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Photo: Yuxi Shan

Yuxi Shan- MS, PhD
Assistant Project Scientist
Molecular Biosciences


   

Research Focus

Mitochondrial iron-sulfur cluster biogenesis and iron metabolism in mammalian cells, Freidriech's ataxia and mitochondria disease.

Specialty Focus

Molecular Biosciences

Education

2005 PhD molecular genetics, Fudan University, 220 Handan Rd, Shanghai, China
2001 MS Zoology, Anhui Normal University, 1 E Beijing Rd, Wuhu, Anhui, China
1994 Biology Education, HuaiBei Coal Industry Teachers College, 100 Dongshan Rd, Huaibei, Anhui, China
2009 Freidriech's Ataxia, UC Davis, One Sheilds Ave, Davis, CA

Active Research Grants

Collaborator, Mitochondrial Iron-Sulfur Cluster Mechanisms and Therapy in Friedreich's Ataxia, G. Cortopassi (Principal Investigator), NIH/NINDS

Most Recent 10 Publications

  • Yuxi Shan: Frataxin Deficiency Leads to Defects in Expression of Antioxidants and Nrf2 Expression in Dorsal Root Ganglia of the Friedreich's Ataxia YG8R Mouse Model 2013 Shan Y, Schoenfeld RA, Hayashi G, Napoli E, Akiyama T, Carstens ML, Carstens EE, Pook MA, Cortopassi GA Frataxin Deficiency Leads to Defects in Expression of Antioxidants and Nrf2 Expression in Dorsal Root Ganglia of the Friedreich's Ataxia YG8R Mouse Model Antioxid Redox Signal,
  • Yuxi Shan: Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression 2012 Song L, Shan Y, Lloyd K, Cortopassi G Mutant Twinkle increases dopaminergic neurodegeneration, mtDNA deletions and modulates Parkin expression Hum Mol Genet,
  • Yuxi Shan: HSC20 interacts with Frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis 2011 Shan Y, Cortopassi G HSC20 interacts with Frataxin and is involved in iron-sulfur cluster biogenesis and iron homeostasis Hum Mol Genet,
  • Yuxi Shan: Frataxin deficiency induced schwann cell inflammation and dealth 2009 Lu C, Schoenfeld R, Shan Y, Tsai C, Hammock B, Cortopassi G Frataxin deficiency induced schwann cell inflammation and dealth Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,
  • Yuxi Shan: Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA) 2008 Chen X, Gu X, Shan Y, Tang W, Yuan J, Zhong Z, Wang Y, Huang W, Wan B, Yu L Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA) Mol Biol Rep,
  • Yuxi Shan: Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones 2007 Shan Y, Napoli E, Corotpassi G Mitochondrial frataxin interacts with ISD11 of the NFS1/ISCU complex and multiple mitochondrial chaperones Human Molecular Genetics,
  • Yuxi Shan: EFCBP1/NECAB1, a brain-specifically expressed gene with highest abundance in temporal lobe, encodes a protein containing EF-hand and antibiotic biosynthesis monooxygenase domains 2007 Wu H, Li D, Shan Y, Wan B, Hexige S, Guo J, Wu C, Yu L EFCBP1/NECAB1, a brain-specifically expressed gene with highest abundance in temporal lobe, encodes a protein containing EF-hand and antibiotic biosynthesis monooxygenase domains DNA Sequence,
  • Yuxi Shan: Cloning, expression and characterization of the human NOB1 gene 2005 Zhang Y, Ni J, Zhou G, Yuan J, Ren W, Shan Y, Tang W, Yu L, Zhao S Cloning, expression and characterization of the human NOB1 gene Molecular Biology Reports,
  • Yuxi Shan: Cloning and characterization of the CDZFP gene which encodes a putative zinc finger protein 2005 Tang W, Yuan J, Chen X, Shan Y, Luo K, Guo Z, Zhang Y, Wan B, Yu L Cloning and characterization of the CDZFP gene which encodes a putative zinc finger protein DNA Sequence,
  • Yuxi Shan: Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B 2005 Yuan J, Shan Y, Chen X, Tang W, Luo K, Ni J, Wan B, Yu L Identification and characterization of RHEBL1, a novel member of Ras family, which activates transcriptional activities of NF-kappa B Molecular Biology Reports,