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Photo: Jose Rafael Lopez-Padrino

Jose Rafael Lopez-Padrino
Researcher
Molecular Biosciences

2005 VM3B
Davis, CA 95616

+1 530 752 3229
jrlopez@ucdavis.edu

   

Education

1970 M.D. , Universidad Nacional Autonoma de Mexico, Mexico, DF
1972 , Intern in Gynecology, Hospital Gabriel Mancera, Universidad Nacianal Autonoma de Mexico, Mexico DF, Mexico
1973 M.D. , Universidad de Los Andes, Merida, Venezuela
1975 , Resident in Gynecology, Hospital Gavriel Mancera, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico
1980 Ph.D. , Mayo Clinic, Rochester, Minnesota
1981 Research Fellowship , Mayo Clinic, Department of Pharmacology, Rochester, Minnesota

Honors and Awards

2005 Alejo Zuluoga medal (Unique Class) for Scientific and Academic Achievements, Universidad de Carabobo, Venezuela
2003 Award Lorenzo Mendoza Fleury, Polar Foundation
2002 Award Agusto Pi Sunyer, El Centre Catala de Caracas and the Institute of Experimental Medicine, Universidad Central de Venezuela
2000 National Annual Award in Basic Medicine, Venezuelan Ministry of Science
1996 Outstanding Contribution Award, Venezuelan Neurology Society
1995 National Annual Award in Basic Medicine, Venezuelan National Council for Scientific Research (CONICIT)
1994 Leti Annual Award in Cellular Mechanism in Hypertension, Leti Pharmaceuticals and Venezuelan Cardiology Society
1993-1994 Training Fellowship, sponsored by Venezuelan National Council for Scientific Research (CONICIT)
1993 National Annual Award in Biological Science, Venezuelan National Council for Scientific Research (CONICIT)
1993 Outstanding Contribution Award, Hospital Carlos Arvelo, Venezuelan Ministry of Defense
1993 Parke Davis Annual Award on Risk Factor and Cardioprotection, Parke Davis pharmaceuticals and Venezuelan Cardiology Society
1992 Outstanding Contribution Award, Venezuelan Cardiology Society
1992 Outstanding Contribution Award, Hospital Carlos Arvelo, Venezuelan Ministry on Defense
1991 Outstanding Contribution Award, Venezuelan Cardiology Society
1991 Parke Davis Annual Award on Risk Factor and Cardioprotection, Parke Davis Pharmaceuticals and Venezuelan Cardiology Society
1990 Scientific Contribution Award, Venezuelan Cardiology Society
1990 National Annual Award in Basic Medicine, Venezuelan National Council for Scientific Research (CONICIT)
1990 Andres Bello medal (First Class) for Scientific Achievement, Venezuelan Government
1988 National Annual Award in Pharmacology, Venezuelan Pharmacology Society
1985 National Annual Award in Biological Science, Venezuelan National Council for Scientific Research (CONICIT)
1980-1981 Postdoctoral Fellowship, sponsored by the Muscular Dystrophy Association, (MDA, USA)
1975-1980 Fellowship, sponsored by Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas, Venezuela
1974-1975 Fellowship, sponsored by Instituto Venezolano de Investigaciones Cientificas (IVIC), Caracas, Venezuela
1967-1970 Fellowshipp Benito Juarez, sponsored by Universidad Nacional Autonoma de Mexico, DF. Mexico

Active Research Grants

Co-Principal Investigator, Uncovering the Molecular Basis of Malignant Hyperthermia, Allen, Paul (Principal Investigator), National Institute of Health (USA)

Co-Principal Investigator, Intracellular calcium dyshomeostasis and pathogenesis of Duchenne muscular dystrophy, Juan Kolster (Principal Investigator), Consejo Nacional de Ciencia y Tecnología (CONACYT) (Mexico)

Co-Principal Investigator, Pathophysiology of Chagas cardiomyopathy , Alfredo Mijares (Principal Investigator), Instituto Venezolano de Investigaciones Científicas, Venezuela

