STAR Mentors - Alphabetical Listing

STAR Faculty Mentors

Faculty from within the School of Veterinary Medicine, the School of Medicine, College of Biological Sciences, College of Agricultural and Environmental Sciences and College of Engineering are eligible to serve as mentors for student Scholars. While serving as mentors, they are expected to fulfill certain criteria.

If you are interested in becoming a STAR mentor, please contact svmstarprogram@ucdavis.edu or visit the STAR Mentor Requirements page for more information.

STAR Mentors - Sorted Alphabetically

The list of faculty mentors is not all-inclusive - other eligible faculty can also be sought after as STAR mentors.  Also, some mentors may be listed under more than one research area.

To find a faculty mentor by research topic, please visit the STAR Mentors - Sorted by Research Topic page.

NOTE: Mentors with an * are affiliated with UC Veterinary Medical Center – San Diego, through the Center for Veterinary Sciences and Comparative Medicine. Please contact Dr. Peter Ernst (pernst@ucsd.edu) or Dr. Christina Sigurdson  (csigurdson@ucsd.edu ) before selecting a mentor at this location.

STARs Abroad

STAR students can complete projects in Dublin, Ireland!

Visit the STARs Abroad page for more information.

Ireland Exchange Notes and Photos

List of Mentors in Dublin, Ireland


 

* Affiliated with UC Veterinary Medical Center – San Diego through the Center for Veterinary Sciences and Comparative Medicine - Contact: Dr. Peter Ernst (pernst@ucsd.edu) or Dr. Christina Sigurdson  (csigurdson@ucsd.edu ) first for further information.

(NOTE: This list of faculty is not all inclusive and other eligible faculty can also be sought after as STAR mentors.)

While all faculty within the School of Veterinary Medicine, the School of Medicine, College of Biological Sciences, College of Agricultural and Environmental Sciences and College of Engineering are eligible to serve as mentors for student Scholars, they are expected to fulfill certain criteria:

Along the guidelines of the American Physiological Society, a successful mentor is one who engages in a dynamic process whereby mentor and mentee both learn to respect and trust each others commitment, expertise, and individuality. To sign up as a mentor, a faculty member must commit to the mentoring process and be willing to invest time, energy and resources into the relationship. The text of the relationship can be difficult to define, because mentoring is in many ways an elusive concept and an individual process. However, a mentor must possess the following characteristics:

  • Be a faculty member in the School of Veterinary Medicine,School of Medicine, College of Biological Sciences, College of Agriculture and Environmental Sciences and College of Engineering
  • Be actively engaged in research
  • Provide adequate funding to support the student's entire 10 week research project expenses, including research supplies, posters, etc.
  • Be available throughout the summer for the student and attend student/mentor activities, including the STAR TG finale
  • Possess the expertise in the subject of the research proposal
  • Agree to ensure the student fulfills his or her conditions of award
  • Commit to active engagement with their students throughout the summer

Faculty in the School of Veterinary Medicine, the School of Medicine, College of Biological Sciences, College of Agricultural and Environmental Sciences and College of Engineering who are eligible to act as a mentor are asked to provide a brief paragraph describing their background, research interests, and other pertinent information.
This information should assist students who have not yet selected a faculty mentor.


Iannis E Adamopoulos BSc(Hons), M.Phil, D.Phil

Division of Rheumatology, Allergy and Clinical Immunology
School of Medicine, University of California at Davis

Osteoimmunology

Our laboratory studies the interface between the skeletal and immune systems, a newly emerging area of research called “osteoimmunology”. Haematopoietic stem cells in the bone marrow give rise to both T cells which are important in inflammation and osteoclasts that regulate bone resorption. Differentiation and activation of osteoclasts from their precursors is tightly regulated by cytokines and growth factors such as receptor activator of nuclear factor kappa beta (RANKL), tumor necrosis factor (TNF) and various interleukins. Receptor engagement of these molecules results in signaling cascades and transcriptional changes that give rise to medical conditions such as rheumatoid arthritis, osteoporosis and osteopetrosis. Using in vivo gene transfer of immune cytokines IL-23 and IL-17, we have established new arthritis animal models that highlight the importance of these immune cytokines in arthritis initiation and bone homeostasis. Using in vitro assays, we continue our attempts to define the cellular and molecular mechanisms that take place in this fascinating interplay of the immune and skeletal systems.

For more information, please contact Dr IE Adamopoulos or visit www.adamopouloslab.com

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Monica Aleman

Department of Medicine & Epidemiology; VMTH: Large Animal Clinic

Dr. Monica Aleman obtained her veterinary degree at the University UNAM-Mexico. She completed residencies in large animal internal medicine (equine emphasis) and neurology and neurosurgery at UC Davis; and achieved board certification for both specialties by the American College of Veterinary Internal Medicine. She completed a PhD in comparative pathology of neuromuscular diseases at UC Davis. Her research and clinical interest has focused in neurology, neuromuscular and muscle disorders in all species with equine emphasis. Currently, she is a faculty member of the equine internal medicine and neurology services, and Director of the Neuromuscular Disease Laboratory at UC Davis. Dr. Aleman is one of the founding members of the Comparative Neurology Research Group, and is affiliated with the Clinical Neurophysiology Laboratory at UC Davis. Dr. Aleman is author of over 90 peer reviewed medical publications, over 100 proceedings and abstracts, and over 25 book chapters; and is a regular speaker in national and international meetings. Currently, she works in the investigation of neuromuscular disorders in multiple species including humans.

For more information, please contact Dr. Aleman at mraleman@ucdavis.edu.

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Amir Ardeshir DVM, MPVM, PhD

Gut flora and immune system development

Dr. Ardeshir is a medical primatologist with interest in gastrointestinal diseases of non-human primates. His research interest lies in the understanding the essential communications of microbiota and immune system. He has worked with STAR students in the past looking at the mechanisms of TLR-ligands on the rhesus macaques ‘immune response. He also has broad interests in application of machine learning in pattern recognition of infectious diseases in non-human primates.

Students will join an ongoing study.

Please contact Dr. Ardeshir at aardeshir@ucdavis.edu for more information.

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Boaz Arzi, DVM, DAVDC

Oral and Maxillofacial Research

My current research fields are 1) regenerating the mandibular bone after resective surgery or due to defect non-unions. This project combines the use of BMP-2 and a scaffold and efforts towards understanding stem-cells recruitments locally and systemically 2) adipose-derived mesanchymal stem cells for the treatment of feline gingivostomatitis. 3) the biomechanics of mandibular reconstruction as dependent on the fixation method. 4) Temporomandibular joint (TMJ) disorders among the mammalian species. These projects extend and bridge the clinical practice at the UC Davis VMTH on one side and basic and regenerative laboratory science on the other side.

The summer STAR project is intended to take place both at the California Academy of Sciences in San Francisco and in my laboratory.

The 2016 STAR student project for the summer of 2016 is "The Temporomandibular Joint of 4 species of Dolphins".

Please visit Dr. Arzi’s website at: http://www.vetmed.ucdavis.edu/vorl/research-programs/oral-maxillofacial-regeneration/index.cfm

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Keith Baar, Assistant Professor

CBS: Neuro, Physio & Behavior

Cranial (or anterior) cruciate ligament (CCL) rupture is one of the most common orthopedic conditions in dogs. CCL rupture results in instability within the stifle that initiates a downward spiral of synovitis, articular cartilage degeneration, and eventually osteoarthritis. Currently, intracapsular techniques replace the ruptured CCL with an autologous tissue or synthetic graft. However, these grafts aren't strong enough and so the repair is usually augmented with some form of extracapsular reconstruction. We have developed a viable alternative that should be strong enough on its own to return joint stability. Our unique method uses stem cells to engineer a ligament in vitro. Our current research is finalizing the optimal growth factor cocktail and mechanical intervention before beginning our implantation trails.

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Melissa Bain

Companion Animal Behavior Program

I am an Associate Professor of Clinical Animal Behavior in the Companion Animal Behavior Service. My areas of interest include: prevention and treatment of behavior problems in companion animals, including the use of behavioral modification and psychotrophic medications; client compliance, especially as it relates to the treatment of behavioral problems; dog parks; and other areas of human-animal bond research, including owner attachment. I am open to ideas for research in other areas of behavior and the human-animal bond. Previous STAR projects include looking at: reasons for relinquishment of dogs to shelters in relation to behavior and training; effect of food enrichment in rhinos kept in zoos; effect of enrichment and hiding boxes on behavioral scores of cats in shelters; and the relationship between owner attachment and the term "guardian".

Please visit Dr. Bain's website for more information.

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Danika Bannasch

Canine and Equine Genetics

Department of Population Health and Reproduction

Our current and future research plans are directed towards elucidating the molecular basis of inherited diseases in companion animals. We are interested in developing tests to help breeders eliminate inherited diseases in dogs and horses. A large number of the diseases seen in veterinary practice that affect purebred animals have a heritable basis.

Characterizing inherited disease in dogs has the added benefit of providing an animal model for human diseases. Presently we have projects in both horses and dogs.  We are working on the molecular basis of chronic progressive lymphedema in horses and susceptibility to pneumonia in horses.  In dogs we are working on the molecular basis of Addison’s disease, cleft palate, Intervertebral disc disease, myopia, vertebral spinal malformations and longevity.  My laboratory has identified the mutations responsible for lethal white foal syndrome (LWFS), HERDA, and Hoof wall separation syndrome (HWSS) in horses and hyperuricosuria (HUU), spinal disraphism (SD), Juvenile Addison’s disease (JADD), Alaskan Husky encephalopathy, Saluki encephalopathy, chondrodystrophy, glioma susceptibility, cleft lip, palate and syndactyly (CLPS) and cleft palate (CP1).

I welcome STAR students interested in genetic diseases.

Please visit Dr. Bannasch's website at: http://faculty.vetmed.ucdavis.edu/faculty/dlbannasch/

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Chris Barker

VM: Pathology, Microbiology and Immunology

Mosquito-borne diseases, Epidemiology, Surveillance

My program focuses on the epidemiology and ecology of mosquito-borne diseases, primarily those caused by West Nile, chikungunya, and dengue viruses, and including other livestock diseases such as Rift Valley fever and bluetongue. My research combines laboratory studies and epidemiological methods to understand the environmental drivers of disease outbreaks, and I manage the UC Davis component of the statewide surveillance program for mosquito-borne viruses.

STAR project opportunities in my lab include [1] development of laboratory assays to monitor feeding by individual mosquitoes over time (methods: MALDI-TOF, mosquito rearing and handling) , [2] experiments to define the relationship between temperature and incubation of chikungunya virus in mosquitoes (methods: RT-PCR, MALDI-TOF, mosquito rearing and handling), or [3] analysis of the relationship between West Nile virus risk and drought in California (methods: epidemiology, GIS, basic statistics).

Dr. Barker can be reached via email at cmbarker@ucdavis.edu.

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Linda Barter, BSc(vet), BVSc, MVSc, Ph.D.

Veterinary anesthesia & analgesia

VM: Surgical and Radiological Sciences

Dr Barter is an veterinary anesthesiologist with broad interests in veterinary anesthesia and analgesia across a wide range of species.

Currently she is researching analgesia and anesthesia in rabbits, specifically evaluating anesthetic protocols and management techniques to improve the quality, and ultimately safety, of anesthesia in a species with a relatively high anesthetic related mortality rate. However, she is willing to discuss potential projects in other species pertaining to anesthesia or analgesia.

Dr Barter works out of the physiologic monitoring laboratory in Tupper which is shared by the anesthesia faculty and equipped with a wide variety of anesthesia equipment and physiologic monitoring capabilities.

Please e-mail Dr Barter for more information or to discuss potential projects at: lsbarter@ucdavis.edu

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Nicole Baumgarth

Center for Comparative Medicine; Immunity to infectious diseases, vector-borne diseases

Dr. Baumgarth is a veterinarian and research immunologist with broad interests in infectious disease immunology. An underlying theme of all research studies in her laboratory is the use of mouse models to dissect the complexity of host-pathogen interactions. For that she has developed new technologies that allow a precise assessment and analysis of in vivo immune events. A major focus of her research involves studies on the regulation of early antiviral B cell immune responses to influenza virus. Ongoing work is directed towards identifying mechanisms by which infection-induced innate cytokines regulate the earliest events that trigger antiviral B cells responses. Members of her lab are working on the concept that innate cytokines regulate the thresholds by which lymphocytes are activated to participate in immune responses in order to avoid the negative consequences of a potentially overshooting immune response (autoimmunity). She is also involved in studies to delineate the causes for the lack of protective immunity to the Lyme disease pathogen Borrelia burgdorferi. Using a mouse model established by her collaborator, Dr. Barthold, they are following their earlier observations that B. burgdorferi subverts the B cell response to this pathogen, with the long-term goal to find targets for therapeutic intervention that could bolster the immune response of an infected individual to clear this bacterial infection.

Please visit Dr. Baumgarth's website at: https://ccm.ucdavis.edu/faculty/baumgarth/

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Andreas J. Baumler

SOM: Medical Microbiology and Immunology

I am a microbiologist interested in Salmonella pathogenesis and host response. Our group has pioneered the use of a calf model to study Salmonella gastroenteritis and a rhesus macaque model to study co-infections with non-typhoidal Salmonella and HIV. In addition, we use the advantages of the mouse model to study host and bacterial factors involved in orchestrating intestinal inflammation. On the host side, we are interested in pattern recognition by the innate immune system (TLRs, NLRs and complement), pathways that amplify responses in tissue (the IL-23/IL-17 axis and the IL-18/IFNg axis) and effector responses induced in the intestinal epithelium (defensins, lipocalin-2, calprotectin, iNOS etc.). On the bacterial end, we study mechanisms that enable typhoidal Salmonella to evade innate immune recognition and mechanisms that enable non-typhoidal Salmonella to take advantage of the host inflammatory response to out-compete the microbiota in the gut.

Please visit Dr. Baumler's website for more information.

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Rebecca Bellone

Equine genetics and genomics

Department of Population Health and Reproduction

Veterinary Genetics Laboratory

Dr. Bellone is a molecular geneticist whose research interests include elucidating the genetics of economically and medically important traits in the horse as well as traits that serve as models for other species.   Current projects in horses involve investigating the genetic and molecular basis of several pigmentation phenotypes and associated pathologies as well as investigating the genetics of the second most common tumor in the horse, limbal squamous cell carcinoma. The primary research goal is to develop tools that assist animal breeders in making informed mating decisions and work towards better management practices, by understanding the biological mechanisms behind complex heritable traits. Dr. Bellone is passionate about training and working closely with students in her laboratory to assist them in making significant contributions to these projects.

Please email Dr. Rebecca Bellone (rbellone@ucdavis.edu) for more information.

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Charles L. Bevins MD, PhD

Department of Microbiology and Immunology, School of Medicine

Our laboratory is interested in innate immunity of mucosal tissues, and we are focused on key effector molecules of host defense: antimicrobial peptides. Antimicrobial peptides are endogenous antibiotics, isolated from diverse species throughout the plant and animal kingdoms. They represent an evolutionary ancient mechanism of host defense. These peptides typically have a broad-spectrum of antimicrobial activity that includes bacteria, fungi and certain viruses.  Defensins are the major class of antimicrobial peptides in humans and other mammals.  Investigations from our laboratory have discovered that certain defensins are expressed in abundance by epithelial cells at wet mucosal surface.  Our studies support a model - antimicrobial peptide constitutes part of an active, early host defense response of challenged epithelial cells.  The long-range goal of our research is to understand the specific role that these epithelial antimicrobial peptides play in mucosal innate immunity, including maintaining homeostasis at baseline and responding to challenge by pathogenic microbes.  Our current collaborative studies include: (i) characterizing the primary structure and biological activity of the tissue forms defensins, (ii) defining the key regulatory steps for the expression of these molecules, (iii) exploring potential mechanisms of therapeutic modulation of these systems. The investigations include biochemical and molecular biological approaches and analysis of transgenic and other animal models.

Please visit Dr. Bevins' website at: http://biosci3.ucdavis.edu/Faculty/Profile/View/14231

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Alexander Borowsky, MD

Center for Comparative Medicine

Dr. Borowsky is a surgical pathologist with expertise in diagnostic breast pathology. His research is focused on development of a mouse model of prostate cancer, focusing on the molecular pathways that are activated or disrupted in various genetically engineered mice, and correlating these findings with the tumor phenotype. Among genes of interest are tumor suppressor genes such as Nes1, which is down regulated by methylation during early breast and prostate cancer. Conditional targeted knockouts of these genes are being developed in mouse models. These findings are being validated and compared with data derived from human tumors, using microarrays, quantitative RNA and laser capture microscopy.

Please visit Dr. Borowsky's website at: http://www.ucdmc.ucdavis.edu/search/faculty/borowsky

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Julie Bossuyt, DVM, PhD

Chair MCIP Graduate Group
Department of Pharmacology, School of Medicine

Cardiovascular Biology/Biochemistry & Cellular Biology

The lab studies the molecular mechanisms that drive activation and function of the related kinases, protein kinase D (PKD) and calmodulin dependent protein kinase (CaMKII) in healthy and failing hearts. We focus on understanding the local regulatory mechanisms that control the myriad cellular outcomes for these multifunctional kinases. Hereto we apply cutting-edge high resolution fluorescence imaging techniques (such as FRET, TIRF, FRAP and confocal) and novel biosensors to obtain unique insight into the spatiotemporal dynamics of the local Ca-CaM, CaMKII and PKD signals.

Potential summer research projects:

  1. PKD regulation of actin dynamics in cardiac myocytes
  2. Role of  PKD in cardiac stress during pregnancy

Contact : jbossuyt@ucdavis.edu

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Jack Bui, M.D., PhD

Innate immunity and cancer

Affiliated with UC Veterinary Medical Center – San Diego

Dr. Bui’s laboratory studies the molecular basis of tumor rejection by the immune system.  His lab uses mouse models to elucidate pathways that activate appropriate anti-tumor immune responses while blocking pro-tumor inflammatory responses.  He has expertise in primary models of sarcoma and breast cancer, transplantable syngeneic models of various cancer cell lines, and xenogeneic transplantation models of human cancer cell lines.  He is especially interested in mobilizing innate immune cells such as natural killer cells and macrophages to destroy cancer cells.  Dr. Bui also studies human immune responses using flow cytometry assays and is the Director of the UCSD Clinical Flow Cytometry Laboratory.

