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Photo: Joshua A Stern

Joshua A Stern- BS, DVM, PhD, Diplomate ACVIM (Cardiology)
Associate Professor
Medicine & Epidemiology

CCAH Room 258
Davis, CA 95616

+1 530 752 2475
jstern@ucdavis.edu

   

Research Focus

Cardiac genetics and cardiac pharmacogenomics are the principal foci of my research. Specifically, mutation identification and subsequent evaluation of the role that these mutations play in the development of congenital heart disease as well as their effects on response to medical therapy. One of my research goals is to further propel the role of individualized medicine in veterinary cardiology patients. Additionally I am dedicated to the development of large animal models of human heart disease such as hypertrophic cardiomyopathy.

Education

2003 BS Agriculture; Animal Science, The Ohio State University, Columbus, Ohio
2008 DVM , The Ohio State University, Columbus, Ohio
2009 , The Ohio State University, College of Veterinary Medicine, Columbus, Ohio
2011 , Washington State University, College of Veterinary Medicine, Pullman, Washington
2012 , North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina
2013 PhD Veterinary Cardiac Genetics Laboratory, Washington State University, Pullman, Washington

Honors and Awards

2011 Jessie Scholarship for Veterinary Cardiology and Neurology
2010 Dr. Lynn A George Endowed Memorial Scholarship for Research
2009 Morris Animal Foundation - Pfizer Animal Health Fellowship
2007 Sam Segall Small Animal Medicine Scholarship
2007 College of Veterinary Medicine (OCUCVM) Research Day Award Winner
2006 Sam Segall Small Animal Medicine Scholarship
2005 OSUCVM Summer Research Stipend Award
2004 Columbus Academy of Veterinary Medicine Scholarship
2003 Ohio Academic Scholarship
2002 Ohio Academic Scholarship
2001 Ohio Academic Scholarship

Licenses

State of Ohio Veterinary Medical Licensure #9330
USDA APHIS National Veterinary Accreditation
Specialty Board Certification - American College of Veterinary Internal Medicine (Cardiology)
State of California Veterinary Medical Licensure #20664

Active Research Grants

Principal Investigator, Evaluation of Genetic Polymorphisms in the Psittacine Cholesterol Transport Pathway, (Principal Investigator), Association of Avian Veterinarians

Principal Investigator, Short-term effects of pimobendan in cats with hypertrophic cardiomyopathy, (Principal Investigator), Center for Companion Animal Health

Co-Investigator, Chylous redistribution, resolution and recurrence after confirmed complete cessation of thoracic duct flow in dogs with naturally occurring idiopathic chylothorax, Philipp Mayhew (Principal Investigator), Center for Companion Animal Health

Principal Investigator, Identification of Genetic Markers for Familial Subvalvular Aortic Stenosis in Newfoundlands, (Principal Investigator), AKC Canine Health Foundation

Principal Investigator, Identification of Genetic Markers for Familial Subvalvular Aortic Stenosis in Bullmastiffs, (Principal Investigator), AKC Canine Health Foundation

Principal Investigator, Genetic Polymorphisms Impact Response to Clopidogrel in Feline Hypertrophic Cardiomyopathy, (Principal Investigator), Morris Animal Foundation

Co-Investigator, A Preliminary Study of Structure and Expression of Opioid Receptor Genes in Pigeons and Cockatiels, Joanne Paul-Murphy (Principal Investigator), Center for Companion Animal Health

Co-Investigator, Echocardiographic effects of butorphanol and atenolol in dogs with pulmonary valve stenosis, Lance C. Visser (Principal Investigator), Center for Companion Animal Health

Principal Investigator, Use of diphenhydramine to reduce infusion-related ventricular arrhythmias in dogs treated with doxorubicin, (Principal Investigator), Center for Companion Animal Health

