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Photo: Pamela J Lein

Pamela J Lein- BS, MS, PhD
Professor and Researcher
Molecular Biosciences

2009 Vet Med 3B
Davis, CA 95616

+1 530 752 1970


Research Focus

Cellular and molecular mechanisms of neurotoxicology; nerve-immune interactions in the developing nervous system and in asthma; medical countermeasures for acute intoxication with seizurogenic compounds

Specialty Focus

Neurotoxicology and neuropharmacology


1992 Postdoctroal training Molecular Immunology, Roswell Park Cancer Institute, Buffalo, NY
1990 PhD Pharmacology and Toxicology, State University of New York at Buffalo, Buffalo, NY
1983 MS Enviornmental Health, East Tennessee Stat University, Johnson City, TN
1981 BS Biology , Cornell University, Ithaca, NY

Honors and Awards

1996-1999 Howard Hughes Medical Institute Program for Undergraduate Science Education, Co-PI, $650,000
1995-1996 Dean's Grant, Arts and Sciences, Canisius College, $5000
1994-1997 Grass Fellowship Exchange, The Grass Foundation, $6,000
1994 National Science Foundation Research Opportunity Award, $10,000
1991 NIH NCI National Research Service Award, Cell biology of human TILs engrafted into SCID mice (1F32 CA09177-01)
1989-1999 NSF ILI grant, Incorporation of imaging techniques into undergraduate cell and molecular laboratories (DUE-9850762, PI, $26,297
1987-1990 March of Dimes Predoctoral Fellowship

Active Research Grants

Principal Investigator, Molecular and Cellular Basis of PCB Developmental Neurotoxicity, MPI (PJ Lein and IN Pessah) (Principal Investigator), NIH NIEHS

Principal Investigator, Enantioselective metabolism influences PCB developmental neurotoxicity, MPI (HJ Lehmler, PJ Lein and IN Pessah) (Principal Investigator), NIH NIEHS

Principal Investigator, Role of macrophages in organophosphorus pesticide-induced airway hyperractivity, MPI (PJ Lein and AD Fryer) (Principal Investigator), NIH NIEHS

Principal Investigator, Novel anticonvulsant and neuroprotective therapies for TETS and OP intoxication, (Principal Investigator), NIH

Collaborator, Role of Epoxygenated Fatty Acids in Modulating Pain, Inceoglu (Principal Investigator), NIH/NIAMS

Co-Investigator, The UC Davis Center for Children’s Environmental Health and Disease Prevention, Van de Water (Principal Investigator), NIH NIEHS/USEPA

Co-Investigator, MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC), Abbeduto (Principal Investigator), NIH/NICHD

Principal Investigator, Identification and scientific validation of AOPs involving genomic and nongenomic intracellular thyroid hormone signaling in neurodevelopment, (Principal Investigator), United States Environmental Protection Agency

Principal Investigator, OPs and autism-linked neuroligin mutations interact to impair synaptogenesis, (Principal Investigator), Jane Botsford Johnson Foundation

Principal Investigator, Molecular and Cellular Basis of PCB Developmental Neurotoxicity , (Principal Investigator), NIH/NIEHS

Most Recent 10 Publications

  • Link Icon 2015 Flannery BM, Silverman JL, Bruun DA, Puhger KR, McCoy MR, Hammock BD, Crawley JN, Lein PJ Behavioral assessment of NIH Swiss mice acutely intoxicated with tetramethylenedisulfotetramine Neurotox Teratol,
  • Link Icon 2015 Wu X, Barnhart CD, Lein PJ, Lehmler HJ Hepatic metabolism affects the atropselective disposition of 2,2',3,3'6,6'-hexachlorobiphenyl (PCB 136) in mice Env Sci Tech ,
  • Link Icon 2015 Bal-Price A, Crofton KM, Shafer T, Sachana M, Behl M, Forsby A, Hargreaves A, Landesmann B, Lein PJ, Louisse J, Monnet-Tschudi F, Paini A, Rolaki A, Schrattenholz A, Suñol C, Van Thriel C, Whelan M, Fritsche E Putative Adverse Outcome Pathways Relevant to Neurotoxicity Crit Rev Toxicol,
  • Link Icon 2015 Singleton ST, Lein PJ, Dadson OA, McGarrigle BP, Farahat FM, Farahat T, Bonner MR, Fenske RA, Galvin K, Laserev MR, Anger WK, Rohlman DS, Olson JR Longitudinal assessment of occupational exposures to the organophosphorous insecticides chlorpyrifos and profenofos in Egyptian cotton field workers Intl J Hyg Environ Health ,
  • Link Icon 2014 Levoe SN, Flannery BM, Brignolo L, Imai DM, Koehne A, Austin AT, Bruun DA, Tancredi DJ, Lein PJ Factors influencing adverse skin responses in rats receiving repeated subcutaneous injections and potential impact on neurobehavior Current Neurobiology,
  • Link Icon 2014 Moore CE, Lein PJ, Puschner B Microcystins alter chemotactic behavior in Caenorhabditis elegans by selectively targeting the AWA sensory neuron Toxins,
  • Link Icon 2014 Stamou M, Wu X, Kania-Korwel I, Lehmler HJ, Lein PJ Cytochrome p450 mRNA expression in the rodent brain: species-, sex-, and region-dependent differences Drug Metabolism and Disposition,
  • Link Icon 2014 Singleton ST, Lein PJ, Farahat FM, Farahat T, Bonner MR, Knaak JB, Olson JR Characterization of a-cypermethrin exposure in Egyptian agricultural workers International Journal of Hygiene and Environmental Health,
  • Link Icon 2014 Vito ST, Austin AT, Banks CN, Iceoglu B, Bruun DA, Zolkowska D, Tancredi DJ, Rogawski MA, Hammock BD, Lein PJ Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication Toxicol Appl Pharmacol ,
  • Link Icon 2014 Lesiak A, Zhu M, Chen H, Appleyard SM, Impey S, Lein PJ, Wayman GA The environmental neurotoxicant PCB 95 promotes synaptogenesis via ryanodine receptor-dependent miR132 upregulation Journal of Neuroscience,

Most Recent 5 Book Chapters

2014 Banks CN, Rogawski MA, Yang D, Lein PJ: Tetramethylenedisulfotetramine, P Wexler, (ed), Encyclopedia of Toxicology, 3rd edition, Oxford, UK. 509-511.

2014 Spencer PS, Lein PJ: Neurotoxicity, P Wexler, (ed), Encyclopedia of Toxicology, 3rd edition, Oxford, UK. 521-537.

2013 Mooney SM, Lein PJ, Miller MW: Fetal alcohol spectrum disorder: targeted effects of ethanol on cell proliferation and survival, Rubenstein J, Rakic P, (ed), Comprehensive Developmental Neuroscience: Neural Circuit Development and Function in the Brain, San Diego, CA. 521-538.

2012 Harry GJ, Lein PJ: Developmental neurotoxicity of dioxins, A Schecter, (ed), Dioxins and Health, Including Other Persistent Organic Pollutants and Endocrine Disruptors, 3rd edition, Hoboken, New Jersey. 193-228.

2011 Lein PJ, Barnhart CD, Pessah IN: Acute hippocampal slice preparations and hippocampal slice cultures, LG Costa, G Giordano and M Guizzetti, (ed), In Vitro Neurotoxicology: Methods and Protocols, New York, NY. 115-134.