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Photo: Jose Rafael Lopez-Padrino

Jose Rafael Lopez-Padrino
Researcher
Molecular Biosciences


jrlopez@ucdavis.edu

   

Education

1970 M.D. , Universidad Nacional Autonoma de Mexico, Mexico, DF
1972 , Intern in Gynecology, Hospital Gabriel Mancera, Universidad Nacianal Autonoma de Mexico, Mexico DG, Mexico
1973 M.D. , Universidad de Los Andes, Merida, Venezuela
1975 , Resident in Gynecology, Hospital Gavriel Mancera, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
1980 Ph.D. , Mayo Clinic, Rochester, Minnesota
1981 Research Fellowship , Mayo Clinic, Department of Pharmacology, Rochester, Minnesota

Honors and Awards

2005 Alejo Zuluoga medal (Unique Class) for Scientific and Academic Achievements, Universidad de Carabobo, Venezuela
2003 Award Lorenzo Mendoza Fleury, Polar Foundation
2002 Award Agusto Pi Sunyer, El Centre Catala de Caracas and the Institute of Experimental Medicine, Universidad Central de Venezuela
2000 National Annual Award in Basic Medicine, Venezuelan Ministry of Science
1996 Outstanding Contribution Award, Venezuelan Neurology Society
1995 National Annual Award in Basic Medicine, Venezuelan National Council for Scientific Research (CONICIT)
1994 Leti Annual Award in Cellular Mechanism in Hypertension, Leti Pharmaceuticals and Venezuelan Cardiology Society
1993-1994 Training Fellowship, sponsored by Venezuelan National Council for Scientific Research (CONICIT)
1993 National Annual Award in Biological Science, Venezuelan National Council for Scientific Research (CONICIT)
1993 Outstanding Contribution Award, Hospital Carlos Arvelo, Venezuelan Ministry of Defense
1993 Parke Davis Annual Award on Risk Factor and Cardioprotection, Parke Davis pharmaceuticals and Venezuelan Cardiology Society
1992 Outstanding Contribution Award, Venezuelan Cardiology Society
1992 Outstanding Contribution Award, Hospital Carlos Arvelo, Venezuelan Ministry on Defense
1991 Outstanding Contribution Award, Venezuelan Cardiology Society
1991 Parke Davis Annual Award on Risk Factor and Cardioprotection, Parke Davis Pharmaceuticals and Venezuelan Cardiology Society
1990 Scientific Contribution Award, Venezuelan Cardiology Society
1990 National Annual Award in Basic Medicine, Venezuelan National Council for Scientific Research (CONICIT)
1990 Andres Bello medal (First Class) for Scientific Achievement, Venezuelan Government
1988 National Annual Award in Pharmacology, Venezuelan Pharmacology Society
1985 National Annual Award in Biological Science, Venezuelan National Council for Scientific Research (CONICIT)
1980-1981 Postdoctoral Fellowship, sponsored by the Muscular Dystrophy Association, (MDA, USA)
1975-1980 Fellowship, sponsored by Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas, Venezuela
1974-1975 Fellowship, sponsored by Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas, Venezuela
1967-1970 Fellowshipp Benito Juarez, sponsored by Universidad Nacional Autonoma de Mexico, DF. Mexico

Active Research Grants

Co-Principal Investigator, Uncovering the Molecular Basis of Malignant Hyperthermia, Allen, Paul (Principal Investigator), National Institute of Health (USA)

Most Recent 10 Publications

  • Link Icon 2012 Boncompagni, S, Thomas, M, Lopez, JR, Allen, PD, Yuan, Q, Kranias, EG, Franzini-Armstrong, C, Perez, CF Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca2+ homeostasis. PloS one,
  • Link Icon 2012 Boncompagni, S, Moussa, CE, Levy, E, Pezone, MJ, Lopez, JR, Protasi, F, Shtifman, A Mitochondrial dysfunction in skeletal muscle of amyloid precursor protein-overexpressing mice. The Journal of biological chemistry,
  • Link Icon 2012 Eltit, JM, Bannister, RA, Moua, O, Altamirano, F, Hopkins, PM, Pessah, IN, Molinski, TF, López, JR, Beam, KG, Allen, PD Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor. Proceedings of the National Academy of Sciences of the United States of America,
  • Link Icon 2012 Yuen, B, Boncompagni, S, Feng, W, Yang, T, Lopez, JR, Matthaei, KI, Goth, SR, Protasi, F, Franzini-Armstrong, C, Allen, PD, Pessah, IN Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage. FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
  • Link Icon 2012 Barrientos, GC, Feng, W, Truong, K, Matthaei, KI, Yang, T, Allen, PD, Lopez, JR, Pessah, IN Gene dose influences cellular and calcium channel dysregulation in heterozygous and homozygous T4826I-RYR1 malignant hyperthermia-susceptible muscle. The Journal of biological chemistry,
  • Link Icon 2012 Altamirano, F, López, JR, Henríquez, C, Molinski, T, Allen, PD, Jaimovich, E Increased resting intracellular calcium modulates NF-?B-dependent inducible nitric-oxide synthase gene expression in dystrophic mdx skeletal myotubes. The Journal of biological chemistry,
  • Link Icon 2011 Feng, W, Barrientos, GC, Cherednichenko, G, Yang, T, Padilla, IT, Truong, K, Allen, PD, Lopez, JR, Pessah, IN Functional and biochemical properties of ryanodine receptor type 1 channels from heterozygous R163C malignant hyperthermia-susceptible mice. Molecular pharmacology,
  • Link Icon 2011 López, JR, Espinosa, R, Landazuru, P, Linares, N, Allen, P, Mijares, A Dysfunction of diastolic [Ca2+] in cardiomyocytes isolated from chagasic patients]. Revista española de cardiología,
  • Link Icon 2011 Eltit, JM, Li, H, Ward, CW, Molinski, T, Pessah, IN, Allen, PD, Lopez, JR Orthograde dihydropyridine receptor signal regulates ryanodine receptor passive leak. Proceedings of the National Academy of Sciences of the United States of America,
  • Link Icon 2011 Shtifman, A, Zhong, N, Lopez, JR, Shen, J, Xu, J Altered Ca2+ homeostasis in the skeletal muscle of DJ-1 null mice. Neurobiology of aging,

Most Recent 5 Book Chapters

1999 López JR: Anesthesia depression of muscle contractility, IBRO, AH Mulisky, (ed), Recent Advance in Muscle Physiology. 78-86.

1989 López JR, Mendoza M, Sreter F: Effects of age on intracellular free calcium concentration in rat skeletal muscle, H Leepman, (ed), In: Proceeding Biomedical Advances in Aging. 258-269.

1989 López JR, Parthe V, Linares N: L-carnitina: un aminoácido con propiedades terapéuticas. Cambios morfo-funcionales en miocardiopatías dilatadas, Editorial MinSAP, G Anselmi, (ed), Miocardiopatías del Niño: Tratamiento y Bases Experimentales. 1-9.

1988 López JR: Mechanism of control of skeletal muscle contraction by dantrolene sodium. In: Muscle Diseases, DL Schotland, (ed), Anchor-brendon Ltd. 166-179.

1987 López JR, Alamo L, Allen PD, Sreter F: Efecto del Dantrolene sobre [Ca2+]i en porcinos susceptibles a Hipertermia Maligna, Editorial Pasa, JR López, (ed), Aspectos Básicos de la Hipertermia Maligna. 38-48.