Research Project Information
I. General Information:
One of the requirements of the MPVM Program is the completion of an applied epidemiologic study which culminates in a written and oral report that is presented to MPVM students and faculty, usually in August of the summer following admission to the program.
The intent of the project is to develop skills in the design and conduct of field research and data analysis, and possibly to explore a new subject area. The study can be designed to uncover facts or principles, or it can involve the development of an educational or disease control program. The research report must represent a careful, systematic and creative study involving an epidemiologic topic. Over the years, research projects have focused on a variety of topics including: diseases of livestock, poultry, wildlife, companion animals, zoonoses and food safety. Data previously obtained may be used in the formulation of this study; however, a data set that has been previously analyzed is not acceptable. If you plan to use a data set from a study that you have previously done, it must be reviewed and approved beforehand by your faculty advisor.
II. Finding a Project:
You are encouraged to bring with you data gathered during previous employment. Or, you may choose to work on a project that is provided by a faculty member at UC Davis. Profiles of veterinary school faculty are available on the web at http://www.vetmed.ucdavis.edu/About_Faculty.html - you can search faculty lists by name or department. These faculty profiles will help identify faculty members who might have research programs in areas of interest to you. Specific projects that they are working on will not necessarily be listed, however.
A major source of help will be your MPVM Academic Advisor. You will be assigned an Academic Advisor soon after entry to the MPVM program, and should make an appointment to visit him/her as soon as possible. He/she will help orient you to the MPVM project, and will suggest persons with whom you can network to find an appropriate project.
More details about research projects will be provided during Fall & Winter Quarters.
III. MPVM Project Advisors:
You must have 2 MPVM project advisors, a Subject-matter advisor, and a Quantitative advisor. It is possible that your MPVM Academic Advisor can also serve as one of your project advisors.
The Subject-matter advisor should be an expert in the topic of your project. For example, a project ”Risk factors for Campyobacter infection in slaughtered hens in Chechnia” could be either an expert in Campylobacter, or poultry slaughter. He/she does not necessarily need to be an MPVM faculty member, or, at times not even a UC-Davis faculty member.
The quantitative advisor is a core MVPM faculty member with much experience in design and analysis of MPVM projects. It is especially important to involve your quantitative advisor at the start of planning for your MPVM project.
Typically, you will sign up for a total of 10 units (credits) for your project – 5 units for each project advisor, either divided between winter and spring quarters, or only in spring quarter. The CRN number for each faculty member’s 299 course is different from all other faculty members’ and changes every quarter. Obtain the CRN number from the faculty member’s departmental office.
IV. Timeline for MPVM Projects:
October-March: Consult Academic Advisor. Find suitable project and subject-matter and quantitative advisors. Begin work on project. Take advantage of courses MPM 408A and 408B (offered fall and winter quarters, respectively) to do literature review and begin writing up project. Collect data and/or collate and clean up data set in preparation for analysis.
March-April: Do data analysis and complete “Results” section
May-June: Complete first draft of project
July 1: Submit first draft of project to project advisors. Find out in advance when they will be available to review your drafts, and plan accordingly. Remember that 3 or more drafts are often necessary before your advisors are ready to sign off on (approve) your project, and you must allow at least 2 weeks for each reading.
August 7 (approximately): submit approved MPVM project to Student Programs (located in Surge IV, Room 125), according to guidelines below.
V. Guidelines for typing and submitting MPVM projects:
A typed double-spaced draft of your paper should be submitted to your advisors approximately 2 months before your presentation is scheduled. The corrected text including tables and figures should be submitted to your advisors for final corrections at least one month prior to your presentation. Your paper must be grammatically acceptable before your advisors approve it. In preparing the paper, follow precisely the style and guidelines of a journal of your choice which accepts papers similar to yours. Remember this paper should be of publishable quality.
Your paper should be typed, double-spaced with a 1-inch margin on the left and a 1-inch margin on the top, right and bottom of the page (the 1-inch left margin is necessary in order to bind the thesis). Papers usually should be no more than 25-30 typed pages.
