VIRC Publications

  1. Kol A., N.J. Walker, M. Nordstrom, D.L. Borjesson. Th17 Pathway as a Target for Multipotent Stromal Cell Therapy in Dogs: Implications for Translational Research. PLoS One. 2016; 11(2): e0148568.
  2. Clark K.C., A. Kol, S. Shahbenderian, J.L. Granick, N.J. Walker, D.L. Borjesson. Caine and Equine Mesenchymal Stem Cells Grown in Serum Free Media Have Altered Immunophenotype. Stem Cell Rev. 2016; 12(2): 245-56.
  3. Arzi B., E. Mills-Ko, F. J.M. Verstraete, A. Kol, N.J. Walker, M.R. Badgley, N. Fazel, W.J Murphy, N. Vapniarsky, D.L. Borjesson. Therapeutic Efficacy of Fresh, Autologous Mesenchymal Stem Cells for Severe Refractory Gingivostomatitis in Cats. Stem Cells Transl Med. 2016; 12(2): 75-86.
  4. Kol A., B. Arzi, K.A. Athanasiou, D.L. Farmer, J.A. Nolta, R.B. Rebhun, X. Chen, L.G. Griffiths, F.J.M. Verstaete, C.J. Murphy, and D.L. Borjesson. Companion Animals: Translational scientist’s new best friends. Sci Transl Med. 2015; 7(308).  
  5. McMahill B.G., M.Spriet, S. Siso, M.D. Manzer, G. Mitchell, J. McGee, T.C. Garcia, D.L. Borjesson, M. Sieber-Blum, J.A. Nolta, B.K. Sturges. Feasibility Study of Canine Epidermal Neural Crest Stem Cell Transplantation in the Spinal Cord of Dogs. Stem Cells Transl Med. 2015; 4(10): 1173-86.
  6. Kol A., J.A. Wood, D.D. Carrade Holt, J.A. Gillette, L.K. Bohannon-Worsley, S.M. Puchalski, N.J. Walker, K.C.Clark, J.L. Watson, D.L. Borjesson. Multiple intravenous injections of allogeneic equine mesenchymal stem cells do not induce a systemic inflammatory response but do alter lymphocyte subsets in healthy horses Stem Cell Res Ther. 2015; (6):73.
  7. Arzi, B., G. D. DuRaine, C.A. Lee, D.J. Huey, D.L. Borjesson, B. Murphy, J.C.Y Hu, N. Baumgarth, K.A. Athanasiou. Cartilage immunoprivilege, dependence on donor source and lesion location. Acta Biomater. 2015; S1742-7061(15)00249-4.
  8. Morgan J.T., H. Sun Kwon, J.A. Wood, D.L. Borjesson, S.I. Tomarev, C.J. Murphy, P. Russell. Thermally labile components of aqueous humor potently induce osteogenic potential in adipose-derived mesenchymal stem cells. Exp Eye Res. 2015; 135: 127-33.
  9. Burton A.G., K.C. Clark, D.L. Borjesson, D.D. Carrade, J.W. Burges and S.D. Owens. 2015. Equine bone marrow volume reduction, red cell depletion and mononuclear cell recovery using the PrepaCyte®-CB processing system. Vet Clin Pathol. 2015; 44(2): 188-93.
  10. Gericota B., D.L. Borjesson, M. Sieber-Blum, J.A. Nolta, B.K. Sturges. Stem Cells in Canine Spinal Cord Injury – Promise for Regenerative Therapy in a Large Animal Model of Human Disease Stem Cell Rev. 2015; 11(1): 180-93.
  11. Arzi B., A. Kol, B. Murphy, N.J. Walker, J.A. Wood, K. Clark, F.J.M. Verstraete, D.L. Borjesson. An endogenous retrovirus adversely affects feline mesenchymal stem cell culture and expansion: implications for animal model development. Stem Cells Dev. 2015; 24(7): 814-23.
  12. Spriet M., G.B. Hunt, N.J. Walker, D.L. Borjesson. Scintigraphic tracking of mesenchymal stem cells after portal, systemic intravenous and splenic administration in healthy beagle dogs. Vet Radiol Ultrasound. 2015; 56 (3): 327-34
  13. Arzi B., F.J. Verstraete, D.J. Huey, D.D. Cissell, K.A. Athanasiou. Regenerating Mandibular Bone Using rhBMP-2: Part 1-Immediate Reconstruction of Segmental Mandibulectomies. Vet Surg. 2015; 44(4): 410-6.
  14. Verstraete F.J., B. Arzi, D.J. Huey, D.D. Cissell, K.A. Athanasiou. Regenerating Mandibular Bone Using rhBMP-2: Part 2-Treatment of Chronic, Defect Non-Union Fractures. Vet Surg. 2015; 44(4): 403-9.
  15. Screven R., E. Kenyon, M.J. Myers, H. F. Yancy, M. Skasko, L. Boxer, E.C. Bigley III, D.L. Borjesson, M. Zhu. Immunophenotype and gene expression profile of mesenchymal stem cells derived from canine adipose tissue and bone marrow. Vet Immuno Immunopath. 2014; 161(1-2): 21-31.