Please contact Peter Ernst pernst@ucsd.edu or Christina Sigurdson csigurdson@ucsd.edu first for more information

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Marie E. Burns, PhD

College of Biological Sciences

The first steps in vision begin in the rod and cone photoreceptors of the retina, which transduce photons of light into electrical signals. Our lab examines the biochemical and biophysical properties of signaling in photoreceptors, as well as the consequences of defective signaling on visual performance.  We are also trying to understand why and how photoreceptors die, which is the ultimate leading cause of untreatable blindness in humans. Photoreceptor degeneration, like all neurodegenerative diseases, leads to microglial activation and neuroinflammation. We are trying to understand the regulation of neuroinflammation, its relationship to neovascularization, and its helpful vs harmful consequences for perserving neuronal and synaptic function.  To this end, we are also exploring how resident and infiltrating immune cells and glial cells can be used to manipulate the local micro environments within the nervous system to mitigate tissue damage and promote regenerative repair.

Burns Lab website

College of Biological Sciences Faculty Page

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Barbara Byrne, DVM

Clinical bacteriology

VM:PMI

The Byrne laboratory focuses primarily on microbiological questions as they apply to clinical veterinary microbiology. Some research areas include:

  1. Evaluation of the marine health by detection of pathogens in marine mammals, their food sources, and the marine environment and appraisal of their connection with terrestrial sources.
  2. Environmental contamination by zoonotic fecal pathogens.
  3. Genotyping of clinical isolates to determine their relatedness
  4. Use of mass spectrometry for isolate and strain identification

Some possible project areas:

1)     Evaluation of marine mammal isolates for virulence factors
2)     Comparison of clinical isolates for genetic relatedness by pulsed-field gel electrophoresis
3)     Use of mass spectroscopy (MALDI-TOF) to identify and classify bacterial and/or fungal strains

Please visit Dr. Byrne's website at: http://faculty.vetmed.ucdavis.edu/faculty/bbyrne/

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Chao-Yin Chen, PhD

Cardiovascular regulation, Neuroscience

Dept. of Pharmacology

Blood pressure and heart rate are regulated by CNS on a moment-to-moment basis. Depending on the interaction between the genetic and environmental factors, the CNS regulatory output can result in either a normal or a pathological outcome.  My current research focuses on cigarette smoke (both conventional and e-cigarette)- induced changes in central regulation of cardiovascular function. 

Potential summer research projects: 

1.  Secondhand smoke- and vaping-induced cardiovascular consequences and their interaction with high fat diet. 

2.  Sex difference in secondhand smoke- and vaping-induced cardiovascular consequences.

Potential techniques involved: BP/ECG recordings using telemetry, heart rate variability and baroreflex sensitivity analysis, whole-cell patch clamp in brain slices.

Website: http://www.ucdmc.ucdavis.edu/publish/providerbio/pharmacology/faculty/701

Please email Dr. Chen for more information at: cych@ucdavis.edu.

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Ching-Hsien (Jean) Chen, PhD

SOM: Nephrology/Internal Medicine

Dr. Chen’s research strives to elucidate the molecular mechanisms underlying cancer malignancy and thereby identify useful biomarkers and/or druggable targets. She seeks to develop peptide-based therapeutics to mitigate cancer metastasis and drug resistance by targeting aberrant oncogenic signaling. Research in her laboratory focuses on how the phospholipids such as PIP2 and PIP3 are regulated during the development of malignancies and inflammatory diseases.

Potential summer research projects: 1) examine the feasibility of phospholipid retention strategies for cancer immunotherapy. This project will use genetic manipulations and pharmacological approaches to elucidate mechanisms of tumor immune evasion and develop targeted therapies for increasing the efficacy of immune checkpoint inhibitors; 2) characterize the mechanisms of cancer stemness in order to discover therapeutic targets for combating cancer progression and overcoming drug resistance. This study will help the development of novel treatments that destroy cancer stem-like cells without adversely affecting self-renewal of normal stem cells.

Please visit Dr. Chen's website at: http://www.ucdmc.ucdavis.edu/publish/providerbio/internalmedicine/22056

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Xinbin Chen, BVM, PhD

VM: Veterinary Oncology, Surgical and Radiological Sciences; Med: Internal Medicine

The p53 family proteins are transcription factors and consist of p53, p63, and p73. Each member regulates a diverse array of both common and unique target genes. These target genes mediate various activities for the p53 family proteins, including the cell cycle control, apoptosis, differentiation, senescence, DNA repair, normal development and tumor suppression. p53 is a tumor suppressor and found to be mutated or inactivated in greater than 60% of all human cancers. Mutant p53 is not only defective in tumor suppression but also promotes tumor formation. However, p63 and p73 appear to be necessary for the development of various tissues and immune response. To address these diverse activities for the p53 family proteins, we focus on the following areas of research: (1) to identify both common and unique target genes for each p53 family member and their functions in tumor suppression and development; (2) to determine the mechanism by which the p53 family proteins differentially regulate gene expression; (3) to determine the mechanism by which mutant p53 obtains a gain of function in promoting tumor formation; and (4) to determine the mechanism by which the expression and activity for each p53 family protein is regulated.

Potential Projects for STAR Students:

  • The p53 pathway, including p53, p63, p73, Mdm2 and MdmX, in dog osteosarcoma, sarcomas, histocytic sarcomas, and melanoma

  • The p53 pathway in cat sarcomas and other cat tumors

Please visit Dr. Chen's website at: http://faculty.vetmed.ucdavis.edu/faculty/xchen/

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Munashe Chigerwe, BVSc, MPH, PhD, DACVIM

VM: Medicine and Epidemiology

Dr. Chigerwe is a food animal medicine and surgery faculty member. His research interests focus on colostrum administration practices in dairy calves. The colostrum feeding practices include timing of feeding of colostrum, volume to be fed and frequency of colostrum feeding.

Expectations during research projects:
The STAR student will participate in framing of the research hypothesis and recognizing the objectives of the study. The STAR student will help with raising dairy calves (feeding, monitoring health) on UC Davis Campus facilities, collect research samples from the calves and help analyze the samples in the laboratory. The STAR student will participate in writing of the manuscript (first authorship) for peer-reviewed publication.

Possible research: Please send a request for possible research projects via Email.

Previous accomplished STAR projects:

1. Sakai RR (STAR), Coons DM, Chigerwe M. Effect of single oroesophageal feeding of 3 L versus 4 L of colostrum on absorption of colostral IgG in Holstein bull calves. Livestock Sci 2012;148: 296-299.

2. Murphy JM (STAR), Hagey JV, Chigerwe M. Comparison of serum immunoglobulin G half-life in dairy calves fed colostrum, colostrum replacer or administered with intravenous bovine plasma. Vet Immunol Immunopath 2014;158: 233-237.

3. Pipkin KM (STAR), Hagey JV, Rayburn MC, Chigerwe M. A randomized clinical trial evaluating metabolism of colostral and plasma derived immunoglobulin G in Jersey Bull calves. J Vet Intern Med 2015;29:961-966.

Please contact Dr. Chigerwe at mchigerwe@ucdavis.edu.

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Bruno Chomel, PhD, DVM

Zoonoses, Bartonella, wildlife, epidemiology

VM: Population Health & Reproduction

Dr. Chomel is a veterinary epidemiologist whose research is focused on the epidemiology of zoonotic diseases, especially Zoonoses transmitted by bites and scratches. Most of Dr. Chomel's recent work has focused on cat scratch disease in its feline reservoir and has expanded to wildlife infection by Bartonella as a potential source of animal and human infection.
Research is presently conducted on molecular epidemiology of feline and canine Bartonella, and more recently in bats and ruminants (deer and cattle). Dr. Chomel's laboratory is also interested in the vectors of Bartonella, including fleas, ticks and biting flies. Development of diagnostic tools for cat infection and potential vaccines for cat protection to prevent human infection are also conducted in his laboratory.
His group is also doing wildlife serological surveys for zoonotic infections, including grizzly bears from Alaska , black bears from Western USA ( California , Oregon , Washington ), polar bears and more recently wild carnivores (foxes, raccoons, gray foxes) from various parts in the world. His work also involves the epidemiology of rabies virus. Dr. Chomel maintains important linkage with the Pasteur Institute in Paris, the Lyon and Alfort's Veterinary Schools.

Please visit Dr. Chomel's website at: http://faculty.vetmed.ucdavis.edu/faculty/bbchomel/

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Bruce W. Christensen, DVM, MS, DACT

Clinical Theriogenology

VMTH

Dr. Christensen is a board-certified theriogenologist whose clinical work focuses on equine and canine reproduction. Dr. Christensen's research interests focus on endangered species reproduction. He has used domestic species as models for their endangered counterparts, such as using dogs as models for the Mexican gray wolf and horses and donkeys as models for Somali Wild Ass or Przewalski horses. Current research that may involve students includes use of the domestic stallion as a model for wild equids. We are testing the effects of a long-acting sedative, fluphenazine, on reproductive parameters in stallions. Fluphenazine is commonly used in zoo animals during introductions, during stressful events, or to make them a little more tractable over a short period of time. It is not known if the drug affects fertility. We want to evaluate its effects on testosterone concentrations, sperm parameters, and reproductive behaviors. Students would be involved with assessing reproductive behaviors, collecting semen and blood, and performing semenalysis.

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Blaine Christiansen, PhD

Musculoskeletal adaptation, post-traumatic osteoarthritis, bone, biomechanics

UCDMC Department of Orthopaedic Surgery

Dr. Christiansen is a faculty member in the Department of Orthopaedic Surgery and the Biomedical Engineering Graduate Group. His research investigates the adaptation of musculoskeletal tissues, particularly bone and articular cartilage, to the mechanical environment, injury, aging, or disease using small animal models. The musculoskeletal system has an innate ability to repair and optimize itself based on the mechanical demands placed on it. By studying this adaptation, we are able to uncover the underlying mechanisms that contribute to diseases such as osteoporosis and osteoarthritis. Musculoskeletal adaptation is quantified in these models using advanced imaging techniques, histology, and mechanical testing. Current projects in the Christiansen lab include investigation of biomechanical and biological mechanisms contributing to the development of post-traumatic osteoarthritis, investigation of systemic bone loss following bone fracture or other musculoskeletal injury, and determining the effect of peripheral sensory nerve function on bone metabolism and bone adaptation to the mechanical environment.

Please visit Dr. Christiansen's website at: http://www.ucdmc.ucdavis.edu/search/faculty/christiansen

Contact Dr. Christiansen at bchristiansen@ucdavis.edu

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Lark L. Coffey, Ph.D.

Davis Arbovirus Research and Training
Center for Vectorborne Diseases
Assistant Professor
Department of Pathology, Microbiology and Immunology

Dr. Coffey  studies the ecology, evolution, and transmission dynamics of mosquito-borne viruses including chikungunya, Zika, West Nile, and St. Louis encephalitis that are significant causes of human disease with no licensed human vaccines or treatments beyond supportive care. The goal of her research is to understand patterns of viral molecular evolution and the viral genetic factors that promote arbovirus emergence and severe disease. Her work focuses on how intrahost viral genetic diversity generated by error-prone viral replication influences infectivity and transmissibility between mosquitoes and people or animals. She and her team also developing cheap and convenient improvements to surveillance in mosquitoes by detecting viral RNA in saliva expectorated by sugar-feeding West Nile virus vectors in California. They are also developing approaches to increase safety of candidate live-attenuated chikungunya virus vaccines by restricting their potential to develop revertant mutations that cause illness in vaccinees. Together with the California National Primate Research Center, the team is developing a non-human primate model of human Zika virus in pregnancy that is being used to define the roles of Zika virus mutations in fetal disease and for pre-clinical testing of therapies and vaccines. 

Please see http://coffeylab.ucdavis.edu for more information.

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Patricia A. Conrad DVM, PhD

VM: Pathology, Microbiology & Immunology

Dr. Conrad is a veterinary research parasitologist whose research focuses on protozoal parasites of animals (domestic and free-ranging) and humans, primarily those that infect the blood and/or neurologic tissues. Her research program includes projects that relate to the immunology, epidemiology/ecology and molecular biology of these parasites. At present, her program has a major focus on protozoal parasites that infect marine mammals and humans, many of which are shed in the feces of terrestrial animals, both wild and domestic. These links will help to illustrate Dr. Conrad's research emphases:

CURRENT RESEARCH FOCUS IN CONRAD LAB

In 1998 my research group was invited by The Marine Mammal Center to participate in an investigation of protozoal brain disease in Southern sea otters and harbor seals in California. We isolated and characterized the protozoal parasites Sarcocystis neurona and Toxoplasma gondii from sea otters and harbor seals with protozoal myeloencephalitis in California. We also developed antibody detection to improve diagnosis, demonstrated the high prevalence of infection and mortality due to T. gondii in California sea otters and conducted epidemiologic studies to determine risk factors for transmission of T. gondii to sea otters in California. The results of our sea otter studies provided the basis for our current research which is focused on protozoal pathogen pollution in coastal ecosystems and the ecology of infectious diseases that are transmitted from terrestrial animals to marine wildlife. In this context, we are particularly interested in zoonotic parasites, like T. gondii and Cryptosporidium species, which are transmissible from domestic and wild animals to humans, as well as marine mammals. We are evaluating the ability of filter-feeding bivalves to serve as bioindicators of fecal contamination, providing clues to contributing sources of the fecal load into aquatic ecosystems. We developed quantitative molecular methods, including TaqMan PCR, for the detection and genotypic analysis of these protozoal parasites which are shed in the feces of animals and contaminate watersheds. Identification and characterization of protozoal parasites in bioindicator species and sentinel wild animals, such as sea otters, can provide valuable clues to the significance and sources of fecal pollution in our watersheds and marine environment. Some sources of fecal contamination are controllable, and as we identify contributing sources, we can take steps to better manage human and animal wastes so as to ensure a sustainable and healthy environment.

Our desire to further investigate the ecology of the zoonotic protozoan T. gondii as it is transmitted from the terrestrial hosts (wild and domestic felids) into the marine environment has been made possible with the recent award of an NSF-NIH Ecology of Infectious Disease Fogarty Grant Award in October 2005. In conjunction with these studies we have initiated an investigation into the ecology of S. neurona in coastal California. {Please email paconrad@ucdavis.edu for more information}

Please visit Dr. Conrad's website at: http://faculty.vetmed.ucdavis.edu/faculty/paconrad/

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Gino Cortopassi

VM: Dept. of Molecular Biosciences

Mitochondrial disease results from inherited defects in mitochondrial genes or exposure to mitochondrial toxins. We investigate pathomechanism, including mitochondrial defect ->neuroinflamation->neurodegeneration. We screen for protective molecules for mitochondrial disease.  We are interested in canine distemper and its relationship to human multiple sclerosis.

Please visit Dr. Cortopassi's website at: http://cortopassilab.com/

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Sheila E. Crowe, M.D.

Affiliated with UC Veterinary Medical Center – San Diego

Dr. Crowe investigates mechanisms of epithelial cell damage in gastrointestinal inflammation to increase our understanding of inflammatory and malignant disorders of the digestive tract. In particular, she studies oxidative damage to epithelial cells by H. pylori, which has been shown to control the transcription of genes that regulate cell growth, repair and programmed death processes. The lab now has a novel mouse model made by the Mouse Biology Program at UC Davis to study DNA damage in the digestive tract and studies are underway to phenotype the mouse and examine how bacteria induce oxidative stress and DNA damage.

Please contact Peter Ernst pernst@ucsd.edu or Christina Sigurdson csigurdson@ucsd.edu first for more information

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Lillian Cruz-Orengo, Ph.D.

Neuroimmunology, sexual dimorphisms, blood-brain barrier

VM: Anatomy, Physiology & Cell Biology

Multiple Sclerosis (MS) is a devastating disease and the second leading cause of neurologic deficits in young adults, characterized by the pathological trafficking of autoreactive-leukocytes into the central nervous system (CNS). MS exhibits a high sex-bias, affecting three times more women than men a phenomenon that we could replicate in the lab when inducing Experimental Autoimmune Encephalomyelitis (EAE) on SJL mice. Specifically, my research focuses on sexual dimorphism of the blood-brain barrier (BBB) as a relevant contributor to MS neuropathogenesis, aiming to develop sex-specific therapeutic targets. Additionally, we are in the developing an animal model using transgenic zebrafish to assess for changes in brain microvasculature as a result to pesticide exposure. This model of BBB disruption will lead to greater understanding of the influences environmental factors may play in this process and consequent induction of neurological and neurodevelopmental disorders.

Keywords:

Autoimmunity, sexual bias/dimorphisms, blood-brain barrier, neuroinflammation/neurodegeneration

Example of research projects:

  1. Developmental onset of sexual dimorphisms of CXCL12 apicobasal polarity among SJL mice.
  2. Assessment of therapeutic outcomes of IL-20 monoclonal antibody treatment during EAE.
  3. Clinical assessment and neuro-immune interactions IL-20RB-/- mice versus wild type.
  4. Quantitation of BBB permeability on juvenile Tg(1-fabp:DBP-EGFP:flk1-mCherry) zebrafish after Chlorpyrifos exposure.
  5. Expression of ZO-1, Claudin-5 and VE-cadherin on Tg(1-fabp:DBP-EGFP:flk1-mCherry) zebrafish during exposure to Diazinon.

Dr. Cruz-Orengo can be reached at (530) 752-7318 or cruzorengo@ucdavis.edu.

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Elva Diaz, PhD

Med: Pharmacology

Dr. Diaz is trained in molecular and cellular biochemistry and functional genomic approaches to understanding nervous system development. The two main areas of interest are neural proliferation and synaptic differentiation in rodent model systems. The Diaz lab uses genomic approaches such as DNA microarrays to identify genes differentially regulated in nervous system development. Individual candidates genes are studied with molecular and cellular techniques including primary neuronal culture, immunocytochemistry, electrophysiology, and transgenic mouse models. Potential projects include: 1) understanding the role of transcription factors during neural proliferation in the cerebellum and potential implications for diseases such as brain tumors; 2) dissecting the role of a novel family of transmembrane proteins in synapse development and potential implications for neurological diseases such as mental retardation and schizophrenia.

