Publications

1: Vernau K, Napoli E, Wong S, Ross-Inta C, Cameron J, Bannasch D, Bollen A,
Dickinson P, Giulivi C. Thiamine Deficiency-Mediated Brain Mitochondrial
Pathology in Alaskan Huskies with Mutation in SLC19A3.1. Brain Pathol. 2014 Aug
13. doi: 10.1111/bpa.12188. [Epub ahead of print] PubMed PMID: 25117056; PubMed
Central PMCID: PMC4326624.

2: Napoli E, Dueñas N, Giulivi C. Potential therapeutic use of the ketogenic diet
in autism spectrum disorders. Front Pediatr. 2014 Jun 30;2:69. doi:
10.3389/fped.2014.00069. eCollection 2014. Review. PubMed PMID: 25072037; PubMed
Central PMCID: PMC4074854.

3: Giulivi C. Grand challenges in cellular biochemistry: the "next-gen"
biochemistry. Front Chem. 2014 Apr 29;2:22. doi: 10.3389/fchem.2014.00022.
eCollection 2014. PubMed PMID: 24809045; PubMed Central PMCID: PMC4010732.

4: Napoli E, Wong S, Hertz-Picciotto I, Giulivi C. Deficits in bioenergetics and
impaired immune response in granulocytes from children with autism. Pediatrics.
2014 May;133(5):e1405-10. doi: 10.1542/peds.2013-1545. Review. PubMed PMID:
24753527; PubMed Central PMCID: PMC4006429.

5: Giulivi C, Napoli E, Schwartzer J, Careaga M, Ashwood P. Gestational exposure
to a viral mimetic poly(i:C) results in long-lasting changes in mitochondrial
function by leucocytes in the adult offspring. Mediators Inflamm.
2013;2013:609602. doi: 10.1155/2013/609602. Epub 2013 Sep 19. PubMed PMID:
24174710; PubMed Central PMCID: PMC3793312.

6: Croft L, Napoli E, Hung CK, St Leger J, Gearhart S, Heym K, Wong S, Sakaguchi
D, Lin A, Puschner B, Giulivi C. Clinical evaluation and biochemical analyses of
thiamine deficiency in Pacific harbor seals (Phoca vitulina) maintained at a
zoological facility. J Am Vet Med Assoc. 2013 Oct 15;243(8):1179-89. doi:
10.2460/javma.243.8.1179. PubMed PMID: 24094267.

7: Vernau KM, Runstadler JA, Brown EA, Cameron JM, Huson HJ, Higgins RJ, Ackerley
C, Sturges BK, Dickinson PJ, Puschner B, Giulivi C, Shelton GD, Robinson BH,
DiMauro S, Bollen AW, Bannasch DL. Genome-wide association analysis identifies a
mutation in the thiamine transporter 2 (SLC19A3) gene associated with Alaskan
Husky encephalopathy. PLoS One. 2013;8(3):e57195. doi:
10.1371/journal.pone.0057195. Epub 2013 Mar 4. PubMed PMID: 23469184; PubMed
Central PMCID: PMC3587633.

8: Luckhart S, Giulivi C, Drexler AL, Antonova-Koch Y, Sakaguchi D, Napoli E,
Wong S, Price MS, Eigenheer R, Phinney BS, Pakpour N, Pietri JE, Cheung K,
Georgis M, Riehle M. Sustained activation of Akt elicits mitochondrial
dysfunction to block Plasmodium falciparum infection in the mosquito host. PLoS
Pathog. 2013 Feb;9(2):e1003180. doi: 10.1371/journal.ppat.1003180. Epub 2013 Feb
28. PubMed PMID: 23468624; PubMed Central PMCID: PMC3585164.

9: Grodzki AC, Giulivi C, Lein PJ. Oxygen tension modulates differentiation and
primary macrophage functions in the human monocytic THP-1 cell line. PLoS One.
2013;8(1):e54926. doi: 10.1371/journal.pone.0054926. Epub 2013 Jan 23. PubMed
PMID: 23355903; PubMed Central PMCID: PMC3552948.

10: Napoli E, Wong S, Giulivi C. Evidence of reactive oxygen species-mediated
damage to mitochondrial DNA in children with typical autism. Mol Autism. 2013 Jan
25;4(1):2. doi: 10.1186/2040-2392-4-2. PubMed PMID: 23347615; PubMed Central
PMCID: PMC3570390.

