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Photo: Paul Denney Allen

Paul Denney Allen- BA, MD, PhD
Health Science Adjunct Professor
Molecular Biosciences

2205 VM3B
Davis, CA 95616

+1 530 752 5022
pdallen@ucdavis.edu

   

Research Focus

Functional consequences of changes in protein structure, particularly the ryanodine receptor involved in excitation-contraction coupling in skeletal muscle.

Education

1967 BA , Boston University, Boston, Massachusetts
1967 MD , Boston University, Boston, Massachusetts
1973 PhD , University of Florida, Gainesville, FL

Honors and Awards

2012 Harvard Club of Australia Foundation, USA/Australia Fellowship
2007 Distinguished Contribution Award, MHAUS
2007 Paul D Allen Chair in Anesthesia established at Brigham and Women's Hospital
2006 FAER Honorary Lecturer, ASA
2004 Academy of Anesthesia Mentors (FAER), Founding Member
2001 Vandam Lecturer, Brigham and Women's Hospital
1976 President's Award, Southeastern Surgical Congress
1971 Conrad Jobst Foundation Award
1967 Aid to Cancer Research Fellowship

Licenses

Diplomate of the American Board of Anesthesiology # 10469

Active Research Grants

Principal Investigator, The Molecular Basis of Malignant Hyperthermia, (Principal Investigator), NIH P01

Most Recent 10 Publications

  • Paul Denney Allen: Altered ROS production, NF-?B activation and interleukin-6 gene expression induced by electrical stimulation in dystrophic mdx skeletal muscle cells. 2015 Henríquez-Olguín C, Altamirano F, Valladares D, López JR, Allen PD, Jaimovich E Altered ROS production, NF-?B activation and interleukin-6 gene expression induced by electrical stimulation in dystrophic mdx skeletal muscle cells. Biochimica et biophysica acta,
  • Paul Denney Allen: Na+ Dysregulation Coupled with Ca2+ Entry through NCX1 Promotes Muscular Dystrophy in Mice 2014 Burr AR, Millay DP, Goonasekera SA, Park KH, Sargent MA, Collins J, Altamirano F, Philipson KD, Allen PD, Ma J, López JR, Molkentin JD Na+ Dysregulation Coupled with Ca2+ Entry through NCX1 Promotes Muscular Dystrophy in Mice Mol Cell Biol,
  • Paul Denney Allen: Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle. 2014 Altamirano F, Eltit JM, Robin G, Linares N, Ding X, Pessah IN, Allen PD, López JR Ca2+ influx via the Na+/Ca2+ exchanger is enhanced in malignant hyperthermia skeletal muscle. The Journal of biological chemistry,
  • Paul Denney Allen: Whole body periodic acceleration is an effective therapy to ameliorate muscular dystrophy in mdx mice. 2014 Altamirano F, Perez CF, Liu M, Widrick J, Barton ER, Allen PD, Adams JA, Lopez JR Whole body periodic acceleration is an effective therapy to ameliorate muscular dystrophy in mdx mice. PloS one,
  • Paul Denney Allen: Mononuclear cells from dedifferentiation of mouse myotubes display remarkable regenerative capability. 2014 Yang Z, Liu Q, Mannix RJ, Xu X, Li H, Ma Z, Ingber DE, Allen PD, Wang Y Mononuclear cells from dedifferentiation of mouse myotubes display remarkable regenerative capability. Stem cells (Dayton, Ohio),
  • Paul Denney Allen: Nifedipine Treatment Reduces Resting Calcium Concentration, Oxidative and Apoptotic Gene Expression, and Improves Muscle Function in Dystrophic mdx Mice. 2013 Altamirano F, Valladares D, Henríquez-Olguín C, Casas M, López JR, Allen PD, Jaimovich E Nifedipine Treatment Reduces Resting Calcium Concentration, Oxidative and Apoptotic Gene Expression, and Improves Muscle Function in Dystrophic mdx Mice. PLoS One,
  • Paul Denney Allen: Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia. 2013 Eltit JM, Ding X, Pessah IN, Allen PD, Lopez JR Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia. FASEB J,
  • Paul Denney Allen: Dynamic measurement of the calcium buffering properties of the sarcoplasmic reticulum in mouse skeletal muscle 2013 Manno C, Sztretye M, Figueroa L, Allen PD, Rios E Dynamic measurement of the calcium buffering properties of the sarcoplasmic reticulum in mouse skeletal muscle J Physiol,
  • Paul Denney Allen: Th2 cytokine antagonists: potential treatments for severe asthma 2013 Hansbro PM, Scott GV, Essilfie AT, Kim RY, Starkey MR, Nguyen DH, Yang M, Allen PD, Kaiko GE, Horvat JC, Foster PS Th2 cytokine antagonists: potential treatments for severe asthma Expert Opin Invest Drugs,
  • Paul Denney Allen: Three-dimensional localization of the Alpha and Beta subunits and of the II-III loop in the skeletal muscle L-type Ca2+ channel 2012 Szpyt J, Lorenzon N, Perez CF, Norris E, Allen PD, Beam K, Samso M Three-dimensional localization of the Alpha and Beta subunits and of the II-III loop in the skeletal muscle L-type Ca2+ channel J Biol Chem,

Most Recent 5 Book Chapters

2012 Lopez JR, Allen PD: Control of resting Ca2+ concentration in skeletal muscle, , (eds Joseph Hill and Eric Olsen) Muscle: Fundamental Biology and Mechanisms of Disease, Oxford. 801-811.

2010 Zhou J, Allen PD, Pessah In, Naguib M: Neuromuscular Disorders and Malignant Hyperthermia, , (eds Ronald Miller et al) Millers Anesthesia 7th Edition, Philadelphia. 1171-1196.

2007 Allen PD, Stefani M, Tsubakihara M, Macdonald PS: Actin and its binding proteins in heart failure, , (eds C G dos Remedios and D Chhabra) Actin-binging proteins and disease. 318-334.

2001 Allen PD, Franzini -Armstrong C, Feliciano Protasi F: The structural basis for RyR-DHPR interactions in muscle cells, , (M Morad and P Kostyuk eds) NATO Sciences series I: Life and Behavioral Sciences. 14-21.

1995 Allen PD: Anesthesia for Minimally Invasive Surgery, , Kevin R. Loughlin and David C Brooks, Principles of Endosurgery. 54-71.