Please visit Dr. Diaz's website at:

http://www.ucdmc.ucdavis.edu/publish/providerbio/pharmacology/faculty/1368

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Peter Dickinson BVSc, PhD, Diplomate ACVIM

VM: Neurology

Dr Dickinson is a board certified neurologist/neurosurgeon with a 50% clinical appointment at the VMTH. His research focus is on brain tumors and covers 3 basic areas.

1) Molecular characterization of spontaneous small animal brain tumors.
2) Development of novel therapeutic strategies for the treatment of brain tumors.
3) Translation of novel therapies into the veterinary clinic.

Dr Dickinson has a laboratory (Paul & Borghild Petersen Brain Tumor Research Laboratory) in Tupper Hall and collaborates closely with Dr Rick LeCouteur and Dr Robert Higgins.

Projects currently underway include:

  • Characterization of growth factor expression in canine spontaneous gliomas.
  • NF2-gene expression in canine meningiomas.
  • Characterization of 1p19q chromosomal deletions in canine oligodendrogliomas.
  • Adeno-associated viral vector delivery of VEGF-TRAP for the treatment of glioblastoma
  • Convection enhanced delivery (CED) of liposomal CPT-11 for the treatment of canine glioma. (clinical trial)

The laboratory utilizes core molecular biology techniques and has several rodent brain tumor models, including models of canine gliomas that are used to investigate novel therapies.

Please visit Dr. Dickinson's website at: http://faculty.vetmed.ucdavis.edu/faculty/pjdickinson/

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Sonja Dieterich, PhD

Department of Radiation Oncology

Dr. Dieterich’s expertise is in the area of medical physics, specifically stereotactic radiosurgery, small field dosimetry and respiratory motion management.

My Research interest: On the human side of Radiation Oncology, I have been working in the field of stereotactic radiosurgery (SRS) for over a decade. SRS delivers very high doses of radiation with submillimeter precision to tumors; early results in local control far exceed traditional radiation regimens. While this treatment modality for cancer has gone from novel phase I trials to general clinical acceptance during this time, much is still unknown concerning the radiation biology and the treatment uncertainty. I believe much can be learned from studying naturally occuring cancers in companion animals vs. the xenografted  mouse models typically used in radiation research

Please visit Dr. Dieterich's website for more information: http://www.ucdmc.ucdavis.edu/publish/providerbio/search/1545/?searchtype=all

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Ghislaine Dujovne, DVM, MS

Assistant Professor in Clinical Theriogenology

VMTH

Dr. Dujovne is a theriogenologist whose clinical work focuses mainly in equine reproduction. Dr. Dujovne's research interests focus on reproductive problems of clinical relevance on mares and stallions. Dr Dujovne’s main interest is efficient clinical management of reproductive diseases and artificial reproductive techniques. She has participated in research related with estrus suppression in performance mares, endometritis treatment in mares, stallion semen quality, post-mortem sperm recovery in stallions and semen evaluation in canine semen.

CONTACT EMAIL:  gadujovne@ucdavis.edu

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Lars Eckmann, M.D.

Affiliated with UC Veterinary Medical Center – San Diego

Dr. Eckmann investigates the cellular and molecular pathogenesis of infections with enteric pathogens and the mechanisms underlying the regulation of intestinal inflammation. His studies employ animal models of intestinal infection and inflammation and apply molecular, microbiological and histological approaches to elucidate the key genes and cellular and molecular mechanisms that govern intestinal host defenses against enteric pathogens and regulate inflammatory responses in the gastrointestinal tract. Current studies define host defense mechanisms against the protozoan pathogen Giardia and the bacterial pathogens Escherichia coli and Salmonella.

Please contact Peter Ernst pernst@ucsd.edu or Christina Sigurdson csigurdson@ucsd.edu first for more information

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Peter Ernst, D.V.M., Ph.D.

Affiliated with UC Veterinary Medical Center – San Diego

Director of the Center of Veterinary Sciences and Comparative Medicine Director of the Division of Comparative Pathology and Medicine
Co-Director of UCVMC
Professor of Pathology, UC San Diego
Professor of Pathology, Microbiology, and Immunology, UC Davis

Our general research interests are in the area of comparative (human to mouse) mucosal immunology with specific projects in immune-epithelial cell interactions involved in the microbial pathogenesis of acute and chronic diseases of the gastrointestinal tract. Our current emphasis in on the role of adenosine as an anti-inflammatory mediator and how it protects from disruption in the microbiota that trigger disease.


Link to Dr. Ernst’s current publications
Link to Dr. Ernst’s website

Please contact Dr. Ernst for more information: pernst@ucsd.edu

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Carrie Finno, DVM, PhD

Equine Genetics

Dr. Finno investigates the molecular basis for genetic diseases in the horse and other companion animals. One of the strong translational focuses of Dr. Finno's laboratory is to investigate the role of vitamin E in neurodegeneration using a well-established mouse model and a naturally-occurring model of equine neuroaxonal dystrophy (eNAD) in the horse. Dr. Finno's research is funded by the NIH, Grayson Jockey Club Foundation, the Arabian Horse Association and the Center for Equine Health at UC Davis.

Potential summer projects: (1) Perform a vitamin E supplementation trial in deficient horses at the Center for Equine Health to determine changes in muscle concentrations (2) Validate a potential biomarker in cerebrospinal fluid from NAD-affected horses (3) Perform genome-wide association studies for equine neuromuscular diseases. These research projects will provide students with training in molecular techniques and provide insight into mechanisms of neurodegeneration.

Please contact Dr. Finno for more information: cjfinno@ucdavis.edu

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Janet Foley, DVM, PHD

Center for Vectorborne Diseases

Tick-borne diseases

Summer veterinary students have several opportunities from which they can choose a summer project. The emphasis in the laboratory is disease ecology, epidemiology, and theory of infectious diseases, primarily in vector-host-pathogen systems although there are several non-vector transmitted diseases being studied as well. Students should expect to work every day all day, learn laboratory and/or field skills appropriate to their interests and project, and meet with Dr. Foley as early as possible (preferably in the spring) to confirm a project. Skills will be acquired through work with other students, technicians, and faculty in the laboratory; once a veterinary student is comfortable, they may expect to spend much of the rest of the summer obtaining data relevant to their project, analyzing the data with faculty supervision, and hopefully prepare it for publication.

Please visit Dr. Foley's website at: http://faculty.vetmed.ucdavis.edu/faculty/jefoley/

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Pascal Gagneux, Ph.D.

Affiliated with UC Veterinary Medical Center – San Diego

Dr. Gagneux is interested in primate molecular diversity. His lab investigates the evolutionary mechanisms responsible for the generation and maintenance of primate diversity, its potential roles in protecting populations from pathogens as well as potential consequences for reproductive compatibility. He is currently studying cell-surface molecules of sperm cells in closely related primate species. His focus is on glycans, the oligosaccharides attached to glycolipids and glycoproteins of the cell surface. The numerous parallels between the surface molecules of successful pathogens and those found on the surface of mammalian sperm, invite the analogy between internal fertilization and “extremely successful infection”. These interests examine the differences in sperm surface molecules  and sexual selection (via sperm competition and cryptic female choice) and whether such differences might contribute to reproductive incompatibility and speciation due to female immune rejection of sperm with incompatible glycoconjugates. Dr. Gagneux has studied the behavioral ecology of wild chimpanzees in the Taï Forest, Ivory Coast, population genetics of West African chimpanzees, and differences in sialic acid biology between humans and great apes with special consideration of their differing pathogen regimes. His great concern is that the current surge in interest for comparative genomics is not being translated into direct support for the conservation of primates in their endangered natural habitats.

Please contact Peter Ernst pernst@ucsd.edu or Christina Sigurdson csigurdson@ucsd.edu first for more information

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Rodrigo Gallardo, DVM, PhD, dACPV

Poultry medicine, preventive veterinary medicine, virology

My research has been focused in poultry medicine specifically poultry viral diseases and immunology. One of my goals is to use of molecular and conventional virology and preventive veterinary medicine strategies to understand and control poultry diseases. Lately I have been focusing in international poultry work towards village poultry improvement controlling Newcastle disease virus in Central America and Africa.

E-mail: ragallardo@ucdavis.edu

Website: http://www.vetmed.ucdavis.edu/faculty/results.cfm?fid=21080

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Melanie Gareau, Ph.D.

Microbiota-gut-brain axis

VM: Anatomy, Physiology and Cell Biology

Dr. Gareau is a physiologist primarily interested in studying the microbiota-gut-brain axis. It is increasingly being recognized that the microbes that live the gastrointestinal tract, collectively referred to as the intestinal microbiota, can contribute to modulating cognition and mood. The research focus of her laboratory is in determining how manipulating the microbiota within the gut, using models of infection with bacterial pathogens or administration of beneficial probiotic bacteria, can change cognitive function, anxiety, and depression-like behaviors in mouse models of disease. Dr. Gareau has a particular interest in how the microbiota-gut-brain axis responds to stimulation with psychological stressors and under conditions of intestinal inflammation, such as in models of inflammatory bowel disease (IBD). Ongoing projects in the laboratory include studying behavior in mouse models of IBD and following pathogenic E. coli infection.

If interested, please contact Dr. Gareau: mgareau@ucdavis.edu

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Angie Gelli, Ph.D.

Microbiology, molecular biology, host-pathogen interactions, blood-brain barrier, fungal pathogens

Dept. of Pharmacology, SOM

Over the past few years our research has focused on understanding how some pathogens are inherently capable of entering the brain, always with the underlying notion that these mechanismsmight be exploited for the development of drug-delivery systems across the blood-brain barrier for the treatment of brain disorders. My research has focused on the human fungal pathogen Cryptococcus neoformans - the leading cause of a life-threatening fungal meningoencephalitis. Approximately 625,000 people die from this infection each year around the globe mostly due to the difficulties associated with destroying the pathogen once it gets into the brain. Most patients succumb to the infection because of increased intracranial pressure and lack of adequate fungicidal drug regime. Not only does this organism represent a medically relevant pathogen with fascinating mechanisms of pathogenesis but also it serves as an excellent model system for studying other fungal pathogens with central nervous system involvement. We use a multidisciplinary approach that includes proteomics and RNA-sequencing to examine the physical and molecular changes in the brain endothelium and to identify gene products in C. neoformans that elicit these changes during attachment to- and migration across the blood-brain barrier.

If interested, please contact Dr. Angie Gelli: acgelli@ucdavis.edu

Visit our websites: http://acgelli.faculty.ucdavis.edu/ and http://pharmacology.ucdavis.edu

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Damian Genetos, Ph.D

VM: Anatomy, Physiology and Cell Biology

My research focuses upon the skeletal system, its development, and the mechanisms whereby it adapts to changes in the local microenvironment.

The skeleton responds to changes in applied loads. Under conditions of reduced use (as occurs during spaceflight or prolonged bed rest), bone is resorbed; when excess loads are applied, more bone is made, to reduce the stress placed upon them. Osteoblasts, the bone-forming cells, are responsive to a variety of stimuli, and we have begun to characterize the downstream signaling events involved in the conversion of an external load into a bone-forming response. This process is termed mechanotransduction. Current areas of research include purinergic signaling and epigenetic regulation in response to in vitro loading.

I also examine how pericellular oxygen tension affects bone cells bone turnover, and bone repair. The oxygen tension within bone can vary under certain circumstances; for example, fracture and limb unloading promotes hypoxia in osteocytes. In collaboration with a colleague at Lawrence Livermore National Laboratory, we are examining the influence of altered oxygen tension perception upon Wnt and BMP signaling in mice.

Additionally, we study how aberrant bone formation can cause pathologic conditions, such as vascular calcification.

Please visit Dr. Genetos's website at: http://faculty.vetmed.ucdavis.edu/faculty/dgenetos/

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Laurel J. Gershwin, DVM, PhD

VM: Pathology, Microbiology & Immunology

Dr. Gershwin is a veterinary immunologist who studies immunopathogenesis of disease in several species.

The laboratory studies bovine respiratory disease, with particular emphasis on Bovine Respiratory Syncytial Virus (BRSV).  Ongoing projects focus on effects of anti-viral compounds and anti-inflammatory drugs on bovine respiratory syncytial virus (BRSV) infection, testing in cattle a new potential BRSV subunit vaccine, and evaluating gene usage during acute and chronic infection. Human and bovine RSV are very similar and cause almost identical disease in their respective hosts. One of our projects has uses a human anti-RSV drug to evaluate its effectiveness in bovine calves.

The Gershwin lab is working with VMTH equine clinicians to evaluate the cellular immune response of grey horses with melanoma that are receiving Merial’s canine melanoma vaccine (off label). This DNA vaccine appears to have great potential and the goal is to document at the cell and molecular level how it works to decrease tumor growth.

STAR projects for summer can involve either of these research areas.

Please visit Dr. Gershwin's website at: http://faculty.vetmed.ucdavis.edu/faculty/ljgershwin/

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Kirsten Gilardi, DVM, Dipl. ACZM

Wildlife Health Center

Dr. Kirsten Gilardi, DVM, Dipl. ACZM is Associate Director of the Wildlife Health Center (WHC). At the WHC, she serves as the Executive Director of the WHC's SeaDoc Society, a marine wildlife and ecosystem health program with on-the-ground operations in Washington state (under the leadership of Dr. Joe Gaydos) and in California, where SeaDoc runs the California Lost Fishing Gear Recovery Project. As well, Gilardi co-directs (with WHC veterinarian Dr. Mike Cranfield) the Gorilla Doctors program, a partnership with the non-profit Mountain Gorilla Veterinary Project that provides in situ veterinary care to wild human-habituated mountain and Grauer's gorillas in east-central Africa. Gilardi's clinical and research areas of expertise are in free-ranging wildlife health, with a current emphasis on One Health approaches to great ape medicine and conservation, and on marine and aquatic species (population health assessments, impacts of lost fishing gear on marine wildlife).

Please contact Dr. Gilardi at kvgilardi@ucdavis.edu.

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Cecilia Giulivi

VM: Molecular Biosciences

Bioenergetics: changes in intermediary metabolism with diets deficient of essential amino acids. Role of mitochondria dysfunction in Huntington's disease. Fragile X, ataxia and tremor syndrome. Autism Neurodegeneration in Alaskan huskies Type 2 diabetes. Role of mitochondria in different organs during prediabetes and diabetes. Citrullinemia: changes in nitric oxide pathways in cerebellum. Aging and protein nitration, oxidative and nitrative stress pathways.

Research: My laboratory focuses at understanding the mechanisms of mitochondrial dysfunction in a variety of phisiopathologies such as triplet nucleotide diseases (Huntington's disease. Fragile X, ataxia and tremor syndrome), autism, and metabolic diseases (diabetes, essential amino acid deficiency, thiamine deficiency).  We use a variety of techniques ranging from biophysics and biochemistry to molecular biology including in silico modeling.

Please visit Dr. Giulivi's website at: http://faculty.vetmed.ucdavis.edu/faculty/cgiulivi/

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Jenessa Gjeltema, DVM, Dipl. ACZM

Research Focus:  Environmental and non-infectious disease affecting zoological species and ecosystem health (see also: Wildlife/Exotic Animal Medicine, Anesthesia)

Affiliated departments:  Karen C. Drayer Wildlife Health Center and Department of Medicine and Epidemiology

As Assistant Professor of Zoological Medicine and Associate Veterinarian at the Sacramento Zoo, Dr. Jenessa Gjeltema, DVM, Dipl. ACZM, a board-certified specialist in Zoological Medicine, provides both clinical services and engages in research in the field of Zoological Medicine through the Karen C. Drayer Wildlife Health Center.  Dr. Gjeltema has particular research interests in non-infectious and environmental diseases affecting zoological species and ecosystem health.

Possible student research projects include:

Investigation of the health effects of microplastic pollution within terrestrial ecosystems

Evaluation of anesthesia protocols in Giant Garter Snakes (Thamophis gigas)

Evaluation of diagnostic, therapeutic, and anesthetic techniques in California Tiger Salamanders (Ambystoma californiense)

Disease pathology and environmental risks affecting captive and free-ranging endangered Puerto Rican crested toads (Peltophryne lemur)

To contact Dr. Gjeltema - jgjeltema@ucdavis.edu


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Aldrin Gomes, PhD

Striated muscle disease

Department of Neurobiology, Physiology and Behavior, Department of Physiology and Membrane Biology

The laboratory investigates cellular and molecular biochemistry and utilizes proteomic approaches to understanding cardiac and skeletal muscle diseases. The two main areas of interest are troponin related cardiomyopathies and proteasome related dysfunction in muscle diseases. The proteasome is investigated at the molecular and cellular level using PCR arrays, biochemical techniques and proteomics. Troponin related cardiomyopathies are investigated in rodent models of hypertrophic and restrictive cardiomyopathies using several biochemical, biophysical and proteomic techniques. Possible summer research projects for veterinary students include 1) mechanisms underlying hyperglycemia-induced changes in cardiac proteasome and its role in diabetic cardiomyopathy, and 2) investigating the role of troponin mutations in a mouse model of restrictive cardiomyopathy.

Please visit Dr. Gomes's websites at: http://biosci3.ucdavis.edu/FacultyAndResearch/FacultyProfile.aspx?FacultyID=375 or http://www.ucdmc.ucdavis.edu/physiology/faculty/gomes.html

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Kristin Grimsrud, DVM, PhD

Assistant Clinical Professor, Dept of Pathology, School of Medicine 

Associate Director of Vivaria and Veterinary Care, Mouse Biology Program (MBP)

Dr. Grimsrud is a laboratory animal veterinarian and her research focuses on translational medicine and animal model optimization and development. Her current major research efforts are in collaboration with the Knockout Mouse Project, Metabolic Mouse Phenotyping Center and Mutant Mouse Resource and Research Center. Additionally, she is involved in a variety of microbiota bariatric surgery research projects that utilize mouse models. Lastly, Dr. Grimsrud has a strong interest in translational clinical pharmacology where she investigates variation in pharmacokinetics and pharmacodynamics in special populations (e.g. burn patients, pediatrics) and assess the influences of polymorphisms on drug efficacy.

Research projects that students could be involved with relate to studies to optimize anesthesia and analgesia protocols, optimizing superovulation techniques in rodents and a variety of other projects related to the genetically engineered rodent models and microbiota/gnotobiotic research.

