Griffiths Cardiovascular Research Laboratory



Mesenchymal Stem Cell Seeding of Porcine Small Intestinal Submucosal Extracellular Matrix for Cardiovascular Applications.
Chang CW, Petrie T, Clark A, Lin X, Sondergaard CS, Griffiths LG
PLoS One. 2016 Apr 12;11(4):e0153412. doi10.1371/journal.pone.0153412. eCollection 2016.

Cardiac extracellular matrix proteomics: Challenges, techniques, and clinical implications.
Chang CW, Dalgliesh AJ, Lopez JE, Griffiths LG
Proteomics Clin Appl. 2016 Jan;10(1):39-50. doi: 10.1002/prca.201500030. Epub 2015 Sep 25.
PMID: 26200932

Companion animals: Translational scientist's new best friends.
Kol A, Arzi B, Athanasiou KA, Farmer DL, Nolta JA, Rebhun RB, Chen X, Griffiths LG, Verstraete FJ, Murphy CJ, Borjesson DL.
Sci Transl Med. 2015 Oct 7;7(308):308ps21. doi: 10.1126/scitranslmed.aaa9116.
PMID: 26446953

Cardiac Extracellular Matrix Scaffold Generated Using Sarcomeric Disassembly and Antigen Removal.
Papalamprou A, Griffiths LG.
Ann Biomed Eng. 2015 July 28 (Epub ahead of print).
PMID: 26215309

Embolization of the first diagonical branch of the left anterior descending coronary artery as a porcine model of chronic trans-mural myocardial infarction.
Hanes DW, Wong ML, Chang CW, Humphrey S, Grayson JK, Boyd WD, Griffiths LG. 
J Transl Med. 2015 Jun 6;13:187. doi: 10.1186/s12967-015-0547-4.
PMID: 26047812

Antigen removal for the production of biomechanically functional, xenogeneic tissue grafts.
Cissell DD, Hu JC, Griffiths LG, Athanasiou KA.
J Biomech. 2014 Jun 27;47(9):1987-96.doi: 10.1016/j.jbiomech.2013.10.041. Epub 2013 Nov 8.
PMID: 24268315

Remineralized bone matrix as a scaffold for bone tissue engineering.
Soicher MA, Christiansen BA, Stover SM, Leach JK, Yellowley CE, Griffiths LG, Fyhrie DP.
J Biomed Mater Res A. 2014 Feb 26.
doi: 10.1002/jbm.a.35118. [Epub ahead of print]
PMID: 24616346

Immunogenicity in xenogeneic scaffold generation: antigen removal vs. decellularization.
Wong ML, Griffiths LG.
Acta Biomater. 2014 May;10(5):1806-16.
doi: 10.1016/j.actbio.2014.01.028. Epub 2014 Jan 31.
PMID: 24486910

Stepwise solubilization-based antigen removal for xenogeneic scaffold generation in tissue engineering.
Wong ML, Wong JL, Athanasiou KA, Griffiths LG.
Acta Biomater. 2013 May;9(5):6492-501. doi: 10.1016/j.actbio.2012.12.034. Epub 2013 Jan 12.
PMID: 23321301 [PubMed – indexed for MEDLINE]

The role of protein solubilization in antigen removal from xenogeneic tissue for heart valve tissue engineering.
Wong ML, Leach JK, Athanasiou KA, Griffiths LG.
Biomaterials. 2011 Nov;32(32):8129-38. doi: 10.1016/j.biomaterials.2011.07.030. Epub 2011 Jul 31.
PMID: 21810537 [PubMed - indexed for MEDLINE]

Protein extraction and 2-DE of water- and lipid-soluble proteins from bovine pericardium, a low-cellularity tissue.
Griffiths LG, Choe L, Lee KH, Reardon KF, Orton EC.
Electrophoresis. 2008 Nov;29(22):4508-15. doi: 10.1002/elps.200800108.
PMID: 18985661 [PubMed - indexed for MEDLINE] Free PMC Article

