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Photo: Joshua A Stern

Joshua A Stern- BS, DVM, PhD, Diplomate ACVIM (Cardiology)
Associate Professor
Medicine & Epidemiology

CCAH Room 258
Davis, CA 95616

+1 530 752 2475
jstern@ucdavis.edu

   

Research Focus

Cardiac genetics and cardiac pharmacogenomics are the principal foci of my research. Specifically, mutation identification and subsequent evaluation of the role that these mutations play in the development of congenital heart disease as well as their effects on response to medical therapy. One of my research goals is to further propel the role of individualized medicine in veterinary cardiology patients. Additionally I am dedicated to the development of large animal models of human heart disease such as hypertrophic cardiomyopathy.

Education

2003 BS Agriculture; Animal Science, The Ohio State University, Columbus, Ohio
2008 DVM , The Ohio State University, Columbus, Ohio
2009 , The Ohio State University, College of Veterinary Medicine, Columbus, Ohio
2011 , Washington State University, College of Veterinary Medicine, Pullman, Washington
2012 , North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina
2013 PhD Veterinary Cardiac Genetics Laboratory, Washington State University, Pullman, Washington

Honors and Awards

2011 Jessie Scholarship for Veterinary Cardiology and Neurology
2010 Dr. Lynn A George Endowed Memorial Scholarship for Research
2009 Morris Animal Foundation - Pfizer Animal Health Fellowship
2007 Sam Segall Small Animal Medicine Scholarship
2007 College of Veterinary Medicine (OCUCVM) Research Day Award Winner
2006 Sam Segall Small Animal Medicine Scholarship
2005 OSUCVM Summer Research Stipend Award
2004 Columbus Academy of Veterinary Medicine Scholarship
2003 Ohio Academic Scholarship
2002 Ohio Academic Scholarship
2001 Ohio Academic Scholarship

Licenses

State of Ohio Veterinary Medical Licensure #9330
USDA APHIS National Veterinary Accreditation
Specialty Board Certification - American College of Veterinary Internal Medicine (Cardiology)
State of California Veterinary Medical Licensure #20664

Active Research Grants

Principal Investigator, An individualized medicine investigation into a Phosphodiesterase-5A gene polymorphism and its effects on the canine response to sildenafil therapy for severe pulmonary hypertension, (Principal Investigator), American Kennel Club, Canine Health Foundation

Co-Investigator, A prospective, genetic evaluation of spontaneous chronic corneal epithelial defects (indolent ulcers) in the boxer dog utilizing a genomic wide association analysis, (Principal Investigator), American Kennel Club, Canine Health Foundation

Principal Investigator, Identification and impact of exercise-induced cardiac fatigue in racing Thoroughbreds: a pre and post race investigation into presence of exercise induced systolic dysfunction, cardiac dysrhythmias and cardiac biomarker derangements, (Principal Investigator), UC Davis: Marcia MacDonald Rivas Grant

Principal Investigator, Next generation sequencing to identify novel genetic causes of feline hypertrophic cardiomyopathy, (Principal Investigator), BGI Signature Research in Genomics Grant

Principal Investigator, Identification of genetic variants associated with myxomatous mitral valve degeneration in the Whippet dog through whole-genome sequencing, (Principal Investigator), American Kennel Club Canine Health Foundation

Co-Principal Investigator, ACTG Canine whole genome sequencing grant for inherited disease, (Principal Investigator), BGI Signature Research in Genomics Grant

Principal Investigator, Identification of genetic markers for ventricular septal defects in Arabian horses using a high density single nucleotide polymorphism array and a genome-wide association analysis, (Principal Investigator), UC Davis: Center for Equine Health

Principal Investigator, The role of genetics in the psittacine cholesterol transport pathway, (Principal Investigator), UC Davis: Center for Companion Animal Health

Principal Investigator, Pilot data to evaluate the genetic basis of sudden death in racing thoroughbred horses through genome wide association study, (Principal Investigator), UC Davis: Center for Equine Health: Bridge Funding

Principal Investigator, Identification of genetic markers of pulmonic stenosis in English Bulldogs, (Principal Investigator), American Kennel Club, Canine Health Foundation

Principal Investigator, Assessing the genetic diversity of North American golden retrievers, (Principal Investigator), American Kennel Club, Canine Health Foundation

Principal Investigator, Evaluation of Genetic Polymorphisms in the Psittacine Cholesterol Transport Pathway, (Principal Investigator), Association of Avian Veterinarians

Principal Investigator, Use of diphenhydramine to reduce infusion-related ventricular arrhythmias in dogs treated with doxorubicin, (Principal Investigator), Center for Companion Animal Health