  16. Kol A., S. Foutouhi, N.J. Walker, Kong, B.C.Weimer and D.L. Borjesson. Gastrointestinal microbes interact with canine adipose derived mesenchymal stem cells in vitro and enhance immunomodulatory functions in a distinct fashion. Stem Cells Dev. 2014; 23(16): 1831-43.
  17. Gericota B., J. S. Anderson, G. Mitchell, D.L. Borjesson, B. K. Sturges, J.A. Nolta, M. Sieber-Blum. Canine Epidermal Neural Crest Stem Cells (cEPI-NCSC) – Characterization and Potential as a Therapy Candidate for a Large Animal Model of Spinal Cord Injury. Stem Cells Transl Med. Mar 2014; 3(3): 334-45.
  18. Wong M.L., L.G. Griffiths. 2014. Immunogenicity in xenogeneic scaffold generation: Antigen removal versus decellularization. Acta Biomater. 2014; 10(5): 1806-16.
  19. Carrade Holt D.D., J.A. Wood, J.L. Granick, N.J. Walker, K.C. Clark, D.L. Borjesson. Equine mesenchymal stem cells inhibit T cell proliferation through different mechanisms depending on tissue source. Stem Cells Dev. 2014; 23(11): 1258-65.
  20. Morgan J.T., J.A. Wood, N.J. Walker, V.K. Raghunathan, D.L. Borjesson, C.J. Murphy, P. Russell. Human Trabecular Meshwork Cells Exhibit Several Characteristics of, but Are Distinct from, Adipose-Derived Mesenchymal Stem Cells. J Ocul Pharmacol Ther. 2014; 30(2-3): 254-66.
  21. Cissell D.D., J.C. Hu, L.G. Griffiths, K.A. Athanasiou. 2013. Antigen removal for the production of biomechanically functional, xenogeneic tissue grafts. J Biomech. 2014; 47(9): 1987-96.
  22. Trela J.M., M. Spriet, K.A. Padgett, L.D. Galuppo, B. Vaughan, M.A. Vidal. Scintigraphic comparison of intra-arterial and distal intra-venous regional limb perfusion for administration of mesenchymal stem cells to the equine foot. Equine Vet J. 2014; 46(4): 479-83.
  23. Park S.A., J.A Wood, C.M. Reilly, D.J. Chung, D.D. Carrade, S.L. Deremer, R.L .Seraphin, K.C. Clark, A.L. Zwingenburger, D.L. Borjesson, K. Hayashi, P. Russell, C.J. Murphy. Safety and immunomodulatory effects of allogeneic canine adipose-derived mesenchymal stem cells transplanted into the region of the lacrimal gland and gland of the third eyelid and the knee joint. Cytotherapy. 2013; 15(12): 1498-1510.
  24. Toupadakis, C.A., J.L. Granick, M. Sagy, A. Wong, E. Ghassemi, D.J. Chung, D.L. Borjesson, C.E. Yellowley. Mobilization of Endogenous Stem Cell Populations Enhances Fracture Healing in Murine Femoral Fracture Model. Cytotherapy. 2013; 15(9): 1136-1147.
  25. Carrade, D.D., and D.L. Borjesson. Immunomodulation by Mesenchymal Stem Cells in Veterinary Species. Comp Med. 2013; 63(3): 207-17.
  26. Sole A., M. Spriet, K. Padgett, B. Vaughan, L.D. Galuppo, D.L. Borjesson, E.R. Wisner, M.A. Vidal. Distribution and persistence of technetium-99 hexamethyl propylene amine oxime-labelled bone marrow-derived mesenchymal stem cells in experimentally induced tendon lesions after intratendinous injection and regional perfusion of the equine distal limb. Equine Vet J. 2013; 45(6): 726-31.
  27. Bohannon, L.K., S.D. Owens, N.J. Walker, .D.D. Carrade, L.D. Galuppo, D.L. Borjesson. The effects of therapeutic concentrations of gentamicin, amikacin, and hyaluronic acid on cultured bone marrow derived equine mesenchymal stem cells. Equine Vet J. 2013; 45(6): 732-6.
  28. Wong M.L., J.L. Wong, K.A. Athanasiou, L.G. Griffiths. Stepwise solubilization-based antigen removal for xenogeneic scaffold generation in tissue engineering. Acta Biomater. 2013; 9(5): 6492- 501.
  29. Wood, J.A., I. Ly, D.L. Borjesson, P. Nealey, P. Russell, C.J. Murphy. The Modulation of Canine Mesenchymal Stem Cells by Nano-topographic Cues. Exp Cell Research. 2012; 318(19): 2438-45.
  30. Kol, A., N.J. Walker, L.D. Galuppo, K.C. Clark, S. Buerchler, A. Bernanke, D.L. Borjesson. Autologous point-of-care cellular therapies variably induce equine mesenchymal stem cell migration, proliferation and cytokine expression. Equine Veterinary Journal. 2012; 45(2): 193-198.
