Dallas Hyde- BA, MS, PhD
+1 530 752 0420
My research is focused on airways epithelial and inflammatory/immune cell interaction. Interaction of these cells maintains homeostasis (ability to combat infectious disease, removal and/or repair of injured cells) in the lung. My laboratory is interested in asthma, pulmonary fibrosis and chronic obstructive lung disease as models for investigation. My current investigations are in the asthma model and its exacerbation by the oxidant air pollutant ozone. I am investigating how perturbation of the airway and parenchymal epithelium influences remodeling of the underlying interstitium which in turn influences the epithelium in an interactive epithelial-mesenchymal trophic unit (EMTU). My goal is to define the critical cytokines produced by the epithelium required to maintain homeostasis in the EMTU and prevent airways and parenchymal remodeling that lead to altered lung function.
Stereology, Inflammation, Airway structure and function, Lung parenchyma structure and function
1971 BA Biological Sciences, University of California at Irvine, Irvine, CA
Honors and Awards
1974-1976 Fellow, Walter Foster Foundation, SVM, Department of Anatomy, University of California, Davis
Active Research Grants
Co-Investigator, Training in Comparative Lung Biology and Medicine, Reen Wu (Principal Investigator), NIH/NHLBI
Co-Investigator, Postdoctoral Training in Environmental Pathology, Dennis Wilson (Principal Investigator), NIH/NIEHS
Co-Investigator, Advanced Training Environmental Health Sciences, Robert Rice (Principal Investigator), NIH/NIEHS
Co-Investigator, Comparative Medical Science Training Program, Stephen Barthold (Principal Investigator), NIH/NCRR
Principal Investigator, Pulmonary Effects of Environmental Oxidant Pollutants, (Principal Investigator), NIH/NIEHS
Principal Investigator, AARA Supplement - Translational - California National Primate Research Center, (Principal Investigator), NIH/NCRR
Co-Investigator, Roles of IL-17-induced gene expression in airway epithelial host defense, Reen Wu (Principal Investigator), National Institutes of Health
Most Recent 10 Publications
Most Recent 5 Book Chapters
2008 Plopper CG, Smiley-Jewell SM, Miller LA, Fanucchi MV, Evans MJ, Buckpitt AR, Avdalovic M, Gershwin LJ, Joad JP, Kajekar R, Larson S, Pinkerton KE, Van Winkle LS, Schelegle ES, Pieczarka EM, Wu R, Hyde DM: Primate Models of Allergic Asthma, Kay AB, Kaplan AP, Bousquet J, Holt PG, (ed), Allergy and Allergic Diseases, Second Edition, London. 1185-1201.
2008 Hyde DM, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdalovic MV, Evans MJ, Kajekar R, Buckpitt AR, Pinkerton KE, Joad JP, Gershwin LJ, Wu R, Plopper CG: Chronic Airway Disease in Nonhuman Primates, N. F. Voelkel and W. MacNee, (ed), Chronic Obstructive Lung Diseases, Hamilton. 235-268.
2005 Albertine KH, Williams MC, Hyde DM: Anatomy and Development of the Respiratory Tract, Mason RJ, Broaddus VC, Murray JF, Nadel JA, (ed), Murray and Nadel's Textbook of Respiratory Medicine, Philadelphia. 3-41.
2001 Plopper CG, Paige R, Schelegle ES, Buckpitt A, Wong V, Tarkington B, Putney L, Hyde DM: Time-response profiles: Implications for injury, repair, and adaptation to ozone, U. Heinrich and U. Mohr, (ed), Relationships Between Acute and Chronic Effects of Air Pollution, Washington, DC. 23-37.
2001 Pinkerton KE, Murphy KM, Hyde DM: Morphology and morphometry of the lung, U. Mohr, W.W. Carlton, D.L. Dungworth, S.A. Benjamin, C.C. Capen and F.F. Hahn, (ed), Pathobiology of the Aging Dog, Ames, IA. 43-56.