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Dallas M Hyde- BA, MS, PhD
Professor Emeritus
Anatomy, Physiology & Cell Biology


Research Focus

My research is focused on airways epithelial and inflammatory/immune cell interaction. Interaction of these cells maintains homeostasis (ability to combat infectious disease, removal and/or repair of injured cells) in the lung. My laboratory is interested in asthma, pulmonary fibrosis and chronic obstructive lung disease as models for investigation. My current investigations are in the asthma model and its exacerbation by the oxidant air pollutant ozone. I am investigating how perturbation of the airway and parenchymal epithelium influences remodeling of the underlying interstitium which in turn influences the epithelium in an interactive epithelial-mesenchymal trophic unit (EMTU). My goal is to define the critical cytokines produced by the epithelium required to maintain homeostasis in the EMTU and prevent airways and parenchymal remodeling that lead to altered lung function.

Specialty Focus

Stereology, Inflammation, Airway structure and function, Lung parenchyma structure and function


1971 BA Biological Sciences, University of California at Irvine, Irvine, CA
1972 MS Biology, Whittier College, Whittier, CA
1976 PhD Anatomy, University of California at Davis, Davis, CA

Honors and Awards

2011 Fellow of the American Association of Anatomists
2010 Distinguished Professor
2009 Outstanding Veterinary Anatomist Award, American Association of Veterinary Anatomists
1999 Pfizer Award for Research Excellence, School of Veterinary Medicine, University of California, Davis
1985-1986 National Research Service Award Senior Fellowship, NIH, National Jewish Hospital Denver, Colorado
1979 Teaching of the Yeard Award given by the Class of 1982, University of Florida
1978 Teaching Award of Appreciation for Musculoskeletal System for Veterinary Class of 1981, University of Florida
1974-1976 Fellow, Walter Foster Foundation, SVM, Department of Anatomy, University of California, Davis

Active Research Grants

Co-Investigator, Training in Comparative Lung Biology and Medicine, Reen Wu (Principal Investigator), NIH/NHLBI

Co-Investigator, Postdoctoral Training in Environmental Pathology, Dennis Wilson (Principal Investigator), NIH/NIEHS

Co-Investigator, Advanced Training Environmental Health Sciences, Robert Rice (Principal Investigator), NIH/NIEHS

Co-Investigator, Comparative Medical Science Training Program, Stephen Barthold (Principal Investigator), NIH/NCRR

Principal Investigator, Pulmonary Effects of Environmental Oxidant Pollutants, (Principal Investigator), NIH/NIEHS

Principal Investigator, AARA Supplement - Translational - California National Primate Research Center, (Principal Investigator), NIH/NCRR

Co-Investigator, Roles of IL-17-induced gene expression in airway epithelial host defense, Reen Wu (Principal Investigator), National Institutes of Health

Most Recent 10 Publications

  • Link Icon 2013 Herring MJ, Avdalovic MV, Quesenberry CL, Putney LF, Tyler NK, Ventimiglia FF, St George JA, Hyde DM Accelerated structural decrements in the aging female rhesus macaque lung compared with males American journal of physiology. Lung cellular and molecular physiology,
  • Link Icon 2012 Murphy SR, Schelegle ES, Edwards PC, Miller LA, Hyde DM, Van Winkle LS Postnatal exposure history and airways: oxidant stress responses in airway explants American journal of respiratory cell and molecular biology,
  • Link Icon 2012 Wongtrakool C, Wang N, Hyde DM, Roman J, Spindel ER Prenatal nicotine exposure alters lung function and airway geometry through a7 nicotinic receptors American journal of respiratory cell and molecular biology,
  • Link Icon 2012 Lara AR, Cosgrove GP, Janssen WJ, Huie TJ, Burnham EL, Heinz DE, Curran-Everett D, Sahin H, Schwarz MI, Cool CD, Groshong SD, Geraci MW, Tuder RM, Hyde DM, Henson PM Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and nonspecific interstitial pneumonia Chest,
  • Link Icon 2012 Moore BD, Hyde D, Miller L, Wong E, Frelinger J, Schelegle ES Allergen and ozone exacerbate serotonin-induced increases in airway smooth muscle contraction in a model of childhood asthma Respiration; international review of thoracic diseases,
  • Link Icon 2012 Carey SA, Plopper CG, Hyde DM, Islam Z, Pestka JJ, Harkema JR Satratoxin-G from the black mold Stachybotrys chartarum induces rhinitis and apoptosis of olfactory sensory neurons in the nasal airways of rhesus monkeys. Toxicologic pathology,
  • Link Icon 2012 Avdalovic MV, Tyler NK, Putney L, Nishio SJ, Quesenberry S, Singh PJ, Miller LA, Schelegle ES, Plopper CG, Vu T, Hyde DM Ozone exposure during the early postnatal period alters the timing and pattern of alveolar growth and development in nonhuman primates Anatomical record (Hoboken, N.J. : 2007),
  • Link Icon 2012 Plopper CG, Joad JP, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdalovic MV, Evans MJ, Lasley WL, Buckpitt AR, Pinkerton KE, Tarkington BK, Davis S, Nishio SJ, Gershwin LJ, Wu R, Hyde DM Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology,
  • Link Icon 2012 Tam S, Maksaereekul S, Hyde DM, Godinez I, Beaman BL IL-17 and ?d T-lymphocytes play a critical role in innate immunity against Nocardia asteroides GUH-2 Microbes and infection / Institut Pasteur,
  • Link Icon 2012 Schuler R, Smith DE, Kumaraguruparan G, Chervenak A, Lewis AD, Hyde DM, Kesselman C A flexible, open, decentralized system for digital pathology networks Studies in health technology and informatics,

Most Recent 5 Book Chapters

2008 Plopper CG, Smiley-Jewell SM, Miller LA, Fanucchi MV, Evans MJ, Buckpitt AR, Avdalovic M, Gershwin LJ, Joad JP, Kajekar R, Larson S, Pinkerton KE, Van Winkle LS, Schelegle ES, Pieczarka EM, Wu R, Hyde DM: Primate Models of Allergic Asthma, Kay AB, Kaplan AP, Bousquet J, Holt PG, (ed), Allergy and Allergic Diseases, Second Edition, London. 1185-1201.

2008 Hyde DM, Miller LA, Schelegle ES, Fanucchi MV, Van Winkle LS, Tyler NK, Avdalovic MV, Evans MJ, Kajekar R, Buckpitt AR, Pinkerton KE, Joad JP, Gershwin LJ, Wu R, Plopper CG: Chronic Airway Disease in Nonhuman Primates, N. F. Voelkel and W. MacNee, (ed), Chronic Obstructive Lung Diseases, Hamilton. 235-268.

2005 Albertine KH, Williams MC, Hyde DM: Anatomy and Development of the Respiratory Tract, Mason RJ, Broaddus VC, Murray JF, Nadel JA, (ed), Murray and Nadel's Textbook of Respiratory Medicine, Philadelphia. 3-41.

2001 Plopper CG, Paige R, Schelegle ES, Buckpitt A, Wong V, Tarkington B, Putney L, Hyde DM: Time-response profiles: Implications for injury, repair, and adaptation to ozone, U. Heinrich and U. Mohr, (ed), Relationships Between Acute and Chronic Effects of Air Pollution, Washington, DC. 23-37.

2001 Pinkerton KE, Murphy KM, Hyde DM: Morphology and morphometry of the lung, U. Mohr, W.W. Carlton, D.L. Dungworth, S.A. Benjamin, C.C. Capen and F.F. Hahn, (ed), Pathobiology of the Aging Dog, Ames, IA. 43-56.