Most Recent 10 Publications

  • Joshua A Stern: Precision medicine in cats: novel Niemann-Pick Type C diagnosed by whole genome sequencing 2017 Mauler DA, Gandolfi B, Reinero CR, O’Brien DP, Spooner JL, Lyons LA, Aderdein D, Alves PC, Barsh GS, Beale HC, Boyko AR, Brockman JA, Castelhano MG, Chan P, Ellinwod NM, Fogle JE, Garrick DJ, Helps CR, Kaelin CB, Leclerc E, Leeb T, Lohi H, Longeri M, Malik R, Montague MJ, Munday JS, Murphy WJ, Pedersen NC, Rothschild MF, Stern JA, Swanson WF, Terio KA, Todhunter RJ, Ueda Y, Warren WC, Wildschutte JH Precision medicine in cats: novel Niemann-Pick Type C diagnosed by whole genome sequencing J Vet Intern Med - March,
  • Joshua A Stern: A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats 2017 Aberdein D, Munday JS, Gandolfi B, Dittmer KE, Malik R, Garrick DJ, Lyons LA; 99 Lives Consortium A FAS-ligand variant associated with autoimmune lymphoproliferative syndrome in cats Mamm Genome - February,
  • Joshua A Stern: A small molecule inhibitor of sarcomere contractility acutely relieves left ventricular outflow tract obstruction in feline hypertrophic cardiomyopathy 2016 Stern JA, Markova S, Ueda Y, Kim JB, Pascoe PJ, Evanchik MJ, Green E, Harris SP A small molecule inhibitor of sarcomere contractility acutely relieves left ventricular outflow tract obstruction in feline hypertrophic cardiomyopathy Plos One - December 14,
  • Joshua A Stern: ECG of the Month: Escape-capture bigeminy in a dog 2016 Belanger C, Visser LC, Stern JA ECG of the Month: Escape-capture bigeminy in a dog J Am Vet Med Assoc - November 15,
  • Joshua A Stern: Platelet activation and clopidogrel effects on ADP-induced platelet activation in cats with or without the A31P mutation in MYBPC3 2016 Li RHL, Stern JA, Ho V, Tablin F, Harris SP Platelet activation and clopidogrel effects on ADP-induced platelet activation in cats with or without the A31P mutation in MYBPC3 J Vet Intern Med - September,
  • Joshua A Stern: Single-energy computed tomography-based pulmonary perfusion imaging: Proof-of-principle in a canine model 2016 Yamamoto T, Kent MS, Wisner ER, Johnson LR, Stern JA, Qi L, Fujita Y, Boone JM Single-energy computed tomography-based pulmonary perfusion imaging: Proof-of-principle in a canine model Med Phys - July,
  • Joshua A Stern: Effects of 0.5% timolol maleate ophthalmic solution on heart rate and selected echocardiographic indices in apparently healthy cats 2016 Gunther-Harrington CT, Ontiveros ES, TE Hodge TE, Visser LC, Stern JA Effects of 0.5% timolol maleate ophthalmic solution on heart rate and selected echocardiographic indices in apparently healthy cats J Vet Intern Med - May,
  • Joshua A Stern: Diagnostic value of right pulmonary artery distensibility index in dogs with pulmonary hypertension: comparison with Doppler echocardiographic estimates of pulmonary arterial pressure 2016 Visser LC, Im MK, Johnson LR, Stern JA Diagnostic value of right pulmonary artery distensibility index in dogs with pulmonary hypertension: comparison with Doppler echocardiographic estimates of pulmonary arterial pressure J Vet Intern Med - March-April,
  • Joshua A Stern: The A31P missense mutation in cardiac myosin binding protein C alters protein structure but does not cause haploinsufficiency 2016 van Dijk SJ, Bezold Kooiker K, Mazzalupo SM, Yang Y, Kostyukova AS, Mustacich DJ, Hoye ER, Stern JA, Kittleson MD, Harris SP The A31P missense mutation in cardiac myosin binding protein C alters protein structure but does not cause haploinsufficiency Arch Biochem Biophys - July 1,
  • Joshua A Stern: Antemortem screening for left ventricular hypertrophy in Rhesus Macaques (Macaca mulatta). 2016 Haertel AJ, Stern JA, Reader JR, Spinner A, Roberts JA, Christe KL Antemortem screening for left ventricular hypertrophy in Rhesus Macaques (Macaca mulatta). Comp Med - August,

Most Recent 5 Book Chapters

2017 Meurs KM, Stern JA: Chapter 252: Myocardial disease: Canine, Ettinger SJ, Feldman EC, Cote E, (ed), Textbook of Veterinary Internal Medicine, Eighth Edition, St. Louis, MO. 1269-77.

2017 Meurs KM, Stern JA: Chapter 4: Clinical genomics, Ettinger SJ, Feldman EC, Cote E, (ed), Textbook of Veterinary Internal Medicine, Eighth Edition, St. Louis, MO. 27-31.

2017 Stern JA, Meurs KM: Chapter 3: Basic genetics, Ettinger SJ, Feldman EC, Cote E, (ed), Textbook of Veterinary Internal Medicine, Eighth Edition, St. Louis, MO. 25-6.

2015 Stern JA: Aortic stenosis (Expanded topic), Tilley LP, Smith FWK, (ed), Blackwell's Five-minute Veterinary Consult: Canine & Feline; Sixth Edition, Hoboken. 104-6.