Most Recent 10 Publications

  • Link Icon 2014 Burr AR, Millay DP, Goonasekera SA, Park KH, Sargent MA, Collins J, Altamirano F, Philipson KD, Allen PD, Ma J, López JR, Molkentin JD Na+ dysregulation coupled with Ca2+ entry through NCX1 promotes muscular dystrophy in mice Molecular and Cellular Biology,
  • Link Icon 2014 Mijares A, Altamirano F, Kolster J, Adams JA, López JR Age-dependent changes in diastolic Ca(2+) and Na(+) concentrations in dystrophic cardiomyopathy: Role of Ca(2+) entry and IP3 Biochem Biophys Res Commun,
  • Link Icon 2014 Chen Y, Xue S, Zou J, Lopez JR, Yang JJ, Perez CF Myoplasmic resting Ca2+ regulation by ryanodine receptors is under the control of a novel Ca2+-binding region of the receptor Biochem J,
  • Link Icon 2014 Altamirano F, Eltit JM, Robin G, Linares, N, Ding X, Pessah IN, Allen PD, López JR Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle J Biol Chem,
  • Link Icon 2014 Altamirano F, Perez CF, Liu M, Widrick J, Barton ER, Allen PD, Adams JA, Lopez JR Whole body periodic acceleration is an effective therapy to ameliorate muscular dystrophy in mdx mice PloS one,
  • Link Icon 2013 Altamirano F, Valladares D, Henríquez-Olguín C, Casas M, López JR, Allen PD, Jaimovich E Nifedipine Treatment Reduces Resting Calcium Concentration, Oxidative and Apoptotic Gene Expression, and Improves Muscle Function in Dystrophic mdx Mice PloS one,
  • Link Icon 2013 Eltit JM, Ding X, Pessah IN, Allen PD, Lopez JR Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia The FASEB Journal,
  • Link Icon 2012 Boncompagni S, Thomas M, Lopez JR, Allen PD, Yuan Q, Kranias EG, Franzini-Armstrong C, Perez CF Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca2+ homeostasis PloS one,
  • Link Icon 2012 Boncompagni S, Moussa CE, Levy E, Pezone MJ, Lopez JR, Protasi F, Shtifman A Mitochondrial dysfunction in skeletal muscle of amyloid precursor protein-overexpressing mice The Journal of Biological Chemistry,
  • Link Icon 2012 Eltit JM, Bannister RA, Moua O, Altamirano F, Hopkins PM, Pessah IN, Molinski TF, López JR, Beam KG, Allen PD Malignant hyperthermia susceptibility arising from altered resting coupling between the skeletal muscle L-type Ca2+ channel and the type 1 ryanodine receptor Proceedings of the National Academy of Sciences of the United States of America,

Most Recent 5 Book Chapters

2012 López JR, Allen PD: Chapter 56, Control of resting Ca2+ concentration in Skeletal Muscle, Joseph E. Hill and Eric N. Olsen, (ed), Muscle: Fundamental Biology and Mechanisms of Disease. 801-810.

1999 López JR: Anesthesia depression of muscle contractility, IBRO, AH Mulisky, (ed), Recent Advance in Muscle Physiology. 78-86.

1989 López JR, Mendoza M, Sreter F: Effects of age on intracellular free calcium concentration in rat skeletal muscle, H Leepman, (ed), In: Proceeding Biomedical Advances in Aging. 258-269.

1989 López JR, Parthe V, Linares N: L-carnitina: un aminoácido con propiedades terapéuticas. Cambios morfo-funcionales en miocardiopatías dilatadas, Editorial MinSAP, G Anselmi, (ed), Miocardiopatías del Niño: Tratamiento y Bases Experimentales. 1-9.

1988 López JR: Mechanism of control of skeletal muscle contraction by dantrolene sodium. In: Muscle Diseases, DL Schotland, (ed), Anchor-brendon Ltd. 166-179.