  31. Carrade, D.D., M.W. Lame, M.S. Kent, K.C. Clark, N.J. Walker, D.L. Borjesson. Comparative analysis of the immunomodulatory properties of equine adult-derived mesenchymal stem cells. Cell Medicine. 2012; 4(1): 1-11.
  32. Wood J.A., D.J. Chung, S.A. Park, A.L. Zwingenberger, C.M. Reilly, I. Ly, N.J. Walker, W. Vernau, K. Hayashi, E.R. Wisner, M.S. Cannon, P.H. Kass, S.R. Cherry, D.L. Borjesson, P. Russell, C.J. Murphy. Peri-ocular and intra-articular injection of canine adipose derived mesenchymal stem cells: an in vivo imaging and migration study. Journal of Ocular Pharmacology and Therapeutics. 2012; 28(3): 307- 317.
  33. Sole A., M. Spriet, L.D. Galuppo, K.A. Padgett, D.L. Borjesson, E. R. Wisner, R.J. Brosnan, M.A. Vidal. Scintigraphic evaluation of intra-arterial and intra-venous regional limb perfusion of allogeneic bone marrow-derived mesenchymal stem cells in the normal equine distal limb using 99mTc- HMPAO. Equine Veterinary Journal. 2012; 44(5): 594-599.
  34. Vidal, M.A., N.J.Walker, E. Napoli, D.L. Borjesson. Evaluation of senescence in mesenchymal stem cells isolated from equine bone marrow, adipose tissue and umbilical cord tissue. Stem Cells and Development. 2012; 21(2): 273-283.
  35. Carrade, D.D., V.K. Affolter, C.A. Outerbridge, J.L. Watson., L.D. Galuppo, S.Buerchler V. Kumar, N. J. Walker, D.L. Borjesson. Intradermal Injections of Equine Allogenic Umbilical Cord Derived Mesenchymal Stem Cells do not Elicit Graft Rejection or a Delayed Type Hypersensitivity Reaction. Cytotherapy. 2011; 13(10): 1190-1192.
  36. Owens, S.D., J. Burges, J.L. Johns, D.D. Carrade, L.D. Galuppo, F. Librach, D.L. Borjesson. Processing of equine bone marrow using the automated MarrowXpress System: RBC depletion, volume reduction, and mononuclear cell recovery. Vet Clin Pathol. 2011; 40(4): 444-449.
  37. Wong M.L., J.K. Leach, K.A. Athanasiou, L.G. Griffiths. The role of protein solubilization in antigen removal from xenogeneic tissue for heart valve tissue engineering. Biomaterials. 2011; 32(32): 8129-38.
  38. Arzi B., B. Murphy, N. Baumgarth, N. Vapniarsky, A. Nemec, D.K. Naydan, D.P. Cox, F.J. Verstraete. Analysis of immune cells within the healthy oral mucosa of specific pathogen-free cats. Anat Histol Embryol. 2011; 40(1): 1-10.
  39. Raheja L.F., D.C. Genetos, A. Wong, C.E. Yellowley. Hypoxic regulation of mesenchymal stem cell migration: the role of RhoA and HIF-1α. Cell Biol Int. 2011; 35(10): 981-9.
  40. Carrade, D.D., S.D. Owens, L.D. Galuppo, M.A.Vidal, G.L. Ferraro, F. Librach, S. Buerchler, M.S. Friedman, N.J. Walker, D.L. Borjesson. Clinicopathologic findings following intra-articular injection of autologous and allogeneic placentally-derived equine mesenchymal stem cells in horses. Cytotherapy. 2011; 13(4): 419-430.
  41. Toupadakis, C.A., A. Wong, D.C. Genetos, W.K. Cheung, D.L. Borjesson, G.L. Ferraro, J.K. Leach, L.D. Galuppo, S.D. Owens, and C.E. Yellowley. Comparison of the osteogenic potential of equine mesenchymal stem cells from bone marrow, adipose tissue, umbilical cord blood and umbilical cord tissue. Am J Vet Res. 2010; 71:1237-1245.
  42. Arzi B, B. Murphy, D.P. Cox, N. Vapniarsky, P.H. Kass, F.J. Verstraete. Presence and quantification of mast cells in the gingiva of cats with tooth resorption, periodontitis and chronic stomatitis. Arch Oral Biol. 2010; 55(2): 148-54.
  43. Schuh, E.M., M. Friedman, D.D. Carrade, J. Li, D. Heeke, S. Oyserman, L. D. Galuppo, D.J. Lara, N. J. Walker, G.L. Ferraro,  S.D. Owens, D.L. Borjesson. Identification of variables that optimize isolation and culture of multipotent mesenchymal stem cells from equine umbilical-cord blood. Am J Vet Res. 2009; 70(12): 1526- 1535.
  44. Bartholomew, S., S.D. Owens, G. L. Ferraro, D.L. Borjesson, D.D Carrade, D. J. Lara, L.D. Galuppo. Collection of Equine Cord Blood and Placental Tissues in Forty Thoroughbred Mares. Equine Veterinary Journal. 2009; 41(8): 724-728.