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Photo: Joshua A Stern

Joshua A Stern- BS, DVM, PhD, Diplomate ACVIM (Cardiology)
Assistant Professor
Medicine & Epidemiology

CCAH Room 258
Davis, CA 95616

+1 530 752 2475
jstern@ucdavis.edu

   

Research Focus

Cardiac genetics and cardiac pharmacogenomics are the principal foci of my research. Specifically, mutation identification and subsequent evaluation of the role that these mutations play in the development of congenital heart disease as well as their effects on response to medical therapy. One of my research goals is to further propel the role of individualized medicine in veterinary cardiology patients. Additionally I am dedicated to the development of large animal models of human heart disease such as hypertrophic cardiomyopathy.

Education

2003 BS Agriculture; Animal Science, The Ohio State University, Columbus, Ohio
2008 DVM , The Ohio State University, Columbus, Ohio
2009 , The Ohio State University, College of Veterinary Medicine, Columbus, Ohio
2011 , Washington State University, College of Veterinary Medicine, Pullman, Washington
2012 , North Carolina State University, College of Veterinary Medicine, Raleigh, North Carolina
2013 PhD Veterinary Cardiac Genetics Laboratory, Washington State University, Pullman, Washington

Honors and Awards

2011 Jessie Scholarship for Veterinary Cardiology and Neurology
2010 Dr. Lynn A George Endowed Memorial Scholarship for Research
2009 Morris Animal Foundation - Pfizer Animal Health Fellowship
2007 Sam Segall Small Animal Medicine Scholarship
2007 College of Veterinary Medicine (OCUCVM) Research Day Award Winner
2006 Sam Segall Small Animal Medicine Scholarship
2005 OSUCVM Summer Research Stipend Award
2004 Columbus Academy of Veterinary Medicine Scholarship
2003 Ohio Academic Scholarship
2002 Ohio Academic Scholarship
2001 Ohio Academic Scholarship

Licenses

State of Ohio Veterinary Medical Licensure #9330
USDA APHIS National Veterinary Accreditation
Specialty Board Certification - American College of Veterinary Internal Medicine (Cardiology)
State of California Veterinary Medical Licensure #20664

Active Research Grants

Co-Investigator, Identification of genetic modifiers that impact clinical expression of arrhythmogenic right ventricular cardiomyopathy in the Boxer dog, (Principal Investigator), American Kennel Club, Canine Health Foundation

Co-Investigator, Effect of angiotensin converting enzyme (ACE) gene polymorphisms on ACE activity before and after CE inhibition in dogs with mitral valve disease, (Principal Investigator), Morris Animal Foundation

Principal Investigator, An individualized medicine investigation into a Phosphodiesterase-5A gene polymorphism and its effects on the canine response to sildenafil therapy for severe pulmonary hypertension, (Principal Investigator), American Kennel Club, Canine Health Foundation

Co-Investigator, A prospective, genetic evaluation of spontaneous chronic corneal epithelial defects (indolent ulcers) in the boxer dog utilizing a genomic wide association analysis, (Principal Investigator), American Kennel Club, Canine Health Foundation

Co-Principal Investigator, Genetic modifiers of subvalvular aortic stenosis in the Dogue de Bordeaux, (Principal Investigator), UC Davis Center for Companion Animal Health Resident Research Grant

Co-Investigator, Whole genome sequencing for great dane dilated cardiomyopathy, (Principal Investigator), American Kennel Club, Canine Health Foundation

Principal Investigator, Genetic investigation of mitral valve degeneration in whippets, (Principal Investigator), UC Davis Center for Companion Animal Health

Principal Investigator, Identification and impact of exercise-induced cardiac fatigue in racing Thoroughbreds: a pre and post race investigation into presence of exercise induced systolic dysfunction, cardiac dysrhythmias and cardiac biomarker derangements, (Principal Investigator), Davis Marcia MacDonald Rivas Grant

Co-Principal Investigator, Genetic analysis of ectopic ureters in dogs, (Principal Investigator), UC Davis Center for Companion Animal Health

Co-Investigator, Whole genome sequencing for feline hypertrophic cardiomyopathy mutations : Determining the molecular basis of disease, (Principal Investigator), Morris Animal Foundation

Co-Principal Investigator, ACTG Canine whole genome sequencing grant for inherited disease, (Principal Investigator), BGI Signature Research in Genomics Grant

Principal Investigator, Next generation sequencing to identify novel genetic causes of feline hypertrophic cardiomyopathy, (Principal Investigator), BGI Signature Research in Genomics Grant

Principal Investigator, Identification of genetic variants associated with myxomatous mitral valve degeneration in the Whippet dog through whole-genome sequencing, (Principal Investigator), American Kennel Club Canine Health Foundation

Most Recent 10 Publications

  • Link Icon 2014 Reina Doreste Y, Stern JA, Keene BW, Tou SP, Atkins CE, DeFrancesco TC, Ames MK, Hodge TE, Meurs KM Case-control study of the effects of pimobendan on survival time in cats with hypertrophic cardiomyopathy and congestive heart failure J Am Vet Med Assoc,
  • Link Icon 2014 Costa AP, Lahmers SM, Barry AL, Stanton J, Stern JA Fungal pericarditis and endocarditis secondary to porcupine quill migration in a dog J Vet Cardiol,
  • Link Icon 2014 Stern JA, Reina-Doreste Y, Chdid L, Meurs KM Identification of PDE5A:E90K: a polymorphism in the canine phosphodiesterase 5A gene affecting basal cGMP concentrations of healthy dogs. J Vet Intern Med,
  • Link Icon 2014 Stern JA, White SN, Lehmkuhl, LB, Reina-Doreste Y, Ferguson, JL, Nascone-Yoder NM, Meurs KM A single codon insertion in PICALM is associated with development of familial subvalvular aortic stenosis in Newfoundland dogs. Hum Genet,
  • Link Icon 2014 Meurs KM, Stern JA, Reina-Doreste Y, Spier AW, Koplitz SL, Baumwart RD Natural history of arrhythmogenic right ventricular cardiomyopathy in the boxer dog: A prospective study J Vet Intern Med,
  • Link Icon 2013 Stern JA, White SN, Meurs KM Extent of linkage disequilibrium in large-breed dogs: chromosomal and breed variation. Mamm Genome,
  • Link Icon 2013 Stern JA, Tou SP, Barker PC, Hill KD, Lodge AJ, Mathews KG, Keene BW Hybrid cutting balloon dilatation for treatment of cor triatriatum sinister in a cat J Vet Cardiol,
  • Link Icon 2013 Meurs KM, Stern JA, Kittleson MD, Sisson D, Ames MK, Atkins CE, DeFrancesco T, Hodge TE, Keene BW, Reina Doreste Y, Leuthy M, Mostinger-Reif AA, Tou SP Association of dilated cardiomyopathy with the striatin mutation genotype in boxer dogs J Vet Int Med,
  • Link Icon 2013 Stern JA, Hinchcliff KW, Constable PD Effect of body position on electrocardiographic recordings in dogs Aust Vet J,
  • Link Icon 2013 Doreste YR, Stern JA, Lahmers SM ECG of the Month: Supraventricular tachycardia with 2:1 atrioventricular conduction and paroxysmal ventricular bigeminy in a syncopal cat J Am Vet Med Assoc,