11: Napoli E, Hung C, Wong S, Giulivi C. Toxicity of the flame-retardant BDE-49
on brain mitochondria and neuronal progenitor striatal cells enhanced by a
PTEN-deficient background. Toxicol Sci. 2013 Mar;132(1):196-210. doi:
10.1093/toxsci/kfs339. Epub 2013 Jan 3. PubMed PMID: 23288049; PubMed Central
PMCID: PMC3693513.

12: Cummings BP, Bettaieb A, Graham JL, Kim J, Ma F, Shibata N, Stanhope KL,
Giulivi C, Hansen F, Jelsing J, Vrang N, Kowala M, Chouinard ML, Haj FG, Havel
PJ. Bile-acid-mediated decrease in endoplasmic reticulum stress: a potential
contributor to the metabolic benefits of ileal interposition surgery in UCD-T2DM
rats. Dis Model Mech. 2013 Mar;6(2):443-56. doi: 10.1242/dmm.010421. Epub 2012
Dec 20. PubMed PMID: 23264565; PubMed Central PMCID: PMC3597026.

13: Napoli E, Wong S, Hung C, Ross-Inta C, Bomdica P, Giulivi C. Defective
mitochondrial disulfide relay system, altered mitochondrial morphology and
function in Huntington's disease. Hum Mol Genet. 2013 Mar 1;22(5):989-1004. doi:
10.1093/hmg/dds503. Epub 2012 Nov 29. PubMed PMID: 23197653.

14: Napoli E, Ross-Inta C, Wong S, Hung C, Fujisawa Y, Sakaguchi D, Angelastro J,
Omanska-Klusek A, Schoenfeld R, Giulivi C. Mitochondrial dysfunction in Pten
haplo-insufficient mice with social deficits and repetitive behavior: interplay
between Pten and p53. PLoS One. 2012;7(8):e42504. doi:
10.1371/journal.pone.0042504. Epub 2012 Aug 10. PubMed PMID: 22900024; PubMed
Central PMCID: PMC3416855.

15: Li Y, Lein PJ, Liu C, Bruun DA, Giulivi C, Ford GD, Tewolde T, Ross-Inta C,
Ford BD. Neuregulin-1 is neuroprotective in a rat model of
organophosphate-induced delayed neuronal injury. Toxicol Appl Pharmacol. 2012 Jul
15;262(2):194-204. doi: 10.1016/j.taap.2012.05.001. Epub 2012 May 11. PubMed
PMID: 22583949; PubMed Central PMCID: PMC3607352.

16: Pon J, Napoli E, Luckhart S, Giulivi C. Mitochondrial NAD+-dependent malic
enzyme from Anopheles stephensi: a possible novel target for malaria mosquito
control. Malar J. 2011 Oct 26;10:318. doi: 10.1186/1475-2875-10-318. PubMed PMID:
22029897; PubMed Central PMCID: PMC3228860.

17: Napoli E, Ross-Inta C, Wong S, Omanska-Klusek A, Barrow C, Iwahashi C,
Garcia-Arocena D, Sakaguchi D, Berry-Kravis E, Hagerman R, Hagerman PJ, Giulivi
C. Altered zinc transport disrupts mitochondrial protein processing/import in
fragile X-associated tremor/ataxia syndrome. Hum Mol Genet. 2011 Aug
1;20(15):3079-92. doi: 10.1093/hmg/ddr211. Epub 2011 May 10. PubMed PMID:
21558427; PubMed Central PMCID: PMC3131047.

18: Giulivi C, Zhang YF, Omanska-Klusek A, Ross-Inta C, Wong S, Hertz-Picciotto
I, Tassone F, Pessah IN. Mitochondrial dysfunction in autism. JAMA. 2010 Dec
1;304(21):2389-96. doi: 10.1001/jama.2010.1706. PubMed PMID: 21119085; PubMed
Central PMCID: PMC3915058.

19: Giulivi C, Ross-Inta C, Omanska-Klusek A, Napoli E, Sakaguchi D, Barrientos
G, Allen PD, Pessah IN. Basal bioenergetic abnormalities in skeletal muscle from
ryanodine receptor malignant hyperthermia-susceptible R163C knock-in mice. J Biol
Chem. 2011 Jan 7;286(1):99-113. doi: 10.1074/jbc.M110.153247. Epub 2010 Oct 26.
PubMed PMID: 20978128; PubMed Central PMCID: PMC3013050.

