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Photo: Alexey A Tomilov

Alexey A Tomilov- BS, MS, PhD
Assistant Project Scientist
Molecular Biosciences

3011 VM3B
Davis, CA 95616

+1 530 754 9341


Research Focus

Organisms: plants, animals, fungi or bacteria are reacting on multiple exogenous stimuli by induction of network of endogenous processes. This includes signal transduction events which bring the organism in balance with the outside world, maintain balanced growth and development of the organism. While in plants there are only five major hormones: auxin, cytokinin, ABA, ethylene and gibberellins, in animals the signal transduction is more complex. Activation of different signal transduction pathways have different effects on cells and whole system and might be antagonistic, pleiotropic, collinear or complementary, and this forms really complicated network of regulatory processes in biological organism. Defects of signal transduction pathways mostly leads to disease, but current studies have developed interventions in signal transduction which lead to increased longevity and fitness. My interests are signal transduction pathways in biological systems and fitness improving manipulations with genes involved in regulation of the signaling events.

Specialty Focus



1995 BS Biotechnology/Fine Organic Chemistry, M.V. Lomonosov Academy of Fine Chemical Technology,, Moscow, Russia
1995 MS Biochemistry, Biotechnology/ Fine Organic Chemistry, Moscow, Russia
2000 PhD Genetics, Vavilov Institute of General Genetics, Laboratory of Genome Variability, Moscow, Russia

Honors and Awards

1997 Travel grant for young scientists from International Centre for Genetic Engineering and Biotechnology and travel grant for young scientists from Vavilov Institute of General Genetics, Russian Academy of Sciences to attend meeting of International Centre for Genetic Engineering and Biotechnology “Transformation Methods and Analysis of Gene Expression in Transgenic Plants” CENARGEN/EMBRAPA, Brasilia, Brazil, October 197

Active Research Grants

Co-Investigator, Shcs, mitochondria, healthy aging and longevity, Gino Cortopassi (Principal Investigator), NIH

Most Recent 10 Publications

  • Link Icon 2014 Sahdeo S, Tomilov A, Komachi K, Iwashashi C, Datta S, Hughes O, Hagerman P, Cortopassi G High-throughput screening of FDA-approved drugs using oxygen biosensor plates reveals secondary mitofunctional effects Mitochondrion,
  • Link Icon 2014 Ramsey JJ, Tran D, Giorgio M, Griffey SM, Koehne A, Laing ST, Taylor SL, Kim K, Cortopassi GA, Lloyd KC, Hagopian K, Tomilov AA, Migliaccio E, Pelicci PG, McDonald RB The influence of Shc proteins on life span in mice J Gerontol A Biol Sci Med Sci,
  • Link Icon 2012 Chen L, Liu T, Tran A, Lu X, Tomilov AA, Davies V, Cortopassi G, Chiamvimonvat N, Bers DM, Votruba M, Knowlton AA OPA1 mutation and late-onset cardiomyopathy: mitochondrial dysfunction and mtDNA instability J Am Heart Assoc,
  • Link Icon 2012 Hagopian K, Tomilov AA, Tomilova N, Kim K, Taylor SL, Lam AK, Cortopassi GA, McDonald RB, Ramsey JJ Shc proteins influence the activities of enzymes involved in fatty acid oxidation and ketogenesis Metabolism,
  • Link Icon 2012 Nagata N, Matsuo K, Bettaieb A, Bakke J, Matsuo I, Graham J, Xi Y, Liu S, Tomilov A, Tomilova N, Gray S, Jung DY, Ramsey JJ, Kim JK, Cortopassi G, Havel PJ, Haj FG Hepatic Src homology phosphatase 2 regulates energy balance in mice Endocrinology,
  • Link Icon 2012 Bandaranayake PC, Tomilov A, Tomilova NB, Ngo QA, Wickett N, dePamphilis CW, Yoder JI The TvPirin gene is necessary for haustorium development in the parasitic plant Triphysaria versicolor Plant Physiol,
  • Link Icon 2010 Bandaranayake PC, Filappova T, Tomilov A, Tomilova NB, Jamison-McClung D, Ngo Q, Inoue K, Yoder JI A single-electron reducing quinone oxidoreductase is necessary to induce haustorium development in the root parasitic plant Triphysaria Plant Cell,
  • Link Icon 2010 Tomilov AA, Ramsey JJ, Hagopian K, Giorgio M, Kim KM, Lam A, Migliaccio E, Lloyd KC, Berniakovich I, Prolla TA, Pelicci P, Cortopassi GA The Shc locus regulates insulin signaling and adiposity in mammals Aging Cell,
  • Link Icon 2009 Yoder JI, Gunathilake P, Wu B, Tomilova N, Tomilov AA Engineering host resistance against parasitic weeds with RNA interference Pest Manag Sci,
  • Link Icon 2009 Tomilov AA, Bicocca V, Schoenfeld RA, Giorgio M, Migliaccio E, Ramsey JJ, Hagopian K, Pelicci PG, Cortopassi GA Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice J Biol Chem,