Contact Information:

Email: kngrimsrud@ucdavis.edu

Office Phone: 530-757-3220

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Bruce Hammock

Pharmacology, analytical chemistry of chemical mediators, regulatory biology, pain

Dr. Hammock’s laboratory has a long collaboration with faculty and students in the school of veterinary medicine.  His laboratory develops mass spectral and biosensor analytical methods for environmental contaminants and drugs in companion animals.  The laboratory is working on a new branch of the arachidonic acid cascade and is developing drugs to block arthritic and laminitic inflammation in horses and inflammatory and post surgical pain in dogs and cats associated with injury, diabetes, age and other criteria.

Projects:

Use of inhibitors of the soluble epoxide hydrolase to potential treat disease in companion animals such as dogs and cats as well as horses and livestock species.

Pharmacokinetic analysis in development of novel pharmaceuticals for veterinary use.

Fundamental mechanism of action of regulatory lipids.

Natural food additives to expand the efficacy of omega 3 fatty acid supplements in food of companion animal and livestock species.

See   http://www.biopestlab.ucdavis.edu/ for additional information.

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Michelle Hawkins, VMD Dipl. ABVP (Avian Practice)

Anesthesia, analgesia, wildlife

Department of Medicine and Epidemiology School of Veterinary Medicine

Dr. Hawkins current research area is in advancing clinical and research techniques aimed at improving the health of wild birds of prey during rehabilitation. Her areas of particular interest include pain management and other therapeutics as well as specific infectious and toxicologic diseases affecting these species. Dr. Hawkins has a number of active research projects, and would be interested in talking to students who have an interest in clinical or basic science research in these areas.

Please visit Dr. Hawkins' website for more information: http://www.vetmed.ucdavis.edu/faculty/results.cfm?fid=14789

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Meera Heller DVM, PhD, DACVIM

Immunology and Infectious Disease, Livestock Medicine, Food Animal Medicine & Food Safety

I’m an Assistant Professor of Clinical Livestock Medicine and Surgery (C barn).   My research interests lie in the area of immunology and infectious disease, specifically in the areas of innate immune response and juvenile immunity.  My research goals are to improve prevention and treatment of calfhood disease, or disease in neonates of any species.  My clinical expertise is in internal medicine and surgery of ruminants and swine, and I have a special interest in cattle and goats.  Potential research projects include bench-top projects working with bovine bacterial pathogens in the lab, field research on a novel approach to prevention pink eye in cattle,  field research to document a vector borne disease  in goat populations in northern California, and clinically important retrospective studies using the VMACS database.  I am also open to project ideas from students, and am happy to help you craft a research question that fits your interests.

Please contact Dr. Heller via email at mcheller@ucdavis.edu.

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Matthias Hess, PhD

Department of Animal Science 

I am a microbiologist with a strong background in biotechnology. My research centers on the multi-scale (from molecule to cell to population to ecosystem) understanding of microbial systems through cultivation-independent as well as cultivation-based techniques. One of the ecosystems my group has been focusing on over the last years is the gut microbiome of ruminants and we have established an artificial rumen system in the laboratory to address questions related to gut and animal health and performance. More recently we have been expanding our work into other animal systems such as fish, pigs and poultry.  

For more information, please visit Dr. Hess’ website.

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Smita Iyer, PhD

Department of Pathology, Microbiology, and Immunology

Our lab’s primary research interests center around delineating immunological and molecular mechanisms of CD4 T cell help. Our ultimate goal is to use this information to design an effective HIV vaccine and in parallel understand mechanisms of HIV susceptibility and pathogenesis.

Well-defined projects in the lab in the area of HIV immunology provide motivated students opportunities to contribute to publications while training in biomedical research. Research projects provide opportunities to learn, implement, and analyze data using powerful tools such as flow cytometry in combination with RNA sequencing analysis.

Contact information:

Email: smiyer@ucdavis.edu

Phone: (530) 752-5716 Office
           (530) 754-2688 Lab

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Michele Jay-Russell, DVM, MPVM, PhD, Dipl., ACVPM

Foodborne pathogens, food safety, good agricultural practices, food policy and regulation, public health, zoonoses

Western Institute for Food Safety and Security (WIFSS)

My research interests are in food safety and veterinary public health with an emphasis on the molecular epidemiology of zoonotic enteric foodborne pathogens. I currently manage the Western Center for Food Safety, an FDA Center of Excellence in partnership with UC Davis. Our mission is to research the interface between production agriculture and food protection to identify real-world solutions to food safety challenges in these systems. Prior to joining the university, I served as the State Public Health Veterinarian and was involved with numerous outbreak investigations at the state and county levels in California. My current research program continues work in the area of public health and food safety. My laboratory conducts on-farm and field trial studies with the aim to reduce the risk of foodborne pathogen transmission to the food supply from domesticated and wild animals, untreated biological soil amendments (raw manure), and other environmental sources. One of my key outreach goals is to work with stakeholders to develop co-management approaches to protect fruits, nuts, and vegetables from microbial contamination while at the same time promoting environmental stewardship on farms. Data generated by applied research and outreach activities in my program have been used to inform policy related to produce food safety and FDA’s Food Safety Modernization Act (FSMA) regulations.

 Please visit Dr. Jay-Russell’s website: http://wcfs.ucdavis.edu/staff/4/Michele_JayRussell.html

Potential STAR Projects Summer 2018:

·         Validation of minimum application intervals for untreated biological soil amendments of animal origin (raw manure and other animal products)

·         Ability of poultry pellet fertilizers and other biological soil amendments to serve as pathogen harbors in fresh produce production

·         Mitigating food safety risks in aquaponics production

·         Quantitative Microbial Risk Assessment (QMRA) of Salmonella in farm ponds used for fresh produce production

·         Development of educational and extension materials on microbial food safety and composting

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Eric G. Johnson, DVM

Associate Professor of Clinical Surgical & Radiological Sciences

My background research interests include mapping of lymphatic pathways with ultrasound, CT and MRI and novel disease descriptions using these cross sectional imaging modalities.

Contact information: egjohnson@ucdavis.edu

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Lynelle Johnson DVM, PhD, Diplomate ACVIM

Small animal respiratory medicine

VM: Department of Medicine & Epidemiology

Dr. Johnson is a small animal internist with a special focus in respiratory diagnostics and respiratory diseases of dogs and cats. She has a 50% clinic appointment in the VMTH and a research laboratory in Tupper Hall with capabilities for western blotting, polymerase chain reaction, microdissection, and vascular phyiosiology. Recent projects have focused on infectious and inflammatory nasal diseases of dogs and cats and respiratory endoscopy in dogs, cats, and rabbits. I would love to talk with students who have an interest in clinical medicine or in basic science research related to respiratory medicine.

STAR:  DA Kogan, LR Johnson, BK Sturges, KE Jandrey, RE Pollard. Etiology and clinical outcome in dogs with aspiration pneumonia:  88 cases (2004-2006). Journal of the American Veterinary Medical Association 233(11): 1748-1755, 2008.
STAR:  DA Kogan, LR Johnson, KE Jandrey, RE Pollard.  Clinicopathologic and radiographic findings in dogs with aspiration pneumonia: 88 cases (2004-2006). Journal of the American Veterinary Medical Association 233(11): 1642-1747, 2008.
RC Windsor, LR Johnson, JE Sykes, TL Drazenovich, CM Leutenegger, HEV De Cock.  Molecular detection of microbes in nasal biopsies of dogs with idiopathic lymphoplasmacytic rhinitis. Journal of Veterinary Internal Medicine 20: 250-256, 2006.

Please visit Dr. Johnson's website at: http://faculty.vetmed.ucdavis.edu/faculty/lrjohnson/

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Sree Kanthaswamy, Ph.D.

California National Primate Research Center

My research focuses on primate genetics and forensic DNA analysis. My primate research uses genetic markers to define the population structures of captive and wild populations of non-human primates. I use comparative genomic methods to understand human and non-human primate biology. My forensic science research is based on the analyses of traces of human and animal blood, saliva and hair collected at crime scenes or from civil cases for DNA-typing. My research also focuses on establishing species-specific DNA markers for accurate and precise genetic identification and to enhance our population genetics database for each species. My research activities provide excellent educational opportunities for students.

Please contact Dr. Kanthaswamy at skanthaswamy@ucdavis.edu for further information.

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Philip Kass

VM: Population Health & Reproduction

"My research falls in the realm of companion animal epidemiology: the study of causes of health and disease in populations of dogs and cats. The studies that I do are non-experimental (or observational), and generally (but not always) do not involve in handling animals and do not involve laboratory work. Examples of STAR projects that I have been involved with in the past include studying factors affecting survival in dogs and cats that underwent cardiopulmonary resuscitation, factors affecting survival in dogs with peripheral nerve sheath tumors, predisposing factors to secondary glaucoma in dogs, determinants of patient outcome in cases of aortic thromboembolism, prognostic factors for recovery of function following intervertebral disk protrusion in Dachshunds, and evaluation of national trends in the submission of biopsies of suspected vaccine-associated sarcomas. These kinds of studies often begin with ideas formulated by students, and we figure out a way to study them in the time allotted for the STAR program.  I am currently trying to obtain funding to conduct epidemiologic studies into novel statistical approaches to studying possible adverse effects of vaccination on chronic diseases in companion animals."

Please visit Dr. Kass's website at: http://faculty.vetmed.ucdavis.edu/faculty/phkass/

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Christine Kreuder Johnson, VMD, PhD

One Health Institute

(See also: Global Health, Wildlife/Zoonoses)

Dr. Kreuder Johnson is a Professor of Epidemiology and Ecosystem Health in the School of Veterinary Medicine and Director of the EpiCenter for Disease Dynamics at the One Health Institute at UC Davis. Her research focuses on wildlife population health and the impact of ecological processes on species at risk and patterns of disease transmission in marine and terrestrial wild animal populations. Recent activities investigate zoonotic disease spillover dynamics, viral host shifts, further characterization of the animal-human interface, and epidemiologic patterns facilitating zoonotic disease transmission and spread. She provides epidemiologic support to federal and state agencies during unusual outbreak events and directs global surveillance activities for the Emerging Pandemic Threats PREDICT program.

 Contact info: ckjohnson@ucdavis.edu

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Amir Kol, DVM, PhD

VM: Pathology, Microbiology & Immunology

My research is in the field of stem cell biology and translational regenerative medicine. Our group is specifically focused on the use of pluripotent stem cells in naturally occurring diseases in companion animals as platforms to conduct high level translational research to facilitate the development of novel regenerative medicine therapeutics for human and veterinary use. Ongoing projects in the lab include the regulatory networks that govern the naive pluripotent state in canine pluripotent stem cells and cellular replacement treatments for canine diabetes mellitus . Our group is always looking for the brightest and most enthusiastic future scientists that are eager to realize the incredible potential and promise of regenerative medicine.

Contact information:  akol@ucdavis.edu

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Nancy E. Lane, MD

Professor of Medicine and Rheumatology
Director: UC Davis Center for Musculoskeletal Health
Director: Building Interdisciplinary Research Careers in Women's Health (BIRCWH)

Dr. Lane is translational scientist in musculoskeletal diseases, specifically osteoporosis and osteoarthritis including laboratory base models for over 20 years.  Her research has included evaluating how agents to treat osteoporosis affect bone quality, performs proof of concept phase 2 on an NIH funded clinical trial to determine how treatment with PTH could stimulate new bone formation in glucocortioid induced osteoporosis and if an antibody to nerve growth factor could reduce pain in osteoarthritis.                                                                                                                                             

Dr. Lane also has performed epidemiologic studies of osteoarthritis of both the knee and hip in men and women. Dr. Lane has received mentoring awards and currently is the director of UC Davis's K12 program on Building Interdisciplinary Research Careers in Women's Health.  Dr. Lane has mentored over 30 trainees in her academic career and has published over 300 articles or chapter.

Currently, Dr. Lane performs preclinical laboratory based studies to determine how bone active agents are used to treat osteoporosis and change bone quality and bone strength; and how a novel hybrid compound, LLP2A-­‐Ale, can direct mesenchymal stem cells to the bone surface and augment bone formation in bone disease states including osteoporosis, osteonecrosis and fracture healing.

Mentees are welcome to work on all aspects of this on‐going research.

Please visit Dr. Lane’s website at http://www.ucdmc.ucdavis.edu/publish/facultybio/search/faculty/1106 and  the  website  for  the  Center for  Musculoskeletal  Health  at  http://www.ucdmc.ucdavis.edu/musculoskeletalhealth/

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Gregory Lanzaro, PhD

Vector Genetics Lab

Variation in maxadilan and its consequences

Maxadilan is a potent vsodilatory protein in the saliva of the sand fly, Lutzomyia longipalpis . Our observation that maxadilan is highly polymorphic was surprising. It would seem that the amino acid sequence of such a protein, with functions presumably vital to the sand fly, would be conserved. We hypothesize that hyper-variation in maxadilan has evolved as a mechanism for the avoidance of host immune response mounted against it. To test this hypothesis we propose studies aimed at determining amino acid sequence polymorphism in maxadilan from Lu. longipalpis (Aim #1). Population genetics studies will be conducted at field sites in Colombia , Nicaragua and Brazil . If variation in maxadilan does represent antigenic polymorphism and is adaptive, then it must be true that anti-maxadilan antibodies have a negative effect on vector fitness. In Aim #2 we propose a series of experiments to test this hypothesis. We will immunize hamsters with recombinant maxadilan. Flies will be fed on immunized and control animals and effects on sand fly fitness evaluated. In Aim #3 we will examine the impact of maxadilan on leishmanial infections. There is compelling evidence that the immunomodulatory activities of sand fly saliva, and maxadilan itself, enhances the establishment of parasite infections. The effects of vector saliva and specific maxadilan proteins on the pathogenesis of Leishmania chagasi will be evaluated by experimental infections (Aim #3). We have discovered that natural Lu. longipalpis populations differ dramatically in the amount of maxadilan present in their saliva. As part of Aim #3 we will conduct epidemiological field studies to determine the distribution of “high” and “low” maxadilan fly populations in relation to the distribution of visceral or atypical cutaneous disease caused by Le. chagasi . In Aim #4, we will study immunological specificity of maxadilan variants. The goal of these experiments is to determine if different maxadilan proteins illicit specific antibodies and to evaluate if these cross react (antigenic specificity).

Population genomics of the mosquito An. gambiae in Africa

Malaria control strategies based on genetic manipulation of vectors will require extensive knowledge of vector population genetics. Critical information includes: population size, patterns of gene flow, the breeding structure of populations and the effects of natural selection on individual gene loci. The overall goal of the proposed research is to provide such a background. We propose to address these questions by: (1) Characterizing spatial variation in the genetic structure of populations of Anopheles gambiae in continental Africa by determining the distribution of chromosomal and molecular polymorphisms. Representative locations will be studied in two countries: Mali in West Africa and Cameroon in Central Africa . The genetic markers we will use include chromosome arrangements, microsatellite DNA loci, and mitochondrial DNA loci. (2) Identifying physical/ecological features and relate these to spatial varoiation in population genetic structure, patterns of gene flow, and as selective forces on individual loci. Migration rates among sites will be established by measuring their genetic similarity, then inferring how much gene flow is required to maintain such observed similarity. Based on this information we will employ a GIS-based procedure termed "Wombling", which will identify areas with high and low levels of gene flow. These will be then be correlated with ecological features determined on the ground and from remote imaging. In this manner ecological features associated with high and low population densities, and also with high and low levels of gene flow can thus be identified. Such information should be helpful to vector control efforts that require an understanding of dispersal and gene flow, including genetic control and insecticide resistance management. The effects of natural selection on individual loci and segregating sites within loci will be studied by taking a population genomics approach. This approach provides the means to study the behavior of individual functional genes in nature, bridging the gap between population genetics and molecular biology.

Please visit Dr. Lanzaro's website at: http://faculty.vetmed.ucdavis.edu/faculty/gclanzaro/

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J. Kent Leach, Ph.D.

Tissue engineering, bone, biomaterials

Research in the Leach laboratory is primarily in the broad area of TISSUE ENGINEERING. Within our research program, we seek to engineer functional replacement and temporary bridge tissues while also developing model systems to study physiological and pathophysiological tissue formation. We initially develop many of our projects with an eye toward bone tissue engineering, and these findings are subsequently applied to other areas of tissue repair including cartilage and cardiovascular engineering, as well as wound healing.

All projects in the lab are linked by the hypothesis that combinatorial approaches to tissue formation are superior to individual stimulation. More specifically, successful tissue engineering approaches will be realized upon the proper spatial and temporal presentation of cells, signaling molecules, biomaterials, and mechanical stimulation.

website: http://bme.ucdavis.edu/leachlab/

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Pamela Lein

Neurodevelopment, neuroinflammation, neurodegeneration, neurotoxicology, seizures, asthma

VM: Molecular Biosciences

The overarching goal in the Lein laboratory is to determine how environmental stressors interact with genetic susceptibilities to influence the risk and severity of neurodevelopmental disorders, neurodegenerative disease, seizures and airway hyperreactivity. Altered patterns of connectivity are associated with functional deficits in the central and peripheral nervous systems; therefore, we are investigating how environmental contaminants, chemical convulsants and inflammation perturb neuronal connectivity as determined using biochemical, morphogenic, functional and electrophysiological endpoints. We are also developing biomarkers of OP neurotoxicity and testing novel therapeutic approaches for protecting against the neurodegenerative effects associated with chemical convulsants.

If interested, please contact Dr. Pamela Lein at pjlein@ucdavis.edu

Visit our website: http://www.vetmed.ucdavis.edu/lein-lab/

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Sarah le Jeune, DVM, CVA, Diplomate ACVS

Clinical Equine Emergency Surgery and Critical Care

Dr. le Jeune is an equine emergency surgeon with a strong interest in acupuncture. Research interests include studies investigating the effectiveness of acupuncture and clinical studies on various facets of equine gastro-intestinal diseases and other equine surgical conditions.

