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Photo: Zhengyu Cao

Zhengyu Cao- BS, PhD
Assistant Project Scientist
Molecular Biosciences


Research Focus

NeuroPharmacology/ NeuroToxicology/ Marine Toxin/ Neurodevelopmental disorders

Specialty Focus

Neurotoxicology and neuropharmacology


2004 PhD Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union
1999 BS , Department of Biochemistry, Nanjing University and China Pharmaceutical Univer

Honors and Awards

2010 Authur E. Schwarting Award, The Hoiamides, Structurally-Intriguing Neurotoxic Lipopeptides from Papua New Guinea Marine Cyanobacteria, The Society of American Pharmacogonosy

Active Research Grants

Co-Investigator, Novel anticonvulsant and neuroprotective therapies for TETS and OP intoxication, Pamela Lein (Principal Investigator), NINDS

Most Recent 10 Publications

  • Link Icon 2012 Liu J, Koscielska K, Cao Z, Hulsizer S, Grace N, Mitchel G, Nacey C, McGee J, Hagerman RJ, Nolta J, Pessah I, Hagerman PJ Signaling defects in iPSC-derived fragile X premutation neurons Human Molecular Genetics,
  • Link Icon 2012 Cao Z, Hulsizer S, Tassone F, Tang H-T, Hagerman RJ, Rogawski MA, Hagerman PJ, Pessah IN Clustered Burst Firing in FMR1 Premutation Hippocampal Neurons: Amelioration with Allopregnanolone Human Molecular Genetics,
  • Link Icon 2012 Nunnery JK, Engene N, Byrum T, Cao Z, Jabba SV, Pereira AR, Matainaho T, Murray TF, Gerwick WH Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria Journal of Organic Chemistry,
  • Link Icon 2012 Malloy KL, Suyama TL, Engene N, Debonsi H, Cao Z, Matainaho T, Spadafora C, Murray TF, Gerwick WH Credneramides A and B: Neuromodulatory Phenethylamine and Isopentylamine Derivatives of a Vinyl Chloride-Containing Fatty Acid from cf. Trichodesmium sp.nov. Journal of Natural Products,
  • Link Icon 2011 Cao Z, Shafer TJ, Gennings C, Murray TF Additivity of Pyrethroid Actions on Sodium Influx in Cerebrocortical Neurons in Primary Culture Environmental Health Perspective,
  • Link Icon 2011 Engene N, Choi H, Esquenazi E, Byrum T, Villa FA, Cao Z, Murray TF, Dorrestein PC, Gerwick L, Gerwick WH Phylogeny-Guided Isolation of Ethyl Tumonoate A from the Marine Cyanobacterium cf. Oscillatoria margaritifera Journal of Natural Products,
  • Link Icon 2011 Cao Z, Shafer TJ, Murray TF Mechanisms of pyrethroid insecticide-induced stimulation of calcium influx in neocortical neurons Journal of Pharmacology and Experimental Therapeutics,
  • Link Icon 2010 Cao Z, Lepage KT, Frederick MO, Nicolaou KC, Murray TF Involvement of caspase activation in azaspiracid-induce neurotoxicity in neocortical neurons Toxicological Sciences,
  • Link Icon 2010 Cao Z, Gerwick WH, Murray TF Antillatoxin Is a Sodium Channel Activator That Displays Unique Efficacy in Heterologously Expressed rNav1.2, rNav1.4 and rNav1.5 Alpha Subunits BMC Neuroscience,
  • Link Icon 2010 Pereira AR, Cao Z, Engene N, Soria-Mercado IE, Murray TF, Gerwick WH Palmyrolide A, An Unusual Stabilized Neuroactive Macrolide from Palmyra Atoll Cyanobacteria Organic Letters,