Science Updates

STAR Project Leads To Discovery Of Bartonella Infection in Coyote Heart Valves

Bartonella are blood-borne bacteria infecting a wide variety of domestic and wild animal species. One species, Bartonella vinsonii subsp. berkhoffii (B. v. berkhoffii), is known to cause severe cardiac disease by destroying the cardiac valves (endocarditis) in domestic dogs and humans. Coyotes are the main reservoir for B. v. berkhoffii, but it was not known if infected coyotes developed endocarditis like their domestic counterparts.

Therefore, Spencer Kehoe (DVM Class 2015) and his STAR mentor Dr. Bruno Chomel (Department of Population Health and Reproduction) hypothesized that coyotes serve as a naturally-occurring epidemiological and physiological sentinel models to study infection kinetics and pathology caused by this bacterium in reservoir (coyotes) and accidental hosts (humans/ dogs).

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American Society of Microbiology (ASM) Responds to CDC Anthrax Exposure

The recent events at the Centers for Disease Control and Prevention (CDC) and the National Institutes of Health (NIH), which are documented in the report below, reveal significant lapses in biosafety, biosecurity, oversight and compliance with the Select Agents and Toxins regulations.  At every level, in teaching, research, and diagnostic laboratories, microbiologists must take all steps possible to guarantee biosafety, to protect themselves, their co-workers, and the broader public from microorganisms that can cause disease.  Microbiologists who work with dangerous pathogens have a responsibility to understand and comply with biosafety and biosecurity regulations.  As such, ASM members must ensure that they are acting with the highest level of responsibility and accountability in their laboratories.

 Microbiologists engage in activities that are essential to detect, respond to and prevent infectious diseases. This work must be conducted as safely as possible. Toward that end, we urge microbiologists to review their laboratory procedures and to ensure that they are compliant with biosafety regulations and best practices. Microbiologists and institutions should regularly inventory all areas of storage to maintain an accurate and up-to-date inventory of materials to be certain there are no unaccounted for infectious agents and toxins.  Identified lapses in biosafety and biosecurity must be reported promptly to the appropriate institutional authorities. Public health and safety are of the utmost importance and we have a professional responsibility to maintain the public trust.  

 The following is a link to the CDC’s July 11 Report on the Potential Exposure to Anthrax

Seeing the Forest for the Trees: How “One Health” Connects Humans, Animals, and Ecosystems

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UC Davis veterinarians mentioned in Futurist article on Expanding Pet Longevity

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Rescuing US biomedical research from its systemic flaws

Bruce Alberts, Marc Kirschner, Shirley Tilghman, and Harold Varmus describe specific ways for "rescuing U.S. biomedical research from its systematic flaws" in this week's Proceedings of the National Academy of Science. They write, "The long-held but erroneous assumption of never-ending rapid growth in biomedical science has created an unsustainable hypercompetitive system that is discouraging even the most outstanding prospective students from entering our profession-and making it difficult for seasoned investigators to produce their best work. This is a recipe for long-term decline, and the problems cannot be solved with simplistic approaches." The authors suggest reforms on the funding of graduate students, postdoc compensation, and peer review. They also would reconsider rules on indirect facilities cost reimbursement and salary support on research project grants.

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