Please visit Dr. le Jeune's website at: http://faculty.vetmed.ucdavis.edu/faculty/sslejeune/

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Richard Levenson, MD, FCAP

Department of Pathology and Laboratory Medicine (see also: Global Health, Pathology/Virology)

BACKGROUND

Richard Levenson, MD, FCAP, is Professor and Vice Chair for Strategic Technologies in the Department of Pathology and Laboratory Medicine, UC Davis. He trained in medicine at University of Michigan and pathology at Washington University, and is Board-certified in Anatomic Pathology. A faculty position at Duke was followed by an appointment at Carnegie Mellon University to explore multispectral imaging approaches for pathology and biology. In 1999, he joined Cambridge Research & Instrumentation (now part of PerkinElmer) to become VP of Research, and helped develop commercially successful multispectral microscopy systems and software for molecular pathology and diagnostics, multispectral and three-dimensional small-animal imaging systems, optical dynamic contrast techniques, and birefringence microscopy. He serves on NIH, NCI and NSF review panels, is section editor for Archives of Pathology, and is on the editorial boards of Laboratory Investigation. Current research includes mass-tagged enabled multiplexed immunohistochemistry, and novel slide-free microscopy.

MUSE MICROSCOPY

How microscopes work in actual clinical pathology has not changed materially in well over a century. Microscopy with Ultraviolet Surface Excitation. MUSE is a novel approach for obtaining high-resolution, diagnostic-quality histological images from unsectioned thick tissue specimens, avoiding the need to perform extensive tissue processing and thin physical sectioning. MUSE is notable for its optical and mechanical simplicity. Micron-deep images of the specimen surface are generated with 280-nm UV excitation provided by off-axis light-emitting diodes (LEDs).  Excitation with such short-wavelength UV light excites a wide range of exogenous dyes, and the resulting visible-band fluorescence images can be captured using ordinary microscopic optics and standard CMOS or CCD cameras. These multicolor fluorescence images have novel contrast but can also be converted to resemble conventional hematoxylin- and eosin-staining. A sample can be prepared for MUSE in around a minute. Extended fields of view can be captured from whole organs with microscopic detail. This non-destructive process leaves the sample intact for subsequent downstream molecular or genetic analysis. In addition, images can include shading and depth cues that reveal surface profiles important in understanding the three-dimensional organization of complex specimens. This inexpensive, rapid, and slide-free, sample-sparing method has potential to replace frozen sections, and may have other applications in both high- and low-resource settings.

EXAMPLES OF POSSIBLE PROJECTS:

1.            Survey a suite of familiar and unfamiliar fluorescent stains to learn what work best for either recapitulating standard hematoxylin-and-eosin stain appearance, or for staining new tissue components that are not easily detected just with H&E, like collagen, elastin, amyloid, PAS, etc.

2.            One of the things we have not yet been quite successful with is getting immunofluorescence to work with MUSE. The problem may be inadequate excitation light power (so we would need different sources), or alternatively, we need brighter labels. There are ways of approaching both these things, but this may be a more difficult project without guarantee of success. Still, it’s very important, and a lot would be learned along the way.

3.            Application to vet path cases would be very relevant, as MUSE can both provide intra-operative guidance, as well as point-of-care histology in veterinarian offices, which could be very helpful in decreasing the need for return visits and accelerating care.

Contact  - levenson@ucdavis.edu

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Ronald Li DVM, MVetMed, DACVECC

Department of Surgical and Radiological Sciences 

The Li Laboratory focuses on the study of hemostasis and thrombosis in various diseases.  We are currently investigating the role of platelets in thrombosis and inflammation during bacterial sepsis in dogs.  We are also investigating the formation of neutrophil extracellular traps (NETs) in horses with sepsis.  Particularly, we are interested in assessing the expression and function of Toll-like receptors on platelets during sepsis and how they mediate interactions with neutrophils and NET formation.  Our other research focus includes the pharmacogenetics of antiplatelet therapy in cats with hypertrophic cardiomyopathy.   

Opportunities for STAR projects involve our current studies in platelet activation and platelet/neutrophil interaction in NET formation in canine and equine sepsis.  Please contact Ronald Li at rhli@ucdavis.edu for more information.

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Fu-Tong Liu, M.D., Ph.D.

SOM: Dermatology

Fu-Tong Liu, MD PhD, is a dermatologist/immunologist currently serving as Distinguished Professor and Chair Emeritus of the Department of Dermatology in the School of Medicine at UC Davis. His primary research interests encompass molecular and cellular mechanisms of allergic disorders and this includes the studies of IgE, IgE receptors, and mast cells. Current projects in his lab related to this area include the studies of mouse models of atopic dermatitis and the mechanism of anti-IgE therapy for allergy. In addition, his group is heavily involved in the investigation of expression, structure and function of a family of animal lectins, galectins. The research is focused on the roles of galectin-3, -7, -9, and -12 in inflammation, infection, skin diseases, and cancer. 

Please visit Dr. Liu website at: http://www.ucdmc.ucdavis.edu/dermatology/faculty/liu.html

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Paul Luciw, PhD

Center for Comparative Medicine

Dr. Luciw is a molecular virologist who leads an internationally recognized research program that interdigitates with research programs all over campus. His group has expertise in virology, cell biology, and molecular virology. The main emphasis of his research is on molecular mechanisms that regulate replication and pathogenesis of viruses that establish chronic infections. Additionally, knowledge of virus/host relationships is being used to design and test live-attenuated viral vaccines and to develop novel DNA immunization strategies aimed at preventing viral infection. Dr. Luciw's group focuses on lentivirus models for AIDS, including SIV and SIV/HIV chimeras in macaques, and FIV in cats. As director of viral oncology research on campus, he works on herpesviruses in macaques as models for Kaposi's sarcoma. In addition, he is developing novel multiplex detection methods for serodiagnosis of infectious diseases of mice and non-human primates, analysis of cytokines and chemokines in various disease states in animal models and humans, and studies on cell signaling pathways in cell culture models for cancer.

Please visit Dr. Luciw's website at: paluciw@ucdavis.edu

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Maria Marco, Ph.D.

Microbiota, obesity, IBD, prebiotics, probiotics

Department of Food Science & Technology

My research focuses on the roles of dietary and intestinal microorganisms in obesity and inflammatory bowel diseases. We are employing pre- and probiotic components to study the interactions between bacteria and the host that influence immune and metabolic function. The overarching goal of the research is to define the ecological basis and molecular mechanisms by which beneficial microorganisms contribute to maintaining good health. Examples of research projects include: application of pre-clinical models to evaluate the benefits of pre/probiotics to prevent pre-diabetic states or IBDs,  the molecular analysis of host responses to probiotic bacteria and prebiotic fermentable dietary fiber; application of genetic analysis to investigate the function of specific probiotic Lactobacillus secreted factors in maintaining intestinal homeostasis; intestinal microbiome assessments using high-throughput DNA sequencing methods.

Please visit Dr. Marco’s website: http://www.marcolab.net

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Stanley Marks , BVSc, PhD, Dip. ACVIM (Internal Medicine, Oncology), Dip. ACVN

VM: Medicine & Epidemiology

Dr. Marks is a veterinary gastroenterologist and nutritionist who runs the Companion Animal Gastrointestinal Laboratory. His research group have been characterizing enteric bacteria (Clostridial species, Campylobacter, Salmonella) and protozoa (Giardia, Cryptosporidium, Tritrichomonas foetus) associated with diarrhea in dogs and cats, and evaluating diagnostic tests and therapeutic strategies to eradicate the organisms. His group has also studied antimicrobial susceptibilities of Clostridium isolates to commonly utilized antimicrobial drugs, and evaluated the incidence of antimicrobial resistance genes in canine Clostridium perfringens isolates. The GI laboratory is fully equipped for performing aerobic and anaerobic microbiology, parasitology examinations, DNA extraction and purification, PCR, gel electrophoresis, and immunoassays. The laboratory has several ongoing studies evaluating the protozoan, Tritrichomonas foetus, an important cause of bovine infertility and abortion, and a recently characterized cause of chronic diarrhea in cats.

Please visit Dr. Marks's website at: http://faculty.vetmed.ucdavis.edu/faculty/slmarks/

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Beatriz Martinez-Lopez, DVM, MPVM, Ph.D.

Quantitative epidemiology, risk assessment, spatial epidemiology, modeling

VM: Medicine & Epidemiology

Dr. Beatriz Martínez López (DVM, MPVM, PhD) is Assistant Professor in the Department of Medicine and Epidemiology, Agricultural Experiment Station (20%) faculty and Director of the UC Davis Center for Animal Disease Modeling and Surveillance (CADMS). Her research is focused on the development and implementation of novel epidemiological methods to gain knowledge about the evolution, spread and economic impact of infectious diseases and to support policies. She uses risk assessment, spatial epidemiology methods, molecular epidemiology, modeling or social network analysis to identify individuals, areas and time periods at higher risk of becoming infected and to detect the most important factors contributing to such risk. She is also working in the integration of these and other methods (i.e. data mining, time-series analysis) in operational, web-based, platforms (i.e., Disease BioPortal, http://bioportal.ucdavis.edu/) with the aim to provide a near real-time monitoring and early warning systems for better prevention and control of transboundary, emerging and re-emerging infectious diseases at a global and local scale. She has been working with diseases affecting domestic and/or wild animal populations such as foot-and-mouth disease, African swine fever, classical swine fever, bovine tuberculosis, Aujeszky´s disease, African horse sickness, bluetongue, avian influenza, West Nile, Rift Valley Fever and diseases affecting aquatic organisms. Many of those diseases are considered to be emerging or re-emerging due to globalization, climate, land use and management changes. CADMS provides a coordinated, interdisciplinary, dynamic environment to develop methods, models and surveillance systems to better prevent, control and eradicate infectious diseases. Currently, CADMS, which accounts with approximately 16 personnel including faculty, analysts, programmers, veterinarians, administrative staff and graduate students, is a FAO Reference Center for modeling and epidemiology and offers diverse opportunities for collaborations in research activities both locally and internationally.

Contact Dr. Martinez-Lopez at beamartinezlopez@ucdavis.edu.

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Jonna Mazet, DVM, MPVM, PhD

Jonna Mazet, DVM, MPVM, PhD, is a Professor of Epidemiology and Disease Ecology and Executive Director of the One Health Institute in the UC Davis School of Veterinary Medicine, where she focuses on global health problem solving, especially for emerging infectious disease and conservation challenges. Dr. Mazet is active in international One Health research programs, most notably in relation to disease transmission among wildlife, domestic animals, and people and the ecological drivers of disease emergence. Currently, she is the Global Director of a $175 million viral emergence early warning project, named PREDICT, that has been developed with the US Agency for International Development’s (USAID) Emerging Pandemic Threats Program. She was elected to the US National Academy of Medicine in 2013 in recognition of her successful and innovative approach to emerging environmental and global health threats.   

Contact info:  jkmazet@ucdavis.edu

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Brenda McCowan, PhD

VM: Population Health and Reproduction, California National Primate Research Center

Building on principles of evolutionary theory and animal behavior, the goal of our research group is to apply current understanding of animal behavior to animal welfare, management and conservation issues, while continuing to expand on this knowledge base. Applied research includes the use of bioacoustics as a conservation and management tool, effects of anthropogenic noise on wildlife behavior and communication, effects of social behavior on disease transmission in livestock and wildlife and the use of complexity theory and mathematical modeling as a social management tool for captive exotics, wildlife, laboratory animals and domesticated species.

Please visit Dr. McCowan's website at: http://faculty.vetmed.ucdavis.edu/faculty/bjmccowan/

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Stephen McSorley, PhD

VM: APC

Dr. McSorley's research is focused on understanding innate and adaptive immunity to bacterial infections particularly at mucosal surfaces. Specific research projects include: examining the role of TLR5 in innate and adaptive immunity to bacterial flagellin; developing a sub-unit vaccine against Salmonella infections; visualizing T cell responses to Salmonella and Chlamydia infection; examining innate activation of T cells during bacterial infections; the role of B cells in immunity to intracellular bacteria. Visit Dr. McSorley's website for more information.

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Stuart Meyers, DVM, PhD

Reproduction, aging and sperm physiology and cryopreservation, male effects on embryo development, and germ cell transplantation in endangered fish

VM: Anatomy, Physiology & Cell Biology

Dr. Meyers is a veterinarian, professor, and researcher in the SVM with special interest in reproduction. Research in our laboratory has centered on gamete cryopreservation and an understanding of the role of the paternal genome on embryo development and mortality. Our newest research area is germ cell transplantation of endangered fish into surrogate non-endangered species. Our study models are the rhesus monkey, stallion, dog, and endangered fish but we also have active research in several other species. Our goals are to develop an understanding of fundamental mechanisms of cellular damage caused by low temperature storage, and then to use this knowledge to develop new methods for gamete preservation and subsequent fertility. We use a variety of techniques including flow cytometry and confocal, fluorescence, and electron microscopy to evaluate the integrity of sperm cell organization and cell function. 

Please visit Dr. Meyers's website at: http://faculty.vetmed.ucdavis.edu/faculty/smeyers/

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Themis J. Michailides

Plant pathology, fungal disease, epidemiology, latent infection, disease management, fungicide resistance, mycotoxins, aflatoxins

Plant Pathology, Kearney Agricultural Research & Extension Center (KARE), Parlier, CA

Dr. Michailides is a leading authority in fungal fruit tree pathology and is nationally and internationally recognized for his innovative ecological, epidemiological and plant disease management studies of devastating diseases of fruit crops such as the brown rot of stone fruit (pre-harvest and post-harvest), Botrytis gray mold of kiwifruit, pomegranate, and pistachio, fig endosepsis and smut of figs, black heart of pomegranate, Botryosphaeria blight and canker of pistachio, almond, and walnut, and aflatoxin contamination of nut crops and figs. We are doing pioneering work on resistance mechanisms of Alternaria alternata and Botrytis cinerea to various fungicides. Our studies also involve the phylogenetic analysis and taxonomy of plant pathogens attacking fruit and nut tree crops and determination of resistance of various tree cultivars to plant diseases.  We focused on detection of pathogens’ latent infections; these studies helped develop practical techniques that are used now commercially by private laboratories to help pest control advisers, California growers, and growers worldwide to make wise decisions regarding disease management. A very recent major accomplishment was the registration of an atoxigenic Aspergillus flavus strain AF36 (inoculum carrier wheat seed) in pistachio to reduce aflatoxin contamination of pistachio. About 77,000 acres of pistachios were treated with AF36 in 2012 for the first time and about 150,000 to 200,000 acres in 2013, 2014, and 2015. We also performed studies to expand the label of AF36 registration for almonds and figs. Registration was obtained for the atoxigenic Aspergillus flavus AF36 Prevail (inoculum carrier sorghum seed) in early August 2017. Funding and collaborations on these projects include the California Pistachio Research Board, the Almond Board of California, the California Fig Institute and other Agricultural Industries, the California Department of Food and Agriculture, and the Agricultural Research Service (ARS) of the USDA. In addition, there is a crew of 8 to 10 people doing research in my plant pathology projects at the KARE Center, so there is ample opportunity for interaction with a variety of individuals in an area of fundamental and traditional plant pathology.

Please visit Dr. Michailides's website at: http://kare.ucanr.edu/programs/Plant_Pathology/

Contact: tjmichailides@ucanr.edu; 559-646-6546; 559-273-8640

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Mike Mienaltowski, DVM, Ph.D.

College of Agriculture and Environmental Sciences

Tendon repair, tendon stem/progenitor cell biology; broiler muscle pathology; foal microbiome

My primary research interests include:

(1) the development, maturation, and repair of musculoskeletal connective tissues like tendon and ligament

(2) cellular mechanisms behind broiler muscle pathology

(3) the roles of the microbiome in proper gut transition in foals from birth to weaning.

In my musculoskeletal research projects, I am particularly interested in how differences in niche affect cells within the environment in growth and repair. Moreover, I am interested in the physiology of usage and elite performance as well as pathophysiology from over-usage, acute and chronic injury for all musculoskeletal tissues on all species as they might be related to use, environment, or genetics, and as they might be related to the manipulation of niche and collagen regulation genes. Furthermore, because the proper development of the musculoskeletal system  depends greatly upon proper foal growth and foal growth subsequently depends upon appropriate nutrition, I am interested in understanding how gut microbes facilitate healthy gut transitions in the foal. More information can be found at: http://animalscience.ucdavis.edu/faculty/mienaltowski/index.html

Contact information for Dr. Mienaltowski:  e-mail: mjmienaltowski@ucdavis.edu

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Christopher Miller, DVM, PhD

Center for Comparative Medicine

Christopher J. Miller, D.V.M., Ph.D. is a Professor of Pathology, Microbiology and Immunology in the School of Veterinary Medicine and an Adjunct Professor of Medicine in the School of Medicine. Dr Miller is a veterinarian and virologist, a core faculty member of the Center for Comparative Medicine and a Staff Scientist at the California National Primate Research Center. His laboratory utilizes non-human primate models of AIDS, Herpes simplex virus, Zika virus and influenza A virus infection to define the pathogenesis of these viral infections, study the nature of protective antiviral immunity, and test vaccines and immunotherapeutic strategies to prevent infections with these agents.

Please visit Dr. Miller's website at: http://faculty.vetmed.ucdavis.edu/faculty/cjmurphy/

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Lisa Miller, PhD

Immunology, respiratory, pediatric

California National Primate Research Center

Dr. Miller's research program is focused on understanding the relationship between early life environmental exposures, immunity and chronic disease.  We study how mucosal and systemic immunity is established during infancy, and determine the impact of air pollutants, allergens, and infectious disease on childhood health.  A major emphasis has been in the elucidation of mechanisms for immune susceptibility that lead to pediatric airways dysfunction, which may ultimately lead to generation of new diagnostics and preventative medicine.  Current research projects that use both in vivo and in vitro approaches include investigation of the airways microbiome during development, epigenetic mechanisms of air pollutants in chronic lung disease, and maturation of innate immune function in airway epithelium.

Please visit Dr. Miller's website at: http://faculty.vetmed.ucdavis.edu/faculty/lmiller/

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Brian Murphy, DVM, PhD

VM: Pathology, Microbiology & Immunology

I am an anatomical pathologist with an interest in viral pathogenesis.   My laboratory has a feline model of lentiviral latency and we our examining the mechanisms of viral persistence in the FIV-infected cat model.   We also have projects exploring FIP pathogenesis and a collaboration with Gilead Sciences to identify pharmacologic agents that will block replication of the FIP virus.  I am also interested in retroviral promoter function and how specific promoter sequences relate to viral tropism and pathogenesis. 

