergraduate Science Education, Co-PI, $650,000
1995-1996 Dean's Grant, Arts and Sciences, Canisius College, $5000
1994-1997 Grass Fellowship Exchange, The Grass Foundation, $6,000
1994 National Science Foundation Research Opportunity Award, $10,000
1991 NIH NCI National Research Service Award, Cell biology of human TILs engrafted into SCID mice (1F32 CA09177-01)
1989-1999 NSF ILI grant, Incorporation of imaging techniques into undergraduate cell and molecular laboratories (DUE-9850762, PI, $26,297
1987-1990 March of Dimes Predoctoral Fellowship

Active Research Grants

Principal Investigator, Molecular and Cellular Basis of PCB Developmental Neurotoxicity, MPI (PJ Lein and IN Pessah) (Principal Investigator), NIH NIEHS

Principal Investigator, Enantioselective metabolism influences PCB developmental neurotoxicity, MPI (HJ Lehmler, PJ Lein and IN Pessah) (Principal Investigator), NIH NIEHS

Principal Investigator, Role of macrophages in organophosphorus pesticide-induced airway hyperractivity, MPI (PJ Lein and AD Fryer) (Principal Investigator), NIH NIEHS

Principal Investigator, Novel anticonvulsant and neuroprotective therapies for TETS and OP intoxication, (Principal Investigator), NIH

Co-Investigator, The UC Davis Center for Children’s Environmental Health and Disease Prevention, Van de Water (Principal Investigator), NIH NIEHS/USEPA

Principal Investigator, Identification and scientific validation of AOPs involving genomic and nongenomic intracellular thyroid hormone signaling in neurodevelopment, (Principal Investigator), United States Environmental Protection Agency

Co-Investigator, MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC), Abbeduto (Principal Investigator), NIH/NICHD

Collaborator, Role of Epoxygenated Fatty Acids in Modulating Pain, Inceoglu (Principal Investigator), NIH/NIAMS

Principal Investigator, OPs and autism-linked neuroligin mutations interact to impair synaptogenesis, (Principal Investigator), Jane Botsford Johnson Foundation

Most Recent 10 Publications

  • Link Icon 2014 Moore CE, Lein PJ, Puschner B Microcystins alter chemotactic behavior in Caenorhabditis elegans by selectively targeting the AWA sensory neuron Toxins,
  • Link Icon 2014 Stamou M, Wu X, Kania-Korwel I, Lehmler HJ, Lein PJ Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences Drug Metabolism and Disposition,
  • Link Icon 2014 Singleton ST, Lein PJ, Farahat FM, Bonner MR, Knaak JB, Olson JR Characterization of a-cypermethrin exposure in Egyptian agricultural workers International Journal of Hygiene and Environmental Health,
  • Link Icon 2014 Lesiak A, Zhu M, Chen H, Appleyard SM, Impey S, Lein PJ, Wayman GA The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation Journal of Neuroscience,
  • Link Icon 2014 Yang D, Kania-Korwel I, Ghogha A, Chen H, Stamou M, Bose DD, Pessah IN, Lehmler HJ, Lein PJ PCB 136 atropselectively alters morphometric and functional parameters of neuronal connectivity in cultured rat hippocampal neurons via ryanodine receptor-dependent mechanisms Toxicological Sciences,
  • Link Icon 2013 Stamou M, Streifel KM, Goines PE, Lein PJ Neuronal connectivity as a convergent target of gene × environment interactions that confer risk for Autism Spectrum Disorders Neurotoxicol Teratol,
  • Link Icon 2013 Wu X, Kania-Korwel I, Chen H, Stamou M, Dammanahalli KJ, Duffel M, Lein PJ, Lehmler HJ Metabolism of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) atropisomers in tissue slices from phenobarbital or dexamethasone-induced rats is sex-dependent Xenobiotica,
  • Link Icon 2013 Dadson OA, Ellison CA, Singleton ST, Chi LH, McGarrigle BP, Lein PJ, Farahat FM, Farahat T, Olson JR Metabolism of profenofos to 4-bromo-2-chlorophenol, a specific and sensitive exposure biomarker Toxicology,
  • Link Icon 2013 Proskocil BJ, Bruun DA, Jacoby DB, van Rooijen N, Lein PJ, Fryer AD Macrophage TNFa mediates parathion-induced airway hyperreactivity in guinea pigs Am J Physiol Lung Cell Mol Physiol,
  • Link Icon 2013 Grodzki AC, Giulivi C, Lein PJ Oxygen Tension Modulates Differentiation and Primary Macrophage Functions in the Human Monocytic THP-1 Cell Line. PloS One,

Most Recent 5 Book Chapters

2014 Banks CN, Rogawski MA, Yang D, Lein PJ: Tetramethylenedisulfotetramine, P Wexler, (ed), Encyclopedia of Toxicology, 3rd edition, Oxford, UK. 509-511.

2014 Spencer PS, Lein PJ: Neurotoxicity, P Wexler, (ed), Encyclopedia of Toxicology, 3rd edition, Oxford, UK. 521-537.

2013 Mooney SM, Lein PJ, Miller MW: Fetal alcohol spectrum disorder: targeted effects of ethanol on cell proliferation and survival, Rubenstein J, Rakic P, (ed), Comprehensive Developmental Neuroscience: Neural Circuit Development and Function in the Brain, San Diego, CA. 521-538.

2012 Harry GJ, Lein PJ: Developmental neurotoxicity of dioxins, A Schecter, (ed), Dioxins and Health, Including Other Persistent Organic Pollutants and Endocrine Disruptors, 3rd edition, Hoboken, New Jersey. 193-228.

2011 Lein PJ, Barnhart CD, Pessah IN: Acute hippocampal slice preparations and hippocampal slice cultures, LG Costa, G Giordano and M Guizzetti, (ed), In Vitro Neurotoxicology: Methods and Protocols, New York, NY. 115-134.