Immunoproteomic identification of bovine pericardium xenoantigens.
Griffiths LG, Choe LH, Reardon KF, Dow SW, Christopher Orton E.
Biomaterials. 2008 Sep;29(26):3514-20. doi: 10.1016/j.biomaterials.2008.05.006. Epub 2008 Jun 2.
PMID: 18514307 [PubMed - indexed for MEDLINE] Free PMC Article

Decellularization of bovine pericardium for tissue-engineering by targeted removal of xenoantigens.
Alves AC, Griffiths LG, Anthony RV, Orton EC.
J Heart Valve Dis. 2005 Mar;14(2):212-7.
PMID: 15792182 [PubMed - indexed for MEDLINE]


Effect of Stepwise, Solubilization-Based Antigen Removal on In Vivo Immune Response to Xenogeneic Scaffolds

CMBE 2013

Stepwise, Solubilization-Based Antigen Removal for Maintained Xenogeneic Scaffold Properties

BMES 2012

poster poster

Sequential, Differential Solubilization for Antigen Removal in Xenogeneic Scaffold Generation


Effect of Chaotropes on Antigen Removal in Xenogeneic Scaffold Generation


poster poster

Protein Solubilization for Antigen Removal from Bovine Pericardium in Heart Valve Tissue Engineering

BMES 2010

Maintained Protein Solubility Enhances Antigen Removal from Xenogeneic Tissue for Heart Valve Tissue Engineering



termis 2010 poster

Antigen Removal for the Production of Immunoacceptable Xenogeneic Scaffolds for Myocardial Patch Tissue Engineering

BMES 2013

Engineering Adult and Neonatal Cardiad Myocardial Patches


bmes sept nihcrmcsept2013jc

Characterization of Porcine SIS ECM Seeded with Human MSCs for Cardiac Tissue Engineering


The Effect of Antigen Removal on Lymphocyte Responses Toward Xenogeneic Rat Myocardium

STAR 2014

termis_2013_jc poster

Mechanistic analysis of lymphocyte responses toward native and antigen-removed xenogeneic myocardium

BMES 2015

Magnesium Presence Prevents Removal of Nuclear-Associated Protein Antigens from Bovine Pericardium for Heart Valve Engineering

BMES 2015

bmes2015_kvg bmes2015_ajd

Immunoproteomic Identification of Antigens Utilizing Affinity Chromatography





Aortic thrombosis in dogs: 31 cases (2000-2010).
Lake-Bakaar GA, Johnson EG, Griffiths LG.
J Am Vet Med Assoc. 2012 Oct 1;241(7):910-5.
PMID: 23013504 [PubMed - in process]

Aortopulmonary window characterized with two- and three-dimensional echocardiogram in a dog.
Jung S, Orvalho J, Griffiths LG.
J Vet Cardiol. 2012;14(2):371-5. doi: 10.1016/j.jvc.2011.10.004. Epub 2012 May 18.
PMID: 22609088 [PubMed - indexed for MEDLINE]

Occlusion devices and approaches in canine patent ductus arteriosus: comparison of outcomes.
Singh MK, Kittleson MD, Kass PH, Griffiths LG.
J Vet Intern Med. 2012 Jan-Feb;26(1):85-92. doi: 10.1111/j.1939-1676.2011.00859.x. Epub 2011 Dec 23.
PMID: 22211471 [PubMed - indexed for MEDLINE]

Echocardiographic assessment of interventricular and intraventricular mechanical synchrony in normal dogs.
Griffiths LG, Fransioli JR, Chigerwe M.
J Vet Cardiol. 2011 Jun;13(2):115-26. doi: 10.1016/j.jvc.2011.02.001. Epub 2011 Jun 8.
PMID: 21641290 [PubMed - indexed for MEDLINE]

Bioprosthesis valve replacement in dogs with congenital tricuspid valve dysplasia: technique and outcome.
Arai S, Griffiths LG, Mama K, Hackett TB, Monnet E, Boon JA, Carter L, Orton EC.
J Vet Cardiol. 2011 Jun;13(2):91-9. doi: 10.1016/j.jvc.2010.12.002. Epub 2011 Jun 2.
PMID: 21640677 [PubMed - indexed for MEDLINE]

