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Photo: Fredric Austin Gorin

Fredric Austin Gorin
Professor
Molecular Biosciences


   

Education

1973. B.S. Biochemistry, University of California, Davis, Davis, CA
1980 internship Internal medicine, Jewish Hospital of St. Louis,
1979 M.D., Ph.D. Biophysics & Physiology, Washington University Medical School, St. Louis, Missouri
1983 Residency Neurology, University of California, San Francisco, San Francisco, California

Honors and Awards

2009 America's Top Doctors
2008-9 Outstanding Teaching Award from Department of Neurology Residents
2008- American Chemical Society
2004- American Society for Pharmacology and Experimental Therapeutics (ASPET)
2004 Society for Neuro-oncology
2000 American Academy of Immunology
1988 John J. Sampson Research Award, American Heart Assn., California Affiliate
1986- Amercian Neurological Association
1986- American Physiological Society (elected regular member)
1983 Sigma Xi Award
1973-79 Medical Scientist Training Program (GM020l6, NIH) Washington University School of Medicine
1972 Phi Beta Kappa
1972 Phi Kappa Phi
1972 Research Summer Fellow, U. So. California, Department of Pharmacology

Licenses

Neurology, American Board of Psychiatry and Neurology- Boarded
American Association for Advancement of Science
American College of Physicians & Surgeons
American Medical Association
American Society for Neurological Investigation
California Childrens' Services (Neurology)
MDA Neuromuscular Clinics, U.C. Davis (senior neurologist)
Society for Experimental Biology and Medicine (member and editorial board)
Society for Neuroscience (regular member)
American Physiological Society (elected regular member)
The American Neurological Association (elected regular member)
The American Academy of Neurology (elected regular member)
The American Academy of Immunotherapy (member)
The Society for Neuro-Oncology
American Academy for Cancer Research
American Chemical Society (elected regular member)

Active Research Grants

Co-Investigator, Training Program in Basic Neuroscience, Edward Jones (Principal Investigator), National Institute of Mental Health

Co-Investigator, Monkey Cortical Connections Database, Edward Jones, Center for Neuroscience (Principal Investigator), National Institute of Mental Health

Principal Investigator, Induction of apoptosis of highly invasive breast cancer cells by novel small molecule inhibitors of intracellular urokinase plasminogen activator, Carraway and Gorin (co-PIs) (Principal Investigator), National Komen Foundation

Principal Investigator, Novel Amiloride Conjugates Selectively Kill Gliomas, Gorin, Fredric (Principal Investigator), NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

Most Recent 10 Publications

  • Link Icon 2012 Pasupuleti, N., Valenzuela, A., Leon, L., Carraway III, K., Gorin, F. 5'benzylglycinyl-amiloride kills proliferating and non-proliferating malignant glioma cells through caspase-independent necroptosis mediated by apoptosis-inducing factor. Pharmacology Experimental Therapeutics,
  • Link Icon 2012 Massey, AP, Harley, WR, Pasupuleti, N, Gorin, FA, Nantz, MH 2-Amidino analogs of glycine-amiloride conjugates: inhibitors of urokinase-type plasminogen activator. Bioorganic & medicinal chemistry letters,
  • Link Icon 2010 Harley, W, Floyd, C, Dunn, T, Zhang, XD, Chen, TY, Hegde, M, Palandoken, H, Nantz, MH, Leon, L, Carraway, KL, Lyeth, B, Gorin, FA Dual inhibition of sodium-mediated proton and calcium efflux triggers non-apoptotic cell death in malignant gliomas. Brain research,
  • Link Icon 2010 Sun, Y, Hatami, N, Yee, M, Phipps, J, Elson, DS, Gorin, F, Schrot, RJ, Marcu, L Fluorescence lifetime imaging microscopy for brain tumor image-guided surgery. Journal of biomedical optics,
  • Link Icon 2008 Zhao X, Gorin F, Berman R, Lyeth B Differential Hippocampal Protection when Blocking Intracellular Sodium and Calcium Entry during Traumatic Brain Injury in Rats Neurotrauma,
  • Link Icon 2008 Schnier JB, Nishi K, Harley WR, Gorin FA An acidic environment changes cyclin D1 localization and alters colony forming ability in gliomas J Neurooncol,
  • Link Icon 2007 Vali S, Mythri RB, Jagatha B, Padiadpu J, Ramanujan KS, Andersen JK, Gorin F, Bharath MM Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinson's disease: a dynamic model Neuroscience,
  • Link Icon 2007 Kaushik P, Gorin F, Vali S Dynamics of tyrosine hydroxylase mediated regulation of dopamine synthesis J Comput Neurosci.,
  • Link Icon 2006 Raichur A, Vali S, Gorin F Dynamic modeling of alpha-synuclein aggregation for the sporadic and genetic forms of Parkinson's disease Neuroscience,
  • Link Icon 2005 Palandoken, H., By, K., Hegde, M., Harley, W.R., Gorin, F.A., and Nantz, M.H. Amiloride peptide conjugates: prodrugs for sodium-proton exchange inhibition J Pharmacol Exp Ther,

Most Recent 5 Book Chapters

1978 Marshall, G.R., F.A. Gorin, and M.L. Moore: Peptide conformation and biological activity, F.H. Clarke, (ed), Annual Reports in Medicinal Chemistry, New York. 227-238.