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Photo: Lark L A Coffey

Lark L A Coffey
Assistant Professor and Researcher
Pathology, Microbiology & Immunology

1 Shields Ave
Davis, CA 95616

+1 530 752 2946
lcoffey@ucdavis.edu

   

Research Focus

Mosquito-borne virus ecology, evolution and emergence

My research seeks to define patterns of mosquito-borne virus ecology and evolution so that shared features can be exploited to prevent emergence and mitigate disease in humans and animals.

Specialty Focus

Genetics of mosquito-borne viruses

Transmission dynamics of mosquito-borne viruses

Surveillance of mosquito-borne viruses

Alphaviruses, flaviviruses

RNA virus evolution

Education

2000 B.S. Biology, University of the South, Sewanee, Tennessee
2005 Ph.D. Experimental Pathology, University of Texas Medical Branch, Galveston, Texas
2011 Virology, Institut Pasteur, Paris, France
2013 Virus Discovery, Blood Systems Research Institute/University of California San Francisco, California, San Francisco, California
2014 Arbovirus ecology, evolution and genetics, University of California, Davis, Davis, California
2016 Arbovirus ecology, evolution and genetics, University of California, Davis, Davis, California

Honors and Awards

2007-2009 Sigma Xi Scientific Honor Society
2005-2008 Philippe Foundation International Scholar, Institut Pasteur, Paris, France
2005 Zhou Sisters Academic Scholarship, University of Texas Medical Branch, Galveston, TX
2002 Bodhan Nechay Academic Scholarship; University of Texas Medical Branch, Galveston, TX

Licenses

UC Davis Biomedical and Engineering Entrepreneurship Academy Graduate

Active Research Grants

Principal Investigator, New methods to detect arbovirus RNA in mosquito saliva, (Principal Investigator), Sandia Corporation/Defense Threat Reduction Agency Subcontract

Principal Investigator, Exploiting sugar feeding to improve mosquito-borne virus surveillance?, (Principal Investigator), Mosquito Research Foundation

Principal Investigator, Sugar baited detection and a field-deployable diagnostic for improved arbovirus surveillance in Coachella Valley, (Principal Investigator), Coachella Valley Mosquito and Vector Control Association

Principal Investigator, Development of a nonhuman primate model of Zika virus infection , (Principal Investigator), California National Primate Research Center

Principal Investigator, Viral genetic determinants of enhanced Zika virus transmission, (Principal Investigator), UC Davis School of Veterinary Medicine Vector Borne Disease Pilot Grant

Principal Investigator, Engineering high fidelity mutations to increase safety of live-attenuated alphavirus vaccines , (Principal Investigator), NIH NIAID

Principal Investigator, Transmissibility of Zika virus by Californian mosquitoes, (Principal Investigator), Coachella Mosquito and Vector Control District Emergency Zika virus Personnel Funds

Principal Investigator, Transmissibility of Zika virus by North American mosquitoes, (Principal Investigator), Abt Associates

Co-Investigator, Characterization of blood transfusion-transmission of Zika virus in macaques, Graham Simmons, Blood Systems Research Institute/UCSF (Principal Investigator), NIH NHLBI extension of Recipient Epidemiology and Donor Evaluation Study-III

Principal Investigator, Tissue distribution of Zika virus in rhesus macaques, (Principal Investigator), Department of Health and Human Services Food and Drug Administration

Co-Investigator, Macaque model of Zika virus infection, Koen Van Rompay (Principal Investigator), NIH NIAID

