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Photo: Pamela J Lein

Pamela J Lein- BS, MS, PhD
Molecular Biosciences

2161 Haring Hall
Davis, CA 95616

+1 530 752 1970


Research Focus

Cellular and molecular mechanisms of developmental neurotoxicology; nerve-immune interactions in the developing nervous system and in asthma

Specialty Focus

Neurotoxicology and neuropharmacology


1992 Postdoctroal training Molecular Immunology, Roswell Park Cancer Institute, Buffalo, NY
1990 PhD Pharmacology and Toxicology, State University of New York at Buffalo, Buffalo, NY
1983 MS Enviornmental Health, East Tennessee Stat University, Johnson City, TN
1981 BS Biology , Cornell University, Ithaca, NY

Honors and Awards

1987-1990 March of Dimes Predoctoral Fellowship
1991 NIH NCI National Research Service Award, Cell biology of human TILs engrafted into SCID mice (1F32 CA09177-01)
1994 National Science Foundation Research Opportunity Award, $10,000
1994-1997 Grass Fellowship Exchange, The Grass Foundation, $6,000
1995-1996 Dean's Grant, Arts and Sciences, Canisius College, $5000
1996-1999 Howard Hughes Medical Institute Program for Undergraduate Science Education, Co-PI, $650,000
1989-1999 NSF ILI grant, Incorporation of imaging techniques into undergraduate cell and molecular laboratories (DUE-9850762, PI, $26,297

Active Research Grants

Principal Investigator, Molecular and Cellular Basis of PCB Developmental Neurotoxicity, MPI (PJ Lein and IN Pessah) (Principal Investigator), NIH NIEHS

Principal Investigator, Biomarkers of Organophosphorus Pesticide-Induced Neurotoxicity, MPI (WK Anger and PJ Lein) (Principal Investigator), NIH NIEHS

Principal Investigator, Enantioselective metabolism influences PCB developmental neurotoxicity, MPI (HJ Lehmler, PJ Lein and IN Pessah) (Principal Investigator), NIH NIEHS

Principal Investigator, Role of macrophages in organophosphorus pesticide-induced airway hyperractivity, MPI (PJ Lein and AD Fryer) (Principal Investigator), NIH NIEHS

Principal Investigator, Identification of novel therapeutic approaches for TETs and OP intoxication, MPI (PJ Lein and MA Rogawski) (Principal Investigator), NIH

Principal Investigator, Novel anticonvulsant and neuroprotective therapies for TETS and OP intoxication, (Principal Investigator), NIH

Most Recent 10 Publications

  • Link Icon 2012 Liu C, Li Y, Lein PJ, Ford BD Spatiotemporal patterns of GFAP upregulation in rat brain following acute intoxication with diisopropylfluorophosphate (DFP) Current Neurobiology,
  • Link Icon 2012 Kania-Korwel I, Barnhart C, Stamou M, Truong KM, El-Komy MH, Lein P, Veng-Pedersen P, Lehmler HJ 2,2',3,5',6-Pentachlorobiphenyl (PCB 95) and Its Hydroxylated Metabolites Are Enantiomerically Enriched in Female Mice Environ Sci Technol,
  • Link Icon 2012 Ellison CA, Crane AL, Bonner MR, Knaak JB, Browne RW, Lein PJ, Olson JR PON1 status does not influence cholinesterase activity in Egyptian agricultural workers exposed to chlorpyrifos Toxicol Appl Pharmacol,
  • Link Icon 2012 Cao Z, Hammock BD, McCoy M, Rogawski MA, Lein PJ, Pessah IN Tetramethylenedisulfotetramine Alters Ca2+ Dynamics in Cultured Hippocampal Neurons: Mitigation by NMDA Blockade and GABAA Receptor Positive Modulation. Toxicol Sci,
  • Link Icon 2012 Bal-Price AK, Coecke S, Costa L, Crofton KM, Fritsche E, Goldberg A, Grandjean P, Lein PJ, Li A, Lucchini R, Mundy WR, Padilla S, Persico AM, Seiler AE, Kreysa J Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation ALTEX,
  • Link Icon 2012 Wayman GA, Bose DD, Yang D, Lesiak A, Bruun D, Impey S, Ledoux V, Pessah IN, Lein PJ PCB-95 Modulates the Calcium-Dependent Signaling Pathway Responsible for Activity-Dependent Dendritic Growth Environ Health Perspect,
  • Link Icon 2012 Wayman GA, Yang D, Bose DD, Lesiak A, Ledoux V, Bruun D, Pessah IN, Lein PJ PCB-95 Promotes Dendritic Growth via Ryanodine Receptor-Dependent Mechanisms Environ Health Perspect,
  • Link Icon 2012 Lein PJ Emerging concepts in neurotoxicology: Models, mechanisms and modifying factors. Neurotoxicology,
  • Link Icon 2012 Li Y, Lein PJ, Liu C, Bruun DA, Giulivi C, Ford GD, Tewolde T, Ross-Inta C, Ford BD Neuregulin-1 is neuroprotective in a rat model of organophosphate-induced delayed neuronal injury Toxicol Appl Pharmacol,
  • Link Icon 2012 Zolkowska D, Banks CN, Dhir A, Inceoglu B, Sanborn JR, McCoy MR, Bruun DA, Hammock BD, Lein PJ, Rogawski MA Characterization of seizures induced by acute and repeated exposure to tetramethylenedisulfotetramine J Pharmacol Exp Ther,

Most Recent 5 Book Chapters

2012 Harry GJ, Lein PJ: Developmental neurotoxicity of dioxins, A Schecter, (ed), Dioxins and Health, Including Other Persistent Organic Pollutants and Endocrine Disruptors, 3rd edition, Hoboken, New Jersey. 193-228.

2011 Lein PJ, Barnhart CD, Pessah IN: Acute hippocampal slice preparations and hippocampal slice cultures, LG Costa, G Giordano and M Guizzetti, (ed), In Vitro Neurotoxicology: Methods and Protocols, New York, NY. 115-134.

2010 Lein PJ, Kim KH, Berman RF, Pessah IN: Exposure of the developing brain to polychlorinated biphenyls influences the susceptibility of the adult brain to stress, C Wang and W Slikker, (ed), Developmental neurotoxicology research: principles, models, techniques, strategies and mechanisms, Somerset, NJ. 211-30.

2009 Lein PJ, Fryer AD, Higgins D: Cell Culture: Autonomic and Enteric Neurons, Squire LR, (ed), Encyclopedia of Neuroscience, Oxford, UK. 625-32.

2008 Pessah IN and Lein PJ: Evidence for Environmental Susceptibility in Autism: What We Need to Know about Gene x Environment Interactions, Zimmerman A, (ed), Autism: Current Theories and Evidence, Totowa, NJ. 409-28.