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Photo: Kimber L. Stanhope

Kimber L. Stanhope- BS, MS, PhD
Associate Researcher
Molecular Biosciences

2211 VM3B
Davis, CA 95616

+1 530 752 3720
klstanhope@ucdavis.edu

  

Research Focus

My research focus is on clinical studies to determine the effects of diet on the development of metabolic disease. Specifically, I have been investigating the effects of sugar consumption on body composition, lipid regulation and insulin sensitivity, utilizing well-controlled diet intervention studies in human subjects. These investigations have definitely demonstrated that there are significant biologic and metabolic differences between fructose and glucose, with fructose consumption promoting the development of dyslipidemia, insulin resistance and visceral adiposity in older, overweight/obese subjects. I am currently comparing the effects of dietary fructose, high fructose corn syrup, sucrose and aspartame in young, healthy subjects. The early results from this study (JCEM, Stanhope, 2011) demonstrate that consumption of HFCS-sweetened beverages at 25% of energy requirement increases risk factors for cardiovascular disease in young adults comparably to fructose and significantly more than glucose. As a recent awardee of an NIH Building Interdisciplinary Research Careers in Women's Health career support grant, I am currently expanding my research focus to issues in women's health. Under this award I will investigate the role of estrogen in the development of diabetes in females of a novel rat model of type 2 diabetes.

Specialty Focus

Molecular Biosciences

Education

1978 BS Nutrition, University of California, Davis, Davis, CA
1982 MS Nutrition Science, University of California, Davis, Davis, California
2008 Ph.D. Nutritional Biology, University of California, Davis, Davis, CA

Honors and Awards

2009-2010 None.

Licenses

Registered Dietitian, Certificate #622598

Active Research Grants

Co-Investigator, Effects of two weeks of fructose and HFCS consumption on lipid dysregulation and insulin resistance, Peter Havel (Principal Investigator), NIH

Co-Investigator, Prevention of type 2 diabetes mellitus using alogliptin and pioglitazone alone and in combination in the UCD-T2DM rat, Peter Havel (Principal Investigator), Takeda Pharmaceutical NA NIH

Co-Investigator, Adipokines and Barrett's Esophagus, Peter Havel (Principal Investigator), NIH/NIDDK

Co-Investigator, Surgical amelioration of type 2 diabetes: hormones, microbiota and mitochondria, Peter Havel & Cecilia Giulivi (Principal Investigator), NIH/NIDDK

Co-Investigator, Diabetes prevention and onset study, Peter Havel (Principal Investigator), Novo Nordisk Co

Co-Investigator, Epidemiology and incidence of Barrett's esophagus, Peter Havel (Principal Investigator), NIH/NIDDK

Principal Investigator, Role of estrogen in the onset of type 2 diabetes in the UCD/T2DM female rat, (Principal Investigator), Building Interdisciplinary Research Careers in Women's Health (BIRCWH)

Co-Investigator, Fatty acid sources of fructose & HFCS-induced postprandial hypertriglyceridemia, Peter Havel & Jean Marc Schwarz (Principal Investigator), NIH/NHLBI

Assistant Researcher, MOUSE METABOLIC PHENOTYPING CENTER (MMPC) AT UC DAVIS, Havel, Peter (Principal Investigator), NIH

Principal Investigator, Oxidative Stress and Nitric Oxide Production Assessed Ex Vivo in Normal Weight and Overweight Subjects Consuming Sugar, (Principal Investigator), Tanita healthy Weight Community Trust (Japan)

Most Recent 10 Publications

  • Link Icon 2012 Lee J, Cummings BP, Martin E, Sharp JW, Graham JL, Stanhope KL, Havel PJ, Raybould HE Glucose sensing by gut endocrine cells and activation of the vagal afferent pathway is impaired in a rodent model of type 2 diabetes mellitus Am J Physiol Regul Integr Comp Physiol,
  • Link Icon 2012 Lemas DJ, Wiener HW, O'Brien DM, Hopkins S, Stanhope KL, Havel PJ, Allison DB, Fernandez JR, Tiwari HK, Boyer BB Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos J Lipid Res,
  • Link Icon 2012 Cox CL, Stanhope KL, Schwarz JM, Graham JL, Hatcher B, Griffen SC, Bremer AA, Berglund L, McGahan JP, Havel PJ, Keim NL Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight/obese men and women Eur J Clin Nutr,
  • Link Icon 2011 Cox CL, Stanhope KL, Schwarz JM, Graham JL, Hatcher B, Griffen SC, Bremer AA, Berglund L, McGahan JP, Keim NL, Havel PJ Circulating concentrations of monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, and soluble leukocyte adhesion molecule-1 in overweight/obese men and women consuming fructose- or glucose-sweetened beverages for 10 weeks J Clin Endocrinol Metab,
  • Link Icon 2011 Bremer AA, Stanhope KL, Graham JL, Cummings BP, Wang W, Saville BR, Havel PJ Fructose-fed rhesus monkeys: a nonhuman primate model of insulin resistance, metabolic syndrome, and type 2 diabetes Clin Transl Sci,
  • Link Icon 2011 Cummings BP, Bettaieb A, Graham JL, Stanhope KL, Dill R, Morton GJ, Haj FG, Havel PJ Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats Proc Natl Acad Sci USA,
  • Link Icon 2011 Stanhope KL, Bremer AA, Medici V, Nakajima K, Ito Y, Nakano T, Chen G, Fong TH, Lee V, Menorca RI, Keim NL, Havel PJ Consumption of fructose and high fructose corn syrup increase postprandial triglycerides, LDL-cholesterol, and apolipoprotein-B in young men and women J Clin Endocrinol Metab,
  • Link Icon 2011 Stanhope KL, Griffen SC, Bremer AA, Vink RG, Schaefer EJ, Nakajima K, Schwarz JM, Beysen C, Berglund L, Keim NL, Havel PJ Metabolic responses to prolonged consumption of glucose- and fructose-sweetened beverages are not associated with postprandial or 24-h glucose and insulin excursions Am J Clin Nutr,
  • Link Icon 2011 Makhoul, Z, Kristal, AR, Gulati, R, Luick, B, Bersamin, A, O'Brien, D, Hopkins, SE, Stephensen, CB, Stanhope, KL, Havel, PJ, Boyer, B Associations of obesity with triglycerides and C-reactive protein are attenuated in adults with high red blood cell eicosapentaenoic and docosahexaenoic acids Eur J Clin Nutr,
  • Link Icon 2010 Cummings BP, Stanhope KL, Graham JL, Baskin DG, Griffen SC, Nilsson C, Sams A, Knudsen LB, Raun K, Havel PJ Chronic administration of the glucagon-like peptide-1 analog, liraglutide, delays the onset of diabetes and lowers triglycerides in UCD-T2DM rats Diabetes,

Most Recent 5 Book Chapters

2012 Stanhope KL: Dietary fructose and the physiology of body weight regulation, Dr. Stanley Bruce, (ed), McGraw-Hill Yearbook of Science & Technology, New York. 57-60.

2012 Stanhope KL: Role of fructose-containing sugars in the epidemics of obesity and metabolic syndrome., , Annual review of medicine. 329-43.