20: Perez CJ, Jaubert J, Guénet JL, Barnhart KF, Ross-Inta CM, Quintanilla VC,
Aubin I, Brandon JL, Otto NW, DiGiovanni J, Gimenez-Conti I, Giulivi C, Kusewitt
DF, Conti CJ, Benavides F. Two hypomorphic alleles of mouse Ass1 as a new animal
model of citrullinemia type I and other hyperammonemic syndromes. Am J Pathol.
2010 Oct;177(4):1958-68. doi: 10.2353/ajpath.2010.100118. Epub 2010 Aug 19.
PubMed PMID: 20724589; PubMed Central PMCID: PMC2947290.

21: Ross-Inta C, Omanska-Klusek A, Wong S, Barrow C, Garcia-Arocena D, Iwahashi
C, Berry-Kravis E, Hagerman RJ, Hagerman PJ, Giulivi C. Evidence of mitochondrial
dysfunction in fragile X-associated tremor/ataxia syndrome. Biochem J. 2010 Aug
1;429(3):545-52. doi: 10.1042/BJ20091960. PubMed PMID: 20513237; PubMed Central
PMCID: PMC4011071.

22: Villanueva C, Giulivi C. Subcellular and cellular locations of nitric oxide
synthase isoforms as determinants of health and disease. Free Radic Biol Med.
2010 Aug 1;49(3):307-16. doi: 10.1016/j.freeradbiomed.2010.04.004. Epub 2010 Apr
11. Review. PubMed PMID: 20388537; PubMed Central PMCID: PMC2900489.

23: Haynes V, Traaseth NJ, Elfering S, Fujisawa Y, Giulivi C. Nitration of
specific tyrosines in FoF1 ATP synthase and activity loss in aging. Am J Physiol
Endocrinol Metab. 2010 May;298(5):E978-87. doi: 10.1152/ajpendo.00739.2009. Epub
2010 Feb 16. PubMed PMID: 20159857; PubMed Central PMCID: PMC2867368.

24: Fujisawa Y, Kato K, Giulivi C. Nitration of tyrosine residues 368 and 345 in
the beta-subunit elicits FoF1-ATPase activity loss. Biochem J. 2009 Sep
25;423(2):219-31. doi: 10.1042/BJ20090594. PubMed PMID: 19650768.

25: Ross-Inta CM, Zhang YF, Almendares A, Giulivi C. Threonine-deficient diets
induced changes in hepatic bioenergetics. Am J Physiol Gastrointest Liver
Physiol. 2009 May;296(5):G1130-9. doi: 10.1152/ajpgi.90545.2008. Epub 2009 Feb
19. PubMed PMID: 19228885; PubMed Central PMCID: PMC2696218.

26: Ross-Inta C, Tsai CY, Giulivi C. The mitochondrial pool of free amino acids
reflects the composition of mitochondrial DNA-encoded proteins: indication of a
post- translational quality control for protein synthesis. Biosci Rep. 2008
Oct;28(5):239-49. doi: 10.1042/BSR20080090. PubMed PMID: 18636966.

27: Giulivi C, Ross-Inta C, Horton AA, Luckhart S. Metabolic pathways in
Anopheles stephensi mitochondria. Biochem J. 2008 Oct 15;415(2):309-16. doi:
10.1042/BJ20080973. PubMed PMID: 18588503.

28: Giulivi C. Mitochondria as generators and targets of nitric oxide. Novartis
Found Symp. 2007;287:92-100; discussion 100-4. Review. PubMed PMID: 18074633.

29: Cooper CE, Giulivi C. Nitric oxide regulation of mitochondrial oxygen
consumption II: Molecular mechanism and tissue physiology. Am J Physiol Cell
Physiol. 2007 Jun;292(6):C1993-2003. Epub 2007 Feb 28. Review. PubMed PMID:
17329402.

30: DiMarco T, Giulivi C. Current analytical methods for the detection of
dityrosine, a biomarker of oxidative stress, in biological samples. Mass Spectrom
Rev. 2007 Jan-Feb;26(1):108-20. Review. PubMed PMID: 17019703.

31: Giulivi C, Kato K, Cooper CE. Nitric oxide regulation of mitochondrial oxygen
consumption I: cellular physiology. Am J Physiol Cell Physiol. 2006
Dec;291(6):C1225-31. Epub 2006 Aug 2. Review. PubMed PMID: 16885394.

32: Mazzanti R, Giulivi C. Coordination of nuclear- and mitochondrial-DNA encoded
proteins in cancer and normal colon tissues. Biochim Biophys Acta. 2006
May-Jun;1757(5-6):618-23. Epub 2006 Apr 20. PubMed PMID: 16730322.

