Kimber L. Stanhope- BS, MS, PhD
+1 530 752 3720
My research focus is on clinical studies to determine the effects of diet on the development of metabolic disease. Specifically, I have been investigating the effects of sugar consumption on body composition, lipid regulation and insulin sensitivity, utilizing well-controlled diet intervention studies in human subjects. These investigations have definitely demonstrated that there are significant biologic and metabolic differences between fructose and glucose, with fructose consumption promoting the development of dyslipidemia, insulin resistance and visceral adiposity in older, overweight/obese subjects. I am currently comparing the effects of dietary fructose, high fructose corn syrup, sucrose and aspartame in young, healthy subjects. The early results from this study (JCEM, Stanhope, 2011) demonstrate that consumption of HFCS-sweetened beverages at 25% of energy requirement increases risk factors for cardiovascular disease in young adults comparably to fructose and significantly more than glucose. As a recent awardee of an NIH Building Interdisciplinary Research Careers in Women's Health career support grant, I am currently expanding my research focus to issues in women's health. Under this award I will investigate the role of estrogen in the development of diabetes in females of a novel rat model of type 2 diabetes.
1978 BS Nutrition, University of California, Davis, Davis, CA
Honors and Awards
Registered Dietitian, Certificate #622598
Active Research Grants
Co-Investigator, Effects of two weeks of fructose and HFCS consumption on lipid dysregulation and insulin resistance, Peter Havel (Principal Investigator), NIH
Co-Investigator, Prevention of type 2 diabetes mellitus using alogliptin and pioglitazone alone and in combination in the UCD-T2DM rat, Peter Havel (Principal Investigator), Takeda Pharmaceutical NA NIH
Co-Investigator, Adipokines and Barrett's Esophagus, Peter Havel (Principal Investigator), NIH/NIDDK
Co-Investigator, Surgical amelioration of type 2 diabetes: hormones, microbiota and mitochondria, Peter Havel & Cecilia Giulivi (Principal Investigator), NIH/NIDDK
Co-Investigator, Diabetes prevention and onset study, Peter Havel (Principal Investigator), Novo Nordisk Co
Co-Investigator, Epidemiology and incidence of Barrett's esophagus, Peter Havel (Principal Investigator), NIH/NIDDK
Principal Investigator, Role of estrogen in the onset of type 2 diabetes in the UCD/T2DM female rat, (Principal Investigator), Building Interdisciplinary Research Careers in Women's Health (BIRCWH)
Co-Investigator, Fatty acid sources of fructose & HFCS-induced postprandial hypertriglyceridemia, Peter Havel & Jean Marc Schwarz (Principal Investigator), NIH/NHLBI
Assistant Researcher, MOUSE METABOLIC PHENOTYPING CENTER (MMPC) AT UC DAVIS, Havel, Peter (Principal Investigator), NIH
Principal Investigator, Oxidative Stress and Nitric Oxide Production Assessed Ex Vivo in Normal Weight and Overweight Subjects Consuming Sugar, (Principal Investigator), Tanita healthy Weight Community Trust (Japan)
Most Recent 10 Publications
Most Recent 5 Book Chapters
2012 Stanhope KL: Dietary fructose and the physiology of body weight regulation, Dr. Stanley Bruce, (ed), McGraw-Hill Yearbook of Science & Technology, New York. 57-60.
2012 Stanhope KL: Role of fructose-containing sugars in the epidemics of obesity and metabolic syndrome., , Annual review of medicine. 329-43.