Co-Investigator, Echocardiographic effects of butorphanol in dogs with subaortic stenosis or pulmonic stenosis, Lance Visser (Principal Investigator), Center for Companion Animal Health

Co-Investigator, Echocardiographic effects of butorphanol in dogs with subaortic stenosis or pulmonic stenosis, Lance Visser (Principal Investigator), Center for Companion Animal Health

Principal Investigator, Short-term effects of pimobendan in cats with hypertrophic cardiomyopathy, (Principal Investigator), Center for Companion Animal Health

Co-Investigator, Chylous redistribution, resolution and recurrence after confirmed complete cessation of thoracic duct flow in dogs with naturally occurring idiopathic chylothorax, Philipp Mayhew (Principal Investigator), Center for Companion Animal Health

Most Recent 10 Publications

  • Joshua A Stern: A Small Molecule Inhibitor of Sarcomere Contractility Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy 2016 Stern JA, Markova S, Ueda Y, Kim JB, Pascoe PJ, Evanchik MJ, Green E, Harris SP A Small Molecule Inhibitor of Sarcomere Contractility Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy PLoS One,
  • Joshua A Stern: ECG of the Month: Escape-capture bigeminy in a dog 2016 Belanger C, Visser LC, Stern JA ECG of the Month: Escape-capture bigeminy in a dog J Am Vet Med Assoc,
  • Joshua A Stern: Platelet activation and clopidogrel effects on ADP-induced platelet activation in cats with or without the A31P mutation in MYBPC3 2016 Li RHL, Stern JA, Ho V, Tablin F, Harris SP Platelet activation and clopidogrel effects on ADP-induced platelet activation in cats with or without the A31P mutation in MYBPC3 J Vet Intern Med,
  • Joshua A Stern: Antemortem assessment of left ventricular hypertrophy in rhesus macaques (Macaca mulatta) 2016 Haertel AJ, Stern JA, Reader RJ Antemortem assessment of left ventricular hypertrophy in rhesus macaques (Macaca mulatta) Comp Med,
  • Joshua A Stern: Single-energy computed tomography-based pulmonary perfusion imaging: Proof-of-principle in a canine model 2016 Yamamoto T, Kent MS, Wisner ER, Johnson LR, Stern JA, Qi L, Yukio F, Boone JM Single-energy computed tomography-based pulmonary perfusion imaging: Proof-of-principle in a canine model Medical Physics,
  • Joshua A Stern: The A31P missense mutation in cardiac myosin binding protein C alters protein structure but does not cause haploinsufficiency 2016 van Dijk SJ, Bezold Kooiker K, Mazzalupo SM, Yang Y, Kostyukova AS, Mustacich DJ, Hoye ER, Stern JA, Kittleson MD, Harris SP The A31P missense mutation in cardiac myosin binding protein C alters protein structure but does not cause haploinsufficiency Arch Biochem Biophys,
  • Joshua A Stern: ECG of the Month: Ischemic ECG changes, cardiac tamponade and pericardial foreign body in a dog 2016 Im MK, Stern JA ECG of the Month: Ischemic ECG changes, cardiac tamponade and pericardial foreign body in a dog J Am Vet Med Assoc,
  • Joshua A Stern: Standardization of the two-dimensional transcoelomic echocardiographic examination in the central bearded dragon (Pogona vitticeps) 2016 Silverman SJ, Guzman DSM, Stern JA, Gustavsen KA, Griffiths LG. Standardization of the two-dimensional transcoelomic echocardiographic examination in the central bearded dragon (Pogona vitticeps) J Vet Cardiol,
  • Joshua A Stern: Atrial fibrillation in eight New World Camelids 2016 Bozorgmanesh R, Magdesian KG, Estell KE, Stern JA, Swain EA, Griffiths LG Atrial fibrillation in eight New World Camelids J Vet Intern Med,
  • Joshua A Stern: Diagnostic value of right pulmonary artery distensibility index in dogs with pulmonary hypertension: comparison with Doppler echocardiographic estimates of pulmonary arterial pressure 2016 Visser LC, Im MK, Johnson LR, Stern JA Diagnostic value of right pulmonary artery distensibility index in dogs with pulmonary hypertension: comparison with Doppler echocardiographic estimates of pulmonary arterial pressure J Vet Intern Med,

Most Recent 5 Book Chapters

2015 Stern JA: Aortic stenosis (Expanded topic), Tilley LP, Smith FWK, (ed), Blackwell's Five-minute Veterinary Consult: Canine & Feline; Sixth Edition, Hoboken. 104-6.