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Photo: Kimber L. Stanhope

Kimber L. Stanhope- BS, MS, PhD
Associate Researcher
Molecular Biosciences

2211 VM3B
Davis, CA 95616

+1 530 752 3720
klstanhope@ucdavis.edu

   

Research Focus

My priority research focus is on clinical studies to determine the effects of diet on the development of metabolic disease. Specifically, I have been investigating the effects of sugar consumption on body composition, lipid regulation and insulin sensitivity, utilizing well-controlled diet intervention studies in human subjects. These investigations have definitely demonstrated that there are significant biologic and metabolic differences between fructose and glucose, with fructose consumption promoting the development of dyslipidemia, insulin resistance and visceral adiposity in older, overweight/obese subjects. We have recently completed our follow-up NIH-funded study comparing the effects of consuming fructose, glucose, high fructose corn syrup (HFCS), sucrose and aspartame in young, healthy subjects. The early results from this study (JCEM, Stanhope, 2011) demonstrate that consumption of HFCS-sweetened beverages at 25% of energy requirement increases risk factors for cardiovascular disease in young adults comparably to fructose and significantly more than glucose. The new results from this study, either in review or in preparation, demonstrate that:

  • Consumption of beverages providing 0, 10, 17.5 or 25% energy requirement from HFCS results in dose-dependent increases of established risk factors for cardiovascular disease within 2 weeks in young men and women.
  • Sugar consumption may provide relief from stress by turning down activity in the HPA axis.
  • The negative effects induced by consumption of beverages containing 25% of energy requirement as sucrose are comparable to those induced by consumption of beverages containing 25% of energy requirement as HFCS

I am also currently conducting a pilot study to test the hypothesis that consumption of naturally-sweetened orange juice will not increase risk factor for cardiovascular disease compared to consumption of sucrose-sweetened beverage. Finally, as an awardee of an NIH Building Interdisciplinary Research Careers in Women's Health career support grant, I am expanding my research focus to issues in women's health. Therefore the pilot study comparing orange juice to sucrose-sweetened beverage will be conducted in women and will also investigate the role of stress in mediating the adverse effects of sugar consumption. Additionally under my BIRCWH award I am investigating the role of estrogen in the development of diabetes in females of a novel rat model of type 2 diabetes.

Specialty Focus

Molecular Biosciences

Education

1978 BS Nutrition, University of California, Davis, Davis, CA
1982 MS Nutrition Science, University of California, Davis, Davis, California
2008 Ph.D. Nutritional Biology, University of California, Davis, Davis, CA

Honors and Awards

2009-2010 None.

Licenses

Registered Dietitian, Certificate #622598

Active Research Grants

Principal Investigator, Role of estrogen in the onset of type 2 diabetes in the UCD/T2DM female rat, (Principal Investigator), NIH/BIRWCH, Dean: School of Medicine, Dean School of Veterinary Medicine

Co-Investigator, Adverse metabolic effects of dietary sugar: Ad libitum vs energy-balanced diets, Jean-Marc Schwarz and Peter Havel (Principal Investigator), National Institute of Health (NIH)

Trainer, Adverse metabolic effects of dietary sugar: Ad libitum vs energy-balanced diets (Administrative supplement), Havel, PJ (Principal Investigator), NIH:NHLBI

Trainer, Adverse metabolic effects of dietary sugar: Ad libitum vs energy-balanced diets (Adminstrative Supplement), Havel, PJ (Principal Investigator), NIH:NHLBI