Please visit Dr. Murphy's website at: http://faculty.vetmed.ucdavis.edu/faculty/bmurphy/

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Christopher Murphy, DVM, PhD

VM: Ophthalmology, Biomedical Engineering, Glaucoma, Corneal Diseases, Wound Healing, Comparative Ocular Anatomy and Physiological Optics

Dr. Christopher Murphy is a clinician-scientist and practicing veterinary ophthalmologist whose laboratories are focused on discovery and translational research. He co-manages a large (approx 30 personnel) highly collaborative interdisciplinary laboratory with Dr Paul Russell, an expert in the biology of glaucoma. The laboratory conducts research at the intersection of biomaterials, cell biology,  biomedical engineering, interfacial science and clinical need. Their laboratories are fully equipped for cell and molecular biology studies as well as in vivo studies. The lab has a fully equipped suite for advanced ocular imaging of the anterior and posterior segment. There are several active areas of research including cell-biomaterial interactions, use of engineering inspired approaches for accelerating wound healing, development of an improved artificial cornea, development of improved surgical approaches for corneal transplantation, biophysical attributes of the extracellular matrix and their relevance to health and disease of the eye, and finally, comparative ocular anatomy and physiological optics. He also has clinical areas of expertise in exotic animal ophthalmology and diseases and surgery of the cornea.

With the breath of projects available, the 1st task for a Star student working in our labs is to identify a project that the student is motivated by and that is accomplishable within the time frame provided.  Murphy Russell Vision Science Lab: Tupper Hall, room 1220.

Please visit Dr. Murphy's website at: http://faculty.vetmed.ucdavis.edu/faculty/cjmurphy/

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Victor Nizet, M.D.

Affiliated with UC Veterinary Medical Center – San Diego

Dr. Nizet is a Pediatric Physician-Scientist, Infectious Diseases Specialist and Chief of the Division of Pediatric Pharmacology & Drug Discovery at UCSD School of Medicine and Skaggs School of Pharmacy & Pharmaceutical Sciences. Dr. Nizet leads a large and productive basic and translational research program focused upon the innate immune system, bacterial pathogenesis and the development of new immune-based infectious disease treatment strategies including novel antibiotics, targeted neutralization of bacterial virulence phenotypes, and pharmacologic augmentation of host phagocyte function.

Please contact Peter Ernst pernst@ucsd.edu or Christina Sigurdson csigurdson@ucsd.edu first for more information

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Sean Owens, DVM

VM: Pathology, Microbiology & Immunology

Dr. Owens, DVM, Diplomate ACVP, Assistant Professor, is a veterinary graduate of Colorado State University. Following an internship in small animal medicine and surgery, he completed a fellowship in small animal transfusion medicine at the University of Pennsylvania's Penn Animal Blood Bank. Dr. Owens completed his residency training in clinical pathology at UC Davis in 2004, and worked as a clinical pathologist with IDEXX Reference Laboratories, Inc., for two years prior to returning to UC Davis. His research interests include stem cell cell compatibility issues as they relate to the development of cell-derived therapeutics, veterinary blood banking, and equine transfusion medicine.

Dr. Owens may be reached via emial at sdowens@ucdavis.edu

Please visist Dr. Owens's website at http://faculty.vetmed.ucdavis.edu/faculty/sdowens/

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Pramod Pandey, PhD

Department of Population Health and Reproduction

My research focuses on understanding of pathogen transport at watershed-scale. I am interested in developing models capable of predicting pathogen influx from crop land and confined feeding operations to surface and ground water. My research is highly interdisciplinary, which involves the basics of fluid dynamics, hydrology, sediment transport, pathogen growth and decay, waste treatment, and water resources management. I use hydrological model such as Soil and Water Assessment Tool (SWAT) and Geographic Information Systems (GIS) to understand the fate and transport of contaminants. In addition to bacterial analysis in stream water column and streambed sediment, animal waste contamination testing, greenhouse gas analysis, volatile organic compound analysis, and hormone transport, my lab will train students on exploiting GIS and SWAT models for understanding the water quality and quantity problems at large scale. I am particularly interested in research that will directly lead to controlling bacteria transport from dairy waste to ambient water. 

Please visit Dr. Pandey’s website at: http://www.pramodpandey.com/

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Peter Pascoe

VM: Dept. of Surgical & Radiological Science

My primary research focus is related to opioid analgesics and pain management. I am also interested in gathering data on clinical patients related to anesthetic management.

Potential projects:
Evaluation of analgesics in a clinical setting – this would entail assessing pain in animal in the peri-operative period.
Retrospective evaluation of anesthetic management of certain types of patients
Evaluation of nerve block techniques in dentistry

Please visit Dr. Pascoe's website at: http://faculty.vetmed.ucdavis.edu/faculty/jrpascoe/

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Joanne Paul-Murphy, DVM, Dipl. ACZM, Dipl. ACAW

Comparative Zoological Animal Research Laboratory

Vet Med: Medicine & Epidemiology

Area of Expertise: Avian and small mammal analgesia, avian and small mammal welfare.

Dr. Paul-Murphy’s current research area is welfare and wellness assessments  for companion birds.  This includes projects to assess behavioral  components as well as health parameters of captive parrots. She continues to maintain a small laboratory working with colleagues in the area of  avian analgesia, clinical and research techniques aimed at improving the health of companion birds.

She is director of the Richard M. Schubot Parrot Wellness & Welfare Program.

Please visit Dr. Paul-Murphy's website at: http://www.vetmed.ucdavis.edu/czar/

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Niels Pedersen, DVM, PhD

Genetic and infectious and immunologic diseases of cats and dogs

VM: Medicine & Epidemiology

Dr. Pedersen's projects within the Center for Companion Animal Health (CCAH) revolve mainly around infectious and genetic disorders of dogs and cats. 

A list of his research publications, which will provide an overview of his varied interests, can be found at: http://www.ncbi.nlm.nih.gov/pubmed/?term=pedersen+nc

Dr. Pedersen prefers students that are committed to spending all of their available time in the laboratory. His laboratory is small, but is well instrumented and managed by an excellent SRA researcher/mentor. His research tends to be of a highly applied or translational nature. A number of small and highly focused projects have been identified during the course of major studies, each involving a number of important research techniques. Projects are designed to be completed in the very limited time period provided for STAR projects and lead to a meaningful scientific publication.

Students interested in any of these areas should contact Dr. Pedersen via e-mailing ncpedersen@ucdavis.edu or phoning (530) 752-7402 to discuss projects that can provide a meaningful summer's research experience.

Please visit Dr. Pedersen's website at: http://faculty.vetmed.ucdavis.edu/faculty/ncpedersen/

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Richard Pereira, DVM, PhD

SVM: Population Health & Reproduction (See also: Food Animal Medicine)

Dr. Pereira research focuses on evidence based medicine on antimicrobial resistance in livestock and judicious use of antimicrobials through interventions that promote livestock health and well-being. Maintaining the effectiveness of antimicrobial drugs to treat infections is of relevance to the health of both animal and human populations. Recent project investigated enteric microbiota of calves using metagenomic sequencing approaches, and herd management impacts on prevalence of resistant enteric bacteria, including evaluation of drug use, feeding practices, and housing management of dairy calves and heifers.

Epidemiology is the foundation of his research which also employs statistics, microbiology, and molecular and genomic approaches. Using these tools, some current research projects include investigating and identifying risk factors for selection and spread of antimicrobial resistance in Salmonella from livestock, and investigating impacts on drug resistance and animal health from feeding pre-weaned calves waste milk (milk containing drug residues) with the aim of identifying interventions to reduce unwanted impacts from this practice.

Previous projects accomplished include:
Spatial-temporal trends in antimicrobial resistant Salmonella isolates recovered from Northern California dairy cattle at a veterinary microbiology laboratory between 2002 and 2017.

Potential 10 week projects for Summer 2018:
Antimicrobial resistance in bacteria causing metritis in dairy cows.

Evaluation of on-farm factors affecting antimicrobial drug on the dairy farms.

Contact information: rvpereira@ucdavis.edu

Please visit Dr. Pereira's website at: www.vetmed.ucdavis.edu/faculty/results.cfm?fid=22811

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Patricia Pesavento, DVM, PhD, dip ACVP

Pathology, Viral Diseases

Vet Med: Pathology, Microbiology & Immunology

The Pesavento laboratory is interested in pathogens that emerge from intensive housing situations such as shelters, or from free ranging wildlife populations. The approach is one of translational research; from examination of the clinical disease and pathology of outbreaks of infectious disease, to molecular and cellular analysis of the causative pathogen/pathogens and their particular virulence.  We extend studies by using cell culture models of primary host target tissues, with the overall aim of the laboratory to form a basic understanding of the pathogen: host relationship. Our laboratory has projects in viral oncogenesis (Raccoon neuroglial tumors) and on emerging viral pathogens (Canine circovirus).

Previous projects accomplished include:
Polarity of Feline Caliciviral invasion of epithelium
Expression of the capsid protein VP1 of Raccoon Polyomavirus
Monoclonal antibodies to the oncogenic Tag protein of the Raccoon polyomavirus

Potential 10 week projects for Summer 2016:
Polyomavirus and brain tumors: identifying proteins that interact with Tag  
Serologic prevalence of exposure to Canine circovirus: a comparison between owned and intensively housed (shelter) dogs

Please visit Dr. Pesavento's website at: http://www.vetmed.ucdavis.edu/pesavento_lab/

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Isaac Pessah

Neurodevelopment, cell signaling pathways, neurotoxicology

Assoc. Dean of Research and Graduate Education

Research focuses investigating the molecular and cellular mechanisms by which neuromodulators, neurotoxicants, and natural products influence Ca2+ signaling pathways in excitable cells (muscle and neurons). The approaches available are highly interdisciplinary and use cutting-edge in vivo and in vitro methods with transgenic and knock-in mice and cells isolated from them. The major disorders currently being studied include malignant hyperthermia (MH) susceptibility conferred by mutations in RYR1 and CACNA1S, FMR1 related disorders, Rett syndrome, and most recently development of model of Timothy Syndrome mutation CACNA1C. Students will be trained basic biophysical, chemical, and cellular physiological methods to answer important questions about etiological factors contributing to neurological and muscle disorders.

Please visit Dr. Pessah's website.

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Kent E. Pinkerton, Ph.D.

Professor of Anatomy, Physiology and Cell Biology

1) To take an innovative approach in addressing air quality issues in dairy and cattle operations by the examination of direct health effects on the cardiopulmonary systems of mice and rats exposed to ambient particles using a concentrator system at the Tulare Veterinary Medicine Teaching and Research Center.

2) To examine the effects of environmental factors (gases and particles in the air) on peri-natal development to affect lung anatomy and pulmonary function in the rat. From conception to adulthood in the rats takes approximately 6 weeks, an easy fit for one summer!

3) To measure heart rate variability as an indicator of change in autonomic control in the mouse exposed to Davis, CA summer particulates.

4) To take a comparative biology approach to elucidate mechanistic environmental pathways leading to increased susceptibility (fetal onset of adult disease).

5) To examine the role of secondhand smoke on increased susceptibility to infection (influenza).

6) To explore the role of metabolomics as an early indicator of disease (asthma, altered immune function, increased susceptibility to infection).

Please visit Dr. Pinkerton's website for more information.

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Alda Pires, DVM, MPVM, Ph.D.

Food Safety, Foodborne and Zoonotic Diseases, Epidemiology of Infectious Diseases

VM:  Population Health and Reproduction; Urban Agriculture and Food Safety

Dr. Pires focuses on quantitative methods to identify strategies that improve animal health and control infectious diseases in livestock on small-scale farms. The goals of her research and extension programs are to identify mitigation strategies to reduce the dissemination of foodborne pathogens in pre-harvest small farm environment. She is interested in applying and developing epidemiological tools such as temporal-spatial, molecular analysis and risk assessment in order to support risk-based surveillance and infectious disease control strategies, and the improvement of animal health and food safety.

Potential summer projects: (1) Needs assessment in small-scale farms and urban animal agriculture; (2) Prevalence of foodborne pathogens in livestock in small-scale farms; (3) Foodborne pathogens and risk factors in milk and dairy products in farms with direct-marketing. These research projects will provide students training in field and laboratory work, and introduction to epidemiological quantitative methods.

Contact Dr. Pires at apires@ucdavis.edu

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Maurice Pitesky, DVM

Department of Poultry Health and Food Safety Epidemiology

My focus is on poultry health and food safety epidemiology.   From a poultry health perspective we work on GIS based approaches toward understanding how diseases move in space and time in order to better mitigate the spread of zoonotic and epizoonitic diseases.   

From a food safety perspective my interests are primarily associated with Salmonella.  Specifically from a molecular perspective we are exploring the use of next generation sequencing technologies to better understand the virulence and pathogenicity of Salmonella Heidelberg. 

California is a national and global leader in sustainable agriculture.  Because of this, the development of ‘micro-commercial’ poultry facilities (smaller than 3,000 hens/broilers) has mushroomed.  Due to their relatively small size they are largely ignored with respect to food safety and poultry health.  Our group is interested in learning more about these type of producers in order to understand their practices from a sustainability perspective and food safety perspective.

Possible 10-week introductory research projects include:

  1. Researching the ‘transcriptome’ (i.e. gene expression) of Salmonella Heidelberg.  Student would learn Next Generation Sequencing laboratory based techniques and data analysis tools. 
  2. GIS based tools for monitoring avian diseases.  Student would use ArcGIS based software coupled with other data analysis tools to analyze avian diseases (some background in GIS preferred).
  3. Student would help develop, administer, and analyze data related to micro-commerical poultry production in California.

Please visit Dr. Pitesky's website for more information: http://ucanr.edu/Find_People/Academic_Directory/?facultyid=24096

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David Pleasure, MD

Dept. of Neurology and Pediatrics, Director, IPRM

School of Medicine:  Neurology and Pediatrics

I am a clinical neurologist with long-standing interests in glial development, glial diseases, and glial/neuronal relationships.  My research is conducted in The Institute for Pediatric Regenerative Medicine (IPRM), which I founded in 2005, and still direct.  The IPRM occupies 27,000 square feet of laboratory space in Shriners Hospitals for Children Northern California on the UC Davis Biomedical Campus in Sacramento, maintains well-equipped optical imaging and molecular cores, and is in close proximity to a veterinarian-staffed, AALAC-approved UC Davis mouse vivarium.   I have served as the primary mentor for 6 predoctoral fellows and 23 postdoctoral fellows.  The majority of my trainees have chosen academic careers, and, thus, far 11 have attained a tenured position.

Click here for more information about Dr. Pleasure

Please visit the IPRM website http://www.iprmd.org for more details.

Dr. Pleasure's email david.pleasure@ucdmc.ucdavis.edu

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Birgit Puschner, DVM, PhD.

VM: Molecular Biosciences

Dr. Puschner is a toxicologist whose research focuses on the detection of toxicants and drugs in source material and biological specimens with a focus on assessing exposure in the context of clinical outcome. The laboratory uses mass spectrometry techniques to identify and quantitate compounds in matrices such as feed, food, blood, milk and urine. My work currently focuses on compounds found in the environment or produced naturally including algal toxins, plant toxins, and persistent organic pollutants. Students in the STAR program will work with a senior researcher in Dr. Puschner’s laboratory on an independent project related to one of the diverse projects of interest to the group. Research in the laboratory utilizes analytical chemistry approaches. Students have an opportunity to gain experience with sample extraction techniques, as well as method validation and mass spectrometry analyses.   

Some of the ongoing research studies include the metabolism of vitamin E in various animal species, THC analogues in foods for animal and human use, microcystin determination in recreational waters, and PCB and PBDE detection in tissues.

Please visit Dr. Puschner’s website at:  http://www.vetmed.ucdavis.edu/faculty/results.cfm?fid=14622

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Jon Ramsey, Ph.D.

Associate Professor

My research focuses on energy metabolism as it relates to obesity and aging. Calorie restriction, without malnutrition, is the only intervention that has consistently been shown to increase maximum life span in mammalian species. My research is investigating possible mechanisms for the retardation of aging with calorie restriction. In the area of obesity, my research focuses on the role alterations in energy expenditure play in either assisting or opposing weight loss. Also, I am interested in preventing obesity in companion animals by better determining the energy requirements of cats and dogs.

Please visit Dr. Ramsey's website at: http://faculty.vetmed.ucdavis.edu/faculty/jjramsey/

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Helen Raybould

VM: Anatomy, Physiology & Cell Biology

My research interest focuses on neurobiology of the gastrointestinal tract. The overall goal of the research is aimed at understanding that mechanism by which neurons that innervate the gut are activated in response to luminal stimuli such as nutrients and how these mechanisms may be altered in disease such as obesity, inflammation and irritable bowel disease. We use a number of different techniques including integrative physiological measurement of GI function, neurotransmitter receptor expression and localization, cell culture and measurement of secretion from endocrine cells, electrophysiological experiments to record nerve activity.

Please visit Dr. Raybould's website at: http://faculty.vetmed.ucdavis.edu/faculty/heraybould/

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Colin Reardon, Ph.D.

Immunology, IBD, T1D

VM: Anatomy, Physiology, & Cell Biology

Dr. Reardon is an immunologist specializing in the regulation of immunology. He is particularly interested in the mechanisms of communication between the nervous and immune systems. Although thought of as disparate fields of study, these two systems have co-evolved and are now appreciated to influence each other. Dr. Reardon’s research focuses on the modification of immune outcomes by neurotransmitters, and on the recently discovered production of the neurotransmitter acetylcholine (Ach) by B- and T-cells. Dr. Reardon’s research has previously identified that the commensal microbiota is involved in the regulation of Ach production by these immune cells. . Various projects are currently ongoing in the laboratory that will seek to establish the role of specific neurons in modulating immunopathologies, including inflammatory bowel disease and diabetes. Based on this, testing of small molecule agonists, and neurostimulator devices (in collaboration with biomedical engineers) to modulate immunopathologies will be performed in the laboratory. To accomplish this a variety of complementary techniques will be used including flow cytometry, confocal and intravital microscopy.

If interested, please contact Dr. Reardon creardon@ucdavis.edu

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Sam Ridgway, D.V.M., Ph.D., D.A.C.Z.M.

