Hormonal and neural mechanisms underlying enterogastric reflexes . Dr. Lloyd is a research physiologist with expertise in targeted mutagenesis of the laboratory mouse. His primary research focuses on the physiology of brain-gut interactions as a model for positive and negative feedback mechanisms and pathways operating between organs. Dr. Lloyd's expertise in gastrointestinal physiology is being applied to understanding how somatostatin plays a fundamental role in physiological regulation of gastric acid secretion by acting as a mediator of the efferent limb of the enterogastric reflex. Dr. Lloyd conducts these studies using a variety of methods, including whole-animal physiological measurements in conscious mice, radioimmunoassay for circulating gastrin, and analysis of histidine decarboxylase activity as a measure of histamine release. Dr. Lloyd also is involved in developing mouse lines carrying promoter-driven recombinases and recombinase-sensitive coding sequences in the germ line, and conducted genetic, histological, immunological, and behavioral analyses of mutant mice in which the gene has been "knocked-out".
Visit Dr. Lloyd's website: http://faculty.vetmed.ucdavis.edu/faculty/kclloyd/