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Photo: Heather Knych

Heather Knych- DVM, PhD, DACCVP
Associate Professor of Clinical
California Animal Health and Food Safety Lab

K.L. Maddy Equine Analytical Chemistry Laboratory
Davis, CA 95616

+1 530 752 8700
hkknych@ucdavis.edu

   

Research Focus

Equine: pharmacokinetics/pharmacodynamics; drug metabolism; biomarkers

Specialty Focus

Equine pharmacology

Education

2010 Residency American College of Veterinary Clinical Pharmacology Residency, University of California, Davis, Davis, CA
2008 PhD Pharmacology and Toxicology, University of California, Davis, Davis, CA
2005 DVM , University of California, Davis, Davis, CA
2000 MS Physiology, San Jose State University, San Jose, CA
1997 BS Biochemistry and Cell Biology, University of California, San Diego, LaJolla, CA

Licenses

Diplomate of the American College of Clinical Veterinary Pharmacology
DVM, California

Active Research Grants

Principal Investigator, Characterization of Intra-Articular Isoflupredone, (Principal Investigator), Grayson Jockey Club

Co-Principal Investigator, EFFICACY OF FUROSEMIDE DOSED 4- VS 24-HOURS PRE-RACE, (Principal Investigator), Grayson Jockey Club Research Foundation

Principal Investigator, Xylazine PK/PD Study in Horses, (Principal Investigator), Racing Medication and Testing Consortium

Co-Principal Investigator, Pharmacokinetics of Simbadol in Red Tailed Hawks, David Guzman (Principal Investigator), Center for Companion Animal Health (Resident Grant)

Most Recent 10 Publications

  • Heather Knych: Effects of acepromazine or dexmedetomidine on fentanyl disposition in dogs during recovery from isoflurane anesthesia 2015 Keating S, Kerr C, McDonell W, Valverde A, Johnson R, Knych H, Edginton A Effects of acepromazine or dexmedetomidine on fentanyl disposition in dogs during recovery from isoflurane anesthesia Veterinary Anaesthesia and Analgesia,
  • Heather Knych: Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes 2015 Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes Drug Testing and Analysis,
  • Heather Knych: Pharmacokinetics of a Single Subcutaneous Dose of Sustained Release Buprenorphine in Northern Elephant Seals (Mirounga Angustirostris) 2015 Molter C, Barbosa L, Johnson S, Chinnadurai S, Knych H, Wack R Pharmacokinetics of a Single Subcutaneous Dose of Sustained Release Buprenorphine in Northern Elephant Seals (Mirounga Angustirostris) Journal of Zoo and Wildlife Medicine,
  • Heather Knych: Pharmacokinetics and Effects on Thromboxane B2 Production Following Intravenous Administration of Flunixin Meglumine to Exercised Thoroughbred Horses 2015 Knych HK, Arthur RM, McKemie DS, Chapman N Pharmacokinetics and Effects on Thromboxane B2 Production Following Intravenous Administration of Flunixin Meglumine to Exercised Thoroughbred Horses Journal of Veterinary Pharmacology and Therapeutics,
  • Heather Knych: Frequency and Severity of Neutropenia Associated with FDA Approved and Compounded Formulations of Lomustine in Dogs with Cancer 2015 Burton J, Stanley S, Knych H, Rodriguez C, Skorupski K, Rebhun R Frequency and Severity of Neutropenia Associated with FDA Approved and Compounded Formulations of Lomustine in Dogs with Cancer Journal of Veterinary Internal Medicine,
  • Heather Knych: Pharmacokinetics and Selected Pharmacodynamics of Cobalt Following A Single Intravenous Administration to Horses 2015 Knych HK, Arthur RM, Mitchell MM, Holser I, Poppenga R, Smith LL, Helm MN, Sams RA, Gaskill CL Pharmacokinetics and Selected Pharmacodynamics of Cobalt Following A Single Intravenous Administration to Horses Drug Testing and Analysis,
  • Heather Knych: Clearance of corticosteroids following intra-articular administration of clinical doses to racehorses 2015 Knych HK, Blea J, Arthur RM, Overly LR, McIlwraith CW Clearance of corticosteroids following intra-articular administration of clinical doses to racehorses Equine Veterinary Education,
  • Heather Knych: Endogenous concentrations, pharmacokinetics, and selected pharmacodynamic effects of a single dose of exogenous GABA in horses 2015 Knych HK, Steinmetz SJ, McKemie DS Endogenous concentrations, pharmacokinetics, and selected pharmacodynamic effects of a single dose of exogenous GABA in horses Journal of Veterinary Pharmacology and Therapeutics,
  • Heather Knych: Determination of the minimum alveolar concentration of isoflurane that blunts adrenergic responses in sheep and evaluation of the effects of fentanyl 2015 Barletta M, Kleine S, Hofmeister EH, Thoresen M, Peroni J, Knych H, Scharf, AM, Quandt JE Determination of the minimum alveolar concentration of isoflurane that blunts adrenergic responses in sheep and evaluation of the effects of fentanyl American Journal of Veterinary Research,
  • Heather Knych: Pharmacokinetics of metronidazole in foals: influence of age within the neonatal period 2015 Swain E, Magdesian K, Edman J, Knych H Pharmacokinetics of metronidazole in foals: influence of age within the neonatal period Journal of Veterinary Pharmacology and Therapeutics,

Most Recent 5 Book Chapters

2014 Knych HK: Chapter 13: Analgesic Pharmacology, , Robinson's Current Therapy in Equine Medicine, 7th Edition. 55-57.