Affiliated with UC Veterinary Medical Center – San Diego

President of the National Marine Mammal Foundation
Dr. Ridgway is one of the founders of the Navy Marine Mammal program starting in 1961 and has 48 years of experience in marine mammal medicine and research.
Link to Dr. Ridgway’s current publications
Link to Dr. Ridgway’s website

Please contact Peter Ernst pernst@ucsd.edu or Christina Sigurdson csigurdson@ucsd.edu first for more information

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Crystal M. Ripplinger, Ph.D.

Cardiology, Arrhythmia, Imaging

MED: Pharmacology

Dr. Ripplinger has a PhD in Biomedical Engineering and advanced training in imaging and physiology. The focus of her research is on using high-speed and molecular imaging techniques to study basic mechanisms of cardiac arrhythmias. Her lab develops and studies pathologic arrhythmias in rodent and rabbit models of cardiovascular disease including healed myocardial infarction, acute ischemia, and heart failure. In vivo and ex vivo imaging on hearts of these animals is then performed to elucidate arrhythmia triggers and discover new anti-arrhythmic strategies. Possible summer research projects for veterinary students include 1) investigating mechanisms of triggered arrhythmias in a rabbit model of heart failure; and 2) investigating the role of inflammation in mediating arrhythmia following myocardial infarction. Both projects involve rodent and rabbit surgery, in vivo and ex vivo imaging, and image analysis.

Please email Dr. Ripplinger for more information at: cripplinger@ucdavis.edu or call (530) 752-1569.

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Jesus Rivera-Nieves, M.D.

Affiliated with UC Veterinary Medical Center – San Diego

Dr. Rivera-Nieves works on the pathogenesis of Crohn’s disease. Leukocytes of the granulocytic, monocytic and lymphocytic lineages are active participants in the chronic inflammatory process. Their recruitment from the circulation is regulated by adhesion molecules and chemokine receptors interacting with their respective ligands expressed or presented by intestinal endothelia cells. These adhesive interactions represent attractive therapeutic targets for the modulation of the destructive chronic inflammatory process. Proof of concept for the viability of this strategy has been provided by the efficacy of natalizumab, which interferes with integrin alpha-4-VCAM-1, MAdCAM-1 interactions. Using novel murine models of Crohn’s-like ileitis, Dr. Rivera-Nieves has continued to explore potential molecules that may be targeted, within the leukocyte recruitment cascade.

Please contact Peter Ernst pernst@ucsd.edu or Christina Sigurdson csigurdson@ucsd.edu first for more information

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Michael Rogawski, MD, Ph.D.

Department of Neurology and Pharmacology

Dr. Rogawski is a neurologist and pharmacologist whose research focuses on new treatment approaches for seizures, epilepsy, headache and other neurological conditions. Many of the treatment approaches involve targeting of ion channels, including GABA-A receptors, glutamate receptors, voltage-gated sodium channels and voltage-gated potassium channel. Students in the STAR program will work with a senior researcher in Dr. Rogawski’s laboratory on an independent project related to one of the diverse areas of interest to the group. Research in the laboratory utilizes animal models and also cellular electrophysiology (brain slice and tissue culture). Students have an opportunity to gain experience with animal surgery, EEG recording, and testing of novel treatments in various neurobehavioral and seizure paradigms. The laboratory also conducts pharmacokinetic studies and operates a UPLC-quadrapole mass spectrometer for the measurement of drug levels.  Some of the therapeutic strategies under investigation include: AMPA receptor antagonists, neuroactive steroids, dietary therapies, cannabinoids, and treatments for genetic epilepsies. Dr. Rogawski’s laboratory is a component of the UC Davis CounterACT Center of Excellence, which investigates treatments for nerve agent seizures. STAR program students may choose a project related to the activities of the CounterACT Center. Students successfully completing a summer project may have an opportunity to present their research at a national meeting.

Please visit Dr. Rogawski's website at: http://mr.ucdavis.edu/

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Benjamin Sacks, Ph.D.

Veterinary Genetics Laboratory, Canid Genetics & Population Health

The Canid Diversity and Conservation Laboratory specializes on ecology and conservation of wild canids and other carnivores, including the application of genetic techniques, disease surveillance, and field methods (see web site below). STAR students will initially learn necessary skills from students, technicians, and faculty, and will spend most of the summer collecting data for their project under faculty supervision.

Please visit Dr. Sacks's website at: http://www.vgl.ucdavis.edu/cdcg/bensacks.php

For the laboratory and projects, visit http://www.vgl.ucdavis.edu/cdcg/home.php

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Daisuke Sato, PhD

SOM: Pharmacology

Research topics:  Computational biology, mathematical modeling, mechanisms of cardiac arrhythmias, excitation-contraction coupling, drug development

Sudden cardiac death is the leading cause of death in the United States. Understanding the mechanisms of ventricular fibrillation is crucial to develop antiarrhythmic drugs and effective therapeutic strategies. The goal of my lab’s research is to understand how molecular level properties are linked to organ level phenomena using multiscale computational modeling of the heart. 

Desired qualifications: Experience in Matlab and C/C++ programming (ECS30 or equivalent). Knowledge and training for mathematical analysis, biological modeling, and simulations. Linear Algebra and Differential Equations.

My lab website is https://basicscience.ucdmc.ucdavis.edu/sato_lab/.

Please email Dr. Sato for more information at: dsato@ucdavis.edu

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David J. Segal, Ph.D.


Genome Center, Biochemistry and Molecular Medicine, Pharmacology, and MIND Institute

Research in the Segal Lab revolves around engineering zinc finger, TALE, and CRISPR/Cas nucleases and transcription factors. Almost every disease has a genetic component. Often this information is used only to determine how condemned a person is to develop disease. We would like to use the genetic information to fix the disease. A guiding principle for our work has been to study how nature does what it does, then attempt to use that knowledge to make useful tools to improve public health. We continue to develop new methodologies for genome editing. Our most recent efforts focus on creating epigenomic editing tools that can precisely manipulate epigenetic information at specific loci. Such tools can be used for the long-term control of gene expression for both research and therapeutic applications. Angelman syndrome is a rare neurogenetic disease that is the textbook example of an imprinting disorder. We are using artificial transcription factors to activate the epigenetically silenced gene in in the brains of mice and other animal models. 

Please visit Dr. Segal's website at: http://www.ucdmc.ucdavis.edu/biochem/faculty/segal/index.html

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Karen Shapiro, DVM, MPVM, PhD

Waterborne zoonoses

Dr. Shapiro is an infectious disease researcher focusing on transmission of zoonotic pathogens that pose a health risk to wildlife populations and people through water or food. Her research program targets the transport and fate of zoonotic pathogens in watersheds and coastal ecosystems; effects of landscape change and climate variability on disease transmission; impacts of water scarcity and impaired quality on human and animal population health, and food safety. Specific projects where STAR students could become involved with include development and validation of molecular methods for detection of zoonotic protozoan parasites in food and water.

CONTACT:  kshapiro@ucdavis.edu

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Christina Sigurdson, DVM, Ph.D., DACVP

Department of Pathology, Microbiology, and Immunology, UC Davis

Department of Pathology, UC San Diego

Our laboratory investigates the spread of prion diseases. We are focused on understanding the molecular basis for prion transmission between species, for example, human and animal susceptibility to prions of deer and elk, known as chronic wasting disease. To this end, we have identified a  loop region in the prion protein that has a major impact on the cross-species transmission of prions. We also study how the prion aggregates spread from cell-to-cell within the brain, leading to fatal neurodegeneration.

A third area of interest is in understanding the molecular basis of the toxicity occurring in prion disease. Aggregates of prion protein lead to neuronal degeneration and inflammation, however the mechanisms are poorly understood.

We would welcome veterinary students to our laboratory at UC San Diego to participate in projects related to prion disease and neurodegeneration.

Please visit Dr. Sigurdson’s website at:  http://www.sigurdsonlab.ucsd.edu/

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Woutrina Smith, DVM, Ph.D.

Infectious disease epidemiology

VM: Medicine & Epidemiology

Dr. Smith is an infectious disease epidemiologist with a special interest in One Health and the molecular epidemiology of zoonotic diseases. She works at local and global study sites where interactions among humans, animals and their environments lead to research questions that can be addressed using laboratory and fieldwork approaches to characterize and manage health at an inidividual, population, and ecosystem level. Her research involves zoonotic protozoa such as Cryptosporidium, Giardia, and Toxoplasma, as well as bacteria that include Mycobacterium, Salmonella, and Campylobacter.

Please visit Dr. Smith at: http://www.vetmed.ucdavis.edu/faculty/results.cfm?fid=18101

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Jay Solnick, MD, Ph.D.

MED: Infectious Diseases
Center for Comparative Medicine

Dr. Solnick is a microbiologist and infectious disease physician whose research seeks to understand the pathogenesis of Helicobacter pylori, a bacterium that causes peptic ulcers and gastric cancer. There are two major lines of investigation in his laboratory. First, how does the bacterium modify outer membrane proteins and other surface structures to avoid host immunity and persistently colonize the gastric epithelium? Second, what is the role of defensins and other innate immune effectors in the chronic colonization by H. pylori? These and related questions are addressed using a wide range of molecular and biochemical methods, as well as primate and murine animal models.

Please visit Dr. Solnick's website for more information.

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Esteban Soto-Martinez, MSc, DVM, PhD, Dipl. ACVM

VM: Medicine and Epidemiology (Aquatic Animal Health)

Dr. Esteban Soto is a board certified veterinary microbiologist who has an interest in aquatic animal health. Our laboratory main research interests are to understand the pathogenesis of important infectious diseases of wild and aquatic animals, and to develop strategies to protect animals from these diseases. Members in our laboratory study One Health, Aquatic Animal Disease, and Fish Disease through a combination of microbiological, molecular, and epidemiological methods. Current projects involve studying the ecology, diversity and host-pathogen interaction of Francisella noatunensis, Piscirickettsia salmonis, Veronaea botryosa, Erysipelothrix rhusiopathiae, Flavobacterium spp., Saprolegnia ferax, Koi herpes virus and other fish pathogens; and studying the ecology, diversity and host-pathogen interaction of hypermucoid Klebsiella pneumoniae in marine mammals.

Email Dr. Soto-Martinez for more information - sotomartinez@ucdavis.edu

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Ellen E. Sparger DVM, Ph.D., DACVIM

VM: Department VM Medicine and Epidemiology

Research Interests:
SIV vaccine development using attenuated rhesus CMV vaccine vectors with TLR 5 ligands as adjuvants.
Assessment of antiviral cellular immune responses in the prevention of FIP in cats infected with feline infectious peritonitis coronaviruses.
Assessment of receptor tyrosine kinases (RTK) as targets for cancer therapeutics in feline oral squamous cell carcinoma (OSCC).

Project Appropriate for a Star Student Summer Project:
A feasible project for a Star Student would involve examination of tumor biopsies from clinical cases of feline OSCC for expression and mutation of specific RTKs. This project would include extraction of DNA and/or RNA from tumor tissues followed by PCR amplification of sequences specific to RTKs, including epidermal growth factor receptor (EGFR) and cKit and possibly other RTKs. PCR products would next be sequenced for detection of possible mutations involving activation domains of these proteins. The student involved in this project would perform research in the laboratory of Dr. Sparger but also work with Dr. Katherine Skorupski in the Veterinary Oncology Service to facilitate the collection of biopsies from clinical patients as well as become familiar with this significant cancer entity in cats for which there is no effective therapeutic protocol. Assimilation of clinical data with correlation of RTK expression and sequence will require the student to work closely with both Drs. Sparger and Korupski. Assessment of RTKs in feline OSCC will be critical for determination of which tyrosine kinase inhibitors currently in use for human OSCC, might be effective for feline OSCC as well. This project is part of a larger effort by Drs. Sparger, Korupski, Michael Kent, Boaz Arzi, and Brian Murphy to characterize feline OSCC as a model for human head and neck cancer.

Please visit Dr. Sparger's website at: http://faculty.vetmed.ucdavis.edu/faculty/eesparger/

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Liz Stelow, DVM, DACVB

VMTH Behavior Service

Research interests: Companion Animal Behavior and Welfare

The Behavior Service does research on many aspects of companion animal behavior, welfare, and the human-animal bond. Current studies involve the role of environmental stressors and personality on the development of urolithiasis in cats and the transition of singly-housed colony Orange Winged Amazon (OWA) parrots into a co-housing setting.

The best opportunity for a STAR project is within the OWA study. Recent laboratory animal housing guidelines are driving the changes in housing for these birds and little existing research is available to educate the transition process. Those factors make this a groundbreaking research project, several aspects of which could be tailored to a stand-alone STAR project for the right student.

Other student-proposed research ideas in the area of animal behavior will be considered individually.

Please contact Dr. Stelow at eastelow@ucdavis.edu

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Joshua Stern, DVM, Ph.D., Diplomate ACVIM (Cardiology)

Cardiac genetics and pharmacogenetics

VM: Department of Medicine & Epidemiology

Dr. Stern is a cardiologist and geneticist in the department of Medicine and Epidemiology.  His lab investigates inherited heart disease in companion animals and pharmacogenomics.  Currently Dr. Stern is working on projects related to the inheritance of valvular degeneration in Whippets and Cavaliers, congenital heart defects in Golden Retrievers and the effect of genetic variation on the ways that common cardiac medications are metabolized. 

In addition to the benefit of identifying genetic defects associated with heart disease in companion animals, many of these projects may overlap and provide continued research opportunities on a comparative medicine basis. 

Please visit Dr. Stern’s website at: http://www.vetmed.ucdavis.edu/faculty/results.cfm?fid=21351

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Susan Stover, DVM, Ph.D., Dipl ACVS

JD Wheat Veterinary Orthopedic Research Laboratory 

Dr. Stover's research focuses on the diagnosis, treatment, and prevention of musculoskeletal injuries, predominantly in horses, but also in small animals. She specialized in equine surgery and lameness until devoting full time to research on musculoskeletal biomechanics and on the causes (epidemiology), development (pathology), and prevention (biomechanics) of musculoskeletal injuries in equine athletes. Current research focuses include 1) the effects of race surface and horseshoes on limb biomechanics (and thus risk for injury), 2) Racing Injury Prevention Program, and 3) investigating a systemic bone fragility syndrome that causes pathologic fractures in horses.

Her laboratory supports the research of undergraduate, professional (DVM), graduate, and postdoctoral students, as well as, clinical residents.  LAB:  Rm 1305 VM3A

Please visit Dr. Stover's website at: http://www.vetmed.ucdavis.edu/vorl/index.cfm

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Fern Tablin, BA, Ph.D., VMD

VM: Anatomy, Physiology & Cell Biology

The Tablin laboratory focuses on the interface between hemostasis, thrombosis and inflammation. Our work is primarily in platelets but also includes platelet-neutrophil interactions and the formation of NETS (neutrophil extracellular traps).   The two main research areas of the laboratory are the effects of air pollution and particulate matter on thrombosis and hemostasis in a rodent model system, and platelets/neutrophils in health and disease of both large and small animals.

Opportunities for STAR projects involve our current studies in platelet–neutrophil activation and NETs formation in normal dogs and horses. Additional opportunities focus on changes in platelet activation and NET formation in dogs with sepsis and horses with laminitis.

Tablin expertise: Flow cytometry, platelet activation, cell signaling – biochemistry and cellular physiology.

Please contact Dr. Tablin at ftablin@ucdavis.edu.

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Swee Teh, Ph.D.

Department of Anatomy, Physiology, and Cell Biology

Independent research in the fields of developmental biology, nutrition, pathology, and ecotoxicology. Special emphasis on adverse effects of environmental endocrine disruptors and other contaminants in the embryonic development, growth, and reproduction of invertebrates, fish and shellfish populations. Development of biomarkers of exposure and deleterious effects in aquatic organisms. Development of a screening assay for endocrine disrupting chemicals utilizing microarray technology.

Research will include:

1. The culture of native (salmon, delta smelt, and splittail) and surrogate (Medaka) fish models for use in carcinogens, endocrine disruptors and toxicants testing;
2. Design QA/QC & safety protocols for animal care & exposure experiment. Acute and chronic toxicity testing of contaminants and toxicants using native and non-native fish;
3. The long-term, sublethal growth and reproductive effects of fish exposed to contaminant-laden diets (metals, and organic chemicals including endocrine disruptors and pesticides);
4. Development and use of biochemical, molecular, and histopathologic indicators (biomarkers) of exposure to determine the sublethal deleterious effects of environmental pollutants on fish and aquatic invertebrate populations;
5. Development and the application of toxicogenomics in aquatic toxicology testing;
6. Effects of toxicants on quality and quantity of food chain organisms and resultant consequences on the higher trophic organisms.
7. Integrate growth, biochemical, molecular, histopathologic, and reproductive indicators into an individual and population health effects and extrapolation of population level effects to ecosystem health effects.

Active Projects's

1. Groundwater ambient monitoring and assessment program - Hexavalent chromium and endocrine disrupting chemicals.
2. Using a Sensitive Japanese Medaka (Oryzias Latipes) Fish Model for Endocrine Disruptors Screening.
3. Histopathological examinations of larval and juvenile pelagic fish.
4. Biomass and Toxicity of a Newly Established Bloom of the Cyanobacteria Microcystis Aeruginosa and its Potential Impact on Beneficial Use in the Sacramento-San Joaquin Delta.

Please visit Dr. Teh's website at: http://faculty.vetmed.ucdavis.edu/faculty/sjteh/

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Lisa A. Tell, DVM

Department of Medicine and Epidemiology

Dr. Tell is the Director of the Veterinary Drug Residue Laboratory and serves as the Regional Director for the Minor Use Animal Drug and the Food Animal Avoidance Database Programs. She has been a full-time faculty member of the School of Veterinary Medicine since 1994. Dr. Tell's research interests are veterinary drug pharmacokinetic studies for zoological and food animal species. She has a particular interest in treatment options for fungal diseases in birds.

Research studies in Dr. Tell's laboratory vary from pivotal data studies seeking label claims for minor food animal species (particularly goats) to clinically related pharmacokinetic studies for companion birds. Many of the food animal related studies focus on drug residues and residue avoidance in the interest of protecting public health. Research experience gained from working in Dr. Tell's laboratory varies from the in life phase of the pharmacokinetic study to the good laboratory practice bench-top research activities.

Dr. Tell is also the lead investigator for the UC Davis Hummingbird Health program that investigates diseases in free ranging hummingbirds in California.  This program bands the birds, takes biometric measurements, and evaluates birds for infectious diseases.