33: Kato K, Giulivi C. Critical overview of mitochondrial nitric-oxide synthase.
Front Biosci. 2006 Sep 1;11:2725-38. Review. PubMed PMID: 16720345.

34: Mazzanti R, Solazzo M, Fantappié O, Elfering S, Pantaleo P, Bechi P, Cianchi
F, Ettl A, Giulivi C. Differential expression proteomics of human colon cancer.
Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1329-38. Epub 2006 Jan
26. PubMed PMID: 16439467.

35: Greene AL, Rutherford MS, Regal RR, Flickinger GH, Hendrickson JA, Giulivi C,
Mohrman ME, Fraser DG, Regal JF. Arginase activity differs with allergen in the
effector phase of ovalbumin- versus trimellitic anhydride-induced asthma. Toxicol
Sci. 2005 Dec;88(2):420-33. Epub 2005 Sep 1. PubMed PMID: 16141432; PubMed
Central PMCID: PMC2978642.

36: Johnson F, Giulivi C. Superoxide dismutases and their impact upon human
health. Mol Aspects Med. 2005 Aug-Oct;26(4-5):340-52. Review. PubMed PMID:
16099495.

37: Solien J, Haynes V, Giulivi C. Differential requirements of calcium for
oxoglutarate dehydrogenase and mitochondrial nitric-oxide synthase under hypoxia:
impact on the regulation of mitochondrial oxygen consumption. Comp Biochem
Physiol A Mol Integr Physiol. 2005 Oct;142(2):111-7. Epub 2005 Jun 21. PubMed
PMID: 15972265.

38: Haynes V, Elfering S, Traaseth N, Giulivi C. Mitochondrial nitric-oxide
synthase: enzyme expression, characterization, and regulation. J Bioenerg
Biomembr. 2004 Aug;36(4):341-6. Review. PubMed PMID: 15377869.

39: Oursler MJ, Bradley EW, Elfering SL, Giulivi C. Native, not nitrated,
cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast
apoptosis. Am J Physiol Cell Physiol. 2005 Jan;288(1):C156-68. Epub 2004 Sep 1.
PubMed PMID: 15342339.

40: Traaseth N, Elfering S, Solien J, Haynes V, Giulivi C. Role of calcium
signaling in the activation of mitochondrial nitric oxide synthase and citric
acid cycle. Biochim Biophys Acta. 2004 Jul 23;1658(1-2):64-71. PubMed PMID:
15282176.

41: Haynes V, Elfering SL, Squires RJ, Traaseth N, Solien J, Ettl A, Giulivi C.
Mitochondrial nitric-oxide synthase: role in pathophysiology. IUBMB Life. 2003
Oct-Nov;55(10-11):599-603. Review. PubMed PMID: 14711005.

42: Elfering SL, Haynes VL, Traaseth NJ, Ettl A, Giulivi C. Aspects, mechanism,
and biological relevance of mitochondrial protein nitration sustained by
mitochondrial nitric oxide synthase. Am J Physiol Heart Circ Physiol. 2004
Jan;286(1):H22-9. Epub 2003 Oct 2. PubMed PMID: 14527943.

43: Xiong S, She H, Takeuchi H, Han B, Engelhardt JF, Barton CH, Zandi E, Giulivi
C, Tsukamoto H. Signaling role of intracellular iron in NF-kappaB activation. J
Biol Chem. 2003 May 16;278(20):17646-54. Epub 2003 Mar 11. PubMed PMID: 12637578.

44: Giulivi C. Characterization and function of mitochondrial nitric-oxide
synthase. Free Radic Biol Med. 2003 Feb 15;34(4):397-408. Review. PubMed PMID:
12566065.
45: She H, Xiong S, Lin M, Zandi E, Giulivi C, Tsukamoto H. Iron activates
NF-kappaB in Kupffer cells. Am J Physiol Gastrointest Liver Physiol. 2002
Sep;283(3):G719-26. PubMed PMID: 12181188.

46: Elfering SL, Sarkela TM, Giulivi C. Biochemistry of mitochondrial
nitric-oxide synthase. J Biol Chem. 2002 Oct 11;277(41):38079-86. Epub 2002 Aug
1. PubMed PMID: 12154090.

47: Sugawara M, Sugawara Y, Wen K, Giulivi C. Generation of oxygen free radicals
in thyroid cells and inhibition of thyroid peroxidase. Exp Biol Med (Maywood).
2002 Feb;227(2):141-6. PubMed PMID: 11815678.