Integrated lung defense mechanisms involving sensory afferents in pulmonary injury . Dr. Schelegle's research focus is in the area pulmonary neurophysiology with a special interest on the role that lung sensory nerves play in the control of breathing pattern, epithelial injury, inflammation and repair in models of acute and chronic lung injury and/or disease. Studies currently ongoing in Dr. Schelegle's laboratory are designed to examine the role that lung vagal afferents play in ozone-induced exacerbation of allergic airway reactivity and inflammation in rat model of allergic asthma. In addition, Dr. Schelegle has played a major role in the development and validation of an inducible model of allergic asthma in Rhesus monkeys and the application of this model to study the interaction of allergen- and ozone-induced responses in infant Rhesus monkeys. New research initiatives in Dr. Schelegle's include studies to examine alterations in neuroimmune relationships within the airway of animals undergoing postnatal development while exposed to aeroallergens and/or ozone.
Visit Dr. Schelegle's website: http://faculty.vetmed.ucdavis.edu/faculty/esschelegle/