PLEASE CONTACT DR. TELL : latell@ucdavis.edu

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Sara Thomasy, Dip. ACVO, DVM, Ph.D.

Corneal endothelial disease, keratoconjunctivitis sicca (dry eye), corneal wound healing, glaucoma

VM: Surgical & Radiological Sciences

Dr. Sara Thomasy is a veterinary ophthalmologist and clinician-scientist with strong interests in advanced ocular imaging, corneal disease and glaucoma. She is a PI in the Murphy-Russell-Thomasy laboratory, a large (approx 15 personnel) highly collaborative interdisciplinary laboratory which conducts research at the intersection of biomaterials, cell biology, biomedical engineering, interfacial science and clinical need. Their laboratories are fully equipped for cell and molecular biology studies as well as in vivo studies. The lab has a fully equipped suite for advanced ocular imaging of the anterior and posterior segment.  With the breath of projects available, the initial task for a STAR student working in our labs is to identify a project that the student is motivated by and that is accomplishable within the time frame provided.  

CONTACT INFORMATION:  Murphy Russell Thomasy Vision Science Lab: Tupper Hall, room 1220; smthomasy@ucdavis.edu

Faculty website pg:  http://www.vetmed.ucdavis.edu/faculty/results.cfm?fid=20599

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Nam K. Tran, PhD, MS, FACB

Department of Pathology and Laboratory Medicine

My expertise is in clinical chemistry and point-of-care testing for critical care and emergency settings. This includes the development and implementation of innovative biomedical devices and technologies for improving the quality of patient care. These technologies include molecular pathogen detection methods for early detection of sepsis, novel biomarkers of organ dysfunction (e.g., acute kidney injury, myocardial infarction, etc), and point-of-care devices (i.e., medical testing at or near the site of patient care) for testing in emergency medicine and critically ill populations. Our team works closely with Biomedical Engineering, as well as the Divisions of Burn Surgery, and Trauma/Emergency Surgery from the School of Medicine. We are also heavily involved with clinical trials including a large multicenter randomized controlled study evaluating the impact of quantitative, PCR-based detection of Staphylococcus aureus in burn sepsis patients. Translational studies with the veterinary medicine involve the use of anti-fibrinolytic therapy in severe hemorrhage models (e.g., swine and sheep), and pharmacokinetic/pharmacodynamic (PK/PD) modeling of drugs in both animal and human models of injury.

Contact: nktran@ucdavis.edu

Please visit Dr. Tran's website at: https://www.ucdmc.ucdavis.edu/pathology/our_team/faculty/tranN.html

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James S. Trimmer, Ph.D.

Director, UC Davis/NIH NeuroMab Facility

James S. Trimmer studies how voltage-gated ion channels are modulated in response to physiological and pathophysiological alterations in hippocampal neuronal activity. His primary experimental approach is to manipulate hippocampal neuronal activity, in either animals in vivo, in organotypic slice cultures or in dissociated neuronal cultures, and analyze effects on phosphorylation as a regulator of ion channel expression, localization and function. These studies use time-lapse and confocal imaging, patch-clamp recording, analyses of phosphorylation state employing phospho-specific antibodies and mass spectrometry, immunohistochemistry, and immuno-electron microscopy. Much of our recent work involves the colocalization of ion channels proteins to specific sub cellular domains, a subject that would be greatly enhanced by studies at the ultra structural level. Access to this highly specialized technology is absolutely essential for our future research plans.

Please visit Dr. Trimmer's website at: http://www.ucdmc.ucdavis.edu/search/faculty/trimmer

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Renée Tsolis

Department of Medical Microbiology and Immunology, School of Medicine

Dr. Tsolis is a microbiologist studying host-pathogen interactions leading to disease during infection. Her laboratory uses a variety of animal models to study how two groups of zoonotic pathogens, non-typhoidal Salmonella and zoonotic Brucella species, interact with the immune system to cause disease. For non-typhoidal Salmonella species, Dr. Tsolis' group is interested in learning why underlying co-morbidities such as malaria and malnutrition increase the incidence of death from systemic infection in the developing world, and her laboratory has developed mouse models to gain insight into immunomodulatory effects of Vitamin A deficiency and malaria. For Brucella, the laboratory has developed models to understand both chronic infection that this group of organisms causes within the mononuclear phagocyte system and to interrogate placental infections in pregnant animals that lead to abortion in domestic animals. Collaborations with UCD research Dr. Luckhart in the Medical Microbiology department, Dr. McSorley in the Center for Comparative Medicine and Dr. Stephensen in the USDA Western Human Nutrition Research Center have been instrumental in establishing this interdisciplinary research program. The long-term goal of Dr. Tsolis' work is to uncover basic principles of how bacterial pathogens manipulate the immune response to cause disease and ensure their transmission to the next host.

Dr. Tsolis' research is described here: https://www.ucdmc.ucdavis.edu/medmicro/Faculty_MR/Tsolis/tsolis_index_mr.html

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Laura S. Van Winkle, Ph.D., DABT

VM: Anatomy, Physiology & Cell Biology

My research focus is on toxicology and pulmonary cell biology. I study cellular responses in the lung.. Airways are a key site for many human lung diseases such as asthma, bronchitis, cystic fibrosis and lung cancer. Exposure to toxic air pollutants contributes to development of these diseases in humans and animals. We utilize unique in vivo and in vitro models to study airway epithelial injury and repair in diverse species from mice to monkeys. We have a substantial archive of tissue sections.  My laboratories are located at the Center for Health and the Environment. Projects available include studies of: 1) The effect of inhaled particles on airway toxicology and histopathology in rats 2) Effect of inhaled toxic vapors, such as naphthalene on cytotoxicity in the nose and lung 3) Using nanoparticles to understand ultrafine particle dosimetry.

Students are invited to participate in any of these ongoing projects. Students may also conduct an original project of special interest to be completed during the summer session. Ongoing research is supported by funding from several grants from NIH.

Please visit Dr. Van Winkle's website for more information.

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Nissi Varki, M.D.

Comparative pathology, mouse models of human disease

Affiliated with UC Veterinary Medical Center – San Diego

Director of Histopathology Resources, Cancer and Mouse Histopathology
Professor of Pathology

Dr. Nissi Varki's research interests include comparative histopathology analysis of genetically altered mice, and models of human diseases including cancer, inflammatory disorders and microbial infections. She is investigating the role of glycosylated molecules in tumor progression and metastasis, including evidence for a human-specific mechanism for diet and antibody-mediated inflammation in human carcinogenesis. Another area of recent exploration is the tissue and species-specific expression of sialic-acid binding lectin receptors known as Siglecs, which play an important role in regulating host innate immune responses and inflammation. Dr. Varki also has a longstanding interest in immunological mechanisms operating at the gastrointestinal mucosal epithelium and their role in chronic colitis and colon cancer development. Dr. Varki serves as Director of the Histopathology Core laboratories Mouse Phenotyping Services at UC San Diego and teaches in the histology and pathology laboratory sessions for medical students, mentors numerous undergraduate students and high school students and serves on the Recruitment and Admissions Committee for the UC San Diego School of Medicine.
Link to Dr. Varki’s current publications
Link to Dr. Varki’s website

Please contact Peter Ernst pernst@ucsd.edu or Christina Sigurdson csigurdson@ucsd.edu first for more information

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Frank J.M. Verstraete, DrMed Vet, MMed Vet, DAVDC, DECVS, DEVDC

VM: Surgical and Radiological Sciences

Comparative oral anatomy, pathology, diagnostic imaging and surgery

My primary research interest is comparative oral pathology: the study of oral and dental diseases, as well as temporomandibular joint problems, in various species, including the similarities and differences in nature and occurrence of these diseases.

The examination of mammalian skull collections for dental and temporomandibular lesions is an established method of determining the nature and prevalence of oral pathology in a particular species. If performed correctly, such studies can reveal valuable information pertaining not only to the dental diseases occurring in the species, but also to systemic diseases, diet, and behavior. Such studies may also contribute to the understanding of oral diseases in related domestic species.

The California Academy of Sciences in San Francisco and the University of California - Berkeley house a treasure-trove of skulls and are within driving distance from Davis. Their Department of Ornithology and Mammalogy and Museum of Vertebrate Zoology are eager to make their collections available for studies in comparative dental and temporomandibular joint pathology.

Potential projects for STAR Students in 2018 are:

The dental pathology of the Virginia opossum (Didelphis virginiana)
The dental pathology of the coyote (Canis latrans)
The dental pathology of the red fox (Vulpes vulpes)
The dental pathology of the island fox (Urocyon littoralis) – in Los Angeles

 Please visit Dr. Verstraete's website for more information.

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Stephanie Venn-Watson, DVM, MPH

Affiliated with UC Veterinary Medical Center – San Diego

Director of the Translational Medicine & Research Program

National Marine Mammal Foundation
Dr. Venn-Watson has served as a veterinary epidemiologist for the Centers for Disease Control, World Health Organization, and since 2001, has studied marine mammal health and disease with the National Oceanic and Atmospheric Administration, Department of Defense, and the National Marine Mammal Foundation. Dr. Venn-Watson's current One Health & translational research focuses on finding common ways to detect, prevent, treat, and cure diabetes, aging-associated diseases, and infectious diseases in human and marine mammal patient populations.

Please contact Peter Ernst pernst@ucsd.edu or Christina Sigurdson csigurdson@ucsd.edu first for more information

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Joseph Vinetz, M. D.

Affiliated with UC Veterinary Medical Center – San Diego

Department of Medicine, UC San Diego

Dr. Joe Vinetz is an infectious disease clinician and scientist investigating brucellosis, malaria, and leptospirosis. One student summer project would be to assess the public health effect of goat vaccination on human brucellosis in Peru.  Brucellosis due to Brucellosis melitensis has long been endemic in Peru.  From 2005-2010, the human brucellosis incidence markedly declined, which seems to be due to vaccination of goats with the Rev-1 vaccine.  Dr. Vinetz has high level contacts in the Peruvian Office of General Epidemiology, the Peruvian Ministry of Agriculture and the Peruvian National Institute of Health, which, in combination with faculty contacts based at Universidad Peruana Cayetano Heredia and the University of California San Diego, will allow a motivated student to obtain country-wide data towards analyzing the human and animal brucellosis trends in Peru.

Note: Student must be fluent in Spanish

Please contact Peter Ernst pernst@ucsd.edu or Christina Sigurdson csigurdson@ucsd.edu first for more information

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Lance Visser, DVM, MS, Diplomate ACVIM (Cardiology)

Cardiology

VM: Medicine & Epidemiology

Dr. Visser is a board-certified veterinary cardiologist in the Department of Medicine & Epidemiology with a 50% clinical appointment in the VMTH. His clinical echocardiography laboratory focuses on the study of noninvasive assessment of cardiac structure and function in various cardiovascular disorders. Recent projects have involved characterizing right ventricular function in healthy dogs and studying a new echocardiographic index that estimates pulmonary arterial pressure in dogs. Dr. Visser hopes to mentor highly motivated students interested in getting involved in clinically oriented research related to cardiology. Students will be involved with all phases of the project, including publication.

For more information and to discuss potential projects please contact Dr. Visser at lcvisser@ucdavis.edu.

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Aijun Wang, PhD

UC Davis Medical Center, Department of Surgery (see also: Translational Research, Orthopedics, Surgery)

My name is Aijun Wang. I am an assistant professor at the Department of Surgery, School of Medicine. My research interests center on engineering stem cells and biomaterials to develop novel regenerative medical therapies, especially surgical treatments for congenital anomalies. Since my employment as Co-Director of the Surgical Bioengineering Laboratory and an Assistant Professor at the University of California Davis School of Medicine in 2012, my lab has successfully combined tissue-engineering technologies with the most advanced fetal intervention, and developed novel biomaterial and stem cell-based treatments (including nanofibrous materials, fetal membrane, decelluarized extracellular matrix, iPSC-derived stem cells, placenta-derived stem cells) for devastating structural and genetic birth defects, such as spina bifida, hemophilia and congenital diaphragmatic hernia. Currently, we are extensively using the mouse, rat, guinea pig, rabbit and sheep experimental models to develop novel regenerative therapies. We are also adapting these novel therapies we developed in the lab for the treatment of naturally occurring diseases in companion animals.

Please visit Dr. Wang’s website at http://www.ucdmc.ucdavis.edu/surgery/research/wang.html or the  website  for  the  Surgical Bioengineering Laboratory at  http://www.ucdmc.ucdavis.edu/surgery/research/index.html

Contact Dr. Wang: aawang@ucdavis.edu.

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Luke A. Wittenburg, DVM, PhD, DACVCP

Dr. Wittenburg is a veterinary clinical pharmacologist with basic research interests in cancer biology and investigational/developmental therapeutics for treatment of cancer in pets and people.  A better understanding of the biology and response to therapy in veterinary patients with cancer is crucial to translate discoveries in our pet populations to potential therapies in humans with cancer.  Dr. Wittenburg’s current projects involve aspects of clinical pharmacology, (pharmacokinetic/pharmacodynamics studies), in vitro pharmacology (comparative metabolism of chemotherapeutic drugs across species), in silico pharmacology (physiologically based pharmacokinetic modeling of chemotherapeutic agents in animals) and molecular biology studies into the importance of protein-protein interactions with regard to transcription factors in the development and survival of osteosarcoma.  Summer projects might involve the use of inhibitors of transcription factor protein-protein interactions in human and canine osteosarcoma cell lines as molecular probes for identification of potential novel therapeutic targets, investigations into the contribution of increased drug efflux pump expression on the surface of lymphoma cell lines following curative-intent therapy and the role of epigenetics in this process, in vitro metabolism studies using isolated liver microsomes and some commonly used chemotherapeutics in veterinary and human medicine and pharmacokinetic/pharmacodynamic studies in veterinary species. 

Please contact Dr. Wittenburg (lwittenburg@ucdavis.edu) for more information.

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Joshua Wood, PhD MBA

Associate Director of Laboratory Operations, Mouse Biology Program (MBP)

My research focuses on optimizing genetic engineering techniques to generate novel animal models. STAR Students in my labs will get an opportunity to work on projects encompassing animal husbandry, genetic engineering and design, pronuclear injection & electroporation, embryo transfer, cryopreservation and recovery, as well as genotyping and sequencing. STAR students will also get an opportunity to learn the business operations and the challenges faced by a large research and production laboratory. In addition to developing new and complex animal models, we are also actively researching previously unmanipulated regions of the genome including enhancers and long noncoding RNAs. As a members of the Knockout Mouse Project, Mutant Mouse Resource and Research Center, Mutant Metabolomic Phenotyping Center, Cancer Center Shared Resource, and Designated Campus Core Facility we offer the opportunity to do fast paced, high throughput research on novel animal models.

Contact Information:

Email: jawood@ucdavis.edu

Office phone: 530-757-3191

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Kevin D. Woolard, DVM, PhD, Dipl, ACVP

Assistant Professor of Anatomic Pathology

The Woolard Laboratory is primarily focused on comparative biology of human and canine glioma brain tumors. These tumors have an aggressive biologic behavior, with median survival times of around 14 months in people, in spite of surgery, chemo-, and radiotherapy. Much of our efforts are focused on identifying how sub-populations within an individual patient’s tumor communicate with each other to establish a dominant population of tumor cells, as well as how cells re-grow following initial treatment. We are also examining how cellular metabolism in glioma may impact epigenetic dysregulation, with the goal of providing a druggable target to delay tumor progression. Finally, we also routinely isolate canine embryonic neural stem cells, which are used as physiologic comparisons to glioma tumor cells. Additionally, we are using these cells to model Zika virus infection in mammalian neural stem cells.

Please contact Dr. Woolard (kdwoolard@ucdavis.edu) for more information.

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Wei Yao, MD

Professor
Associate Director, Center for Musculoskeletal Health
Internal Medicine, University of California at Davis Medical Center

Dr. Yao is a distinguish bone biologist focus on translational research using animal models on bone diseases to evaluate bone active agents on bone metabolisms.  One of Dr. Yao’s research focuses for the past nine years is to investigate bone regenerative approaches using mesenchymal stromal cells (MSCs), including bone targeted delivery and activation of MSCs, use of genetic modified MSCs or novel bone specific, osteogenic peptides for bone regenerative medicine.  Dr. Yao’s research group has performed many studies to test this approach in animal models of primary osteoporosis, aging, glucocorticoid-induced bone fragility, fracture healing and in inflammatory arthritis.  Dr. Yao has been using bone seeking agent to delivery MSCs to bone in an IND-enabling study.  Dr. Yao has collaborated with many pharmaceutical companies, including Eli Lilly, Pfizer, P&G, Glaxo and Smith Kline and Amgen et al, in their bone - active drug developments over the past 20 years.

Please visit Dr. Yao's website for more information -

http://www.ucdmc.ucdavis.edu/musculoskeletalhealth/bios/yao.html

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Clare Yellowley

Department of Anatomy, Physiology and Cell Biology

Dr Yellowley is a orthopedic cell biologist in the department of Anatomy, Physiology and Cell Biology in the Vet School. We are focused on normal bone physiology, bone pathology (fracture) and bone tissue regeneration. We employ both in vitro cell culture models and in vivo fracture models. Our current projects involve assessing the influence of mechanical load and oxygen availability on bone cell signaling and the ability of stem cells to enhance fracture healing.

Please visit Dr. Yellowley's website at: http://faculty.vetmed.ucdavis.edu/faculty/cyellowley/

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Michael Ziccardi, DVM, Ph.D.

Wildlife health, epidemiology, ecotoxicology

VM: Karen C. Drayer Wildlife Health Center and VM: Medicine & Epidemiology

Dr. Michael Ziccardi DVM MPVM PhD is Co-Director of the Karen C. Drayer Wildlife Health Center (WHC). At the WHC, he serves as the Director of the WHC's Oiled Wildlife Care Network, an extensive oil spill preparedness, response, and research program responsible for animal care throughout California, but also participating in emergencies and contingency planning worldwide. Ziccard's clinical and research areas of expertise are in free-ranging wildlife health, with an emphasis on epidemiology. His current research focus is on the effects of petroleum on marine species and health concerns in California free-ranging wildlife.

Please email Dr. Ziccardi for more information at: mhziccardi@ucdavis.edu

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