Dr. Lloyd is a research physiologist with expertise in targeted mutagenesis of the laboratory mouse. His primary research focuses on the physiology of brain-gut interactions as a model for positive and negative feedback mechanisms and pathways operating between organs. Dr. Lloyd’s expertise in gastrointestinal physiology is being applied to understanding how somatostatin plays a fundamental role in physiological regulation of gastric acid secretion by acting as a mediator of the efferent limb of the enterogastric reflex. Dr. Lloyd conducts these studies using a variety of methods, including whole-animal physiological measurements in conscious mice, radioimmunoassay for circulating gastrin, and analysis of histidine decarboxylase activity as a measure of histamine release. Dr. Lloyd is also involved in developing mouse lines carrying promoter‑driven recombinases and recombinase‑sensitive coding sequences in the germ line, and is conducting genetic, histologic, immunologic, and behavioral analyses of mutant mice in which the gene has been "knocked-out". Please contact Dr. Lloyd at kclloyd@ucdavis.edu for further information.