Most Recent 10 Publications

  • Lark L A Coffey: West Nile Virus fitness costs in different mosquito species 2016 Coffey LL, Reisen WK West Nile Virus fitness costs in different mosquito species Trends Microbiol,
  • Lark L A Coffey: Reemergence of St. Louis Encephalitis Virus, California, 2016 White GS, Symmes K, Sun P, Fang Y, Garcia S, Steiner C, Smith K, Reisen WK, and Coffey LL. Reemergence of St. Louis Encephalitis Virus, California, Emerging Infectious Diseases,
  • Lark L A Coffey: Quenching of unincorporated amplification signal reporters in reverse-transcription loop-mediated isothermal amplification enabling bright, single-step, closed-tube, and multiplexed detection of RNA viruses 2016 Ball CS, Light YK, Koh CY, Wheeler SS, Coffey LL, Meagher RJ Quenching of unincorporated amplification signal reporters in reverse-transcription loop-mediated isothermal amplification enabling bright, single-step, closed-tube, and multiplexed detection of RNA viruses Anal Chem,
  • Lark L A Coffey: Reorganization and expansion of the nidoviral family Arteriviridae 2016 Kuhn JH, Lauck M, Bailey AL, Shchetinin AM, Vishnevskaya TV, Bào Y, Ng TF, LeBreton M, Schneider BS, Gillis A, Tamoufe U, Diffo Jle D, Takuo JM, Kondov NO, Coffey LL, Wolfe ND, Delwart E, Clawson AN, Postnikova E, Bollinger L, Lackemeyer MG, Radoshitzky SR, Palacios G, Wada J, Shevtsova ZV, Jahrling PB, Lapin BA, Deriabin PG, Dunowska M, Alkhovsky SV, Rogers J, Friedrich TC, O'Connor DH, Goldberg TL Reorganization and expansion of the nidoviral family Arteriviridae Arch Virol,
  • Lark L A Coffey: Surveillance for Western Equine Encephalitis, St. Louis Encephalitis, and West Nile Viruses using reverse transcription loop-mediated isothermal amplification 2016 Wheeler SS, Ball CS, Langevin SA, Fang Y, Coffey LL, Meagher RJ Surveillance for Western Equine Encephalitis, St. Louis Encephalitis, and West Nile Viruses using reverse transcription loop-mediated isothermal amplification PLoS One,
  • Lark L A Coffey: Chikungunya virus–Vector interactions 2014 Coffey LL, Failloux AB, Weaver SC. Chikungunya virus–Vector interactions Viruses,
  • Lark L A Coffey: Arboviral bottlenecks and challenges to maintaining diversity and fitness during mosquito transmission 2014 Forrester NL Coffey LL, Weaver SC Arboviral bottlenecks and challenges to maintaining diversity and fitness during mosquito transmission Viruses,
  • Lark L A Coffey: Emergence and transmission of arbovirus evolutionary intermediates with epidemic potential 2014 Stapleford KA, Coffey LL, Lay S, Duong V, Isakov O, Blanc H, Borderia A, Beaucourt S, Haliloglu T, Schmitt C, Bonne I, Tal NB, Shomron N, Failloux AB, Buchy P, Vignuzzi M Emergence and transmission of arbovirus evolutionary intermediates with epidemic potential Cell, Host and Microbe,
  • Lark L A Coffey: Enhanced arbovirus surveillance with deep sequencing: Identification of novel rhabdoviruses and bunyaviruses in Australian mosquitoes. 2014 Coffey LL, Page BL, Greninger AL, Herring BL, Russell RC, Doggett SL, Haniotis J, Wang C, Deng X, Delwart EL Enhanced arbovirus surveillance with deep sequencing: Identification of novel rhabdoviruses and bunyaviruses in Australian mosquitoes. Virology,
  • Lark L A Coffey: The perils of pathogen discovery: origin of a novel parvovirus-like hybrid genome traced to nucleic acid extraction spin columns. 2013 Naccache SN, Greninger AL, Lee D, Coffey LL, Phan T, Rein-Weston A, Aronsohn A, Hackett J, Delwart EL, Chiu CY The perils of pathogen discovery: origin of a novel parvovirus-like hybrid genome traced to nucleic acid extraction spin columns. J Virol,

Most Recent 5 Book Chapters

2016 Coffey L: The Nature of Viruses, MacLachlan, NJ, Dubai, EJ, (ed), Fenner’s Veterinary Virology, London. 13-16.

2016 Coffey LL, Weaver SC, Forrester N: Alphavirus Evolution, , Alphaviruses: Molecular Biology, Pathogenesis and Host Interactions. 21-26.

2016 Forrester NL, Gutierrez S, Coffey LL: The Evolution and Transmission of Vector-Borne Viruses, Weaver, Denison, Roossinck, Vignuzzi, (ed), Virus Evolution: Current Research and Future Directions. 61-100.

2008 Coffey LL: Togaviruses not associated with human disease, Mahy B, Van Regenmortel M, (ed), Encyclopedia of Virology, 3rd Edition, Oxford. 91-6.

2004 Weaver SC, Coffey LL, Nussenzveig R, Ortiz D, Smith D: Vector Competence, Gillespie SH, Smith GL, Osbourn A, (ed), Vector Competence, Cambridge. 139-80.

External Links

Lab Website