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Photo: Kimber L. Stanhope

Kimber L. Stanhope- BS, MS, PhD
Associate Researcher
Molecular Biosciences

2211 VM3B
Davis, CA 95616

+1 530 752 3720


Research Focus

My priority research focus is on clinical studies to determine the effects of diet on the development of metabolic disease. Specifically, I have been investigating the effects of sugar consumption on body composition, lipid regulation and insulin sensitivity, utilizing well-controlled diet intervention studies in human subjects. These investigations have definitely demonstrated that there are significant biologic and metabolic differences between fructose and glucose, with fructose consumption promoting the development of dyslipidemia, insulin resistance and visceral adiposity in older, overweight/obese subjects. We have recently completed our follow-up NIH-funded study comparing the effects of consuming fructose, glucose, high fructose corn syrup (HFCS), sucrose and aspartame in young, healthy subjects. The early results from this study (JCEM, Stanhope, 2011) demonstrate that consumption of HFCS-sweetened beverages at 25% of energy requirement increases risk factors for cardiovascular disease in young adults comparably to fructose and significantly more than glucose. The new results from this study, either in review or in preparation, demonstrate that:

  • Consumption of beverages providing 0, 10, 17.5 or 25% energy requirement from HFCS results in dose-dependent increases of established risk factors for cardiovascular disease within 2 weeks in young men and women.
  • Sugar consumption may provide relief from stress by turning down activity in the HPA axis.
  • The negative effects induced by consumption of beverages containing 25% of energy requirement as sucrose are comparable to those induced by consumption of beverages containing 25% of energy requirement as HFCS

I am also currently conducting a pilot study to test the hypothesis that consumption of naturally-sweetened orange juice will not increase risk factor for cardiovascular disease compared to consumption of sucrose-sweetened beverage. Finally, as an awardee of an NIH Building Interdisciplinary Research Careers in Women's Health career support grant, I am expanding my research focus to issues in women's health. Therefore the pilot study comparing orange juice to sucrose-sweetened beverage will be conducted in women and will also investigate the role of stress in mediating the adverse effects of sugar consumption. Additionally under my BIRCWH award I am investigating the role of estrogen in the development of diabetes in females of a novel rat model of type 2 diabetes.

Specialty Focus

Molecular Biosciences


1978 BS Nutrition, University of California, Davis, Davis, CA
1982 MS Nutrition Science, University of California, Davis, Davis, California
2008 Ph.D. Nutritional Biology, University of California, Davis, Davis, CA

Honors and Awards

2009-2010 None.


Registered Dietitian, Certificate #622598

Active Research Grants

Co-Investigator, Fatty acid sources of fructose & HFCS-induced postprandial hypertriglyceridemia, Peter Havel & Jean Marc Schwarz (Principal Investigator), NIH/NHLBI

Assistant Researcher, Mouse Metabolic Phenotyping Center (MMPC) at UC Davis, Havel, Peter (Principal Investigator), NIH

Principal Investigator, Role of estrogen in the onset of type 2 diabetes in the UCD/T2DM female rat, (Principal Investigator), Building Interdisciplinary Research Careers in Women's Health (BIRCWH)

Collaborator, Stress, Socioeconomic Status, and Obesity, Elissa Epel, UCSF (Principal Investigator), UC Office of the President

Most Recent 10 Publications

  • Link Icon 2013 Rezvani R, Cianflone K, McGahan JP, Berglund L, Bremer AA, Keim NL, Griffen SC, Havel PJ, Stanhope KL Effects of sugar-sweetened beverages on plasma acylation stimulating protein, leptin and adiponectin: relationships with metabolic outcomes Obesity (Silver Spring, Md.),
  • Link Icon 2013 Cummings BP, Graham JL, Stanhope KL, Chouinard ML, Havel PJ Maternal ileal interposition surgery confers metabolic improvements to offspring independent of effects on maternal body weight in UCD-T2DM rats Obesity surgery,
  • Link Icon 2013 Bray M, Pomeroy J, Knowler WC, Bersamin A, Hopkins S, Brage S, Stanhope K, Havel PJ, Boyer BB Simple anthropometrics are more correlated with health variables than are estimates of body composition in Yup'ik people Obesity (Silver Spring, Md.),
  • Link Icon 2013 Aslibekyan S, Vaughan LK, Wiener HW, Lemas DJ, Klimentidis YC, Havel PJ, Stanhope KL, O'Brien DM, Hopkins SE, Boyer BB, Tiwari HK Evidence for novel genetic loci associated with metabolic traits in Yup'ik people American journal of human biology : the official journal of the Human Biology Council,
  • Link Icon 2013 Rozga MR, Stern JS, Stanhope K, Havel PJ, Kazaks AG Dietary supplement users vary in attitudes and sources of dietary supplement information in East and West geographic regions: a cross-sectional study BMC complementary and alternative medicine,
  • Link Icon 2013 Rountree AM, Reed BJ, Cummings BP, Jung SR, Stanhope KL, Graham JL, Griffen SC, Hull RL, Havel PJ, Sweet IR Loss of coupling between calcium influx, energy consumption and insulin secretion associated with development of hyperglycaemia in the UCD-T2DM rat model of type 2 diabetes Diabetologia,
  • Link Icon 2013 Miyashita K, Kobayashi J, Imamura S, Kinoshita N, Stanhope KL, Havel PJ, Nakajima K, Machida T, Sumino H, Nara M, Murakami M A new enzyme-linked immunosorbent assay system for human hepatic triglyceride lipase Clinica chimica acta; international journal of clinical chemistry,
  • Link Icon 2013 Foster GA, Gowe, RM, Stanhope KL, Havel PJ, Simon SI, Armstrong EJ On-chip phenotypic analysis of inflammatory monocytes in atherogenesis and myocardial infarction Proceedings of the National Academy of Sciences of the United States of America,
  • Link Icon 2013 Bettaieb A, Bakke J, Nagata N, Matsuo K, Xi Y, Liu S, AbouBechara D, Melhem R, Stanhope K, Cummings B, Graham J, Bremer A, Zhang S, Lyssiotis, CA, Zhang ZY, Cantley LC, Havel PJ, Haj FG Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation The Journal of biological chemistry,
  • Link Icon 2013 Cummings BP, Bettaieb A, Graham JL, Kim J, Ma F, Shibata N, Stanhope KL, Giulivi C, Hansen F, Jelsing J, Vrang N, Kowala M, Chouinard ML, Haj FG, Havel PJ Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM rats Dis Model Mech,

Most Recent 5 Book Chapters

2012 Stanhope KL: Dietary fructose and the physiology of body weight regulation, Dr. Stanley Bruce, (ed), McGraw-Hill Yearbook of Science & Technology, New York. 57-60.