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Photo: Pamela J Lein

Pamela J Lein- BS, MS, PhD
Professor and Researcher
Molecular Biosciences

2009 Vet Med 3B
Davis, CA 95616

+1 530 752 1970
pjlein@ucdavis.edu

   

Research Focus

Cellular and molecular mechanisms of neurotoxicology; nerve-immune interactions in the developing nervous system and in asthma; medical countermeasures for acute intoxication with seizurogenic compounds

Specialty Focus

Neurotoxicology and neuropharmacology

Education

1992 Postdoctroal training Molecular Immunology, Roswell Park Cancer Institute, Buffalo, NY
1990 PhD Pharmacology and Toxicology, State University of New York at Buffalo, Buffalo, NY
1983 MS Enviornmental Health, East Tennessee Stat University, Johnson City, TN
1981 BS Biology , Cornell University, Ithaca, NY

Honors and Awards

1996-1999 Howard Hughes Medical Institute Program for Undergraduate Science Education, Co-PI, $650,000
1995-1996 Dean's Grant, Arts and Sciences, Canisius College, $5000
1994-1997 Grass Fellowship Exchange, The Grass Foundation, $6,000
1994 National Science Foundation Research Opportunity Award, $10,000
1991 NIH NCI National Research Service Award, Cell biology of human TILs engrafted into SCID mice (1F32 CA09177-01)
1989-1999 NSF ILI grant, Incorporation of imaging techniques into undergraduate cell and molecular laboratories (DUE-9850762, PI, $26,297
1987-1990 March of Dimes Predoctoral Fellowship

Active Research Grants

Principal Investigator, Molecular and Cellular Basis of PCB Developmental Neurotoxicity, MPI (PJ Lein and IN Pessah) (Principal Investigator), NIH NIEHS

Principal Investigator, Enantioselective metabolism influences PCB developmental neurotoxicity, MPI (HJ Lehmler, PJ Lein and IN Pessah) (Principal Investigator), NIH NIEHS

Principal Investigator, Role of macrophages in organophosphorus pesticide-induced airway hyperractivity, MPI (PJ Lein and AD Fryer) (Principal Investigator), NIH NIEHS

Principal Investigator, Novel anticonvulsant and neuroprotective therapies for TETS and OP intoxication, (Principal Investigator), NIH

Collaborator, Role of Epoxygenated Fatty Acids in Modulating Pain, Inceoglu (Principal Investigator), NIH/NIAMS

Co-Investigator, The UC Davis Center for Children’s Environmental Health and Disease Prevention, Van de Water (Principal Investigator), NIH NIEHS/USEPA

Co-Investigator, MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC), Abbeduto (Principal Investigator), NIH/NICHD

Principal Investigator, Identification and scientific validation of AOPs involving genomic and nongenomic intracellular thyroid hormone signaling in neurodevelopment, (Principal Investigator), United States Environmental Protection Agency

Principal Investigator, OPs and autism-linked neuroligin mutations interact to impair synaptogenesis, (Principal Investigator), Jane Botsford Johnson Foundation

Principal Investigator, Molecular and Cellular Basis of PCB Developmental Neurotoxicity , (Principal Investigator), NIH/NIEHS

Most Recent 10 Publications

  • Pamela J Lein: Neurotoxicity in preclinical models of occupational exposure to organophosphorus compounds 2017 Voorhees JR, Rohlman DS, Lein PJ, Pieper AA Neurotoxicity in preclinical models of occupational exposure to organophosphorus compounds Front Neurosci,
  • Pamela J Lein: Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication 2016 Flannery BM, Bruun DA, Rowland DJ, Banks CN, Austin AT, Kukis DL, Li Y, Ford BD, Tancredi DJ, Silverman JL, Cherry SR, Lein PJ Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication J Neuroinflammation,
  • Pamela J Lein: Mechanisms of reduced astrocyte surface coverage in cortical neuron-glia co-cultures on nanoporous gold surfaces. 2016 Chapman CA, Chen H, Stamou M, Lein PJ, Seker E Mechanisms of reduced astrocyte surface coverage in cortical neuron-glia co-cultures on nanoporous gold surfaces. Cell Mol Bioeng,
  • Pamela J Lein: Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents. 2016 Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents. Ann N Y Acad Sci,
  • Pamela J Lein: Chasing the elusive benzofuran impurity of the THR antagonist NH-3: Synthesis, isotope labeling, and biological activity. 2016 Singh L, Pressly B, Mengeling BJ, Fettinger JC, Furlow JD, Lein PJ, Wulff H, Singh V Chasing the elusive benzofuran impurity of the THR antagonist NH-3: Synthesis, isotope labeling, and biological activity. J Org Chem,
  • Pamela J Lein: Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat. 2015 Stamou M, Uwimana E, Flannery BM, Kania-Korwel I, Lehmler HJ, Lein PJ Subacute nicotine co-exposure has no effect on 2,2',3,5',6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat. Toxicology,
  • Pamela J Lein: The influence of sensitization on mechanisms of organophosphorus pesticide-induced airway hyperreactivity 2015 Proskocil BJ, Bruun DA, Garg JA, Villagomez CC, Jacoby DB, Lein PJ, Fryer AD The influence of sensitization on mechanisms of organophosphorus pesticide-induced airway hyperreactivity Am J Respir Cell Mol Biol,
  • Pamela J Lein: Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio 2015 Bui-Nguyen TM, Baer CE, Lewis JA, Yang D, Lein PJ, Jackson DA Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio BMC Genomics,
  • Pamela J Lein: Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice 2015 Kania-Korwel I, Barnhart CD, Lein PJ, Lehmler HJ Effect of pregnancy on the disposition of 2,2',3,5',6-pentachlorobiphenyl (PCB 95) atropisomers and their hydroxylated metabolites in female mice Chem Res Toxicol,
  • Pamela J Lein: Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. 2015 Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. Neuropharmacology,

Most Recent 5 Book Chapters

2014 Banks CN, Rogawski MA, Yang D, Lein PJ: Tetramethylenedisulfotetramine, Wexler P, (ed), Encyclopedia of Toxicology, 3rd edition, Oxford, UK. 509-11.

2014 Spencer PS, Lein PJ: Neurotoxicity, Wexler P, (ed), Encyclopedia of Toxicology, 3rd edition, Oxford, UK. 521-37.

2013 Mooney SM, Lein PJ, Miller MW: Fetal alcohol spectrum disorder: targeted effects of ethanol on cell proliferation and survival, Rubenstein J, Rakic P, (ed), Comprehensive Developmental Neuroscience: Neural Circuit Development and Function in the Brain, San Diego, CA. 521-38.

2012 Harry GJ, Lein PJ: Developmental neurotoxicity of dioxins, Schecter A, (ed), Dioxins and Health, Including Other Persistent Organic Pollutants and Endocrine Disruptors, 3rd edition, Hoboken, New Jersey. 193-228.

2011 Lein PJ, Barnhart CD, Pessah IN: Acute hippocampal slice preparations and hippocampal slice cultures, Costa LG, Giordano G, Guizzetti M, (ed), In Vitro Neurotoxicology: Methods and Protocols, New York, NY. 115-34.