ECG of the Month. Atrial fibrillation.
Jung S, Griffiths LG.
J Am Vet Med Assoc. 2011 May 15;238(10):1258-60. doi: 10.2460/javma.238.10.1258. No abstract available.
PMID: 21568768 [PubMed - indexed for MEDLINE]

Transvenous occlusion of patent ductus arteriosus in 56 consecutive dogs.
Blossom JE, Bright JM, Griffiths LG.
J Vet Cardiol. 2010 Aug;12(2):75-84. doi: 10.1016/j.jvc.2010.04.002. Epub 2010 Jul 1.
PMID: 20594928 [PubMed - indexed for MEDLINE]

Surgery for cardiac disease in small animals: current techniques.
Griffiths LG.
Vet Clin North Am Small Anim Pract. 2010 Jul;40(4):605-22. doi: 10.1016/j.cvsm.2010.04.001. Review.
PMID: 20610014 [PubMed - indexed for MEDLINE]

Transcatheter intravascular stent placement to relieve supravalvular pulmonic stenosis.
Griffiths LG, Bright JM, Chan KC.
J Vet Cardiol. 2006 Nov;8(2):145-55. doi: 10.1016/j.jvc.2006.01.004. Epub 2006 Oct 2.
PMID: 19083348 [PubMed]

Evaluation of techniques and outcomes of mitral valve repair in dogs.
Griffiths LG, Orton EC, Boon JA.
J Am Vet Med Assoc. 2004 Jun 15;224(12):1941-5.
PMID: 15230448 [PubMed - indexed for MEDLINE]

Ultrasonography versus radiography for detection of fluid in the canine tympanic bulla.
Griffiths LG, Sullivan M, O'Neill T, Reid SW.
Vet Radiol Ultrasound. 2003 Mar-Apr;44(2):210-3.
PMID: 12718358 [PubMed - indexed for MEDLINE]

Evaluation of once daily treatment with cyclosporine for anal furunculosis in dogs.
Doust R, Griffiths LG, Sullivan M.
Vet Rec. 2003 Feb 22;152(8):225-9.
PMID: 12625536 [PubMed - indexed for MEDLINE]

A comparison of the effects of unilateral thyroarytenoid lateralization versus cricoarytenoid laryngoplasty on the area of the rima glottidis and clinical outcome in dogs with laryngeal paralysis.
Griffiths LG, Sullivan M, Reid SW.
Vet Surg. 2001 Jul-Aug;30(4):359-65.
PMID: 11443597 [PubMed - indexed for MEDLINE]

Bilateral overlapping mucosal single-pedicle flaps for correction of soft palate defects.
Griffiths LG, Sullivan M.
J Am Anim Hosp Assoc. 2001 Mar-Apr;37(2):183-6.
PMID: 11300527 [PubMed - indexed for MEDLINE]

Spontaneous laryngeal paralysis in four white-coated German shepherd dogs.
Ridyard AE, Corcoran BM, Tasker S, Willis R, Welsh EM, Demetriou JL, Griffiths LG.
J Small Anim Pract. 2000 Dec;41(12):558-61.
PMID: 11138855 [PubMed - indexed for MEDLINE]

Oropharyngeal penetrating injuries in 50 dogs: a retrospective study.
Griffiths LG, Tiruneh R, Sullivan M, Reid SW.
Vet Surg. 2000 Sep-Oct;29(5):383-8.
PMID: 10999451 [PubMed - indexed for MEDLINE]

Cyclosporin as the sole treatment for anal furunculosis: preliminary results.
Griffiths LG, Sullivan M, Borland WW.
J Small Anim Pract. 1999 Dec;40(12):569-72.
PMID: 10664953 [PubMed - indexed for MEDLINE]

Intrathoracic tracheal avulsion and pseudodiverticulum following pneumomediastinum in a cat.
Griffiths LG, Sullivan M, Lerche P.
Vet Rec. 1998 Jun 20;142(25):693-6.
PMID: 9670458 [PubMed - indexed for MEDLINE]