Please submit a hard copy (with title page signed by your two advisors) AND an electronic copy (in Word) of your research report, abstract and title page (sample of abstract and title page form attached) to the Student Programs Office (located in Surge IV, room 125) at least 14 days prior to the presentation. A copy of all abstracts will be provided to everyone at the presentation. We MUST have your paper in by the deadline in order to allow time for your it to be read by a third reviewer (assigned by the Director of the MPVM Program), prior to your oral presentation. We suggest that you also provide your two advisors with a copy of your paper.
The third reader will review the MPVM project as any reviewer would review a manuscriptsubmitted for publication in a scientific journal. He/she will share his/her comments with you before the MPVM project presentation date, and you should revise your MPVM project accordingly, in consultation with your two project advisors. Ideally, the third reader will also be present at the oral presentations to ask questions during the discussion session for your paper.
When your paper is completely finalized (i.e., after you have made all corrections and changes requested by the third reviewer) and ready for binding, provide the original Student Programs Office.
Format for title page and abstract:
Comparison of histologic reproductive lesions and serologic responses in virgin heifers experimentally inoculated with Tritrichomonas foetus, Pentatrichomonas hominis or Tetratrichomonas sp.: Are Non-T. foetus trichomonads pathogenic for cattle?
Alana C. McQuarry, D.V.M.
Submitted in Partial Fulfillment of the
Requirements for the Degree
MASTER OF PREVENTIVE VETERINARY MEDICINE
School of Veterinary Medicine
University of California, Davis
Reviewed and Approved by
Robert H. BonDurant, D.V.M.
Professor and Department Chair; Veterinary Medicine: Population Health and Reproduction
Philip H. Kass, D.V.M., Ph.D.
Professor; Veterinary Medicine: Population Health and Reproduction
Objective – To evaluate whether non – T. foetus trichomonads are pathogenic to cattle.
Design – Randomized experimental trial.
Animals – 44 virgin beef heifers.
Procedure – Heifers were placed into one of four groups and intravaginally inoculated with either T. foetus (n=8), Pentatrichomonas hominis (n=14), Tetratrichomonas sp. (n=14), or media control (n=8). Cervical vaginal mucus (CVM) was cultured weekly in a commercially prepared media and assayed with an ELISA for anti-trichomonad IgA antibodies. Blood samples were taken from each heifer, and a hemolytic assay (HA) for antibodies to T. foetus was performed on these samples from weeks 0, 2, 4, 6, and 8. Histopathology was performed on all layers of vaginal and uterine tissue to evaluate overall inflammation and cell types involved.
Results – Of the four groups, only T. foetus-inoculated heifers had persistently positive culture results. Additionally, vaginal and uterine mucosal inflammation scores were worse for T. foetus infected heifers than controls. All trichomonads were found to incite a serosal eosinophilic response. Tissues from heifers inoculated with Pentatrichomonas and Tetratrichomonas were not significantly different (p > 0.20) from media control heifers.
Conclusions and Clinical Relevance – Given that trichomonosis is a disease wherein long term presence of the etiologic agent is associated with tissue-damaging host responses, the failure of non-T. foetus trichomonads to colonize and persist in the female genital tract strongly suggests that they do not contribute to a trichomonosis-like disease syndrome.
VI. Oral Presentation of MPVM Projects
Four oral presentation dates are scheduled each year:
a. The last Friday in August (main (preferred) presentation date).
b. The last Friday of instruction for Fall Quarter.
c. The last Friday of instruction for Winter Quarter.
c. The last Friday of instruction for Spring Quarter.
Format for presentations is similar to that of international scientific meegins. Each presentation is allocated a total of 15 minutes: 10 minutes for presentation of the project and 5 minutes for discussion.
Most presentations are in Powerpoint. Be sure to review with your advisors the tables, graphs, etc. that you select, and include only those necessary to effectively communicate your message. Be especially careful that tables and figures do not include too much information and that they can be read in the back of the room.
As presentations last no longer than ten minutes, it would be helpful to have a mock presentation with both advisors well in advance of the presentation date, allowing sufficient time to make any suggested changes in your presentation.
VII.Certification of Completion of MPVM Requirements
Immediately after your MPVM project presentation, meet with the MPVM Director to complete final forms to certify your completion of MPVM degree requirements.