Most Recent 10 Publications

  • Kimber L. Stanhope: Sugar consumption, metabolic disease and obesity: The state of the controversy
2016 Stanhope KL Sugar consumption, metabolic disease and obesity: The state of the controversy Crit Rev Clin Lab Sci,
  • Kimber L. Stanhope: Linkage and association analysis of circulating vitamin D and parathyroid hormone identifies novel loci in Alaska Native Yup'ik people. 2016 Aslibekyan S, Vaughan LK, Wiener HW, Hidalgo BA, Lemas DJ, O'Brien DM, Hopkins SE, Stanhope KL, Havel PJ, Thummel KE, Boyer BB, Tiwari HK Linkage and association analysis of circulating vitamin D and parathyroid hormone identifies novel loci in Alaska Native Yup'ik people. Genes Nutr,
  • Kimber L. Stanhope: Effects of exercise on the plasma lipid profile in hispaniolan amazon parrots (amazona ventralis) with naturally occurring hypercholesterolemia
2016 Gustavsen KA, Stanhope KL, Lin AS, Graham JL, Havel PJ, Paul-Murphy JR Effects of exercise on the plasma lipid profile in hispaniolan amazon parrots (amazona ventralis) with naturally occurring hypercholesterolemia J Zoo Wildl Med,
  • Kimber L. Stanhope: Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model 2016 Piccolo BD, Graham JL, Stanhope KL, Fiehn O, Havel PJ, Adams SH Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model Am J Physiol Endocrinol Metab,
  • Kimber L. Stanhope: The majority of lipoprotein lipase in plasma is bound to remnant lipoproteins: A new definition of remnant lipoproteins 2016 Sato K, Okajima F, Miyashita K, Imamura S, Kobayashi J, Stanhope KL, Havel PJ, Machida T, Sumino H, Murakami M, Schaefer E, Nakajima K The majority of lipoprotein lipase in plasma is bound to remnant lipoproteins: A new definition of remnant lipoproteins Clin Chim Acta,
  • Kimber L. Stanhope: Inverse association between carbohydrate consumption and plasma adropin concentrations in humans. 2016 Stevens JR, Kearney ML, St-Onge MP, Stanhope KL, Havel PJ, Kanaley JA, Thyfault JP, Weiss EP, Butler AA Inverse association between carbohydrate consumption and plasma adropin concentrations in humans. Obesity (Silver Spring),
  • Kimber L. Stanhope: Comparison of the effect of post-heparin and pre-heparin lipoprotein lipase and hepatic triglyceride lipase on remnant lipoprotein metabolism 2015 Shirakawa T, Nakajima K, Shimomura Y, Kobayashi J, Stanhope K, Havel P, Machida T, Sumino H, Murakami M Comparison of the effect of post-heparin and pre-heparin lipoprotein lipase and hepatic triglyceride lipase on remnant lipoprotein metabolism Clinica Chimica Acta,
  • Kimber L. Stanhope: Determination of serum lipoprotein lipase using a 
latex particle-enhanced turbidimetric immunoassay with an automated analyzer 2015 Machida T, Miyashita K, Sone T, Tanaka S, Nakajima K, Saito M, Stanhope K, Havel P, Sumino H, Murakami M Determination of serum lipoprotein lipase using a latex particle-enhanced turbidimetric immunoassay with an automated analyzer Clin Chim Acta,
  • Kimber L. Stanhope: A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults 2015 Stanhope KL, Medici V, Bremer AA, Lee V, Lam H, Nunez MV, Chen G, Keim NL, Havel PJ A dose-response study of consuming high-fructose corn syrup-sweetened beverages on lipid/lipoprotein risk factors for cardiovascular disease in young adults Am J Clin Nutr,
  • Kimber L. Stanhope: Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes 2015 Agrawal R, Zhuang Y, Cummings BP, Stanhope KL, Graham JL, Havel PJ, Gomez-Pinilla F Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes Biochim Biophys Acta,

Most Recent 5 Book Chapters

2016 Keim NL, Stanhope KL, Havel PJ.: Fructose & high fructose corn syrup., , Encyclopedia of Human Nutrition. .

2016 Stanhope KL, Havel PJ: Effects and Mechanisms of Fructose-containing Sugars in the Pathophysiology of Metabolic Syndrome , Ronald Krauss, Nathalie Bergeron, (ed), Clinical Nutrition in the Management of Cardiovascular Disease. .

2015 Stanhope KL: Carbohydrates—Glycemia & hepatic overload, Louse Goff, Pamela Dyson, (ed), Advanced Nutrition and Dietetics in Diabetes. 29-40.

2014 Stanhope KL, Havel PJ: Mechanisms by which Dietary Sugars Influence Lipid Metabolism, Circulating Lipids and Lipoproteins, and Cardiovascular Risk, Michael Goran, Luc Tappy, (ed), Dietary Sugars and Health. 267-282.

2012 Stanhope KL: Dietary fructose and the physiology of body weight regulation, Dr. Stanley Bruce, (ed), McGraw-Hill Yearbook of Science & Technology, New York. 57-60.