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Photo: Peter B Ernst

Peter B Ernst- BSc, DVM, MS, PhD

Pathology, Microbiology & Immunology


Research Focus

Regulation of gastrointestinal immunity to bacterial infections and the role of engulfment in adenosine production and immune regulation.

Specialty Focus



1977 BSc GI Physiology, University of Toronto, Toronto, Canada
1981 DVM Veterinary Medicine, University of Guelph, Guelph, Canada
1981 MS Epidemiology, University of Guelph, Guelph, Canada
1985 PhD Med Sci - Immunology, McMaster University, Hamilton, Canada


College of Ontario Veterinarians
College of Ontario Veterinarians, Academic License
Association of Medical Laboratory Immunologists
Canadian Society for Clinical Chemists, Elected

Active Research Grants

Principal Investigator, Mechanisms of apoptotic cell clearance in the human stomach, (Principal Investigator), NIH

Principal Investigator, The role of adenosine receptors in Th cell development and function, (Principal Investigator), NIH

Most Recent 10 Publications

  • Link Icon 2013 Tlaxca JL, Rychak JJ, Ernst PB, Konkalmatt PR, Shevchenko TI, Pizzaro TT, Rivera-Nieves J, Klibanov AL, Lawrence MB Ultrasound-based molecular imaging and specific gene delivery to mesenteric vasculature by endothelial adhesion molecule targeted microbubbles in a mouse model of Crohn's disease J Control Release,
  • Link Icon 2013 Mauldin JP, Lu M, Das S, Park D, Ernst PB, Ravichandran KS A link between the cytoplasmic engulfment protein Elmo1 and the Mediator complex subunit Med31 Curr Biol,
  • Link Icon 2012 Luo Y, Kong Q, Yang J, Mitra A, Golden G, Wanda SY, Roland KL, Jensen RV, Ernst PB, Curtiss R Comparative genome analysis of the high pathogenicity Salmonella Typhimurium strain UK-1 PloS one,
  • Link Icon 2012 Warren CA, Calabrese GM, Li Y, Pawlowski SW, Figler RA, Rieger J, Ernst PB, Linden J, Guerrant RL Effects of adenosine A2A receptor activation and alanyl-glutamine in Clostridium difficile toxin-induced ileitis in rabbits and cecitis in mice BMC Infect Dis,
  • Link Icon 2012 Ernst PB, Erickson LD, Loo WM, Scott KG, Wiznerowicz EB, Brown CC, Torres-Velez FJ, Alam MS, Black SG, McDuffie M, Feldman SH, Wallace JL, McKnight GW, Padol IT, Hunt RH, Tung KS Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice Am J Physiol Gastrointest Liver Physiol,
  • Link Icon 2011 Drygiannakis, I, Ernst, PB, Lowe, D, Glomski, IJ Immunological alterations mediated by adenosine during host-microbial interactions. Immunologic research,
  • Link Icon 2011 Luo Y, Kong Q, Yang J, Golden G, Wanda SY, Jensen RV, Ernst PB, Curtiss R Complete genome sequence of the universal killer Salmonella enterica Serovar Typhimurium UK-1 (ATCC 68169) J Bacteriol,
  • Link Icon 2011 Ernst PB, Wiznerowicz EB, Feldman SH, Tung KS Pathogenesis of gastritis in ileitis-prone SAMP1/Yit mice Keio J Med,
  • Link Icon 2011 Das S, Owen KA, Ly KT, Park D, Black SG, Wilson JM, Sifri CD, Ravichandran KS, Ernst PB, Casanova JE Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria Proc Natl Acad Sci U S A,
  • Link Icon 2011 Wilson JM, Kurtz CC, Black SG, Ross WG, Alam MS, Linden J, Ernst PB The A2B adenosine receptor promotes Th17 differentiation via stimulation of dendritic cell IL-6 J Immunol,

Most Recent 5 Book Chapters

2011 Kurtz CC, Wilson JM, Black SG, Ernst PB: Cytokine production by T helper subsets in response to infection and their role in health and disease, Preedy VR, Hunter R, (ed), Cytokines (Modern Insights into Disease from Molecules to Man), Enfield, NH. .

2011 Kurtz CC, Wilson JM, Black SG, Ernst PB: Chapter 7. Cytokine production by T helper subsets in response to infection and their role in health and disease, Preedy VR, Hunter RJ, (ed), Cytokines (Modern Insights into Disease from Molecules to Man), Enfield, NH. 93-106.

2009 Crowe SE, Alam MS, Bhattacharyya A, Ernst PB: Host immunity in the development of gastric preneoplasia, Wang TC, Giraud AS, Fox JG, (ed), The Biology of Gastric Cancer, New York, NY. 425-448.

2006 Ernst PB: The Molecular Mechanisms of Helicobacter pylori Associated Gastroduodenal Disease, Runge MS, Patterson C, (ed), Molecular Medicine, New York. 590-602.

2003 Ernst PB, Ryan K, Goldberg J: What is the exact role of Lewis antigens and autoantibodies in Helicobacter related disease, Hunt RH, Tytgat GNJ, (ed), Helicobacter pylori: Basic mechanisms to clinical cure 2002, Amsterdam. 73-78.