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Photo: Robert B Rebhun

Robert B Rebhun- BS, DVM, PhD
Associate Professor and Associate Professor and Associate Researcher and Associate Researcher
Surgical & Radiological Sciences

Center for Companion Animal Health
Davis, CA 95616

+1 530 754 5028
rbrebhun@ucdavis.edu

   

Research Focus

The Biology and Therapy of Cancer Metastasis

Specialty Focus

Comparative and Translational Oncology

Education

1995 BS Animal Science, Cornell University, Ithaca, NY
2002 DVM Veterinary Medicine, Cornell University, Ithaca, NY
2006 PhD Cancer Biology, UT Houston/M.D. Anderson Cancer Center, Houston, TX
2008 Residency Medical Oncology, Colorado State University, Fort Collins, CO

Honors and Awards

2005 - 2006 American Legion Auxiliary Fellowship in Cancer Research, University of Texas Houston/M.D. Anderson Cancer Center
2002 - 2006 Faculty/Alumni Merit Scholarship, University of Texas Houston/M.D. Anderson Cancer Center
2002 Pharmacia Veterinary Student Proficiency Award, Cornell University College of Veterinary Medicine
2002 Daphne Award for Clinical Proficiency and Excellence in the Practice of Veterinary Medicine, Cornell University College of Veterinary Medicine

Licenses

State Licensure - New York, (active)
State Licensure - Texas, (inactive)
State of Colorado, Academic License, (inactive)
Diplomate American College of Veterinary Internal Medicine (Oncology)
Certified in Good Clinical Practice (GCP)

Active Research Grants

Principal Investigator, The relationship between epidermal growth factor receptor and hedgehog signaling in colon cancer, (Principal Investigator), NIH NCRR

Co-Investigator, Canine Cancer Stem Cell Initiative, Xinbin Chen (Principal Investigator), The Bernice Barbour Foundation

Principal Investigator, Effects of fasting on the incidence of delayed-type chemotherapy induced nausea and vomiting in dogs receiving doxorubicin chemotherapy, (Principal Investigator), Center for Companion Animal Health

Principal Investigator, Differential role of sonic hedgehog transcription factors Gli1 and Gli2 in canine osteosarcoma, (Principal Investigator), Center for Companion Animal Health

Principal Investigator, Evaluation of four or six doses of adjuvant carboplatin for dogs with osteosarcoma, (Principal Investigator), Center for Companion Animal Health

Principal Investigator, Concordance of histology between needle-core biopsies and lymph node extirpation in canine lymphoma, (Principal Investigator), Center for Companion Animal Health

Principal Investigator, Evaluation of liposomal curcumin for spontaneously arising canine cancer, (Principal Investigator), Center for Companion Animal Health

Co-Investigator, Evaluation of the Use of Chemoembolization in the Treatment of Prostatic Neoplasia, William Culp (Principal Investigator), Center for Companion Animal Health

Co-Investigator, Adoptive immunotherapy in the dog: In-vitro proof of concept, Peter Moore (Principal Investigator), Center for Companion Animal Health

Co-Investigator, Phase II evaluation of vinblastine for the treatment of canine histiocytic sarcoma, Skorupski (Principal Investigator), Center for Companion Animal Health

Co-Investigator, Argininosuccinate synthetase expression in canine bladder and prostate tumors, Carlos Rodriguez (Principal Investigator), Center for Companion Animal Health

Co-Investigator, Intra-arterial chemotherapy and radiotherapy to treat nasal carcinoma, William T.N. Culp (Principal Investigator), Center for Companion Animal Health

Co-Investigator, Assessment and comparison of lower urinary tract neoplasia size and location with multiple imaging modalities, William T.N. Culp (Principal Investigator), Center for Companion Animal Health

Principal Investigator, Assessment of in vivo efficacy of fluoroquinolone and carboplatin combination therapy in treating canine osteosarcoma lung metastasis, (Principal Investigator), Center for Companion Animal Health

Co-Investigator, Potency and stability of compounded chemotherapy drugs, Jenna Burton (Principal Investigator), Center for Companion Animal Health

Co-Investigator, Evaluation of outcome in dogs with thymic epithelial neoplasia, William T.N. Culp (Principal Investigator), Center for Companion Animal Health

Most Recent 10 Publications

  • Link Icon 2014 Culp, WT, Olea-Popelka, F, Sefton, J, Aldridge, CF, Withrow, SJ, Lafferty, MH, Rebhun, RB, Kent, MS, Ehrhart, N Evaluation of outcome and prognostic factors for dogs living greater than one year after diagnosis of osteosarcoma: 90 cases (1997-2008). Journal of the American Veterinary Medical Association,
  • Link Icon 2014 Shahi, MH, Zazpe, I, Afzal, M, Sinha, S, Rebhun, RB, MelĂ©ndez, B, Rey, JA, Castresana, JS Epigenetic regulation of human hedgehog interacting protein in glioma cell lines and primary tumor samples. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine,
  • Link Icon 2014 Withers, SS, Kass, PH, Rodriguez, CO, Skorupski, KA, O'Brien, D, Guerrero, TA, Sein, KD, Rebhun, RB Fasting Reduces the Incidence of Delayed-Type Vomiting Associated with Doxorubicin Treatment in Dogs with Lymphoma. Translational oncology,
  • Link Icon 2014 Shahi, MH, Holt, R, Rebhun, RB Blocking Signaling at the Level of GLI Regulates Downstream Gene Expression and Inhibits Proliferation of Canine Osteosarcoma Cells. PloS one,
  • Link Icon 2014 Seo, KW, Coh, YR, Rebhun, RB, Ahn, JO, Han, SM, Lee, HW, Youn, HY Antitumor effects of celecoxib in COX-2 expressing and non-expressing canine melanoma cell lines. Research in veterinary science,
  • Link Icon 2013 Skorupski, KA, Uhl, JM, Szivek, A, Allstadt Frazier, SD, Rebhun, RB, Rodriguez, CO Carboplatin versus alternating carboplatin and doxorubicin for the adjuvant treatment of canine appendicular osteosarcoma: a randomized, phase III trial. Veterinary and comparative oncology,
  • Link Icon 2013 O'Brien D, Moore PF, Vernau W, Peauroi JR, Rebhun RB, Rodriguez CO, Skorupski KA Clinical Characteristics and Outcome in Dogs with Splenic Marginal Zone Lymphoma J Vet Intern Med,
  • Link Icon 2013 LeJeune A, Skorupski K, Frazier S, Vanhaezebrouck I, Rebhun RB, Reilly CM, Rodriguez CO Aggressive local therapy combined with systemic chemotherapy provides long-term control in grade II stage 2 canine mast cell tumour: 21 cases (1999-2012)(*) Vet Comp Oncol doi: 10.1111/vco.12042,
  • Link Icon 2013 Boostrom BO, Good KL, Maggs DJ, Rebhun RB, Johns JL, Kent MS Unilateral intraocular mastocytosis and anterior uveitis in a dog with subcutaneous mast cell tumors Vet Ophthalmol,
  • Link Icon 2013 Lux CN, Culp WT, Mayhew PD, Tong K, Rebhun RB, Kass PH Perioperative outcome in dogs with hemoperitoneum: 83 cases (2005-2010) J Am Vet Med Assoc,

Most Recent 5 Book Chapters

2011 Rebhun RB, Culp W: Lung Cancer, Stephen J. Withrow, David M. Vail, Rodney Page, (ed), Withrow & MacEwen's Small Animal Clinical Oncology. .